Yini i-Coagulation Factor IX (Recombinant, Glycopegylated)? Izimpawu, Izimbangela, & Ukuphathwa Ekhaya

I-Coagulation Factor IX (recombinant, glycopegylated) iyimithi ekhethekile eyenzelwe ukusiza igazi lakho ukuba ligqame kahle uma unegciwane le-hemophilia B. Le nguqulo eyenziwe e-lab yeqoqo lemvelo elinqamulayo lingabuyisela ikhono lomzimba wakho lokumisa ukopha ngempumelelo. Umuthi unikezwa nge-IV futhi usebenza ngokufaka esikhundleni se-Factor IX protein elahlekile noma enezinkinga ezidingwa umzimba wakho ukuze wakhe amahlule egazi.

Yini i-Coagulation Factor IX (Recombinant, Glycopegylated)?

Lo muthi uyinguqulo eyenziwe ngumuntu ye-Factor IX, iphrotheni ebalulekile edingwa igazi lakho ukuze ligqame ngokujwayelekile. Uma une-hemophilia B, umzimba wakho awukhiqizi ngokwanele le phrotheni noma wenza inguqulo engasebenzi kahle. Ingxenye ethi "recombinant" isho ukuthi idalwe e-laboratory kusetshenziswa i-biotechnology ethuthukisiwe kunokuba ithathwe egazini lomuntu.

Ingxenye ethi "glycopegylated" ibhekisela ekugcotshweni okukhethekile okungezwe emuthini okusiza ukuthi uhlale isikhathi eside emgudwini wakho wegazi. Lokhu kugcotshwa kusebenza njengesihlangu esivikelayo, okuvumela umuthi ukuthi usebenze isikhathi eside futhi kunciphisa ukuthi udinga kangaki imijovo. Cabanga ngakho njengokunika umuthi umthombo wamandla ohlala isikhathi eside.

Kuzizwa kanjani ukuphathwa nge-Coagulation Factor IX?

Abantu abaningi bathola ukuthi inqubo yokufakwa kwe-IV inethezekile futhi iqondile. Uzohlala esihlalweni ngenkathi umuthi ugeleza kancane emthanjeni wakho ngemizuzu eyi-15 kuya kwengama-30. Okuhlangenwe nakho kufana nokuthola i-IV kwezinye izindlela zokwelapha, ngentambo encane ekuqaleni.

Ngesikhathi sokufakwa, ungase ungazizwa lutho, okuyinto ejwayelekile. Abanye abantu bazwa umuzwa opholile kancane njengoba imithi ingena emsingeni wabo wegazi. Ngemuva kokwelashwa, iziguli eziningi zibika ukuzizwa ziqinisekisiwe zazi ukuthi igazi labo lingagqama ngempumelelo, ikakhulukazi uma bebhekene nezigameko zokopha.

Imiphumela emibi, uma yenzeka, ivamise ukuba mnene futhi ingabandakanya ikhanda elibuhlungu, isiyezi, noma isicanucanu esincane. Le mizwa ngokuvamile idlula ngokushesha ngemuva kokuthi ukufakwa kuqediwe. Ithimba lakho lezempilo lizokuqapha ngesikhathi nangemuva kokwelashwa ukuze liqinisekise ukuthi uzizwa ukhululekile.

Yini ebangela isidingo sokwelashwa nge-Coagulation Factor IX?

Isizathu esiyinhloko sokuthi ungase udinge lo muthi yi-hemophilia B, isifo sokopha esingokwemvelo esithinta indlela igazi lakho eligqama ngayo. Lesi simo senzeka lapho uzuza izakhi zofuzo ezishintshiwe ezingavimbeli umzimba wakho ukuthi wenze iphrotheni evamile ye-Factor IX. Ngaphandle kwe-Factor IX esebenzayo eyanele, igazi lakho alikwazi ukwakha amahlule ngempumelelo, okuholela ekopheni okude.

I-Hemophilia B idluliselwa emindenini, ngokuvamile isuka konina iye ezinganeni zabo. Lesi simo sithinta i-chromosome X, okusho ukuthi sivame ukuthinta amadoda, nakuba abesifazane nabo bengaba ngabathwali noma, ezimweni ezingavamile, babe nesimo ngokwabo. Uzalwa nale ndlela, nakuba izimpawu zokopha zingase zingaveli kuze kube kamuva ebuntwaneni noma ngisho nasebudaleni.

Ngezinye izikhathi, abantu bathuthukisa isidingo sokushintshwa kwe-Factor IX ngenxa yezifo zokopha ezitholiwe. Lokhu kungase kubangelwe imithi ethile, izimo ze-autoimmune, noma isifo sesibindi esithinta ikhono lomzimba wakho lokukhiqiza izinto ezigqamayo ngokwemvelo. Udokotela wakho uzoqaphela imbangela eyisisekelo ngokusebenzisa ukuhlolwa kwegazi nomlando wezokwelapha.

Ukuntuleka kwe-Factor IX kuyisibonakaliso noma uphawu lwani?

Ukushoda kwe-Factor IX ikakhulukazi kuyisici se-hemophilia B, eyaziwa nangokuthi isifo sikaKhisimusi. Lesi simo sezakhi zofuzo sisho ukuthi umzimba wakho ukhiqiza amaprotheni amancane noma angewona nhlobo e-Factor IX asebenzayo. Ubukhulu be-hemophilia yakho buxhomeke ekutheni umzimba wakho ugcina kangakanani umsebenzi we-Factor IX.

I-hemophilia B eqinile yenzeka lapho unomsebenzi we-Factor IX ongaphansi kuka-1% ojwayelekile. Abantu abanezinhlobo ezinzima bavame ukuzwa ukuphuma kwegazi okuzenzakalelayo emalungeni, emisipheni, nasezithweni zangaphakathi. I-hemophilia B emaphakathi ihilela u-1-5% womsebenzi ojwayelekile, ngokuvamile ibangela ukuphuma kwegazi ngemva kokulimala okuncane noma izinqubo zezokwelapha.

I-hemophilia B emnene isho ukuthi unomsebenzi we-Factor IX ojwayelekile ongu-5-40%. Ungase ungaboni ukuthi unalesi simo size senzeke ukuphuma kwegazi okukhulu ngesikhathi sokuhlinzwa, umsebenzi wamazinyo, noma ukulimala okukhulu. Abanye abantu abane-hemophilia B emnene bachitha iminyaka ngaphandle kokuxilongwa okufanele.

Ezimweni ezingavamile, ukushoda kwe-Factor IX kungase kwenzeke kamuva empilweni ngenxa yezimo ze-autoimmune lapho amasosha akho omzimba ehlasela ngokungaqondile izinto zakho zokujiya igazi. Isifo sesibindi esiqinile singanciphisa nokukhiqizwa kwe-Factor IX, njengoba isibindi sakho sikhiqiza iningi lamaprotheni akho okujiya igazi.

Ingabe ukushoda kwe-Factor IX kungase kuqede ngokwako?

Ngeshwa, ukushoda kwe-Factor IX kwezakhi zofuzo okuvela ku-hemophilia B kuyisimo sempilo yonke esingaqedi ngokwazo. Njengoba kubangelwa izakhi zofuzo ezishintshiwe, umzimba wakho uzoqhubeka nokuba nobunzima bokukhiqiza amaprotheni e-Factor IX ajwayelekile empilweni yakho yonke. Nokho, lokhu akusho ukuthi awukwazi ukuphila impilo egcwele, esebenzayo ngokwelashwa nokulawulwa okufanele.

Izindaba ezikhuthazayo ukuthi ukwelashwa ngokufaka i-Factor IX kungakwazi ukuphatha isimo sakho ngempumelelo. Ukwelashwa okuvamile kusiza ukuvimbela izigameko zokuphuma kwegazi futhi kukuvumela ukuthi uhlanganyele emisebenzini eminingi ejwayelekile. Abantu abaningi abane-hemophilia B baphila impilo ejwayelekile ngokuphelele ngokunakekelwa kwezokwelapha okufanele.

Uma ukushoda kwakho kwe-Factor IX kubangelwa ezinye izimo ezinjengesifo sesibindi noma izifo ze-autoimmune, ukwelapha isimo esiyisisekelo kungase kuthuthukise amazinga akho e-Factor IX. Udokotela wakho uzosebenza nawe ukubhekana nalezi zimbangela eziyisisekelo ngenkathi enikeza ukushintshwa kwe-Factor IX njengoba kudingeka.

Ungayelapha kanjani ukushoda kwe-Factor IX ekhaya?

Ngenkathi ungeke ukwazi ukwelapha ukushoda kwe-Factor IX ngemithi yasekhaya, ungafunda ukuphatha isimo sakho ngempumelelo ekhaya ngokuqeqeshwa okufanele kwezokwelapha. Abantu abaningi abane-hemophilia B bafunda ukuzijova i-Factor IX ekhaya, enikeza ukuguquguquka okukhulu nokwelashwa okusheshayo uma kudingeka.

Ithimba lakho lokunakekelwa kwezempilo lizokufundisa wena noma amalungu omndeni wakho ukuthi alungiselele futhi anikeze imithi ngokuphepha. Le nqubo ihlanganisa ukugcinwa okufanele komuthi, inqubo engeyona inzalo yokuxuba nokujova, kanye nokubona lapho ukwelashwa kudingeka. Ukwelashwa ekhaya kungaba usizo ikakhulukazi ekuphatheni izigameko zokopha ezincane ngokushesha.

Ukwakha indawo ephephile yasekhaya kubaluleke ngokulinganayo. Lokhu kusho ukusebenzisa amaphedi okuvikela ngesikhathi semisebenzi, ukugcina izindlela ezicacile zokuvimbela ukuwa, nokugcina imininingwane yokuxhumana esheshayo itholakala kalula. Udokotela wakho angase ancome izinguquko ezithile ngokusekelwe kumaphethini akho okopha nendlela yokuphila.

Ukugcina amarekhodi anemininingwane yezigameko zakho zokopha, ukufakwa kwe-Factor IX, kanye nanoma yimaphi imiphumela emibi kusiza ithimba lakho lokunakekelwa kwezempilo ukuthi lithuthukise uhlelo lwakho lokwelashwa. Abantu abaningi basebenzisa izinhlelo zokusebenza ezikhethekile noma amaphephabhuku aklanyelwe ukulandelela ukuphathwa kwe-hemophilia.

Yini ukwelashwa kwezokwelapha kokushoda kwe-Factor IX?

Ukwelashwa okushintshayo kwe-Factor IX kuyindlela yokwelapha yezokwelapha eyinhloko ye-hemophilia B. Udokotela wakho uzonquma uhlobo olufanele kanye nomthamo ngokusekelwe emazingeni akho e-Factor IX, umlando wokopha, nezidingo zokuphila. Ukwelashwa kunganikezwa ngokucela lapho ukopha kwenzeka noma njenge-prophylaxis ukuvimbela izigameko zokopha.

Ukwelashwa okudingeka ngokushesha kusho ukuthi uthola i-Factor IX uma unezigameko zokuphuma igazi noma ngaphambi kwemisebenzi engase ibangele ukuphuma igazi. Le ndlela isebenza kahle kubantu abane-hemophilia B elula noma labo abahlangabezana nokuphuma igazi okungavamile. Udokotela wakho uzobala umthamo ngokuya ngesisindo somzimba wakho nobukhulu bokuphuma igazi.

Ukwelashwa kokuvimbela kuhilela ukufakwa kwe-Factor IX njalo ukuze kugcinwe amazinga okuvikela egazini lakho. Le ndlela ivame ukunconywa kubantu abane-hemophilia B enzima noma labo abahlangabezana nokuphuma igazi okuningi emalungeni. Uhlobo lwe-glycopegylated lwe-Factor IX luvumela ukuthi kuthathwe imithamo engavamile, ngezinye izikhathi kwandiswe izikhawu phakathi kokwelashwa.

Uhlelo lwakho lokwelashwa lungase futhi luhlanganise ezinye izindlela zokwelapha ezisekelayo. Lokhu kungabandakanya ukwelashwa ngokomzimba ukuze kugcinwe impilo yamalunga, imithi yokulawula ubuhlungu noma ukuvuvukala, kanye nokuhlolwa njalo ngezivivinyo zegazi ukuze kuqinisekiswe amazinga aphezulu e-Factor IX.

Kufanele ngibone nini udokotela ngenxa yokuntuleka kwe-Factor IX?

Kufanele uthinte umhlinzeki wakho wezempilo ngokushesha uma uhlangabezana nanoma yiziphi izimpawu zokuphuma igazi okukhulu, ngisho noma usanda kuthola ukwelashwa nge-Factor IX. Lokhu kufaka phakathi ikhanda elibuhlungu elibuhlungu, izinguquko embonweni, ubuhlungu obuqhubekayo besisu, noma noma yikuphi ukuphuma igazi okungaphenduli emthethweni wakho ojwayelekile wokwelapha.

Hlela ama-aphoyintimenti okulandelayo njalo ukuze uqaphe isimo sakho futhi ulungise uhlelo lwakho lokwelashwa njengoba kudingeka. Udokotela wakho ngokuvamile uzofuna ukukubona njalo emavikini ama-3-6 ukuze ahlulele amaphethini akho okuphuma igazi, ahlole izinkinga, futhi aqinisekise ukuthi ukwelashwa kwakho okungena esikhundleni se-Factor IX kusebenza ngempumelelo.

