Yini i-Belinostat: Ukusetshenziswa, Umthamo, Imiphumela Eceleni nokuningi

I-Belinostat iyimithi yomdlavuza eqondiswe ngqo esiza ukwelapha izinhlobo ezithile zomdlavuza wegazi ngokuvimba amaprotheni athile adingwa amaseli omdlavuza ukuze akhule. Le mithi enikezwa ngomthambo ingeyeqembu elibizwa ngokuthi ama-histone deacetylase inhibitors, asebenza ngokungenelela ekukwazini kweseli lomdlavuza ukuziphindaphinda nokusinda.

Uzothola le mithi ngokufakwa ngomthambo esikhungweni sokwelashwa komdlavuza, lapho ithimba lakho lezempilo lingakuqapha khona eduze. Nakuba i-belinostat iyithuluzi elinamandla ekulweni nomdlavuza, ukuqonda ukuthi isebenza kanjani nokuthi yini ongayilindela kungakusiza ukuthi uzizwe ulungiseleleke kangcono ohambweni lwakho lokwelashwa.

Yini i-Belinostat?

I-Belinostat iyimithi yomdlavuza kadokotela eqondise ngqo ama-enzyme athile ngaphakathi kwamaseli omdlavuza ukusiza ukumisa ukukhula kwawo. Le mithi isebenza ngokuvimba ama-histone deacetylases, okuyiwona maprotheni asiza amaseli omdlavuza ukuthi asinde futhi aziphindaphinde ngokungakwazi ukulawulwa.

Le mithi iza njengempushana exutshwa namanzi ahlanzekile futhi inikezwe ngomugqa we-IV ngqo egazini lakho. I-FDA ivume i-belinostat ngokuqondile ukwelapha i-peripheral T-cell lymphoma, uhlobo olungavamile kodwa olunamandla lomdlavuza wegazi oluthinta amasosha akho omzimba.

Udkt wakho wezifo zomdlavuza uzoqoka ukuthi i-belinostat ilungele yini isimo sakho esithile ngokusekelwe ohlotsheni lwakho lomdlavuza, impilo yonke, nokuthi usabele kanjani ekwelashweni okuhlukile.

Isetshenziselwani i-Belinostat?

I-Belinostat isetshenziswa ikakhulukazi ukwelapha i-peripheral T-cell lymphoma (PTCL) ezigulini ezizame okungenani elinye elinye ukwelashwa elingasebenzanga kahle ngokwanele. I-PTCL iqembu lemivimbo yomdlavuza wegazi elinamandla elenzeka lapho amaseli amhlophe egazi athile abizwa ngokuthi ama-T-cells eba nomdlavuza.

Udktela wakho angase ancome i-belinostat uma i-lymphoma yakho ibuyile ngemuva kokuxolelwa noma uma ingaphendulanga ngokwanele ekwelashweni ngamakhemikhali kwangaphambilini. Lo muthi uvame ukucatshangelwa uma okunye ukwelashwa okujwayelekile kungaphumelelanga.

Ngezinye izikhathi, odokotela bangase basebenzise i-belinostat njengengxenye yezifundo zocwaningo ezinye izinhlobo zomdlavuza, kodwa ukusetshenziswa kwayo okuyinhloko okuvunyelwe kuseyile hlobo oluthile lwe-lymphoma.

Isebenza Kanjani I-Belinostat?

I-Belinostat isebenza ngokugxila kuma-enzyme abizwa ngokuthi ama-histone deacetylases (HDACs) eselula yomdlavuza ancike kuwo ukuze ahlale ephila futhi azale. Cabanga ngala ma-enzyme njengama-switch amangqamuzana asetshenziswa amaseli omdlavuza ukuvula nokuvala ama-gene athile.

Lapho i-belinostat ivimba la ma-enzyme, iphazamisa ikhono leselula yomdlavuza lokulawula ukukhula kwayo nezindlela zokusinda. Lokhu kuphazamisa kubangela ukuthi amaseli omdlavuza ayeke ukuzihlukanisa futhi ekugcineni afe, kuyilapho ngokuvamile kubangela ukulimala okuncane kumaseli anempilo.

Lo muthi ubhekwa njengonamandla ngokulinganisela, okusho ukuthi ungasebenza ngempumelelo ngomdlavuza ononya kodwa futhi ungase ubangele imiphumela emibi ebalulekile. Ithimba lakho lezempilo lizolinganisela ngokucophelela izinzuzo ezingozini ezingaba khona ngokusekelwe esimweni sakho.

