C1 esterase inhibitor, uman (indlela ye- intravenous, indlela ye- subcutaneous)
Imikhiqizo etholakalayo
Berinert, Cinryze, Haegarda
Mayelana naleli khambi
I-C1 esterase inhibitor isetyenziselwa ukwelapha noma ukuvimbela isifo se-hereditary angioedema (HAE). I-HAE yisifo esingavamile esibangela ukukhula kwesikhumba sobuso, izandla, izinyawo, umlomo, isisu, amabele, noma izitho zangasese. Abantu abane-HAE banezinga eliphansi le-C1 esterase inhibitor emizimbeni yabo. Lolu lwemi lwasiza ekuthuthukiseni inani le-C1 esterase inhibitors emzimbeni. Lolu lwemi luyatholakala kuphela ngomyalelo wochwepheshe wezokwelapha. Lo mkhiqizo uyatholakala ngezindlela zokulinganisa ezilandelayo:
Ngaphambi kokusebenzisa leli khambi
Uma ukhetha ukusebenzisa imithi, kufanele kuqhathaniswe ingozi yokusebenzisa imithi nezinzuzo ezizoletha. Lo ngumqondo owenzayo wena nodokotela wakho. Kule mithi, kufanele kucabangelwe okulandelayo: Tshela udokotela wakho uma uke waba nanoma yiluphi uhlobo oluqondile noma olukhulu lokuphazamiseka kule mithi noma kunoma iyiphi enye imithi. Tshela futhi ochwepheshe bakho bezempilo uma unezinye izinhlobo zokuphazamiseka, njengokudla, izidakamizwa, izigcina, noma izilwane. Ngomkhiqizo ongenayo iresiphi, funda ilebula noma izithako zephakheji ngokucophelela. Izifundo ezifanele ezenziwe kuze kube manje azibonisi izinkinga ezikhethekile zezingane ezingalimi ukusetshenziswa kweBerinert®ezinganeni. Izifundo ezifanele ezenziwe kuze kube manje azibonisi izinkinga ezikhethekile zezingane ezingalimi ukusetshenziswa kweCinryze®ezinganeni ezineminyaka engu-6 nangaphezulu. Ukuphepha nokusebenza kahle kuye kwaqiniswa. Azikho izifundo ezifanele ezenziwe ngokuphathelene nobudala nemiphumela yeHaegarda®ezinganeni ezineminyaka engaphansi kwengu-8. Ukuphepha nokusebenza kahle akukaqiniswanga. Azikho izifundo ezifanele ezenziwe ngokuphathelene nobudala nemiphumela yeBerinert®kubantu abadala. Ukuphepha nokusebenza kahle akukaqiniswanga. Izifundo ezifanele ezenziwe kuze kube manje azibonisi izinkinga ezikhethekile zabantu abadala ezingalimi ukusetshenziswa kweHaegarda®noma iCinryze®kubantu abadala. Noma kunjalo, abantu abadala banesikhathi esiningi sokuhlupheka ngezinkinga ze-liver, izinkalankala, noma inhliziyo ezihlobene nobudala, okungase kudinge ukuba uqaphele futhi ulungise umthamo wabantu abamukela iCinryze®. Ayikho izifundo ezifanele kubesifazane zokunquma ingozi yengane uma usebenzisa le mithi ngesikhathi sokuncelisa. Linganisa izinzuzo ezingaba khona nezingozi ezingaba khona ngaphambi kokuthatha le mithi ngesikhathi sokuncelisa. Nakuba ezinye izidakamizwa kufanele zingasetshenziswa ndawonye nhlobo, kwezinye izimo imithi emibili ehlukene ingasetshenziswa ndawonye ngisho noma kungenzeka ukuhlangana. Kulezi zimo, udokotela wakho angase afune ukushintsha umthamo, noma ezinye izinyathelo zokuphepha zingase zidingeke. Tshela ochwepheshe bakho bezempilo uma uthatha noma iyiphi enye imithi yokuqaphela noma engekho iresiphi (over-the-counter [OTC]). Ezinye izidakamizwa akufanele zisetshenziswe ngesikhathi noma eduze kwesikhathi sokudla ukudla noma ukudla izinhlobo ezithile zokudla njengoba kungenzeka ukuhlangana. Ukusebenzisa utshwala noma utshaba ngezinye izidakamizwa kungase futhi kubangele ukuhlangana. Xoxa nochwepheshe bakho bezempilo ngokusetshenziswa kwemithi yakho ngokudla, utshwala, noma utshaba. Ukuba khona kwezinye izinkinga zezokwelapha kungathinta ukusetshenziswa kwale mithi. Qiniseka ukuthi utshela udokotela wakho uma unezinye izinkinga zezokwelapha, ikakhulukazi:
Indlela yokusebenzisa leli khambi
Umshula oqeqeshwe kahle noma omunye ochwepheshe wezempilo uzokunika wena noma ingane yakho le miyeke. Inikezwa ngenhlanzi ebekwe kwenye yezinsimbi zakho noma njengokuqhuma phansi kwesikhumba sakho. Le miyeke ngezinye izikhathi inganikezwa ekhaya kubantu abangadingi ukuba esibhedlela noma ekliniki. Uma usebenzisa le miyeke ekhaya, udokotela wakho noma ushula uzokufundisa ukuthi ungayilungiselela kanjani futhi uyibeke kanjani. Qiniseka ukuthi uyayiqonda indlela yokusebenzisa le miyeke. Le miyeke iza nepheshana lolwazi lwabaguli. Funda futhi ulandele imiyalo ngokucophelela. Buza udokotela wakho noma umthengisi wemithi uma unemibuzo. Uzoboniswa izindawo zomzimba lapho le shoot inganikezwa khona. Sebenzisa indawo yomzimba ehlukile njalo lapho uzinikezela ishoti. Gcina uqaphele ukuthi unikeza kuphi ishoti ngalinye ukuqinisekisa ukuthi uqala izindawo zomzimba. Lokhu kuzosiza ukuvimbela izinkinga zesikhumba. Qiniseka ukuthi amalungu omndeni noma abanye abantu obaphethe bayazi ukuthi bangayifaka kanjani imithi uma ungakwazi ukuyenza ngokwakho ngesikhathi sokuhlaselwa kwe-HAE. Sebenzisa inhlanzi ne-syringe entsha njalo lapho ufakela imithi yakho. Futhi, sebenzisa i-syringe engenayo i-silicone uma usebenzisa le miyeke. Ungayifaki ezindaweni zesikhumba eziswela, ezivuvukile, ezibuhlungu, ezipinki, eziqhumile, noma ezinemibala noma imikhawulo. Hlola ama-injection kits njalo ukuqinisekisa ukuthi uthuli noma ulwelo alushintshanga umbala walo. Ungasebenzisi le miyeke uma i-discolored noma uma kukhona izinhlayiya ekuhlanganiseni okulwelo. Yithwale le miyeke nawe njalo ukuze uyisebenzise ngesikhathi esiphuthumayo uma une-HAE attack. Inani lemiyeke leyo miyeke lizohluka kubantu abahlukene. Landela imiyalo yodokotela wakho noma imiyalo elabelini. Ulwazi olulandelayo luhlanganisa kuphela amanani aphakathi ale miyeke. Uma inani lakho lihlukile, ungalishintshi ngaphandle kokuthi udokotela wakho akuyale ukuba wenze njalo. Inani lemiyeke oyithatha lixhomeke emandleni emiyeke. Futhi, inani lezinye ulizithatha nsuku zonke, isikhathi esivunyelwe phakathi kwezinye, nobude besikhathi othatha imithi kuya ngenkinga yezokwelapha oyisebenzisela imithi. Shaya udokotela wakho noma umthengisi wemithi ukuze uthole imiyalo. Gcina ungafinyeleleki ezinganeni. Ungagcini imithi eliphelile noma imithi engasadingi. Buza ochwepheshe bezempilo ukuthi kufanele uyilahule kanjani noma iyiphi imithi ongayisebenzisi. Gcina ama-injection kits ekushiseni kwegumbi, kude nokushisa, ukufuma, nokukhanya okulungile. Gcina imithi ebhokisini lokuqala kuze kube yilapho ulungele ukuyisebenzisa. Ungagcina futhi i-powder vial esihlalweni. Ungayifrizi. Ungagcina ulwelo oluhlanganisiwe ekushiseni kwegumbi. Sebenzisa iBerinert® neHaegarda® ngaphakathi kwamahora angu-8 ngemuva kokuxuba, futhi sebenzisa iCinryze® ngaphakathi kwamahora angu-3 ngemuva kokuxuba. Ungayifrizi noma uyifrize ulwelo oluhlanganisiwe. Ungayisebenzisi imithi esele. Lahla i-vial ngemuva kokuba uyisebenzise. Lahla izinhlanzi ezisetshenzisiwe ebhodweni eliqinile, evaliwe lapho izinhlanzi zingakwazi ukugqobhoza khona. Gcina leli bhodwe kude nezingane nezilwane ezifuywayo.