Xhumana nethimba lakho lezempilo ngaphambi kwanoma yikuphi ukuhlinzwa okuhleliwe, izinqubo zamazinyo, noma ukwelashwa kwezokwelapha. Lezi zimo zivame ukudinga imithetho ekhethekile yokulinganisa i-Factor IX ukuvimbela ukuphuma igazi okukhulu. Udokotela wakho angahlela nabanye abahlinzeki bezempilo ukuze baqinisekise ukwelashwa okuphephile, okuphumelelayo.

Uma uqaphela noma yiziphi izimpawu ezintsha noma izinguquko emaphethini akho okuphuma igazi, unganqikazi ukuxhumana nodokotela wakho. Lokhu kuhlanganisa izigameko zokuphuma igazi ezivame kakhulu, ukuphuma igazi ezindaweni ezintsha, noma izinguquko endleleni ozabela ngayo ekwelashweni kwe-Factor IX. Ukungenelela ngokushesha kungavimbela izinkinga futhi kuthuthukise ukunakekelwa kwakho.

Yiziphi izici eziyingozi zokuthuthukisa ukuntuleka kwe-Factor IX?

Isici esiyinhloko esiyingozi sokuntuleka kwe-Factor IX ukuba nomlando womndeni we-hemophilia B. Njengoba lesi simo sitholakala nge-X chromosome, amadoda maningi amathuba okuthi athinteke, kuyilapho abesifazane maningi amathuba okuba ngabathwali. Uma unyoko engumthwali, unethuba elingama-50% lokuthola ifayela elishintshiwe.

Ukuzalwa njengomuntu wesilisa kwandisa ingozi yakho yokuthuthukisa i-hemophilia B enezimpawu uma uthola ifayela elishintshiwe. Abesifazane nabo bangathinteka, kodwa lokhu akuvamile futhi kuvame ukwenzeka lapho bethola amafayela ashintshiwe kubazali bobabili noma benokuhlukahluka okuthile kwe-chromosomal.

Ezinye izimo zezokwelapha zingakhuphula ingozi yakho yokuthuthukisa ukuntuleka kwe-Factor IX okutholakele kamuva empilweni. Lokhu kuhlanganisa izifo ze-autoimmune lapho amasosha akho omzimba ehlasela izici zakho zokujiya, isifo sesibindi esibi esiphazamisa ukukhiqizwa kwezici zokujiya, kanye nemithi ethile ethinta ukujiya kwegazi.

Ubudala bungadlala indima ekuntulekeni kwe-Factor IX okutholakele, njengoba ezinye izimo ze-autoimmune ezithinta izici zokujiya ziba zivamile ngokukhula kweminyaka. Kodwa-ke, i-hemophilia B yofuzo ikhona kusukela ekuzalweni, ngisho noma izimpawu zingaveli kuze kube kamuva empilweni.

Yiziphi izinkinga ezingaba khona zokuntuleka kwe-Factor IX?

Umonakalo wamajoyinti ungomunye wezinkinga ezingathi sína zesikhathi eside zokuntuleka kwe-Factor IX okungelashwa. Ukuphuma igazi okuphindaphindiwe emalungeni, ikakhulukazi emadolweni, emaqakaleni, nasemigqeni, kungabangela ubuhlungu obungapheli, ukuqina, nokuncipha kokuhamba. Lesi simo, esibizwa ngokuthi i-hemophilic arthropathy, singathinta kakhulu izinga lempilo yakho uma lingalawulwa kahle.

Ukuphuma kwegazi kwangaphakathi kumele enye into ebalulekile okumele ikhathazwe ngayo, ikakhulukazi ukuphuma kwegazi ebuchosheni, esiswini, noma emgodini wesifuba. Lezi zigameko zokuphuma kwegazi zingaba yingozi empilweni futhi zidinga ukunakekelwa kwezokwelapha ngokushesha. Ukuphuma kwegazi ebuchosheni kungase kubangele ikhanda elibuhlungu, ukudideka, noma izimpawu ze-neurological, kuyilapho ukuphuma kwegazi esiswini kungase kubangele ubuhlungu obukhulu nokulimala kwezitho zangaphakathi.

Ukuphuma kwegazi emsipheni, noma ama-hematomas, kungacindezela imizwa nemithambo yegazi, okuholela ebuhlungwini, ukuba ndikindiki, noma ukuncipha komsebenzi ezindaweni ezithintekile. Ukuphuma kwegazi okukhulu emsipheni kungase kudingeke ukungenelela kokuhlinzwa ukuze kukhululwe ingcindezi futhi kuvinjelwe ukulimala unomphela.

Abantu abanokuntuleka kwe-Factor IX nabo babhekana nezingozi ezengeziwe ngesikhathi senqubo yezokwelapha, ukuzala, noma ukuhlukumezeka. Ngaphandle kokufaka esikhundleni se-Factor IX okufanele, lezi zimo zingaholela ekuphumeni kwegazi okukhulu okunzima ukukulawula. Kodwa-ke, ngohlelo olufanele lokwelashwa, lezi zingozi zingalawulwa ngempumelelo.

Ezimweni ezingavamile, abanye abantu bathuthukisa ama-inhibitors - ama-antibody enza ukufaka esikhundleni se-Factor IX kungasebenzi kahle. Lokhu kuba nzima kudinga izindlela zokwelapha ezikhethekile nokuqapha okuseduze ngongoti be-hemophilia.

Ingabe ukwelashwa ngokufaka esikhundleni se-Factor IX kulungile noma kubi nge-hemophilia B?

Ukwelashwa ngokufaka esikhundleni se-Factor IX kunenzuzo enkulu kubantu abane-hemophilia B futhi kumele izinga legolide lokwelashwa. Lo muthi ungalithuthukisa kakhulu izinga lempilo yakho ngokuqeda izigameko zokuphuma kwegazi, ukunciphisa ukulimala kwamalunga, nokukuvumela ukuthi uhlanganyele emisebenzini eminingi ejwayelekile ngokuphepha.

Ukwelashwa kusebenza ngokufaka esikhundleni sephrotheni ye-Factor IX elahlekile noma enesici umzimba wakho oyidingayo ukuze wakhe amahlule egazi ngempumelelo. Ukwelashwa njalo kungavimbela ukulimala kwamalunga nobuhlungu obungapheli obuvame ukuthuthuka lapho i-hemophilia B ingelashwa. Abantu abaningi bathola ukuthi ukwelashwa kwe-Factor IX okuqhubekayo kubavumela ukuthi bagcine izindlela zokuphila ezisebenzayo, ezigcwalisayo.

Imikhiqizo yesimanje ye-Factor IX, ikakhulukazi izinhlobo ze-glycopegylated, inikeza ukulula okuthuthukisiwe ngemiphumela ehlala isikhathi eside. Lokhu kusho ukujova okuncane nokuvikeleka okungcono ekuphumeni kwegazi. Umuthi unohlu oluhle kakhulu lokuphepha uma usetshenziswa njengoba uqondiswe yithimba lakho lokunakekelwa kwezempilo.

Ngenkathi ukwelashwa ngokufaka i-Factor IX kunenzuzo enkulu, kubalulekile ukulandela uhlelo lwakho lokwelashwa ngokucophelela futhi ugcine ukuxhumana njalo nabanikezeli bakho bezempilo. Ukusetshenziswa kahle kwalo muthi kungakusiza ukuthi uphile impilo ejwayelekile, enempilo naphezu kokuba ne-hemophilia B.

Yini ukuntuleka kwe-Factor IX okungase kudidaniswe nayo?

Ukuntuleka kwe-Factor IX ngezinye izikhathi kungadidaniswa nezinye izifo zokuphuma kwegazi, ikakhulukazi i-hemophilia A (ukuntuleka kwe-Factor VIII). Zombili lezi zimo zibangela izimpawu ezifanayo zokuphuma kwegazi, kodwa zihilela izinto ezihlukene zokugcotshwa futhi zidinga ukwelashwa okuhlukene. Ukuhlolwa okufanele kwegazi kungahlukanisa phakathi kwalezi zimo.

Isifo sikaVon Willebrand, isifo esivamile sokuphuma kwegazi esizuzwe ngofuzo, singase futhi siveze izimpawu ezifanayo. Kodwa-ke, lesi simo ngokuvamile sithinta kokubili amadoda nabesifazane ngokulinganayo futhi sivame ukuhlanganisa amaphethini ahlukene okuphuma kwegazi, njengokuya esikhathini okunzima noma ukulimala kalula ekuqhumeni okuncane.

