Calcium oxybate, magnesium oxybate, potassium oxybate, kanye ne-sodium oxybate (indlela yokwelapha ngomlomo)
Imikhiqizo etholakalayo
Xywav
Mayelana naleli khambi
Ukuhlanganiswa kwe-calcium oxybate, i-magnesium oxybate, i-potassium oxybate, ne-sodium oxybate kusetshenziswa ukwelapha i-cataplexy (imisipha ebuthakathaka noma ephumule) noma ukulala okukhulu emini (EDS) kubantu abane-narcolepsy. I-Narcolepsy yisifiso esingenakulawuleka sokulala noma ukuhlaselwa ngokuzumayo kokulala okujulile. Lolu dokotela lusetshenziswa futhi ekwelapheni i-hypersomnia idiopathic (IH). Lolu dokotela lutholakala kuphela ngaphansi kohlelo lokusabalalisa oluqediwe oluthiwa yi-Xywav® ne-Xyrem® REMS (Uhlelo Lokunciphisa Ubungozi Bokulinganisa). Ungaluthola kuphela kufomu yefama yasempumalanga. Lo mkhiqizo utholakala ngezindlela zokwelapha ezilandelayo:
Ngaphambi kokusebenzisa leli khambi
Ekucatshweni kokusebenzisa imithi, izingozi zokuthatha imithi kufanele ziqhathaniswe nezinzuzo ezizokwenza. Lo ngumqondo owenzayo wena nodokotela wakho. Kule mithi, okulandelayo kufanele kucabangelwe: Tshela udokotela wakho uma uke waba nanoma yiluphi uhlobo oluhlukile noma ukusabela okungokwe-allergy kule mithi noma kunoma iyiphi enye imithi. Tshela futhi ochwepheshe bakho bezempilo uma unanoma yiluphi olunye uhlobo lwe-allergies, njengokudla, izibhebhe, izigcini, noma izilwane. Ngomkhiqizo ongenayo iresiphi, funda ilebula noma izithako zephakheji ngokucophelela. Izifundo ezifanele azikwenzelwanga ubudlelwano bobudala nemiphumela ye-calcium oxybate, i-magnesium oxybate, i-potassium oxybate, kanye nokuhlanganiswa kwe-sodium oxybate ukuze kuphathwe i-hypersomnia idiopathic kubantwana nokuze kuphathwe i-cataplexy noma ukulala okukhulu emini kubantwana abaneminyaka engaphansi kwengu-7. Ukuphepha nokuphumelela akukaqiniswa. Izifundo ezifanele ebudlelwaneni bobudala nemiphumela ye-sodium oxybate azikwenzelwanga kubantu abadala. Kodwa-ke, iziguli ezikhulile zinezinkinga eziningi zokungafuni (isib. i-headache) noma izinkinga ze-liver, i-kidney, noma inhliziyo ezihlobene nobudala, okungadinga ukuqapha nokulungiswa komthamo kwabaguli abamukela le mithi. Ayikho izifundo ezifanele kwabesifazane zokunquma ingozi yengane uma usebenzisa le mithi ngesikhathi sokuncelisa. Linganisa izinzuzo ezingaba khona nezingozi ezingaba khona ngaphambi kokuthatha le mithi ngesikhathi sokuncelisa. Nakuba imithi ethile ingafanele isetshenziswe ndawonye nhlobo, kwezinye izimo imithi emibili ehlukene ingasetshenziswa ndawonye ngisho noma kungaba khona ukusebenzisana. Kulezi zimo, udokotela wakho angafuna ukushintsha umthamo, noma ezinye izinyathelo zokuphepha zingadingeka. Uma uthatha le mithi, kubalulekile ngokukhethekile ukuthi ochwepheshe bakho bezempilo bazi uma uthatha noma iyiphi imithi ehlanganisiwe ngezansi. Ukusebenzisana okulandelayo kukhethwe ngesisekelo sokubaluleka kwabo okungenzeka futhi akuyona yonke into. Ukusebenzisa le mithi nanoma iyiphi imithi elandelayo ayinconywa. Udokotela wakho anganquma ukungakwelaphi ngale mithi noma ashintshe ezinye zezinto ozithathayo. Ukusebenzisa le mithi nanoma iyiphi imithi elandelayo ngokuvamile ayinconywa, kodwa kungadingeka kwezinye izimo. Uma kokubili imithi ilotshiwe ndawonye, udokotela wakho angashintsha umthamo noma ukuthi uyayisebenzisa kangaki enye noma kokubili imithi. Imithi ethile akufanele isetshenziswe ngesikhathi noma eduze kwesikhathi sokudla ukudla noma ukudla izinhlobo ezithile zokudla njengoba ukusebenzisana kungase kwenzeke. Ukusebenzisa utshwala noma utshako nanoma iyiphi imithi kungase futhi kubangele