Kufanele Ngiyithathe Kanjani I-Belinostat?

Uzothola i-belinostat njengokufakwa ngemithambo ngemizuzu engama-30 ezinsukwini zokuqala kwezi-5 zomjikelezo wokwelashwa wezinsuku ezingama-21. Umuthi kufanele unikezwe esikhungweni sokwelashwa komdlavuza lapho ochwepheshe bezempilo abaqeqeshiwe bengawulungisa futhi bawuphathe ngokuphepha.

Ngaphambi kokufakwa ngakunye, ithimba lakho lezempilo lizohlola ukubalwa kwegazi lakho nempilo yonke ukuze liqinisekise ukuthi umzimba wakho ulungele ukwelashwa. Akudingeki ukuthi uthathe i-belinostat nokudla ngoba ingena ngqo emgudwini wakho wegazi, kodwa ukuhlala unamanzi kahle ngaphambi nangemva kokwelashwa kungasiza umzimba wakho ukuthi uqhubeke nomuthi.

Umnakekeli wakho uzofaka umugqa we-IV engalweni yakho noma afinyelele echwebeni lakho uma unalo. Ngesikhathi sokufakwa, uzoqashwa nganoma yiziphi izimo eziphuthumayo, futhi ngokuvamile ungafunda, usebenzise amadivayisi kagesi, noma uphumule ngokunethezeka.

Kufanele ngithathe isikhathi esingakanani i-Belinostat?

Ubude bokwelashwa nge-belinostat buhlukahluka kakhulu kumuntu nomuntu, kuye ngokuthi umdlavuza wakho usabela kahle kangakanani nokuthi umzimba wakho ukubekezelela kanjani imithi. Abantu abaningi bathola imijikelezo eminingi, umjikelezo ngamunye uthatha izinsuku ezingama-21.

Udokotela wakho we-oncologist uzoqapha inqubekela phambili yakho ngokuhlolwa kwegazi okuvamile, ukuskena izithombe, nokuhlolwa komzimba ukuze anqume ukuthi ukwelashwa kusebenza ngempumelelo yini. Uma umdlavuza wakho usabela kahle futhi ukubekezelela imithi ngendlela efanele, ungaqhubeka nokwelashwa izinyanga eziningana.

Ukwelashwa ngokuvamile kuqhubeka kuze kube yilapho umdlavuza wakho uyeka ukusabela emuthini, imiphumela emibi iba nzima kakhulu ukuphatha, noma umdlavuza wakho ungena ekuxolelweni. Ithimba lakho lezempilo lizoxoxa ngalezi zinqumo nawe kuyo yonke indlela yakho yokwelashwa.

Yini Imiphumela Eceleni ye-Belinostat?

Njengemithi eminingi yomdlavuza, i-belinostat ingabangela imiphumela emibi evela kokulula kuye kokukhulu. Ukuqonda okulindelekile kungakusiza ukuthi ulungiselele futhi wazi ukuthi ungaxhumana nini nethimba lakho lezempilo.

Imiphumela emibi evame kakhulu ongase uyithole ihlanganisa ukukhathala, isicanucanu, umkhuhlane, nokuncipha kwesifiso sokudla. Abantu abaningi baphinde bathuthukise ukubala kwamangqamuzana egazi okuphansi, okungandisa ingozi yakho yokutheleleka, ukopha, noma i-anemia.

Imiphumela Evamile Eceleni

Le miphumela emibi yenzeka kubantu abaningi abathatha i-belinostat futhi ngokuvamile iphathwa ngokunakekelwa okufanele nokuqapha:

• Ukukhathala nobuthakathaka obungase buqhubeke phakathi kwemijikelezo yokwelashwa
• Isicanucanu nokuhlanza, okuvame ukulawulwa ngemithi elwa nesicanucanu
• Umkhuhlane namakhaza, ikakhulukazi ezinsukwini ezilandelayo ukwelashwa
• Ukuncipha kwesifiso sokudla kanye nezinguquko ekunambithekeni
• Ukuqunjelwa noma isifo sohudo
• Ukuphefumula kanzima ngesikhathi sokuzivocavoca
• Ukucindezeleka kwekhanda nesiyezi
• Ukuqubuka kwesikhumba noma ukuluma

Ithimba lakho lezempilo lizohlinzeka ngemithi namasu okusiza ukuphatha lezi zimpawu futhi ligcine izinga lempilo yakho ngesikhathi sokwelashwa.