Izifo ze-platelet zingase zixutshwe nokuntuleka kwe-Factor IX ngoba zombili zingabangela ukulimala kalula nokuphuma kwegazi. Kodwa-ke, izinkinga ze-platelet ngokuvamile zibangela amabala amancane, amancane okuphuma kwegazi abizwa ngokuthi i-petechiae, ngenkathi ukuntuleka kwe-Factor IX kuvame kakhulu ukubangela ukuphuma kwegazi okujulile emalungeni nasemisipheni.

Ngezinye izikhathi, isifo sesibindi noma ukuntuleka kwe-vitamin K kungalingisa ukuntuleka kwe-Factor IX ngokuthinta izinto eziningi zokugcotshwa. Udokotela wakho angahlukanisa lezi zimo ngokuhlolwa kwegazi okubanzi nokuhlola umlando wezokwelapha.

Ezinganeni, ukuntuleka kwe-Factor IX kungase kuqale kudidaniswe nokuhlukunyezwa kwezingane ngenxa yokulimala noma ukopha okungachazeki. Kodwa-ke, iphethini ethile yokopha nomlando womndeni ngokuvamile kusiza abahlinzeki bezempilo ukuthi benze ukuxilongwa okulungile.

Imibuzo evame ukubuzwa mayelana nokuntuleka kwe-Factor IX

Ingabe ukwelashwa nge-Factor IX kuhlala isikhathi esingakanani emzimbeni wami?

Uhlobo lwe-glycopegylated lwe-Factor IX ngokuvamile luhlala isikhathi eside egazini lakho kunezinto ezijwayelekile ze-Factor IX. Ngokuya ngemetabolism yakho kanye nomkhiqizo othile osetshenzisiwe, ukuvikeleka kungahlala noma yikuphi kusukela ezinsukwini ezimbalwa kuya ngaphezu kwesonto elilodwa. Udokotela wakho uzochaza uhlelo lokulinganisa olufanele olususelwe emazingeni akho e-Factor IX namaphethini okopha.

Ngingakwazi yini ukuzivocavoca noma ukudlala imidlalo ngokuntuleka kwe-Factor IX?

Yebo, ngemithi efanele yokufaka i-Factor IX nesiqondiso sezokwelapha, ungahlanganyela emisebenzini eminingi yomzimba nemidlalo. Ithimba lakho lezempilo lizokusiza ukuthi wakhe uhlelo lomsebenzi oluhlanganisa ukulinganisa okufanele kwe-Factor IX ngaphambi kwemisebenzi enobungozi obukhulu. Ukubhukuda, ukuhamba ngebhayisikili, nokuhamba ngokuvamile kuthathwa njengokuphephile, kuyilapho imidlalo yokuxhumana ingase idinge izinyathelo zokuphepha ezikhethekile.

Ngizodinga yini ukwelashwa nge-Factor IX impilo yami yonke?

Uma une-hemophilia B yofuzo, cishe uzodinga ukwelashwa nge-Factor IX impilo yakho yonke. Kodwa-ke, izindlela zokwelapha zingashintsha njengoba imithi emisha nobuchwepheshe obusha buvela. Ithimba lakho lezempilo lizoqhubeka nokuhlola nokulungisa uhlelo lwakho lokwelapha ukuze kuqinisekiswe ukunakekelwa okufanele njengoba izidingo zakho zishintsha.

Ingabe zikhona ukudla noma imithi okufanele ngiyigweme ngokwelashwa nge-Factor IX?

Ngokuvamile, azikho izithiyo ezithile zokudla ngemithi ye-Factor IX. Nokho, kufanele ugweme imithi ethinta ukujiya kwegazi, njenge-aspirin noma izidambisi zinhlungu ezithile, ngaphandle uma kuvunywe udokotela wakho. Njalo yazisa abahlinzeki bezempilo nge-hemophilia B yakho kanye nokwelashwa kwe-Factor IX ngaphambi kokuqala noma yimiphi imithi emisha.

Ingabe abesifazane bangaba nokuntuleka kwe-Factor IX?

Yebo, nakuba kungavamile, abesifazane bangaba nokuntuleka kwe-Factor IX. Lokhu kuvame ukwenzeka lapho bethola izakhi zofuzo ezishintshiwe kubazali bobabili noma benokwehluka okuthile kwama-chromosome. Abesifazane abangabathwali bangase futhi babe nezimpawu zokuphuma igazi, ikakhulukazi ngesikhathi sokuya esikhathini, ukuzala, noma ukuhlinzwa, futhi bangazuza ekwelashweni kwe-Factor IX kulezi zimo.