Canakinumab (indlela yokungenisa ngaphansi kwesikhumba)

Ilaris

Isikhubekiso seCanakinumab sisetshenziswa ekwelapheni izifo ezihambisana ne-cryopyrin (CAPS), okuhlanganisa i-familial cold autoinflammatory syndrome (FCAS) ne-Muckle-Wells syndrome (MWS). I-CAPS yisifo esingavamile, esidluliselwa ngezofu, sesistimu yokuzikhusela. Isikhubekiso seCanakinumab sisetshenziswa futhi ekwelapheni i-tumor necrosis factor receptor associated periodic syndrome (TRAPS), i-hyperimmunoglobulin D syndrome (HIDS)/mevalonate kinase deficiency (MKD), ne-familial Mediterranean fever (FMF). Isikhubekiso seCanakinumab sisetshenziswa futhi ekwelapheni i-Still's disease esebenzayo, okuhlanganisa i-adult-onset Still's disease (AOSD) ne-systemic juvenile idiopathic arthritis (SJIA). Isikhubekiso seCanakinumab sisetshenziswa futhi ekwelapheni izimpawu ezibuhlungu ze-gout kubantu abangenakukwamukela noma abangakutholi kahle ukwelashwa, noma abangaphendulanga ekwelapheni nge-colchicine ne-NSAIDs. Kusetshenziswa futhi ekwelapheni izimpawu ezibuhlungu ze-gout kubantu abangenakukwamukela ukwelashwa okuphindaphindwayo ngemithi ye-steroid. I-CAPS, i-TRAPS, i-HIDS/MKD, ne-FMF yizifo ezibangela ukuvuvukala okuphindaphindwayo, futhi i-Still's disease yisifo esibangela ukuvuvukala. Isimo sokuvuvukala kwenzeka uma umzimba ukhulula kakhulu ikhemikhali ebizwa nge-interleukin-1 beta. Le khemikhali ibangela ukuvuvukala (ukukhula) futhi iziguli zingaba nomkhuhlane, ikhanda, isihlungu sesikhumba, ubuhlungu bezingxenye zomzimba noma zemisipha, noma ukukhathala okungavamile noma ubuthakathaka. I-Canakinumab iyilokhi le-interleukin-1 beta. Lisiza ukuvimbela ukuvuvukala ngokuvimbela i-interleukin-1 beta ukuba isebenze kahle. Lolu lwemi lusetshenziswa kuphela ngudokotela noma ngaphansi kokunakekelwa okuqondile kudokotela. Lo mkhiqizo uyatholakala ngezindlela zokwelapha ezilandelayo:

Umakuqondisa ekusebenziseni imithi, kufanele kuqhathaniswe ingozi yokuthatha imithi nezinzuzo ezizoletha. Lo ngumqondo owenzayo wena nodokotela wakho. Kule mithi, kufanele kucabangelwe okulandelayo: Tshela udokotela wakho uma uke waba nanoma yiluphi uhlobo oluqhelile noma oluhambisana nokwaleka kule mithi noma kunoma iyiphi enye imithi. Tshela futhi ochwepheshe bakho bezempilo uma unezinye izinhlobo zokwaleka, njengokudla, izibonakaliso, izigcini, noma izilwane. Ngomkhiqizo ongenalo iresiphi, funda ilebula noma izithako zephakheji ngokucophelela. Izifundo ezifanele ezenziwe kuze kube yimanje azibonisi izinkinga ezikhethekile zezingane ezizobeka umkhawulo ekusebenziseni ukugxilwa kwe-canakinumab kubantwana abane-TRAPS, i-HIDS / MKD, ne-FMF. Noma kunjalo, ukuphepha nokuphumelela akukaqiniswa kubantwana abane-gout flares, kubantwana abane-CAPS, i-FCAS, noma i-MWS eneminyaka engaphansi kwengu-4, nakubantwana abane-SJIA abaneminyaka engaphansi kwengu-2. Izifundo ezifanele mayelana nobudlelwano bobukhulu nemiphumela yokugxilwa kwe-canakinumab azikazenziwa kubantu abadala. Noma kunjalo, azikho izinkinga ezikhethekile zabantu abadala ezibhalwe kuze kube yimanje. Azikho izifundo ezifanele kubesifazane zokunquma ingozi yengane uma usebenzisa le mithi ngesikhathi sokuncelisa. Linganisa izinzuzo ezingaba khona nezingozi ezingaba khona ngaphambi kokuthatha le mithi ngesikhathi sokuncelisa. Nakuba ezinye izidakamizwa kufanele zingasetshenziswa ndawonye nhlobo, kwezinye izimo imithi emibili ehlukene ingasetshenziswa ndawonye ngisho noma kungenzeka ukuthi kube khona ukusebenzisana. Kulezi zimo, udokotela wakho angafuna ukushintsha umthamo, noma ezinye izinyathelo zokuphepha zingadingeka. Uma uthola le mithi, kubalulekile kakhulu ukuthi ochwepheshe bakho bezempilo bazi uma uthatha noma iyiphi imithi ehlwini elingezansi. Ukusebenzisana okulandelayo kukhethwe ngokusekelwe ekubalulekeni kwabo okungenzeka futhi akuyona yonke into. Ukusebenzisa le mithi nanoma iyiphi imithi elandelayo ngokuvamile akuyona into enconywayo, kodwa kungadingeka kwezinye izimo. Uma kokubili imithi ilotshiwe ndawonye, udokotela wakho angashintsha umthamo noma ukuthi uyisebenzisa kangakanani enye noma kokubili imithi. Ezinye izidakamizwa akufanele zisetshenziswe ngesikhathi sokudla noma ngesikhathi sokudla izinhlobo ezithile zokudla ngoba ukusebenzisana kungase kwenzeke. Ukusebenzisa utshwala noma utshaba ngezinye izidakamizwa kungabangela ukusebenzisana. Xoxa nochwepheshe bakho bezempilo ngokusebenzisa imithi yakho ngokudla, utshwala, noma utshaba. Ukuba khona kwezinye izinkinga zezokwelapha kungathinta ukusetshenziswa kwale mithi. Qiniseka ukuthi utshela udokotela wakho uma unezinye izinkinga zezokwelapha, ikakhulukazi: