Yini i-Boceprevir: Ukusetshenziswa, Umthamo, Imiphumela Eceleni nokuningi

I-Boceprevir iyimithi elwa namagciwane eyenzelwe ngqo ukwelapha ukutheleleka okungamahlalakhona kwe-hepatitis C. Lo muthi oqoshwe ngudokotela ungowesigaba semithi ebizwa ngokuthi ama-protease inhibitors, asebenza ngokuvimba i-enzyme i-hepatitis C virus eyidingayo ukuze iphindaphindeke emzimbeni wakho.

Ngenkathi i-boceprevir yayike yaba yindlela ebalulekile yokwelapha, kufanelekile ukuqaphela ukuthi imithi emisha, esebenza kahle kakhulu ye-hepatitis C isiyithathe indawo enkulu ekusebenzeni komtholampilo. Udokotela wakho uzosiza ekunqumeni indlela engcono kakhulu yokwelapha isimo sakho esithile.

Yini i-Boceprevir Esetshenziselwa Yona?

I-Boceprevir isetshenziselwa ukwelapha ukutheleleka okungamahlalakhona kwe-hepatitis C, ikakhulukazi i-genotype 1 yegciwane. Lo muthi wagunyazwa ukusiza abantu abangakwazanga ukususa i-hepatitis C virus bodwa.

Lo muthi uhlala usetshenziswa ngokuhlanganyela neminye imithi ye-hepatitis C, awusetshenziswa wodwa. Umhlinzeki wakho wezempilo ngokuvamile uzoyiqoka kanye ne-peginterferon alfa kanye ne-ribavirin njengengxenye yalokho okubizwa ngokuthi i-triple therapy.

Kubalulekile ukuqonda ukuthi i-boceprevir ayisathathwa njengokwelashwa kokuqala kwe-hepatitis C. Imithi emisha enemiphumela emincane eceleni kanye namazinga angcono okuphulukisa isibe yindinganiso yokunakekelwa ezimweni eziningi.

Isebenza Kanjani i-Boceprevir?

I-Boceprevir isebenza ngokugxila ku-enzyme ethile ebizwa nge-NS3/4A protease edingwa yi-hepatitis C virus ukuze iphindaphindeke. Cabanga ngale enzyme njengombhangqwana wemishini yezinhlayiya ezincane ezisetshenziswa yigciwane ukusika amaprotheni eliwadingayo ukuze lenze amakhophi alo.

Lapho i-boceprevir ivimba le enzyme, empeleni isusa ikhono legciwane lokuziphindaphinda ngempumelelo. Lokhu kunikeza amasosha akho omzimba neminye imithi ithuba elingcono lokususa ukutheleleka emzimbeni wakho.

Njengomvimbi we-protease, i-boceprevir ithathwa njengomuthi olinganiselwe oqinile wokulwa namagciwane. Kodwa-ke, igciwane le-hepatitis C lingakwazi ukumelana nayo, yingakho kufanele isetshenziswe neminye imithi futhi kungani ukwelashwa okusha sekukhethwa.

Kufanele Ngiyithathe Kanjani I-Boceprevir?

I-Boceprevir kufanele ithathwe ngendlela eqondile udokotela wakho ayiyalayo, ngokuvamile kathathu ngosuku ngokudla. Ukuyithatha ngokudla kusiza umzimba wakho ukuba umunce imithi kahle futhi kunganciphisa ukuphazamiseka kwesisu.

Umthamo ojwayelekile uvamise ukuba ngu-800 mg kathathu ngosuku, okusho ukuthatha amaphilisi amane e-200 mg ngaso sonke isikhathi. Uzodinga ukuhlukanisa le mithi cishe ngamahora angu-7 kuya kwangu-9 ngosuku lonke ukuze ugcine amazinga aqhubekayo egazini lakho.