Imiphumela emibi engathi sína

Nakuba ingavamile, eminye imiphumela emibi idinga ukunakekelwa kwezempilo ngokushesha kanye nokuqapha ngokucophelela ngesikhathi sokwelashwa kwakho:

• Ukwehla okukhulu kwenani lamaseli egazi (i-neutropenia, i-thrombocytopenia, i-anemia)
• Izifo ezingathi sína ngenxa yesistimu yokuzivikela ebuthakathaka
• Ukuphuma kwegazi okukhulu noma ukulimala
• Izinkinga zesibindi, okuhlanganisa ama-enzyme esibindi aphakeme
• Ukuphazamiseka kwesigqi senhliziyo noma ezinye izinkinga zenhliziyo
• Ukungezwani komzimba okukhulu ngesikhathi noma ngemva kokufakwa
• I-Tumor lysis syndrome, lapho amaseli omdlavuza ewohloka ngokushesha kakhulu

Ithimba lakho lezokwelapha lizogada lezi zinkinga ngokusebenzisa ukuhlolwa kwegazi njalo nokuhlolwa, futhi lizolungisa uhlelo lwakho lokwelashwa uma kudingeka.

Imiphumela emibi engavamile kodwa engathi sína

Ezimweni ezingavamile kakhulu, i-belinostat ingase ibangele izinkinga ezingathi sína ezidinga ukungenelela kwezokwelapha ngokushesha:

• Umonakalo omkhulu wesibindi noma ukwehluleka kwesibindi
• Izifo ezisongela impilo noma i-sepsis
• Izinkinga zenhliziyo ezingathi sína noma ukwehluleka kwenhliziyo
• Imidlavaza yesibili engase ithuthuke eminyakeni eminingi kamuva
• Ukuphendula kwesikhumba okukhulu noma ukulimala kwesicubu

Nakuba lezi zinkinga zingavamile, ithimba lakho lezempilo lizohlala liqaphile ngezimpawu zokuqala zokuxwayisa futhi lithathe isinyathelo esifanele uma zenzeka.

Ubani okungafanele athathe i-Belinostat?

I-Belinostat ayifanele wonke umuntu, futhi udokotela wakho uzohlola ngokucophelela ukuthi lo muthi uphephile yini esimweni sakho esithile. Ezinye izimo zempilo noma izimo zingenza lokhu kwelashwa kube yingozi kakhulu.

Akufanele uthole i-belinostat uma wazi ukuthi unokungezwani komzimba nomuthi noma yiziphi izingxenye zawo. Ngaphezu kwalokho, uma unesifo esibi sesibindi, udokotela wakho angase agweme lokhu kwelashwa ngoba i-belinostat ingathinta ukusebenza kwesibindi.

Abantu abanezinkinga ezinkulu zenhliziyo, izifo ezinzima ezisebenzayo, noma ukubala kwamangqamuzana egazi okuphansi kakhulu kungenzeka bangabi ngabazali abahle bokwelashwa nge-belinostat. Udokotela wakho we-oncologist uzohlola lezi zici ngokumelene nezinzuzo ezingaba khona zokwelashwa.

Izinto Ezikhethekile Okufanele Zicatshangelwe

Amaqembu athile abantu adinga ukuhlolwa nokuqapha okwengeziwe uma kucatshangelwa ukwelashwa nge-belinostat:

• Abesifazane abakhulelwe noma abancelisayo (i-belinostat ingalimaza izingane ezisakhula)
• Abantu abanezinkinga zesibindi ezikhona noma i-hepatitis
• Iziguli ezinokuphazamiseka kwesigqi senhliziyo noma isifo senhliziyo
• Labo abanezinkinga zezinso noma ukusebenza kwezinso okuncishisiwe
• Abantu abathatha ama-blood thinners noma abanezifo zokuphuma kwegazi
• Iziguli ezinamasistimu omzimba angavikelekile ngenxa yezinye izimbangela

Ithimba lakho lezempilo lizobuyekeza ngokucophelela umlando wakho wezokwelapha kanye nesimo sakho sempilo yamanje ngaphambi kokuncoma ukwelashwa nge-belinostat.

