Yini i-Capecitabine: Ukusetshenziswa, Umthamo, Imiphumela Eceleni nokuningi

I-Capecitabine iyimithi yokwelapha ngomlomo esetshenziselwa ikakhulukazi ukwelapha izinhlobo ezahlukene zomdlavuza, okuhlanganisa umdlavuza wamathumbu nomdlavuza webele. Lo muthi oqokiwe ungowesigaba semithi ebizwa ngokuthi ama-antimetabolites, asebenza ngokuphazamisa ikhono lamaseli omdlavuza lokukhula nokuzala. Ngokungafani nokwelashwa ngamakhemikhali okwesintu okudinga ukufakwa ngemithambo emithanjeni esibhedlela, i-capecitabine iza ngesimo samaphilisi ongawathatha ekhaya ngaphansi kokuqondisa okucophelelayo kukadokotela wakho.

Yini i-Capecitabine?

I-Capecitabine iyidakamizwa lokwelapha ngamakhemikhali eliza ngesimo samaphilisi, okwenza ukwelashwa komdlavuza kube lula ezigulini eziningi. Yilokho odokotela abakubiza ngokuthi “i-prodrug,” okusho ukuthi iba semsebenzini kuphela ngemuva kokuthi umzimba wakho uyicubungule. Uma uselume iphilisi, umzimba wakho uguqula i-capecitabine ibe yi-5-fluorouracil (5-FU), umuthi oqiniswe kahle wokulwa nomdlavuza osetshenziswe amashumi eminyaka.

Lo muthi wenzelwe ukuthi uqondise amaseli omdlavuza ngempumelelo enkulu kunamaseli anempilo. Lapho i-capecitabine iguquka ibe yifomu layo elisebenzayo, igxila kakhulu ezicutshini zomdlavuza, okusiza ukunciphisa eminye yemiphumela emibi ongase uyithole ngokwelashwa ngamakhemikhali okwesintu. Udokotela wakho we-oncologist uzoqoka ukuthi i-capecitabine ingabe iyindlela efanele yokwelapha ngokuya ngohlobo oluthile lomdlavuza wakho kanye nesimo sempilo yakho esiphelele.

Yini i-Capecitabine Esetshenziselwa Yona?

I-Capecitabine iphatha izinhlobo eziningana zomdlavuza, lapho umdlavuza wamathumbu nomdlavuza webele kuyizinto ezisetshenziswa kakhulu. Udokotela wakho angase akunikeze lo muthi uma unomdlavuza wamathumbu wesigaba III ngemuva kokuhlinzwa, noma uma unomdlavuza wamathumbu ometastatic oye wasabalala kwezinye izingxenye zomzimba wakho. Isetshenziselwa futhi umdlavuza webele ometastatic, ikakhulukazi lapho ezinye izindlela zokwelapha zingasebenzi.

Ngaphandle kokusetshenziswa okuyinhloko, i-capecitabine ingase inikezwe eminye iminyango yomdlavuza okuhlanganisa umdlavuza wesisu, umdlavuza wendlala yamanyikwe, kanye nezinhlobo ezithile zomdlavuza wekhanda nentamo. Udokotela wakho we-oncologist uzocabangela izinto ezinjengesigaba somdlavuza wakho, ukwelashwa kwangaphambilini, kanye nempilo yonke lapho enquma ukuthi i-capecitabine ilungele yini isimo sakho. Ngezinye izikhathi isetshenziswa yodwa, kanti ngezinye izikhathi ihlanganiswa nezinye izindlela zokwelapha umdlavuza ukuze kuthuthukiswe ukusebenza kahle.

Isebenza Kanjani I-Capecitabine?

I-Capecitabine isebenza ngokuphazamisa inqubo yokukhiqizwa kwe-DNA edingwa amaseli omdlavuza ukuze asinde futhi azale. Uma uthatha ithebhulethi, umzimba wakho uyiguqula ngezinyathelo ezithile ibe yi-5-fluorouracil, ekhona iphazamisa ikhono lamaseli omdlavuza lokwenza i-DNA entsha. Ngaphandle kwe-DNA efanele, amaseli omdlavuza awakwazi ukuhlukanisa futhi ekugcineni ayafa.

Lo muthi uthathwa njengomuthi oqinile ngokulinganisela phakathi kwemithi ye-chemotherapy. Yenzelwe ukuba ikhetheke kakhulu kumaseli omdlavuza ngoba izinso zinomthamo ophezulu wama-enzyme athile avula i-capecitabine. Lokhu kukhetha kusiza ukuchaza ukuthi kungani iziguli eziningi zingathatha i-capecitabine ekhaya kunokuthi zidinge ukwelashwa esibhedlela. Noma kunjalo, iseyilapha elinamandla elidinga ukuqapha ngokucophelela nokunamathela esimisweni sakho esinqunyiwe.

Kufanele Ngiyithathe Kanjani I-Capecitabine?

Thatha i-capecitabine ngendlela udokotela wakho ayala ngayo, ngokuvamile kabili ngosuku cishe ngamahora ayi-12 ngaphandle. Kufanele uthathe amaphilisi kungakapheli imizuzu engama-30 ngemva kokuqeda ukudla, njengoba ukudla kusiza umzimba wakho ukuba umunce umuthi ngempumelelo futhi kunganciphisa isisu esicasulayo. Gwinya amaphilisi wonke ngamanzi – ungaqedi, uhlafune, noma uwaphule.

Ukwelashwa kwakho kuvame ukulandela iphethini yomjikelezo, ngokuvamile izinsuku eziyi-14 zokuthatha umuthi zilandelwa yisikhathi sokuphumula sezinsuku eziyi-7. Ngesonto lokuphumula, umzimba wakho uyalulama emiphumeleni yokwelashwa. Kubalulekile ukuthatha i-capecitabine ngezikhathi ezifanayo nsuku zonke ukuze kugcinwe amazinga aqhubekayo egazini lakho. Uma uhlanza kungakapheli ihora ngemuva kokuthatha umthamo wakho, xhumana nethimba lakho lezempilo ukuze uthole isiqondiso esikhundleni sokuthatha omunye umthamo ngokushesha.

Gcina amaphilisi akho esitsheni sawo sokuqala ekamelweni lokushisa, kude nomswakama nokushisa. Ungalokothi wabelane ngemithi yakho nabanye, futhi njalo hlola usuku lokuphelelwa yisikhathi ngaphambi kokuthatha noma yimuphi umthamo.

Ngingayithatha isikhathi esingakanani i-Capecitabine?

Ubude bokwelashwa nge-capecitabine buhlukahluka kakhulu ngokuya ngohlobo lomdlavuza wakho oluthile nokuthi usabela kahle kangakanani emuthini. Ezinye iziguli ziyayithatha izinyanga ezimbalwa, kanti ezinye zingase zidinge izikhathi zokwelashwa ezinde. Udokotela wakho we-oncologist uzohlola njalo inqubekela phambili yakho ngokusebenzisa ukuhlolwa kwegazi, ukuskena kwezithombe, nokuhlolwa komzimba ukuze kunqunywe ubude bokwelashwa obufanele.

Ukwelashwa okungemuva kokuhlinzwa komdlavuza wamathumbu, ubude obujwayelekile bungamanye izinyanga eziyi-6. Ngomdlavuza oqhubekayo, ukwelashwa kuvame ukuqhubeka uma nje umuthi ulawula umdlavuza futhi ubekezelela kahle imiphumela emibi. Udokotela wakho uzolungisa umugqa wesikhathi ngokuya ngokuthi umdlavuza wakho usabela kanjani kanye nanoma yimiphi imiphumela emibi oyitholayo.

Ungalokothi uyeke ukuthatha i-capecitabine noma ushintshe isimiso sakho ngaphandle kokuxoxa ngakho nodokotela wakho we-oncologist kuqala. Noma ngabe uzizwa kahle, umuthi usengasebenza ukulawula umdlavuza wakho. Ithimba lakho lezempilo lizokuqondisa kunoma yikuphi ukulungiswa okudingekayo ukuze uqinisekise ukuthi uthola ukwelashwa okuphumelela kakhulu ngenkathi ugcina izinga lempilo yakho.

Yiziphi Imiphumela Emibi ye-Capecitabine?

I-Capecitabine ingabangela imiphumela eminingi emibi, nakuba kungewona wonke umuntu oyitholayo yonke. Imiphumela eminingi emibi ingalawulwa ngokunakekela okufanele nokuqashwa ithimba lakho lezempilo. Ukuqonda ukuthi yini ongayilindela kungakusiza ukuthi ubone ukuthi nini okufanele ufune ukwelashwa kanye nendlela yokulawula izimpawu ngempumelelo ekhaya.