Kubalulekile ukuthatha i-boceprevir ngokudla okuqukethe amafutha athile, ngoba lokhu kuthuthukisa kakhulu ukuthi umzimba wakho uyimunca kangakanani imithi. Ukudla okulula ngamafutha amancane, njengamantongomane noma ushizi, kuvame ukwanele uma ungadli ukudla okugcwele.

Ungalokothi uchoboze noma uvule amaphilisi, ngoba lokhu kungathinta ukuthi imithi ikhishwe kanjani emzimbeni wakho. Uma unenkinga yokugwinya amaphilisi, khuluma nomhlinzeki wakho wezempilo mayelana nezinketho ezingezinye.

Kufanele Ngiyithathe Isikhathi Esingakanani I-Boceprevir?

Ubude bokwelashwa nge-boceprevir buvame ukusuka kumaviki angu-24 kuya kwangu-48, kuye ngokuthi usabela kahle kangakanani emithini kanye nesimo sakho sezokwelapha esithile. Udokotela wakho uzoqapha inqubekela phambili yakho ngokuhlolwa kwegazi okujwayelekile ukuze anqume ubude obufanele kuwe.

Abantu abaningi baqala ngesikhathi sokuhola samaviki angu-4 bethatha i-peginterferon ne-ribavirin ngaphambi kokwengeza i-boceprevir. Le ndlela isiza ithimba lakho lezempilo ukuthi libone ukuthi uyayibekezelela kanjani imithi yokuqala futhi ingathuthukisa impendulo yakho yonke ekwelashweni.

Uma amazinga akho e-viral engabonakali ekuqaleni kokwelashwa, ungase ukwazi ukuqeda ukwelashwa ngamaviki angu-24. Kodwa-ke, uma igciwane lisabonakala ezingqondweni ezithile, ukwelashwa kungase kudingeke kuqhubeke kuze kube ngamaviki angu-48.

Kubaluleke kakhulu ukuqeda inkambo ephelele yokwelashwa ngisho noma uqala ukuzizwa ungcono. Ukuyeka ngaphambi kwesikhathi kungaholela ekwehlulekeni kokwelashwa futhi kungenzeka kuvumele igciwane ukuthi likwazi ukumelana nemithi.

Yiziphi Izimo Ezingezinhle Zokuthatha i-Boceprevir?

I-Boceprevir ingabangela imiphumela eminingi engemihle, futhi kubalulekile ukwazi okulindelekile ukuze ukwazi ukusebenza nethimba lakho lezempilo ukuze uliphatha ngempumelelo. Abantu abaningi bahlangabezana nemiphumela ethile engemihle, kodwa eminingi iyaphathwa ngosizo olufanele.

Imiphumela eminingi engemihle ongase uyithole ihlanganisa ukukhathala, isicanucanu, ikhanda, kanye nezinguquko ekunambithekeni. Lezi zimpawu zivame ukuthuthuka ngoba i-boceprevir isetshenziswa neminye imithi enayo imiphumela yayo engemihle.

Imiphumela Ejwayelekile Engemihle

Nansi imiphumela engemihle abantu abaningi abayitholayo ngenkathi bethatha i-boceprevir:

• Ukukhathala nobuthakathaka obungaba bukhulu kakhulu
• Isicanucanu nokuhlanza, ikakhulukazi emasontweni ambalwa okuqala
• Ikhanda elingasukela kokuncane kuya kokulingene
• Ukunambitheka okuyinsimbi noma okuguquliwe emlonyeni wakho
• Ukuncipha kwesifiso sokudla nokwehla kwesisindo
• Ukuqunjelwa noma ezinye izinkinga zokugaya ukudla
• Ubunzima bokulala noma ukuqwasha
• Isikhumba esomile nokuluma

Le miphumela ejwayelekile engemihle ivame ukuphathwa ngokunakekelwa okusekelayo futhi ivame ukuthuthuka njengoba umzimba wakho ujwayela imithi. Ithimba lakho lezempilo linganikeza amasu okukusiza ukuthi ubhekane nalezi zimpawu.

Imiphumela Engemihle Engathi Sína

Nakuba ingavamile, i-boceprevir ingabangela imiphumela engemihle engathi sína edinga ukunakekelwa kwezokwelapha ngokushesha. Kubalulekile ukuqaphela lezi zimpawu zokuxwayisa futhi uthinte udokotela wakho ngokushesha uma zenzeka.

Imiphumela emibi ekhathazayo kakhulu ihlanganisa i-anemia ebucayi, ukusabela kwesikhumba okukhulu, kanye nezinguquko zemizwa ezingabonisa ukucindezeleka noma ezinye izinkinga zempilo yengqondo.

• I-anemia ebucayi edinga ukumpontshelwa igazi noma ukulungiswa kwemithi
• Ukusabela kwesikhumba okukhulu okuhlanganisa ukuqubuka okukhulu noma ukuvuvukala
• Izimpawu zokucindezeleka, ukukhathazeka, noma imicabango yokuzilimaza
• Ukukhathala okukhulu okuphazamisa imisebenzi yansuku zonke
• Ukuphuma kwegazi okungavamile noma ukulimala
• Izimpawu zokutheleleka njengomkhuhlane oqhubekayo
• Ukuphefumula kanzima noma ubuhlungu besifuba

Uma uhlangabezana nanoma yimiphi yale miphumela emibi engathi sína, unganqikazi ukuxhumana nomhlinzeki wakho wezempilo ngokushesha. Ukungenelela ngokushesha kungasiza ekuvikeleni izinkinga futhi kuqinisekise ukuphepha kwakho kuyo yonke imithi.

Imiphumela emibi engavamile kodwa ebalulekile

Kunemiphumela emibi engavamile, nakuba ingavamile, ebalulekile ukuyazi ngoba ingaba yingozi uma yenzeka.

Lokhu kuhlanganisa izinkinga ezinkulu zesibindi, izifo zegazi, kanye nokusabela okungavamile kodwa okukhulu komzimba. Udokotela wakho uzokuhlola ngokucophelela ngalezi zinto ezingenzeka ngokusebenzisa izivivinyo zokuhlolwa ezivamile.

• Ubuthi obukhulu besibindi, nakuba lokhu kungavamile kakhulu
• Izifo zegazi ezingathi sína ezithinta amaseli amhlophe egazi noma ama-platelet
• Ukusabela okukhulu komzimba okuhlanganisa ukuphefumula kanzima noma ukuvuvukala
• Izinkinga zesigqi senhliziyo, ikakhulukazi kubantu abanezimo zenhliziyo ezikhona
• Izimpawu ezinzima ze-neurological njengokudideka noma ukushaywa yisithuthwane

Nakuba le miphumela emibi engavamile ikhathaza, khumbula ukuthi ithimba lakho lezempilo lizokuhlola ngokucophelela kuyo yonke imithi ukuze libambe noma yiziphi izinkinga ngokushesha.

Ubani okungafanele athathe i-Boceprevir?

I-Boceprevir ayifanele wonke umuntu, futhi kunezimo eziningana lapho le mithi kufanele igwenywe noma isetshenziswe ngokuqapha okukhulu. Udokotela wakho uzobuyekeza ngokucophelela umlando wakho wezokwelapha ngaphambi kokuyinika.

Abantu abanezimo ezithile zezokwelapha noma labo abathatha imithi ethile kungenzeka bangabi ngabakhethekile ekwelashweni kwe-boceprevir. Yingakho ukuhlolwa okujulile kwezokwelapha kubalulekile ngaphambi kokuqala ukwelashwa.

Izimo Zezokwelapha Ezingase Zivimbele Ukusetshenziswa

Izimo eziningana zempilo zingenza ukwelashwa nge-boceprevir kungafaneleki noma kudingeke ukuqashwa okukhethekile:

• Isifo sesibindi esibi noma ukuhluleka kwesibindi
• Izinkinga ezinzima zezinso noma i-dialysis
• Isifo senhliziyo esibi noma ukuhlaselwa yinhliziyo kwakamuva
• Umfutho wegazi ophezulu ongagadiwe
• Ukucindezeleka okukhulu noma umlando wokuzama ukuzibulala
• Izifo ze-Autoimmune ezingase zibe zimbi ngokwelashwa
• Isifo samaphaphu esibi
• Isifo sikashukela esingagadiwe

Uma unezinye zalezi zimo, akusho ngempela ukuthi awukwazi ukuthola ukwelashwa, kodwa udokotela wakho uzodinga ukukala ngokucophelela izingozi nezinzuzo.

Ukukhulelwa Nokuncelisa Ibele

I-Boceprevir akufanele isetshenziswe ngesikhathi sokukhulelwa ngoba ihlanganiswe ne-ribavirin, engabangela ukukhubazeka okukhulu kokuzalwa. Uma ukhulelwe noma uhlela ukukhulelwa, udokotela wakho uzoxoxa ngezinketho zokwelashwa ezingezinye.

Bobabili abesilisa nabesifazane abathatha ukwelashwa okuhlanganisiwe kwe-boceprevir kumele basebenzise izindlela zokuvimbela inzalo ezisebenzayo ngesikhathi sokwelashwa kanye nasezinyangeni eziningana ngemva kwalokho. Ingxenye ye-ribavirin ingahlala ohlelweni lwakho izinyanga ngemva kokuyeka ukwelashwa.

Uma uncelisa, uzodinga ukuxoxa nodokotela wakho ukuthi uzoqhubeka yini nokuncelisa noma uqale ukwelashwa kwe-hepatitis C, njengoba imithi ingadlulela obisini lwebele.

Amagama Omkhiqizo we-Boceprevir

I-Boceprevir itholakala ngaphansi kwegama lomkhiqizo elithi Victrelis. Leli kwakuyigama lomkhiqizo lokuqala lapho umuthi uthola imvume evela e-FDA.

Noma kunjalo, kubalulekile ukuqaphela ukuthi i-Victrelis ayisatholakali ngumenzi wayo futhi ayisatholakali emazweni amaningi. Isinqumo sokuyeka ukukhiqizwa senziwe ngoba kwatholakala imithi emisha, esebenza kahle kakhulu yokwelapha i-hepatitis C.

Uma ngabe uke wathatha i-Victrelis ngaphambili, udokotela wakho wayezosebenza nawe ukuze ushintshele komunye wemithi emisha eqondile yokulwa namagciwane enikeza amazinga angcono okuphulukisa nemiphumela emibi embalwa.

Ezinye izindlela ze-Boceprevir

Imithi eminingi emisha isithathe indawo ye-boceprevir njengendlela ejwayelekile yokwelapha i-hepatitis C. Lezi ezinye izindlela zinikeza izinzuzo ezinkulu ezihlanganisa amazinga aphezulu okuphulukisa, imiphumela emibi embalwa, kanye nobude bokwelashwa obufushane.

Indlela ejwayelekile yokwelapha njengamanje ihlanganisa imithi eqondile yokulwa namagciwane (DAA) engaphulukisa i-hepatitis C emasontweni ayi-8 kuya kwayi-12 ngemiphumela emibi embalwa. Umhlinzeki wakho wezempilo angasiza ekunqumeni ukuthi iyiphi inketho engcono kakhulu esimweni sakho esithile.