Amagama Omkhiqizo we-Belinostat

I-Belinostat iyatholakala ngaphansi kwegama lomkhiqizo elithi Beleodaq e-United States. Le yiyona kuphela ifomula ye-belinostat etholakala ngokuhweba okwamanje evunywe yi-FDA.

I-Beleodaq iza njengempushana eyomile eyenziwa kabusha ochwepheshe bezempilo ngamanzi ahlanzekile ngaphambi kokuphathwa. Umuthi ukhiqizwa yi-Acrotech Biopharma futhi utholakala kuphela ngemithi ekhethekile kanye nezikhungo zokwelapha umdlavuza.

Ngeke uthole izinhlobo ezivamile ze-belinostat okwamanje, njengoba umuthi usavikelwe ngamalungelo obunikazi. Lokhu kusho ukuthi i-Beleodaq okwamanje iyona kuphela inketho etholakalayo yokwelashwa nge-belinostat.

Ezinye Izindlela Zokwelapha Nge-Belinostat

Uma i-belinostat ingakulungele noma iyeka ukusebenza ngempumelelo, udokotela wakho we-oncologist unezinye izinketho zokwelapha i-peripheral T-cell lymphoma. Lezi ezinye izindlela zokwelapha zisebenza ngezindlela ezihlukene futhi zingase zikulungele kangcono isimo sakho esithile.

Ezinye izithiyo ze-HDAC ezifana ne-romidepsin (Istodax) zisebenza ngendlela efanayo ne-belinostat futhi zingase zicatshangelwe uma ungenakukwazi ukubekezelela i-belinostat. Ngaphezu kwalokho, izindlela zokwelapha ezintsha ezihloswe ngqo kanye nezinketho ze-immunotherapy ziya ngokuya zitholakala kuma-T-cell lymphomas.

Izinhlanganisela zokwelapha ngamakhemikhali zendabuko, ukufakelwa kwamaseli esiqu, noma ukubamba iqhaza ezivivinyweni zemitholampilo zokwelashwa okungokwesikhashana kungase kube ezinye izinketho kuye ngempilo yakho yonke kanye nomlando wokwelashwa.

Ingabe i-Belinostat Ingcono Kune-Romidepsin?

Kokubili i-belinostat ne-romidepsin ziyizithiyo ze-HDAC ezisetshenziselwa ukwelapha i-peripheral T-cell lymphoma, kodwa akudingeki ukuthi zibe ngcono noma zibe zimbi kunomunye nomunye. Umuthi ngamunye unezinzuzo zawo kanye nephrofayili yemiphumela engemihle engenza omunye ukuthi ukulungele kangcono isimo sakho esithile.

I-Belinostat inikezwa njenge-infusion emfushane ngemizuzu engama-30 izinsuku ezinhlanu zilandelana, kuyilapho i-romidepsin idinga ama-infusion amade ezinsukwini ezithile zomjikelezo. Abanye abantu bayabekezelela umuthi owodwa kangcono kunomunye mayelana nemiphumela engemihle.

Udokotela wakho we-oncologist uzocabangela izinto ezinjengempilo yakho yonke, ukwelashwa kwangaphambilini, ukusebenzisana okungenzeka kwemithi, kanye nezintandokazi zomuntu siqu lapho ekhetha phakathi kwalezi zinketho. Ukukhetha

I-Belinostat idinga ukucatshangelwa ngokucophelela kubantu abanezinkinga zesibindi ezikhona ngoba umuthi ungase uthinte ukusebenza kwesibindi. Udokotela wakho uzodinga ukuhlola ubukhulu besifo sakho sesibindi futhi alinganise izinzuzo ezingaba khona nezingozi.

Uma unezinkinga zesibindi ezincane, udokotela wakho angase asacabange ukusebenzisa i-belinostat kodwa ngokuhlola njalo izivivinyo zakho zokusebenza kwesibindi. Kodwa-ke, uma unesifo sesibindi esibi noma i-hepatitis esebenzayo, i-belinostat kungenzeka ingaphephile kuwe.

Ithimba lakho lezempilo lizokwenza izivivinyo zokusebenza kwesibindi ngaphambi kokuqala ukwelashwa futhi lizihlole njalo ngesikhathi sokwelashwa kwakho ukuze liqinisekise ukuthi isibindi sakho siphatha umuthi ngokuphepha.