Nawa amanye emiphumela emibi evame kakhulu ongase uyithole ngesikhathi sokwelashwa:

• I-Hand-foot syndrome: Ukubomvu, ukuvuvukala, nobubele ezintendeni zezandla zakho nezinyawo, ngezinye izikhathi kuqhubekela ekuqhumeni noma ekuqhumeni
• Ukuqunjelwa: Izihlalo ezixekile noma ezinamanzi ezingahluka kusuka kokuncane kuya kokukhulu
• Ukucasuka kwesisu nokuhlanza: Ukucasuka kwesisu okuvame ukuthuthuka ngemithi elwa nokucasuka kwesisu
• Ukukhathala: Ukuzizwa ukhathele ngokungavamile noma ubuthakathaka, okungase kube kubi kakhulu ngesikhathi somjikelezo wakho wokwelashwa
• Ukulahlekelwa isifiso sokudla: Ukuncipha kwesifiso sokudla, okungaholela ekunciphiseni isisindo
• Izilonda zomlomo: Izilonda ezibuhlungu ngaphakathi emlonyeni wakho noma ezindebeni zakho
• Ushintsho esikhumbeni: Isikhumba esomile, ukuqubuka, noma ukwanda kokuzwela elangeni

Le miphumela emibi ejwayelekile ivame ukuthuthuka kancane kancane futhi ivame ukuthuthuka ngesikhathi samaviki akho okuphumula phakathi nemijikelezo yokwelashwa. Ithimba lakho lezempilo linganikeza amasu nemithi yokusiza ukulawula lezi zimpawu ngempumelelo.

Ngenkathi kungavamile, ezinye iziguli zingase zibe nemiphumela emibi engathi sína edinga ukwelashwa ngokushesha:

• Ukuphelelwa amanzi emzimbeni okukhulu: Ngenxa yokuhlanza okuqhubekayo noma isifo sohudo, okuholela esizungwini noma ukudideka
• Izimpawu zokutheleleka: Umkhuhlane, amaqhwa, noma umphimbo obuhlungu oqhubekayo ngenxa yokwehla kwamaseli amhlophe egazi
• Ubuhlungu besifuba noma ukuphefumula kanzima: Ikakhulukazi uma unomlando wezinkinga zenhliziyo
• Ukuphuma kwegazi okungavamile noma ukuqina: Ngenxa yokwehla kwama-platelet
• Ubuhlungu obukhulu besisu: Ikakhulukazi uma kuhambisana nesicanucanu noma izinguquko ekuhambeni kwamathumbu
• Ushintsho embonweni: Ukubona okungacacile noma ukucasuka kwamehlo

Xhumana nethimba lakho lezempilo ngokushesha uma uhlangabezana nanoma yiziphi zalezi zimpawu ezingathi sína. Kungase kudingeke ukuthi balungise umthamo wakho noma banikeze ukunakekelwa okwengeziwe okusekelayo ukukusiza ukuthi uqhubeke nokwelashwa ngokuphepha.

Ubani Ongafanele Athathe I-Capecitabine?

Abantu abathile akufanele bathathe i-capecitabine ngenxa yengozi eyengeziwe yezinkinga ezingathi sína. Udokotela wakho uzobuyekeza ngokucophelela umlando wakho wezokwelapha kanye nesimo sakho sempilo yamanje ngaphambi kokukuyalela lo muthi. Lokhu kuhlola okuphelele kusiza ekuqinisekiseni ukuthi i-capecitabine iphephile futhi ifanele isimo sakho esithile.

Akufanele uthathe i-capecitabine uma unezimo ezilandelayo:

• Izinkinga ezinzima zezinso: Izinso zakho zidinga ukucubungula lo muthi ngempumelelo
• Ukungezwani okwaziwayo ne-capecitabine noma i-5-fluorouracil: Ukusabela okwedlule kokungezwani komzimba kubonisa ingozi enkulu yokusabela okuzayo
• Ukuntula kwe-dihydropyrimidine dehydrogenase (DPD): Lokhu kungasebenzi kahle kwe-enzyme kuvimbela ukuhlukaniswa komuthi okufanele
• Isifo sesibindi esibi: Isibindi sakho sinendima ebalulekile ekucubunguleni i-capecitabine
• Izinkinga ezinzima zenhliziyo: Ikakhulukazi uma unomlando wokuhlaselwa yinhliziyo noma i-angina engazinzile

Udktela wakho uzophinda asebenzise ukuqapha okwengeziwe uma unezimo ezithile ezingakuvimbeli ngokuphelele ukusebenzisa i-capecitabine kodwa zidinga ukuqapha okucophelelayo:

• Izinkinga eziphansi kuya kweziphakathi zezinso noma zesibindi: Kungadingeka ukulungiswa komthamo
• Umlando wesifo senhliziyo: Kudinga ukuqapha kwenhliziyo ngesikhathi sokwelashwa
• Ubudala obungaphezu kwama-80: Abantu abadala bangase bazwe kalula imiphumela emibi
• Ukwelashwa ngemisebe kwangaphambilini: Kungase kwandise ingozi yemiphumela emibi ethile
• Umehluko othile wezakhi zofuzo: Kungathinta indlela umzimba wakho osebenzisa ngayo umuthi

Ngaphambi kokuqala ukwelashwa, yazisa udktela wakho ngayo yonke imithi oyithathayo, okuhlanganisa nemithi etholakala ngaphandle kwemvume kadokotela kanye nezithasiselo. Eminye imithi ingase ihlangane ne-capecitabine, okungenzeka ukuthi kwandisa imiphumela emibi noma kunciphisa ukusebenza kahle.

Amagama Omkhiqizo we-Capecitabine

I-Capecitabine ivame ukwaziwa ngegama lomkhiqizo wayo elithi Xeloda, elikhiqizwa yi-Roche. Lona umkhiqizo wokuqala owathola imvume ye-FDA futhi usaqhubeka ukunconywa kakhulu ngongoti bezifo zomdlavuza. Ungase futhi uhlangane nezinhlobo ezivamile ze-capecitabine, eziqulathe isithako esifanayo esisebenzayo kodwa ngokuvamile zibiza kancane kunezinhlobo ezinamagama omkhiqizo.

Amaphilisi e-capecitabine ajwayelekile atholakala kubakhiqizi abahlukahlukene bemithi futhi athathwa njengabalingana ne-Xeloda. Lokhu kusho ukuthi basebenza emzimbeni wakho ngendlela efanayo nomkhiqizo wokuqala. Ikhemisi lakho lingase lithathele indawo i-capecitabine ejwayelekile ngaphandle uma udktela wakho ecela ngokuqondile uhlobo olinegama lomkhiqizo. Noma ngabe uthola i-Xeloda noma i-capecitabine ejwayelekile, ukusebenza kahle komuthi kanye nephrofayili yokuphepha kuhlala kufana.

Ezinye izindlela ze-Capecitabine

Kukhona ezinye izindlela zokwelapha izimo ezivame ukwelashwa yi-capecitabine, nakuba inketho engcono kakhulu incike ohlotsheni lwakho lomdlavuza kanye nezimo zakho ngazinye. Udokotela wakho we-oncologist uzocabangela izinto ezinjengesigaba somdlavuza wakho, ukwelashwa kwangaphambilini, impilo yonke, kanye nezintandokazi zomuntu siqu lapho kuxoxwa ngezindlela zokwelapha.

Ngenxa yomdlavuza wamathumbu, ezinye izindlela zingabandakanya izindlela zokwelapha ngamakhemikhali ngomjovo njenge-FOLFOX (ehlanganisa i-5-fluorouracil, i-leucovorin, kanye ne-oxaliplatin) noma i-FOLFIRI (ehlanganisa i-5-fluorouracil, i-leucovorin, kanye ne-irinotecan). Lokhu kwelashwa kuvame ukunikezwa esikhungweni sokufaka umjovo kodwa kungase kufaneleke kakhulu ezigulini ezithile noma ezigabeni zomdlavuza.

Ngenxa yomdlavuza webele, ezinye izindlela zingabandakanya eminye imithi yomlomo efana ne-CDK4/6 inhibitors (njenge-palbociclib noma i-ribociclib) uma isetshenziswa kanye nokwelashwa ngamahomoni, noma inhlanganisela ehlukene yamakhemikhali kuye ngezici ezithile zomdlavuza wakho. Ukwelashwa okuqondiwe njenge-trastuzumab kungase kube ezinye izinketho uma umdlavuza wakho unezici ezithile zofuzo.

Ithimba lakho lezempilo lizokusiza ukuthi ulinganise izinzuzo kanye nobubi benketho ngayinye yokwelapha, ucabangela izinto ezinjengokulula, amaphrofayili emiphumela emibi, kanye nokusebenza kahle esimweni sakho esithile.

Ingabe i-Capecitabine ingcono kune-5-Fluorouracil?

I-Capecitabine kanye ne-5-fluorouracil (5-FU) ngomjovo yimithi ehlobene eduze esebenza ngendlela efanayo emzimbeni wakho, kodwa ngamunye unezinzuzo ezihlukile kuye ngesimo sakho. I-Capecitabine empeleni iguqulwa ibe yi-5-FU uma isemzimbeni wakho, ngakho-ke ekugcineni uthola ukwelashwa okusebenzayo okufanayo. Umehluko omkhulu usekulawuleni ukuthi uthola kanjani imithi kanye nezici ezingokoqobo zokwelashwa.

I-Capecitabine inikeza izinzuzo ezinkulu zokulula ngoba ungayithatha ekhaya ngesimo samaphilisi kunokuthi udinge ukuvakashela njalo esibhedlela ukuze uthole ukumnika nge-IV. Lokhu kungathuthukisa izinga lempilo yakho futhi kunciphise ukucindezeleka okuhlobene nokwelashwa. Ucwaningo lubonise ukuthi i-capecitabine okungenani isebenza kahle njenge-5-FU ezinhlotsheni eziningi zomdlavuza, ngocwaningo oluthile olusikisela ukuthi ingase isebenze kangcono kancane ezimweni ezithile.

Kodwa-ke, i-5-FU ingase ithandwe kwezinye izimo, ikakhulukazi uma iyingxenye yokwelashwa okuhlanganisiwe okudinga isikhathi esiqondile nokuxhumana neminye imithi ye-IV. Udokotela wakho we-oncologist uzocabangela uhlobo lomdlavuza wakho oluthile, isigaba, ezinye izimo zezempilo, nezintandokazi zakho lapho enquma ukuthi iyiphi inketho engcono kuwe. Yomibili imithi inezindlela zokulandela ezifakazelwe ekwelashweni komdlavuza, ngakho-ke ukukhetha kuvame ukwehla kulokho okusebenza kahle kakhulu ezimweni zakho.

Imibuzo Evame Ukubuzwa Mayelana ne-Capecitabine

Q1. Ingabe i-Capecitabine iphephile ku-Diabetes?

I-Capecitabine ingasetshenziswa ngabantu abanesifo sikashukela, kodwa idinga ukuqapha ngokucophelela nokuxhumana phakathi kukadokotela wakho we-oncologist kanye nethimba lokunakekelwa kwesifo sikashukela. Umuthi ngokwawo awuthinti ngokuqondile amazinga kashukela egazini, kodwa eminye imiphumela emibi efana nesicanucanu, ukuhlanza, noma izinguquko ekudleni kungenza ukuphathwa kwesifo sikashukela kube yinselele enkulu.

Amazinga akho kashukela egazini angashintshashintsha ngesikhathi sokwelashwa ngenxa yezinguquko emikhubeni yokudla, ukucindezeleka, noma eminye imithi ongase uyidinge ukuphatha imiphumela emibi. Kubalulekile ukuhlola ushukela wakho wegazi kaningi ngesikhathi sokwelashwa nge-capecitabine futhi ugcine kokubili udokotela wakho we-oncologist kanye nodokotela wesifo sikashukela benolwazi nganoma yiziphi izinguquko ezinkulu. Bangasebenzisana ukulungisa imithi yakho yesifo sikashukela uma kudingeka ngenkathi beqinisekisa ukuthi ukwelashwa kwakho umdlavuza kuhlala kusebenza.

Q2. Kufanele ngenzeni uma ngiphuthelwa ngisebenzisa i-Capecitabine eningi kakhulu?

Uma ngabe uthathe i-capecitabine eningi kunaleyo oyinikiwe, xhumana nethimba lakho lezempilo noma izikhungo zokulawula ubuthi ngokushesha, ngisho noma uzizwa ulungile. Ukuthatha okuningi kungakhuphula ingozi yakho yemiphumela emibi engathi sína njengokuhuda okukhulu, ukushoda kwamanzi emzimbeni, noma ukwehla okuyingozi kwenani lamaseli egazi. Ungalindi ukubona ukuthi ngabe izimpawu ziyavela yini – ukungenelela ngokushesha kuhlala kungcono.

Bhala phansi ngqo ukuthi ungakanani umuthi owengeziwe owuthathile nokuthi uwuthathe nini, ngoba lolu lwazi luzosiza ithimba lakho lezempilo ukuthi linqume ukuthi yini okufanele yenziwe. Bangase bakufunele ukuhlolwa kwegazi noma ukukuqapha, noma bangase banikeze imiyalelo ethile yokulawula izimpawu ezingase zibe khona. Ungalokothi uzame ukukhokhela ukuthatha okuningi ngokweqa imithamo yesikhathi esizayo ngaphandle uma uqondiswe ngqo ngudokotela wakho.