Ukwelashwa Okujwayelekile Kwamanje

Ukwelashwa kwesimanje kwe-hepatitis C kuvame ukubandakanya enye yalezi ezinye izindlela ezisebenza kahle kakhulu:

• I-Sofosbuvir/velpatasvir (Epclusa) - isebenza ngokumelene nazo zonke izinhlobo ze-hepatitis C
• I-Glecaprevir/pibrentasvir (Mavyret) - enye inketho ye-pan-genotypic
• I-Sofosbuvir/ledipasvir (Harvoni) - isebenza ngempumelelo ngohlobo 1
• Izinhlanganisela ze-Sofosbuvir/ribavirin ezigulini ezithile

Lezi zindlela zokwelapha ezintsha zinikeza amazinga okuphulukisa angaphezu kuka-95% futhi ngokuvamile zidinga amasonto angu-8 kuya kwayi-12 kuphela okwelashwa. Ziphinde zibe nemiphumela emibi eminingi ebekezelelekayo uma iqhathaniswa nezindlela ezisekelwe ku-boceprevir.

Ingabe i-Boceprevir Ingcono Kune-Telaprevir?

Kokubili i-boceprevir ne-telaprevir kwakuyizinto zokuqala zokuvimbela i-protease ezazisetshenziselwa ukwelapha i-hepatitis C, futhi zazinempumelelo efanayo ezivivinyweni zomtholampilo. Ukukhetha phakathi kwazo kwavame ukwehla emiphumeleni emibi kanye nokulula kokulinganisa.

I-Boceprevir ngokuvamile yayibhekwa njengenenkinga encane yokuthola imiphumela emibi, ikakhulukazi mayelana nokuqubuka kwesikhumba, okwakuvamile nge-telaprevir. Kodwa-ke, i-boceprevir idinga ukuthathwa kaningi usuku lonke.

Lokhu kuqhathanisa manje sekuyisifundo nje ngoba womabili lawo machiza ayekisiwe ukuze kuthathwe imithi emisha, esebenza kahle kakhulu. Ukwelashwa kwamanje kwe-hepatitis C kungcono kakhulu kune-boceprevir ne-telaprevir mayelana nokusebenza kahle nokubekezeleleka.

Imibuzo Evame Ukubuzwa Mayelana ne-Boceprevir

Ingabe i-Boceprevir iphephile kubantu abanezifo zezinso?

I-Boceprevir ingasetshenziswa kubantu abanezinkinga zezinso eziphakathi nendawo, kodwa idinga ukuqashwa ngokucophelela nokulungiswa kwemithamo okungenzeka. Umuthi ucubungulwa yisibindi sakho kunokuba izinso zakho, ngakho ukusebenza kwezinso akuthinti ngokuqondile indlela i-boceprevir esuswa ngayo emzimbeni wakho.

Kodwa-ke, abantu abanezifo ezinzima zezinso noma labo abase-dialysis kungenzeka bangabi ngabantu abafanelekayo ekwelashweni nge-boceprevir. Lokhu kungenxa yokuthi ukwelashwa okuhlanganisiwe kufaka phakathi eminye imithi engaba yinkinga kubantu abanezinkinga zezinso.

Uma unezinkinga zezinso, udokotela wakho uzodinga ukuqapha ukusebenza kwezinso zakho ngokucophelela ngaso sonke isikhathi sokwelashwa futhi kungase kudingeke alungise imithamo yeminye imithi oyithathayo nge-boceprevir.

Ngingenzani uma ngithatha i-Boceprevir eningi ngengozi?

Uma ngengozi uthatha i-boceprevir eningi kunaleyo ebekiwe, xhumana nomhlinzeki wakho wezempilo noma isikhungo sokulawula ubuthi ngokushesha. Ngenkathi kungekho umuthi oqondile wokweqisa we-boceprevir, ochwepheshe bezokwelapha bangahlinzeka ngokunakekelwa okusekelayo futhi bakuqaphe ngezinkinga.

Ukuthatha i-boceprevir eningi kungase kwandise ingozi yakho yemiphumela emibi, ikakhulukazi lezo ezithinta ukubalwa kwegazi lakho noma ukusebenza kwesibindi. Ungazami ukuthi "ulungise" ukweqisa ngokweqa umthamo wakho olandelayo.

Ukuvimbela ukweqisa kwemithi ngengozi, cabangela ukusebenzisa umhleli wamaphilisi noma ukusetha izikhumbuzi ocingweni lwakho. Uma unenkinga yokukhumbula imithamo yakho, khuluma nethimba lakho lezempilo mayelana namasu okukusiza ukuthi uhlale emgwaqeni.

Ngingenzani uma ngiphuthelwa umthamo we-Boceprevir?

Uma uphuthelwa umthamo we-boceprevir, yithathe ngokushesha nje lapho ukhumbula, uma nje kungaphakathi kwamahora amabili esikhathi sakho somthamo esihleliwe. Uma sekudlule amahora angaphezu kwama-2, weqa umthamo ophuthelwe bese uthatha umthamo wakho olandelayo ohleliwe ngesikhathi esijwayelekile.

Ungalokothi uthathe imithamo emibili ngesikhathi esisodwa ukuze ulungise umthamo ophuthelwe, ngoba lokhu kungakhuphula ingozi yakho yemiphumela emibi. Ukuqina ekuthathweni kwemithi yakho kubalulekile ekugcineni amazinga asebenzayo egazini lakho.

Uma uvame ukukhohlwa imithamo, lokhu kungathinta ukuthi ukwelashwa kwakho kusebenza kahle kangakanani. Khuluma nomhlinzeki wakho wezempilo mayelana namasu okukusiza ukuthi ukhumbule, njengokusetha ama-alamu ocingweni noma ukusebenzisa uhlelo lokusebenza lwesikhumbuzi semithi.

Ngingayeka nini ukuthatha i-Boceprevir?

Kufanele uyeke kuphela ukuthatha i-boceprevir lapho udokotela wakho ekutshela ukuthi wenze njalo. Isinqumo sokuyeka ukwelashwa sisekelwe ezintweni eziningana okuhlanganisa imiphumela yakho yomthwalo we-viral, ukuthi ukubekezelela kanjani imithi, nokuthi usunesikhathi esingakanani ekwelashweni.

Umhlinzeki wakho wezempilo uzoqapha amazinga akho e-hepatitis C viral ngesikhathi sokwelashwa ukuze anqume ukuthi kufanele nini ukuyeka. Kwezinye izimo, ukwelashwa kungase kudingeke ukuthi kumiswe ngaphambi kwesikhathi uma imiphumela emibi emibi ithuthuka noma uma igciwane lingaphenduli njengoba kulindelekile.

Ukuyeka i-boceprevir ngaphambi kwesikhathi kungaholela ekwehlulekeni kokwelashwa futhi kungavumela igciwane ukuthi lithuthukise ukumelana nemithi. Hlala uxoxa nganoma yikuphi ukukhathazeka mayelana nokuqhubeka nokwelashwa nethimba lakho lezempilo kunokuyeka ngokwakho.

Ngingakwazi yini ukuphuza utshwala ngenkathi ngithatha i-Boceprevir?

Kufanele ukugweme utshwala ngokuphelele ngenkathi uthatha i-boceprevir kanye nakuyo yonke imithi yakho ye-hepatitis C. Utshwala bungase buqhubekisele phambili ukulimala kwesibindi okubangelwa yi-hepatitis C virus futhi bungase buphazamise ukuthi imithi yakho isebenza kahle kangakanani.

Njengoba i-boceprevir isetshenziswa ngokuhlangana neminye imithi engase ithinte nesibindi sakho, ukwengeza utshwala kule ngxube kungase kwandise ingozi yakho yezinkinga zesibindi. Ngisho namanani amancane otshwala angaba yingozi uma une-hepatitis C.

Uma ukhathazeka ngokusebenzisa utshwala, kubalulekile ukuxoxa lokhu ngobuqotho nomhlinzeki wakho wezempilo. Bangakuxhuma nezinsiza zokukusiza ukuthi ugcine ukuzithiba ngesikhathi sokwelashwa, okuzokunika ithuba elingcono kakhulu lokususa leli gciwane ngempumelelo.