Yini i-Cabozantinib: Ukusetshenziswa, Umthamo, Imiphumela Eceleni nokuningi

I-Cabozantinib iyimithi yomdlavuza eqondiwe esiza ukunciphisa ukukhula kwezinhlobo ezithile zamaseli omdlavuza. Ingaphansi kohlu lwemithi ebizwa ngokuthi ama-tyrosine kinase inhibitors, asebenza ngokuvala amaprotheni athile amaseli omdlavuza awadingayo ukuze akhule futhi asakazeke emzimbeni wakho wonke.

Le mithi imelela inketho ebalulekile yokwelapha abantu ababhekene nomdlavuza wezinso oqhubekayo, umdlavuza wesibindi, kanye nomdlavuza wendlala yegilo. Udokotela wakho angase ancome i-cabozantinib uma ezinye izindlela zokwelapha zingasebenzi noma uma umdlavuza wakho unezici ezithile ezenza lo muthi ube yindlela enhle yokwelapha isimo sakho.

Isetshenziselwani i-Cabozantinib?

I-Cabozantinib iphatha izinhlobo ezintathu eziyinhloko zomdlavuza oqhubekayo. Udokotela wakho we-oncologist uzoqaphela ukuthi le mithi ilungele isimo sakho esithile ngokuya ngohlobo lomdlavuza wakho, isigaba, nokuthi usabele kanjani kwezinye izindlela zokwelapha.

Ukusetshenziswa okuvamile kakhulu kungokomdlavuza wezinso oqhubekayo, obizwa nangokuthi i-renal cell carcinoma. Le mithi ingasiza ukunciphisa ukukhula kwesimila lapho umdlavuza usakazekela ezinye izingxenye zomzimba wakho noma lapho ukuhlinzwa kungenzeki.

Odokotela baphinda babhale i-cabozantinib ye-hepatocellular carcinoma, okuyilona hlobo oluvamile lomdlavuza wesibindi. Ngokuvamile isetshenziswa lapho umdlavuza usuthuthukile futhi ezinye izindlela zokwelapha njengokuhlinzwa noma ukufakelwa kwesibindi akuzona izinketho.

Ngaphezu kwalokho, le mithi iphatha umdlavuza wendlala yegilo ohlukanisiwe osakazekile futhi ongayiphenduli imithi ye-iodine eyenziwe ngomoya. Udokotela wakho ngokuvamile uzozama ezinye izindlela zokwelapha umdlavuza wendlala yegilo kuqala ngaphambi kokucabangela i-cabozantinib.

Isebenza kanjani i-Cabozantinib?

I-Cabozantinib ithathwa njengemithi yomdlavuza eqondiwe eqinile evala izindlela eziningi amaseli omdlavuza azisebenzisayo ukuze asinde futhi akhule. Ngokungafani ne-chemotherapy ethinta wonke amaseli ahlukanisa ngokushesha, lo muthi uqondisa ngqo amaprotheni amaseli omdlavuza ancike kuwo.

Umuthi usebenza ngokuvimba ama-tyrosine kinases, okuyizinto ezi-enzymes ezithumela izimpawu zokukhula emangqamuzaneni omdlavuza. Uma lezi zimpawu zivinjwa, amangqamuzana omdlavuza awakwazi ukuzala ngokushesha futhi angase afe.

Lo muthi futhi uqondise imithambo yegazi enakekela izimila, unqamule umoya-mpilo kanye nokudla kwazo. Ngokuvimba lezi zindlela, i-cabozantinib ingasiza ekunciphiseni izimila noma ukunciphisa ukukhula kwazo, ikunikeze isikhathi esiningi futhi mhlawumbe izinga elingcono lempilo.

Imiphumela ayisheshayo ngoba lo muthi usebenza kancane kancane emasontweni kuya ezinyangeni. Udokotela wakho uzoqapha impendulo yakho ngokusebenzisa izithombe ezivamile kanye nokuhlolwa kwegazi ukuze abone ukuthi ukwelashwa kusebenza kahle kangakanani.

Kufanele Ngiyithathe Kanjani I-Cabozantinib?

Thatha i-cabozantinib ngendlela enembile njengoba udokotela wakho ekunqumela ngayo, ngokuvamile kanye ngosuku ngesikhathi esifanayo nsuku zonke. Umuthi uza ngama-capsules okufanele uwagwinye wonke ngengilazi yamanzi egcwele.

Kufanele uthathe lo muthi esiswini esingenalutho, okusho okungenani ihora elilodwa ngaphambi kokudla noma amahora amabili ngemuva kokudla. Ukudla kungathinta ukuthi umzimba wakho umunca kangakanani umuthi, okungenzeka ukuthi kuwenze ungasebenzi kahle.

Uma unenkinga yokugwinya ama-capsules, ungawavuli noma uwaqhekezi. Kunalokho, khuluma nodokotela wakho ngezindlela ezingezinye zokuthatha umuthi. Ama-capsules aqukethe ukwakheka okuthile okudingeka kuhlale kuphelele.

Udokotela wakho cishe uzoqala ngomthamo ojwayelekile kodwa angawulungisa ngokuya ngendlela ozosabela ngayo kanye nemiphumela emibi oyitholayo. Ungashintshi umthamo wakho noma uyeke ukuthatha umuthi ngaphandle kokukhuluma neqembu lakho lezempilo kuqala.

Kufanele Ngiyithathe Isikhathi Eside Kangakanani I-Cabozantinib?

Ngokuvamile uzothatha i-cabozantinib uma nje isiza ukulawula umdlavuza wakho futhi ubekezelela imiphumela emibi kahle. Lokhu ngokuvamile kusho ukuyithatha izinyanga noma iminyaka, njengoba yakhelwe ukuba ibe ukwelashwa kwesikhathi eside.

Udktela wakho uzohlola njalo ukuthi imithi isasebenza yini ngokusebenzisa izithombe, ukuhlolwa kwegazi, kanye nokubheka izimpawu zakho. Uma umdlavuza wakho uqala ukukhula futhi noma imiphumela emibi iba nzima kakhulu ukuyilawula, udokotela wakho angase axoxe ngokushintsha uhlelo lwakho lokwelapha.

Abanye abantu bathatha i-cabozantinib izinyanga eziningi ngemiphumela emihle, kanti abanye bangase badinge ukuyeka ngokushesha ngenxa yemiphumela emibi noma uma umdlavuza ungaziphenduli. Isikhathi sakho sokwelashwa sihlukile esimweni sakho futhi sizobhekwa ngokucophelela yithimba lakho lezempilo.

Ungalokothi uyeke ukuthatha i-cabozantinib ngokuzumayo ngaphandle kwesiqondiso sikadokotela wakho, ngisho noma uzizwa ungcono. Ukuyeka imithi kungavumela umdlavuza wakho ukuthi ukhule ngokushesha.

Yini Imiphumela Emibi ye-Cabozantinib?

Njengayo yonke imithi yomdlavuza, i-cabozantinib ingabangela imiphumela emibi, nakuba kungewona wonke umuntu oyithola ngendlela efanayo. Udokotela wakho uzokusiza ukulawula le miphumela ukuze ukwazi ukuqhubeka nokwelashwa ngokuphepha.

Nansi imiphumela emibi evame kakhulu ongase uyithole:

• Ukukhathala nobuthakathaka obungase buthinte imisebenzi yakho yansuku zonke
• Ukuqunjelwa, okungase ngezinye izikhathi kube kubi kakhulu
• Ukucanuzela kwenhliziyo nokuncipha kwesifiso sokudla
• I-Hand-foot syndrome, ebangela ubuhlungu, ukuvuvukala, kanye nezinguquko zesikhumba ezintendeni nasezinyaweni
• Umfutho wegazi ophezulu odinga ukubhekwa
• Ukuncipha kwesisindo
• Ushintsho lombala wezinwele noma ukuncipha kwezinwele
• Izilonda zomlomo noma izinguquko zokunambitheka

Ithimba lakho lezempilo lizokubheka ngokucophelela le miphumela futhi linganikeza imithi noma amasu okusiza ukuwalawula. Imiphumela eminingi emibi iyathuthuka njengoba umzimba wakho ujwayela ukwelashwa.

Imiphumela emibi engathi sína kodwa engavamile idinga ukunakekelwa kwezokwelapha ngokushesha. Lokhu kuhlanganisa ukopha okukhulu, amahlule egazi, izinkinga zenhliziyo, noma izimpawu zomonakalo wesibindi njengokushintsha kombala wesikhumba noma ubuhlungu obukhulu besisu.

Ezinye izinkinga ezingavamile kodwa ezinzima zingenzeka, okuhlanganisa umfutho wegazi ophezulu kakhulu, amahlule egazi emaphashini noma emilenzeni, nezinkinga zokuphola kwamanxeba. Udokotela wakho uzobheka lokhu ngokucophelela futhi kungase kudingeke alungise ukwelashwa kwakho uma kwenzeka.

Ubani Ongafanele Athathe i-Cabozantinib?

I-Cabozantinib ayiphephile kuwo wonke umuntu, futhi udokotela wakho uzobuyekeza ngokucophelela umlando wakho wezokwelapha ngaphambi kokuyinika. Izimo ezithile zezempilo noma imithi kungenza lo muthi ungafaneleki noma uyingozi kuwe.

Akufanele uthathe i-cabozantinib uma ukhulelwe noma uhlela ukukhulelwa, njengoba kungalimaza ingane esakhula. Abesifazane abaneminyaka yokuzala badinga ukusebenzisa izindlela zokulawula inzalo ezisebenzayo ngesikhathi sokwelashwa kanye nasezinyangeni ezimbalwa ngemva kokuyeka imithi.

Abantu abanezinkinga ezinkulu zesibindi kungenzeka bangakwazi ukuthatha lo muthi ngokuphepha, njengoba isibindi sisebenzisa umuthi. Udokotela wakho uzohlola ukusebenza kwesibindi sakho ngaphambi kokuqala ukwelashwa futhi akubheke njalo.

Uma uhlinzwe noma unamanxeba angazange aphole kahle, udokotela wakho angase akuhlehlisele ukuqala i-cabozantinib. Umuthi ungaphazamisa ukuphola kwamanxeba futhi wandise ingozi yokopha.

Ezinye izimo ezingenza i-cabozantinib ingafaneleki zihlanganisa izinkinga ezinkulu zenhliziyo, umfutho wegazi ophezulu ongagadiwe, noma amahlule egazi asanda kwenzeka. Udokotela wakho uzokala lezi zingozi ngokumelene nezinzuzo ezingaba khona zokwelashwa.

Amagama e-Cabozantinib Brand

I-Cabozantinib itholakala ngaphansi kwamagama amabili amakhulu ebhrendi, ngalinye linokwakheka okuhlukile kokusetshenziswa okuthile. Udokotela wakho uzoqoka inguqulo efanele kakhulu uhlobo lwakho lomdlavuza.

I-Cabometyx yigama lebhrendi lamaphilisi e-cabozantinib asetshenziselwa ukwelapha umdlavuza wezinso nomdlavuza wesibindi. Lolu uhlobo oluvame kakhulu lwemithi.

I-Cometriq yigama lebhrendi lama-capsules e-cabozantinib agunyazwe ngokuqondile izinhlobo ezithile zomdlavuza wendlala yegilo. Ukulinganisa nokwakheka kuhluka kancane ku-Cabometyx.

Zombili zombili ziqukethe isithako esifanayo esisebenzayo kodwa zenziwe ngezindlela ezehlukene, ngakho akufanele ushintshe phakathi kwazo ngaphandle kokuqondiswa udokotela wakho. Ikhemisi lizokhipha noma iyiphi inguqulo udokotela wakho ayincomayo ngqo.

Ezinye Izindlela Zokwelapha ze-Cabozantinib

Eminye imithi eminingi yokwelapha eqondiwe ingelapha iminyango efanayo yomdlavuza lapho i-cabozantinib ingafaneleki noma iyeka ukusebenza ngempumelelo. Udokotela wakho we-oncologist uzocabangela lezi ezinye izindlela ngokusekelwe ohlotsheni lwakho oluthile lomdlavuza nesimo.