Q3. Kufanele ngenzeni uma ngiphuthelwa umthamo we-Capecitabine?

Uma uphuthelwa umthamo we-capecitabine, isikhathi sokuthi ukhumbula nini sibalulekile ekunqumeni isinyathelo sakho esilandelayo. Uma ukhumbula kungakapheli amahora angu-6 ngesikhathi obekufanele uthathe ngaso umthamo wakho, qhubeka uwuthathe uma nje usengawuthatha nokudla noma ngemva kokudla. Kodwa-ke, uma sekudlule amahora angaphezu kwangu-6, weqa umthamo ophuthelwe bese uthatha umthamo wakho olandelayo ohleliwe ngesikhathi esijwayelekile.

Ungalokothi uthathe imithamo emibili ngesikhathi esisodwa ukuze ubuyisele umthamo ophuthelwe, ngoba lokhu kungakhuphula ingozi yakho yemiphumela emibi. Uma uzithola uvame ukuphuthelwa imithamo, khuluma nethimba lakho lezempilo ngamasu okukusiza ukuthi ukhumbule, njengokusetha ama-alamu ocingo noma ukusebenzisa umhleli wamaphilisi. Isikhathi esiqhubekayo sibalulekile ekugcineni amazinga aqhubekayo omuthi ohlelweni lwakho.

Q4. Ngingayeka nini ukuthatha i-Capecitabine?

Kufanele uyeke kuphela ukuthatha i-capecitabine uma udokotela wakho we-oncologist ekutshela ukuthi kufanelekile ukwenza kanjalo. Lesi sinqumo sisekelwe ezintweni eziningana ezihlanganisa ukuthi umdlavuza wakho usabela kahle kangakanani ekwelashweni, noma yimaphi imiphumela emibi oyitholayo, kanye nesimo sakho sempilo esiphelele. Udokotela wakho uzosebenzisa izivivinyo zegazi ezivamile, izithombe zokuhlola, kanye nokuhlolwa komzimba ukuze aqaphe inqubekela phambili yakho futhi anqume ubude bokwelashwa obufanele.

Ezinye iziguli ziqeda inani elinqunywe ngaphambilini lemijikelezo, kanti ezinye ziqhubeka nokwelashwa uma nje kulawula umdlavuza wazo futhi nemiphumela emibi ihlala ilawuleka. Noma ngabe uzizwa kahle, ukuyeka ukwelashwa ngaphambi kwesikhathi kungavumela umdlavuza wakho ukuthi ukhule noma usabalale. Uma ukhathazekile ngemiphumela emibi noma ufuna ukuxoxa ngomugqa wesikhathi sokwelashwa kwakho, xoxa ngokukhululekile nethimba lakho lezempilo kunokwenza izinguquko ngokwakho.

Q5. Ngingakwazi yini ukuphuza utshwala ngenkathi ngithatha i-Capecitabine?

Ngokuvamile kungcono ukugwema noma ukunciphisa kakhulu ukusetshenziswa kotshwala ngenkathi uthatha i-capecitabine. Utshwala bungenza imiphumela emibi ethile ibe mibi njengokucasuka, ukushoda kwamanzi emzimbeni, nokukhathala, futhi kungase futhi kuphazamise ikhono lesibindi sakho lokucubungula imithi ngempumelelo. Ngaphezu kwalokho, utshwala bungacindezela amasosha akho omzimba, asevele ethintekile yi-chemotherapy.

Uma ukhetha ukuphuza ngezikhathi ezithile, xoxa ngalokhu nethimba lakho lezempilo kuqala. Bangakunikeza isiqondiso esiqondene nawe esisekelwe empilweni yakho yonke, eminye imithi oyithathayo, nokuthi ukwelashwa ukubekezelela kahle kangakanani. Ezinye iziguli zithola ukuthi ngisho namanani amancane otshwala azenza bazizwe bebi kakhulu ngesikhathi sokwelashwa, kanti ezinye zingase zikwazi ukujabulela iziphuzo ngezikhathi ezithile ngaphandle kwezinkinga. Udokotela wakho angakusiza ukuthi wenze ukukhetha okuphephe kakhulu esimweni sakho ngasinye.