Yini iCabotegravir kanye neRilpivirine: Ukusetshenziswa, Umthamo, Imiphumela Eceleni nokuningi

ICabotegravir kanye ne-rilpivirine kuyinhlanganisela yemithi ye-HIV enikezwa njengomjovo wanyanga zonke noma njalo ngenyanga. Lokhu kwelashwa kumelele ukuqhubeka okukhulu kubantu abaphila ne-HIV abafuna inkululeko emaphilisi ansuku zonke ngenkathi begcina ukulawulwa okuhle kakhulu kwegciwane labo.

Umjovo uhlanganisa imithi emibili enamandla ye-HIV ibe munye umjovo owuthola ehhovisi lomhlinzeki wakho wezempilo. Abantu abaningi bathola ukuthi le ndlela ilula kakhulu kunokukhumbula imithi yansuku zonke, futhi inganikeza ukucindezelwa okuhle kakhulu kwegciwane njengokwelashwa kwendabuko okusekelwe emaphilisi.

Yini iCabotegravir kanye neRilpivirine?

ICabotegravir kanye ne-rilpivirine kuyinhlanganisela enesikhathi eside yokujova yemithi emibili ye-HIV esebenza ngokubambisana ukucindezela igciwane. I-Cabotegravir ingeyodwa yeqembu elibizwa ngokuthi ama-integrase inhibitors, kuyilapho i-rilpivirine iyi-non-nucleoside reverse transcriptase inhibitor.

Le mithi iza njengemijovo emibili ehlukene enikezwa emisipheni yakho yezinqe ngesikhathi esifanayo sokuvakasha. Umuthi uhlala ohlelweni lwakho amasonto, ukhulula kancane izithako ezisebenzayo ukuze ugcine i-HIV yakho ilawulwa ngaphandle kwamaphilisi ansuku zonke.

Udkt wakho ngokuvamile uzoqala ngohlobo oluthathwa ngomlomo lwale mithi efanayo cishe inyanga eyodwa kuqala. Lokhu kusiza ukuqinisekisa ukuthi umzimba wakho uyayibekezelela kahle imithi ngaphambi kokushintshela emijovweni yesikhathi eside.

Yini iCabotegravir kanye neRilpivirine Esetshenziselwa Yona?

Le nhlanganisela ejovwayo iphatha ukutheleleka nge-HIV-1 kubantu abadala asebenomthwalo wegciwane ongatholakali. Udinga ukuthi ube nokucindezelwa kwegciwane ngeminye imithi ye-HIV kuqala ngaphambi kokushintshela kule mijovo.

Ukwelashwa kusebenza kahle kakhulu kubantu abangakaze babe nokwehluleka kokwelashwa ngama-integrase inhibitors noma imithi yohlobo lwe-rilpivirine. Udkt wakho uzobuyekeza umlando wakho wokwelashwa ukuze aqinisekise ukuthi le nketho ilungile esimweni sakho esithile.

Abantu abaningi bakhetha lolu hlobo lwemithi ngoba luqeda isidingo sokuthatha amaphilisi nsuku zonke ngenkathi kugcinwa ukulawulwa okuhle kwe-HIV. Lusiza ikakhulukazi uma ukhathazeka ngamaphilisi amaningi, kunzima ukukhumbula imithi yansuku zonke, noma umane ukhethe izikhumbuzi ezimbalwa zezokwelapha ekuphileni kwakho kwansuku zonke.

Isebenza Kanjani I-Cabotegravir ne-Rilpivirine?

Le mithi ehlanganisiwe isebenza ngokuvimba i-HIV ezigabeni ezimbili ezihlukene zomjikelezo wayo wokuzala. I-Cabotegravir ivimbela igciwane ukuthi lingafaki izinto zalo zofuzo emangqamuzaneni akho anempilo, kanti i-rilpivirine imisa igciwane ekuzenzeleni amakhophi alo.

Yomibili le mithi ithathwa njengemithi enamandla ye-HIV enikeza ukucindezelwa okuqinile kwegciwane. Ifomula esebenza isikhathi eside isho ukuthi imithi ihlala isebenza ohlelweni lwakho amasonto ngemuva komjovo ngamunye, igcina amazinga aqhubekayo ukuze igciwane lilawulwe.