Kufanele ngenzeni uma ngithola i-Belinostat eningi ngengozi?

Njengoba i-belinostat inikezwa ochwepheshe bezempilo endaweni elawulwayo yezokwelapha, ukweqisa ngengozi akuvamile kakhulu. Kodwa-ke, uma usola ukuthi uthole umuthi omningi kakhulu, yazisa ngokushesha umhlengikazi wakho noma udokotela.

Akukho umuthi oqondile wokweqisa i-belinostat, ngakho ukwelashwa kungagxila ekuphatheni noma yiziphi izimpawu eziqhamukayo. Ithimba lakho lezokwelapha lizokuhlola ngokucophelela izimpawu zokwanda kwemiphumela emibi, ikakhulukazi ukwehla kwenani lamaseli egazi noma izinkinga zesibindi.

Imvelo yokuphatha elawulwayo nokubalwa kwemithamo ngokucophelela kusiza ekuvimbeleni izimo zokweqisa, kodwa ithimba lakho lezempilo lilungele ukusabela ngokushesha uma kwenzeka noma yimaphi amaphutha emithamo.

Kufanele ngenzeni uma ngiphuthelwa umthamo we-Belinostat?

Uma uphuthelwa ukufakwa kwe-belinostat okuhleliwe, xhumana nethimba lakho le-oncology ngokushesha ukuze lihlehlise. Ungazami ukwenza imithamo ephuthelwe ngokwenza kabili noma ukushintsha isimiso sakho ngaphandle kwesiqondiso sezokwelapha.

Udokotela wakho uzonquma indlela engcono kakhulu yokuqhubeka ngokuya ngokuthi kungani uphuthelwe umthamo nokuthi ukuphi emjikelezweni wakho wokwelashwa. Ngezinye izikhathi, bangase balungise isimiso sakho somjikelezo noma bashintshe uhlelo lwakho lokulinganisa.

Imithamo elahlekile ingathinta ukusebenza kokwelashwa kwakho, ngakho kubalulekile ukugcina zonke izikhathi zakho ezihleliwe futhi uxhumane nethimba lakho uma unenkinga yokufika ekwelashweni.

Ngingayeka nini ukuthatha i-Belinostat?

Kufanele uyeke kuphela ukwelashwa nge-belinostat ngaphansi kokuqondisa udokotela wakho we-oncologist. Isinqumo sokuyeka ukwelashwa sincike ezintweni eziningana, okuhlanganisa ukuthi umdlavuza wakho usabela kahle kangakanani, yiziphi imiphumela emibi oyitholayo, kanye nesimo sakho sempilo esiphelele.

Udokotela wakho angase ancome ukuyeka i-belinostat uma umdlavuza wakho ungena ekuxoleleni, uma imiphumela emibi iba nzima kakhulu ukuyilawula, noma uma umuthi uyeka ukusebenza ngempumelelo ngomdlavuza wakho.

Ungalokothi uyeke ukwelashwa nge-belinostat ngokwakho, ngisho noma uzizwa ungcono noma uthola imiphumela emibi. Udokotela wakho we-oncologist udinga ukuhlola isimo sakho esiphelele futhi angase adinge ukukushintshela kwezinye izindlela zokwelapha noma ukunakekelwa okusekelayo.

Ngingathatha eminye imithi ngenkathi ngise-Belinostat?

Ungathatha eminye imithi ethile ngenkathi uthola i-belinostat, kodwa ithimba lakho lezempilo lidinga ukubuyekeza konke okuthathayo ukuze ugweme ukuxhumana okuyingozi. Eminye imithi ingandisa imiphumela emibi ye-belinostat noma iphazamise ukusebenza kwayo.

Ngaso sonke isikhathi yazisa udokotela wakho we-oncologist ngayo yonke imithi kadokotela, imithi etholakala ngaphandle kwe-oda, amavithamini, nezithasiselo ozithathayo. Bazonquma ukuthi yini ephephile ukuqhubeka nokuthi yini okungenzeka idinge ukulungiswa noma ukuyekwa.

Usokhemisi wakho nethimba le-oncology bazosebenza ndawonye ukuqinisekisa ukuthi yonke imithi yakho iyahambisana nokuthi uthola ukwelashwa okuphephe kakhulu, okusebenzayo.