ukusebenzisana. Ukusebenzisana okulandelayo kukhethwe ngesisekelo sokubaluleka kwabo okungenzeka futhi akuyona yonke into. Ukusebenzisa le mithi nanoma yini elandelayo ayinconywa. Udokotela wakho anganquma ukungakwelaphi ngale mithi, ashintshe ezinye zezinto ozithathayo, noma akunikeze imiyalo ekhethekile mayelana nokusetshenziswa kokudla, utshwala, noma utshako. Ukuba khona kwezinye izinkinga zezokwelapha kungathinta ukusetshenziswa kwale mithi. Qiniseka ukuthi utshela udokotela wakho uma unanoma yiziphi ezinye izinkinga zezokwelapha, ikakhulukazi:
Indlela yokusebenzisa leli khambi
Thatha leli lemithi kuphela njengoba kunqunyiwe udokotela wakho. Ungayithathi ngaphezulu kwalokho, ungayithathi kaningi kakhulu, futhi ungayithathi isikhathi eside kunalokho udokotela wakho akuqondile. Uma kuthathwe okuningi, kungaba yinto yokujwayela. Uma ucabanga ukuthi le mithi ayisebenzi kahle ngemuva kokuthatha amasonto amaningana, xhumana nodokotela wakho kuqala futhi ungayandisi inani. Kubalulekile kakhulu ukuthi uqonde izidingo ze-Xywav® ne-Xyrem® REMS program, futhi uqonde i-Xywav® Medication Guide nemiyalelo yokuqondisa. Buza udokotela wakho uma unemibuzo. Le mithi ingathathwa njengesihluthulelo esisodwa (ngokulala okungapheli) noma ihlukaniswe zibe izilinganiso ezimbili zobusuku. Isihluthulelo sokuqala sobusuku kufanele sithathwe okungenani amahora angu-2 ngemuva kokudla. Le mithi ingakwenza ulale ngokushesha (ngaphakathi kwemizuzu emi-5 kuya kwengu-15) ngaphandle kokuzwa uvila. Kungcono ukuthatha imithi kuphela ngesikhathi sokulala noma uma usukulungele ukulala. Yithathe kuphela ngesikhathi sokulala futhi ulele. Linganisa inani lakho ngesipuni sepulasitiki esiphawuliwe esiza nemithi. Yixuba ngekomityi le-1/4 lamanzi. Xuba zombili izilinganiso ngaphambi kokuba uhambe ubuthongo. Gcina isihluthulelo sesibili eduze kombhede wakho, endaweni abantwana abangafinyeleli kuyo. Thatha isihluthulelo sesibili amahora angu-2 1/2 kuya kwangu-4 ngemuva kokuthatha isihluthulelo sokuqala. Kungadingeka ubeke i-alamu ukuze ikuphakamise ukuze uthathe isihluthulelo sesibili ngesikhathi. Hlala embhedeni wakho ngemuva kokuthatha isihluthulelo sokuqala nesesibili sale mithi. Sebenzisa imithi ngaphakathi kwamahora angu-24 ngemuva kokuxubana namanzi. Inani lemithi lizohluka kubantu abahlukene. Landela imiyalo yodokotela wakho noma imiyalelo esemthethweni. Ulwazi olulandelayo luhlanganisa kuphela izilinganiso ezijwayelekile zale mithi. Uma inani lakho lihlukile, ungalishintshi ngaphandle kokuthi udokotela wakho akuqondile. Inani lemithi olithathayo lixhomeke emandleni emithi. Futhi, inani lezingxenye olithathayo nsuku zonke, isikhathi esivunyelwe phakathi kwezingxenye, nobude besikhathi olithatha imithi kuya ngenkinga yezokwelapha oyisebenzisayo. Uma uphuthelwa isihluthulelo sale mithi, susa isihluthulelo esiphuthelwe bese ubuyela esimisweni sakho sokuthatha imithi. Ungawandisi izilinganiso. Uma uphuthelwa isihluthulelo sesibili, susa leso sihluthulelo futhi ungayithathi imithi eminingi kuze kube ngobusuku obulandelayo. Ungasebenzisi imithi eyengeziwe ukuze uthole isihluthulelo esiphuthelwe. Gcina imithi esitsheni esivalekile ezingeni lokushisa kwegumbi, kude nokushisa, ukufuma, nokukhanya okulungile. Gcina ungayivumeli ukuba iqhube. Gcina ingafinyeleleki kubantwana. Ungagcini imithi esele iphelile noma imithi engasadingeki. Buza ochwepheshe bakho bezempilo ukuthi kufanele uyilahla kanjani imithi oyisebenzisayo. Chithela imithi engasetshenzisiwe phansi kwesinki ngemuva kwamahora angu-24. Sebenzisa uphawu ukuze uqede ilebula ebhodleleni, bese uyilahla ebhini.