Indlela ekabili yenza kube nzima kakhulu ukuthi i-HIV yakhe ukumelana, ngoba igciwane lizodinga ukunqoba izindlela ezimbili ezihlukene zokuvimba ngasikhathi sinye. Lokhu kwenza le nhlanganisela ibe yiyo yomibili esebenzayo futhi ehlala isikhathi eside ekwelashweni kwe-HIV kwesikhathi eside.

Kufanele Ngiyithathe Kanjani I-Cabotegravir ne-Rilpivirine?

Uzothola le mithi yokujova ehhovisi likahulumeni wakho wezempilo, hhayi ekhaya. Ukwelashwa kuhilela imijovo emibili ehlukene enikezwa emisipheni yakho yezinqe ngesikhathi esifanayo sokuqokwa.

Ngaphambi kokuqala imijovo, ngokuvamile uzothatha izinguqulo zomlomo zayo yomibili imithi cishe amasonto amane. Lesi sikhathi sokuhola ngomlomo sisiza udokotela wakho ukuthi aqinisekise ukuthi uyayibekezelela kahle imithi futhi uthole amazinga amahle egazi ngaphambi kokushintshela efomini elisebenza isikhathi eside.

Ngesikhathi sokuvakasha kwakho komjovo, uzothola umjovo owodwa we-cabotegravir kanye nomjovo owodwa we-rilpivirine ezindaweni ezihlukene zezinqe zakho. Inqubo yokujova ithatha imizuzu embalwa nje, yize kungadingeka ukuthi uhlale isikhathi esifushane sokubheka ngemuva kwalokho.

Akukho kulungiselela okukhethekile okudingekayo ngaphambi kokuqokwa kwakho komjovo. Ungadla ngokujwayelekile futhi akudingeki ukuthi uthathe amaphilisi ngosuku lomjovo uma usuqedile isikhathi sokuthatha ngomlomo.

Kufanele Ngithathe Isikhathi Esingakanani I-Cabotegravir kanye ne-Rilpivirine?

Uzoqhubeka nale mijovo uma nje ilawula ngempumelelo i-HIV yakho futhi uyayibekezelela kahle. Abantu abaningi bahlala kulokhu kwelashwa isikhathi eside, njenganoma yimuphi omunye umuthi we-HIV.

Udokotela wakho uzoqapha umthwalo wakho wegciwane njalo ukuze aqinisekise ukuthi ukwelashwa kuqhubeka nokusebenza ngempumelelo. Uma nje igciwane lakho lingabonakali futhi ungenazo izinkinga ezingezinhle, ungaqhubeka nemijovo unomphela.

Uma unquma ukuyeka imijovo nganoma yisiphi isizathu, udokotela wakho uzokusiza ukuthi ubuyele emithini ye-HIV yansuku zonke yomlomo. Lokhu kuguquka kudingeka kuhlelwe ngokucophelela ukuze kugwenywe noma yiziphi izikhala ekwelashweni kwakho kwe-HIV ezingavumela igciwane ukuthi libuye.

Yiziphi Imiphumela Eceleni ye-Cabotegravir kanye ne-Rilpivirine?

Abantu abaningi bayayibekezelela kahle le mijovo, kodwa ungase uhlangabezane nemiphumela ethile eceleni, ikakhulukazi ezinyangeni ezimbalwa zokuqala. Izinkinga ezivame kakhulu zihlobene nendawo yokujova kanye nezimpawu ezithile zomzimba jikelele.

Nansi imiphumela eceleni ongase uhlangabezane nayo njengoba umzimba wakho ujwayela lokhu kwelashwa:

• Ubuhlungu, ukuvuvukala, noma ukuzwela ezindaweni zokujova
• Ikhanda nokukhathala
• Ukuluma kwemisipha nobuhlungu bamalunga
• Isicanucanu noma ukungakhululeki kwesisu
• Isiyezi noma ukungakwazi ukulala
• Umkhuhlane noma izimpawu ezinjengomkhuhlane

Le miphumela ejwayelekile eceleni ivamise ukuthuthuka kakhulu ngemva kwemijikelezo yokuqala embalwa yokujova njengoba umzimba wakho ujwayela umkhuba wemithi.

Abanye abantu bangase bahlangabezane nemiphumela eceleni ebaluleke kakhulu edinga ukunakekelwa kwezokwelapha. Nakuba lokhu kungavamile, kubalulekile ukwazi ukuthi yini okufanele uyibheke ukuze uthole usizo uma kudingeka.

Xhumana nomhlinzeki wakho wezempilo uma uhlangabezana nanoma yikuphi kwalokhu okukhathazayo okungathi sína:

• Ukusabela okukhulu endaweni yokujova nokuvuvukala ngokweqile, ukuqina, noma izimpawu zokutheleleka
• Ushintsho oluqhubekayo lwemizwa, ukucindezeleka, noma imicabango yokuzibulala
• Ukusabela okukhulu kwesikhumba noma ukuqubuka
• Izimpawu zezinkinga zesibindi njengokuba phuzi kwesikhumba noma amehlo
• Ubuthakathaka obungavamile bemisipha noma ubuhlungu
• Ukusabela okukhulu komzimba wonke okunezinkinga zokuphefumula

Nakuba kungavamile, abanye abantu bangase bathuthukise ukusabela ngemva komjovo okungenzeka phakathi nemizuzu noma amahora ngemva kokuthola imijovo. Lokhu kusabela akuvamile kodwa kudinga ukunakekelwa kwezempilo ngokushesha uma kuhilela ubunzima bokuphefumula noma izimpawu ezinzima zomzimba wonke.

Ubani Ongafanele Athole i-Cabotegravir ne-Rilpivirine?

Le nhlanganisela yomjovo ayifanele wonke umuntu one-HIV. Udokotela wakho uzobukeza ngokucophelela umlando wakho wezokwelapha kanye nesimo sakho sempilo yamanje ukuze anqume ukuthi le mithi iphephile yini kuwe.

Akufanele uthole le mijovo uma unezimo ezithile zezokwelapha noma usebenzisa imithi ethile engase ihlangane ngendlela eyingozi nokwelashwa.

Nazi izimo eziyinhloko lapho lokhu kwelashwa ngokuvamile kungathenjiswa khona:

• Ukusabela okwedlule komzimba wonke ku-cabotegravir noma i-rilpivirine
• Ukutheleleka kwamanje nge-hepatitis B (kudinga ukucatshangelwa okukhethekile)
• Ukuphuza imithi ethile ehlangana ngokuphawulekayo nale mithi
• Umlando wokwehluleka kokwelashwa ngama-integrase inhibitors noma imithi yohlobo lwe-rilpivirine
• Isifo sesibindi esibi noma ama-enzyme esibindi aphakanyiswe kakhulu
• Ukukhulelwa noma ukuhlela ukukhulelwa

Udokotela wakho uzophinda acabangele ukuthi ngabe usebenzisa eminye imithi engase iphazamise le mijovo, okuhlanganisa ezinye izilwa-asidi, imithi yokulwa nokuthuthumela, noma ama-antibiotics athile.

Abanye abantu abanezinkinga zezinso, izimo zempilo yengqondo, noma ezinye izinkinga zezokwelapha bangase badinge ukuqashwa okwengeziwe noma izindlela zokwelapha ezihlukile. Ithimba lakho lokunakekelwa kwezempilo lizosebenza nawe ukuthola uhlelo lokwelapha i-HIV oliphephe kakhulu futhi olusebenza kahle kakhulu esimweni sakho esithile.

Amagama Omkhiqizo we-Cabotegravir kanye ne-Rilpivirine

Igama lomkhiqizo lalesi sihlanganisela esijovwayo yi-Cabenuva. Le yiyo kuphela ifomula etholakalayo njengamanje ehlanganisa womabili imithi ibe uhlelo lokujova olusebenza isikhathi eside.

I-Cabenuva yenziwa yi-ViiV Healthcare futhi yakhelwe ngqo njengenye indlela yokujova yanyanga zonke noma njalo ngenyanga emva kwenye yamaphilisi e-HIV ansuku zonke. Igama lomkhiqizo lifana kungakhathaliseki ukuthi uthola umthamo wanyanga zonke noma njalo ngenyanga emva kwenye.

Ikhemisi lakho nomshuwalense kungase kubhekisele kulo muthi ngegama lawo lomkhiqizo (Cabenuva) noma ngamagama emithi ngayinye (i-cabotegravir kanye ne-rilpivirine extended-release injectable suspension).