Umdlavuza wezinso, ezinye izindlela zihlanganisa i-sunitinib, i-pazopanib, i-axitinib, ne-nivolumab. Ngamunye usebenza ngendlela ehlukile futhi angase afaneleke kangcono ezigabeni ezihlukene zesifo noma izici zomuntu ngamunye wesiguli.

Ezinye izindlela zokwelapha umdlavuza wesibindi zihlanganisa i-sorafenib, i-lenvatinib, ne-regorafenib. Udokotela wakho angase azame le mithi ngaphambi noma ngemuva kwe-cabozantinib kuye ngezici zomdlavuza wakho.

Umdlavuza wendlala yegilo, ezinye izindlela zihlanganisa i-sorafenib, i-lenvatinib, ne-vandetanib. Ukukhetha kuncike ohlotsheni lwakho lomdlavuza wendlala yegilo nokuthi uphendule kanjani ekwelashweni kwangaphambilini.

Udokotela wakho uzocabangela izici ezinjengempilo yakho yonke, ukwelashwa kwangaphambilini, nezici ezithile zomdlavuza lapho ekhetha enye indlela engcono kakhulu yesimo sakho.

Ingabe i-Cabozantinib Ingcono Kune-Sunitinib?

Kokubili i-cabozantinib ne-sunitinib ziyimithi esebenzayo yokwelapha umdlavuza wezinso oqhubekile, kodwa zisebenza ngezindlela ezehlukile kancane. Udokotela wakho uzokhetha leyo engase isize isimo sakho esithile.

Izifundo zemitholampilo zikhomba ukuthi i-cabozantinib ingase isize abantu ukuthi baphile isikhathi eside kune-sunitinib uma isetshenziswa njengokwelashwa komugqa wesibili ngemuva kokunye ukwelashwa. Kodwa-ke, lokhu akusho ukuthi kungcono ngokuzenzakalelayo kuwo wonke umuntu.

Amaphrofayili emiphumela emibi ahlukile phakathi kwale mithi. I-Cabozantinib ivame ukubangela i-syndrome yezandla nezinyawo kanye nohudo, kuyilapho i-sunitinib ingase ibangele ukukhathala okwengeziwe nokushintsha kwenani legazi.

Udktela wakho uzobheka impilo yakho iyonke, ukwelashwa kwangaphambilini, kanye nekhono lakho lokubekezelela imiphumela ethile engemihle lapho ekhetha phakathi kwalezi zinketho. Okusebenza kahle kakhulu kuyahlukahluka kumuntu nomuntu.

Imibuzo Evame Ukubuzwa Mayelana ne-Cabozantinib

Ingabe i-Cabozantinib iphephile kubantu abanezifo zenhliziyo?

I-Cabozantinib ingayithinta inhliziyo yakho nomfutho wegazi, ngakho-ke abantu abanezinkinga zenhliziyo ezikhona badinga ukuqashwa ngokucophelela. Udktela wakho uzohlola impilo yenhliziyo yakho ngaphambi kokuqala ukwelashwa futhi akuqaphele eduze ngesikhathi sokwelashwa.

Umuthi ungakhuphula umfutho wegazi futhi ungase ubangele izinkinga zesigqi senhliziyo kwabanye abantu. Uma unomlando wesifo senhliziyo, udokotela wakho wenhliziyo kanye nodokotela wakho we-oncologist bazosebenzisana ukuqinisekisa ukwelashwa okuphephile.

Uzodinga ukuhlolwa komfutho wegazi njalo futhi mhlawumbe nezivivinyo zomsebenzi wenhliziyo ngenkathi uthatha i-cabozantinib. Unganqikazi ukubika noma yikuphi ukucindezeleka esifubeni, ukuphefumula kanzima, noma ukushaya kwenhliziyo okungajwayelekile eqenjini lakho lezempilo ngokushesha.

Ngingenzani uma ngiphuthelwa ngengozi ukuthatha i-Cabozantinib eningi kakhulu?