Ezinye Izindlela ze-Cabotegravir kanye ne-Rilpivirine

Ezinye izinketho eziningana zokwelapha i-HIV ziyatholakala uma ukwelashwa okujovwayo kungakulungele. Udokotela wakho angakusiza ukuthi ukhethe okungcono kakhulu ngokusekelwe ezidingweni zakho ezithile, umlando wezokwelapha, nezintandokazi.

Imithi yomlomo yansuku zonke ye-HIV isahlala iyindlela yokwelapha ejwayelekile futhi isebenza kahle kakhulu kubantu abaningi. Lokhu kungase kuhlanganise izinhlanganisela ezinjenge-bictegravir/tenofovir alafenamide/emtricitabine noma i-dolutegravir kanye neminye imithi.

Ezinye izinketho ezisebenza isikhathi eside ziyathuthukiswa, okuhlanganisa izinhlanganisela ezihlukene ezijovwayo kanye namafomula asebenza isikhathi eside. Umhlinzeki wakho wokunakekelwa kwezempilo angaxoxa ngokuthi yiziphi izindlela zokwelapha ezingase zitholakale esikhathini esizayo uma izinketho zamanje zingahlangabezani nezidingo zakho.

Abanye abantu bayazuza ekushintsheni phakathi kwezindlela ezihlukene zokwelapha i-HIV ngokuhamba kwesikhathi njengoba izimo zabo zempilo zishintsha. Into ebaluleke kakhulu ukugcina ukucindezelwa kwamagciwane okuqhubekayo, okusebenzayo nganoma yikuphi ukwelashwa okusebenza kahle kakhulu esimweni sakho.

Ingabe iCabotegravir kanye neRilpivirine Ingcono Kunezinye Izidakamizwa ze-HIV?

Le nhlanganisela ejovwayo akudingeki ukuthi "ingcono" kunezinye izindlela zokwelapha i-HIV, kodwa inikeza izinzuzo eziyingqayizivele eziyenza ilungele abantu abathile. Inzuzo enkulu ukulula - awekho amaphilisi ansuku zonke okufanele uwakhumbule ngenkathi ugcina ukulawula okuhle kakhulu kwamagciwane.

Izifundo zomtholampilo zibonisa ukuthi iCabenuva isebenza kahle njengezidakamizwa ze-HIV zansuku zonke ngomlomo ekugcineni imithwalo yamagciwane ingabonakali. Amazinga empumelelo ayafana, nabantu abaningi begcina ukucindezelwa kwamagciwane uma nje beqhubeka nemijovo yabo ehleliwe.

Ukukhetha phakathi kokwelashwa okujovwayo nokomlomo kuvame ukwehla ekuthandeni komuntu siqu nezici zokuphila. Abanye abantu bakhetha inkululeko evela emaphilisi ansuku zonke, kanti abanye bakhetha ukulawula nokuguquguquka kokuthatha imithi ekhaya.

Udokotela wakho uzokusiza ukuthi ulinganise izinzuzo kanye nokubi okungenzeka ngokuya ngesimo sakho esithile, umlando wokwelashwa, nezintandokazi zakho. Ukwelashwa kwe-HIV "okungcono kakhulu" ngaso sonke isikhathi yilowo ongakwazi ukunamathela kuwo ngokuqhubekayo futhi ogcina igciwane lakho lingabonakali.

Imibuzo Evame Ukubuzwa Mayelana neCabotegravir kanye neRilpivirine

Ingabe iCabotegravir kanye neRilpivirine Kuphephile Kubantu Abane-Hepatitis B?

Lokhu kwelashwa kudinga ukucatshangelwa okukhethekile uma une-hepatitis B infection. Ingxenye ye-rilpivirine ingase ibangele i-hepatitis B ukuthi ivuthe lapho amazinga emithi ehla, okungaba yingozi.

Udokotela wakho uzohlola ngokucophelela isimo sakho se-hepatitis B ngaphambi kokuqala le mijovo. Uma une-hepatitis B esebenzayo, ungase udinge eminye imithi yokulawula lokho kutheleleka ngenkathi uthola ukwelashwa kwe-HIV.

Ukuqapha njalo ukusebenza kwesibindi kubaluleke kakhulu uma une-HIV ne-hepatitis B. Ithimba lakho lokunakekelwa kwezempilo lizosebenza nawe ukuqinisekisa ukuthi zombili izifo ziphathwa kahle ngasikhathi sinye.

Ngingenzani Uma Ngingaphuthelwa Umjovo Ohleliwe?