Uma ngengozi uthatha i-cabozantinib eningi kunaleyo ebekiwe, xhumana nodokotela wakho noma isikhungo sokulawula ubuthi ngokushesha. Ungalindi ukubona ukuthi ngabe izimpawu ziyavela yini, njengoba ukuthatha okuningi kungadala imiphumela emibi engathí sina.

Ukweqisa kungase kubangele isifo sohudo esibi, umfutho wegazi ophezulu, noma ezinye izinkinga eziyingozi. Ithimba lakho lezempilo lidinga ukwazi ngokushesha ukuze likuqaphele futhi linikeze ukwelashwa okufanele.

Letha ibhodlela lomuthi nawe uma udinga ukuya esibhedlela, ngoba lokhu kusiza abasebenzi bezokwelapha ukuthi baqonde kahle ukuthi uthathe ini nokuthi ungakanani. Isikhathi sibalulekile nganoma yikuphi ukweqisa komuthi.

Ngingenzani uma ngiphuthelwa umthamo we-Cabozantinib?

Uma uphuthelwa umthamo futhi sekudlule amahora angaphansi kwangu-12 kusukela ngesikhathi sakho esijwayelekile sokulinganisa, thatha umthamo ophuthelwe ngokushesha lapho ukhumbula. Uma sekudlule amahora angaphezu kwangu-12, weqa umthamo ophuthelwe bese uthatha umthamo wakho olandelayo ohleliwe.

Ungalokothi uthathe imithamo emibili ngesikhathi esisodwa ukuze ulungise umthamo owuphuthelwe, ngoba lokhu kungakhuphula ingozi yakho yemiphumela emibi engathi sína. Kungcono ukweqa umthamo owodwa kunokuphinda.

Uma uvame ukukhohlwa imithamo, setha izikhumbuzi zocingo noma usebenzise umhleli wamaphilisi ukukusiza ukuthi uhlale emgwaqeni. Ukuthatha imithamo yansuku zonke ngokuqhubekayo kubalulekile ukuze umuthi usebenze ngempumelelo.

Ngingayeka nini ukuthatha i-Cabozantinib?

Kufanele uyeke kuphela ukuthatha i-cabozantinib ngaphansi kokuqondisa kukadokotela wakho, ngokuvamile lapho ukuskena kukhombisa ukuthi umdlavuza wakho ukhula naphezu kokwelashwa noma lapho imiphumela emibi iba nzima ukuyilawula. Ungayeki umuthi wedwa, ngisho noma uzizwa ungcono.

Udokotela wakho uzohlola njalo ukuthi ngabe umuthi usasiza yini ukulawula umdlavuza wakho ngocwaningo lokucabanga nokuhlolwa kwegazi. Uma ukwelashwa kuyeka ukusebenza noma uma uthola imiphumela emibi engathi sína, bazoxoxa ngezinketho ezingezinye.

Abanye abantu bakhathazeka ngokuthatha imithi yomdlavuza isikhathi eside, kodwa i-cabozantinib yenzelwe ukuba yitherape yokuqhubeka. Ukuyeka ngaphambi kwesikhathi kungavumela umdlavuza wakho ukuthi ukhule ngokushesha.

Ngingakwazi yini ukuphuza utshwala ngenkathi ngithatha i-Cabozantinib?

Kungcono ukugwema utshwala noma ukuphuza amanani amancane kuphela ngenkathi uthatha i-cabozantinib. Utshwala bungenza kube kubi eminye imiphumela emibi efana nesicanucanu nokukhathala, futhi kungase kuphazamise indlela isibindi sakho esisebenzisa ngayo umuthi.

Kokubili utshwala ne-cabozantinib kungathinta isibindi sakho, ngakho ukuzihlanganisa kungase kwandise ingozi yezinkinga zesibindi. Udokotela wakho uqapha ukusebenza kwesibindi sakho njalo, futhi utshwala bungenza lezi zivivinyo zibe nzima ukuzichaza.

Uma ukhetha ukuphuza ngezikhathi ezithile, xoxa ngalokhu neqembu lakho lezempilo kuqala. Bangakunikeza iseluleko ngemikhawulo ephephile esekelwe empilweni yakho yonke nokuthi usabela kanjani ekwelashweni.