Xhumana nomhlinzeki wakho wezempilo ngokushesha uma uphuthelwa noma uzophuthelwa i-aphoyintimenti yakho yokujova. Isikhathi sokujova lezi kubalulekile ukugcina amazinga emfithi afanele ohlelweni lwakho.

Ngokuya ngokuthi usheshe kangakanani, udokotela wakho angase ancome ukuthatha imithi ye-HIV yomlomo okwesikhashana ukuvala igebe kuze kube yilapho ungathola khona umjovo wakho. Lokhu kuvimbela noma yikuphi ukuphazamiseka ekwelashweni kwakho kwe-HIV.

Ithimba lakho lezempilo lizohlela kabusha umjovo wakho ngokushesha okukhulu futhi lingase lilungise uhlelo lwakho lokujova oluzayo. Ungazami ukulungisa imijovo ephuthelwe ngokuthatha imithi eyengeziwe noma ukushintsha uhlelo lwakho ngaphandle kwesiqondiso sezokwelapha.

Ngingayeka Ngokuzumayo Ukuthatha i-Cabotegravir ne-Rilpivirine?

Akufanele neze uyeke le mijovo ngokuzumayo ngaphandle kokuqashwa kwezokwelapha. Imithi ihlala ohlelweni lwakho amasonto ngemuva komjovo wakho wokugcina, kodwa ukuyeka kungazelelwe kungaholela ekwehlulekeni kokwelashwa nasekuthuthukisweni okungenzeka kokumelana.

Uma ufuna ukuyeka imijovo, udokotela wakho uzokusiza ukuthi udlulele ngokuphepha emithini ye-HIV yomlomo. Lokhu kuguquka kumele kwenziwe ngesikhathi esifanele ukuqinisekisa ukucindezelwa okuqhubekayo kwamagciwane kuyo yonke le ntshisekelo.

Imvelo yesikhathi eside yale mijovo isho ukuthi udinga isiqondiso sezokwelapha ukuze uyeke ngokuphepha. Umhlinzeki wakho wezempilo uzokwenza uhlelo oluvikela impilo yakho ngenkathi uhlonipha izintandokazi zakho zokwelashwa.

Ingabe Le Mijovo Izothinta Ikhono Lami Lokuthola Izingane?

Le mijovo ayinconyelwe ngesikhathi sokukhulelwa, futhi kunolwazi olulinganiselwe mayelana nemiphumela yayo ekuzaleni. Uma uhlela ukukhulelwa, xoxa ngezindlela zokwelapha ezinye ze-HIV nodokotela wakho.

Kwabesilisa, akukho bufakazi bokuthi le mithi ithinta ukuzala noma ukukhiqizwa kwesidoda. Kodwa-ke, ukugcina imithwalo yamagciwane engatholakali nganoma yikuphi ukwelashwa kwe-HIV okuphumelelayo kubalulekile ekunciphiseni ingozi yokudlulisela kozakwethu.

Uma ukhulelwa ngenkathi uthola le mithi yokujova, xhumana nodokotela wakho ngokushesha. Bazokusiza ukuthi ushintshele emithini ye-HIV ephephile ngesikhathi sokukhulelwa ukuvikela wena nomntwana wakho osakhulayo.

Zihlala Isikhathi Esingakanani Izimpawu Endaweni Yokujova?

Izimpawu eziningi endaweni yokujova zithuthuka phakathi nezinsuku ezimbalwa kuya evikini ngemuva kokujova ngakunye. Ubuhlungu, ukuvuvukala, nobumnene ezindaweni zokujova kuvamile, ikakhulukazi ngesikhathi sokujova kwakho kokuqala.

Ungasebenzisa imithi yokwelapha ubuhlungu etholakala ngaphandle kwemvume kadokotela futhi usebenzise iqhwa noma ukushisa ezindaweni zokujova ukusiza ukuphatha ukungakhululeki. Ukubhucungwa ngobumnene nomsebenzi olula kungase futhi kusize ukunciphisa ubuhlungu.

Izimpawu endaweni yokujova ngokuvamile ziba ngaphansi uma umzimba wakho ujwayela inqubo yokwelashwa. Uma izimpawu zibonakala ziba zimbi noma zingathuthuki ngemuva kwesonto, xhumana nodokotela wakho ukuze ahlolwe.