Yini i-Colistimethate: Ukusetshenziswa, Umthamo, Imiphumela Eceleni nokuningi

I-Colistimethate iyisibulala-magciwane esinamandla esisetshenziswa odokotela lapho ezinye izindlela zokwelapha zingasebenzanga ekuqhumeni kwamagciwane okukhulu. Ingaphansi kweqembu lemithi ebizwa ngokuthi ama-polymyxins, athathwa njengama-antibiotics "okugcina" ezifo ezisongela impilo ezibangelwa amagciwane amelana neminye imithi eminingi.

Lo muthi unikezwa njengomjovo, kungaba emthanjeni noma emisipheni, ngoba udinga ukusebenza ngokushesha nangempumelelo emzimbeni wakho wonke. Ngenkathi kungumuthi onamandla ongonga izimpilo, uza nezinye izingozi okufanele iqembu lakho lezempilo liqaphele ngokucophelela.

Yini i-Colistimethate Esetshenziselwa Yona?

I-Colistimethate iphatha izifo ezinzima ezibangelwa amagciwane e-gram-negative angasabeli kwamanye ama-antibiotics. Udokotela wakho ngokuvamile uzonquma lo muthi uma unesifo esibi futhi ezinye izindlela zokwelapha zingasebenzi.

Izifo ezivame kakhulu eziphathwa nge-colistimethate zihlanganisa umkhuhlane wamaphaphu, izifo zegazi, izifo zomgudu womchamo, nezifo zesikhumba. Isebenza ikakhulukazi ngamagciwane afana ne-Pseudomonas aeruginosa, Acinetobacter, kanye nezinhlobo ezithile ze-E. coli eziye zamelana nama-antibiotics amaningi.

Ngezinye izikhathi odokotela basebenzisa i-colistimethate ukuvimbela izifo kubantu abasengozini enkulu, njengalabo abane-cystic fibrosis noma iziguli ezikunakekelwa okukhulu. Kodwa-ke, lokhu kusetshenziswa kokuvimbela akuvamile futhi kudinga ukucatshangelwa ngokucophelela kwezinzuzo uma kuqhathaniswa nezingozi.

Isebenza Kanjani i-Colistimethate?

I-Colistimethate isebenza ngokuhlasela udonga olungaphandle lwamaseli amagciwane, okubangela ukuthi ahlukane futhi afe. Cabanga ngakho njengokugwaza izimbobo ebhalonini - uma udonga lweseli lamagciwane selonakele, amagciwane awasakwazi ukusinda.

Leli yi-antibiotic eqinile eyenzelwe ngqo ukulwa namagciwane asekhe akwazi ukumelana neminye imithi. Yilokho odokotela abakubiza ngokuthi i-“bactericidal” antibiotic, okusho ukuthi empeleni ibulala amagciwane kunokumane imise ukukhula kwawo.

Umuthi uguqulwa ube yifomu lawo elisebenzayo elibizwa ngokuthi i-colistin uma ungena emzimbeni wakho. Le nqubo yokuguqula isiza ukunciphisa eminye imiphumela emibi ngenkathi isagcina imiphumela enamandla yomuthi yokulwa namagciwane.

Kufanele Ngiyithathe Kanjani I-Colistimethate?

Uzothola i-colistimethate njengomjovo esibhedlela noma endaweni yezokwelapha, ungalokothi njengemithi oyithatha ekhaya. Umuthi unikezwa ngomugqa we-IV ungene emthanjeni wakho noma njengomjovo emsipheni wakho, kuye ngesimo sakho esithile.

Ithimba lakho lezempilo lizobala umthamo wakho oqondile ngokusekelwe esisindweni sakho, ukusebenza kwezinso, nobukhulu bokutheleleka kwakho. Ukwelashwa okuvamile kuhilela ukuthola umuthi izikhathi ezi-2-4 ngosuku, ngomthamo ngamunye onikezwa kancane kancane ngaphezu kwemizuzu engama-30 kuya emahoreni ama-2 uma kungokusebenzisa i-IV.

Akudingeki ukhathazeke ngokuthatha lo muthi nokudla ngoba unikezwa njengomjovo. Kodwa-ke, kubalulekile ukuhlala unamanzi kahle ngesikhathi sokwelashwa, ngakho phuza amanzi amaningi ngaphandle uma udokotela wakho ekutshela ngenye indlela.

Ithimba lakho lezokwelapha lizokuqapha eduze ngesikhathi sokwelashwa, lihlola igazi lakho njalo ukuze liqinisekise ukuthi umuthi usebenza kahle futhi awubangeli imiphumela emibi.

Kufanele Ngiyithathe Isikhathi Esingakanani I-Colistimethate?

Ubude bokwelashwa nge-colistimethate buvame ukusuka ezinsukwini eziyi-7 kuya kweziyi-14, kodwa lokhu kungahluka kakhulu ngokuya ngokutheleleka kwakho okuthile nokuthi usabela kanjani ekwelashweni. Udokotela wakho uzonquma ubude obuqondile ngokusekelwe ezintweni eziningana.

Eziningi zezifo ezibangelwa amagciwane, uzodinga ukuqhubeka nokwelashwa kuze kube yilapho izivivinyo zaselabhorethri zikhombisa ukuthi amagciwane aselahlekile futhi izimpawu zakho zithuthukile. Ezinye izifo ezinzima zingase zidinge izikhathi zokwelashwa ezinde, kanti ezinye zingase ziphendule ngokushesha.

Ithimba lakho lezempilo lizobheka intuthuko yakho ngokusebenzisa izivivinyo zegazi ezivamile, izifundo zokuthwebula izithombe, kanye nokuhlolwa komzimba. Bazobheka futhi izimpawu zokuthi ukutheleleka kuyaphela, njengokuncipha komkhuhlane, ukuthuthuka kokuphefumula, noma ukuphola kwamanxeba anamagciwane.

Kubalulekile ukuqeda lonke uhlelo lokwelashwa ngisho noma uqala ukuzizwa ungcono. Ukuyeka ngaphambi kwesikhathi kungavumela amagciwane ukuthi abuye abe namandla futhi amelane nokwelashwa.

Yiziphi Imiphumela Eceleni Ye-Colistimethate?

Njengayo yonke imithi enamandla, i-colistimethate ingabangela imiphumela emibi, nakuba kungewona wonke umuntu oyitholayo. Imiphumela emibi evame kakhulu ngokuvamile iyalawuleka futhi ithimba lakho lezokwelapha lizoyibheka ngokucophelela.

Nansi imiphumela emibi ongase uyithole, iqala ngaleyo evame kakhulu:

• Izinkinga zezinso, okuhlanganisa izinguquko ekuchameni noma ukuvuvukala emilenzeni yakho noma ezinyaweni
• Isiyezi noma ukuzizwa ungaqinile, ikakhulukazi uma usukuma
• Ukuzwa ukuluma noma ukuba ndikindiki ezandleni zakho, ezinyaweni, noma ngomlomo wakho
• Isicanucanu noma isisu esibuhlungu
• Ubuhlungu noma ukucasuka endaweni yokujova
• Ikhanda elibuhlungu noma ukuzizwa udidekile
• Ubuthakathaka bemisipha noma ubunzima bokuhlela

Iningi lale miphumela ithambile futhi yesikhashana, kodwa ithimba lakho lezempilo lizokubheka eduze ukuze libambe noma yiziphi izinkinga ngokushesha. Bazohlola njalo ukusebenza kwezinso zakho kanye nokuphendula kwemizwa ngesikhathi sokwelashwa.

Ezinye izimpawu ezingavamile kodwa ezinzima zihlanganisa ukulimala okukhulu kwezinso, izinkinga zokuphefumula, noma izinguquko ezinkulu esimweni sakho sengqondo. Ithimba lakho lezokwelapha liqeqeshwe ukubona lezi zimpawu futhi lizothatha isinyathelo ngokushesha uma zenzeka.

Ubani Ongafanele Athole I-Colistimethate?

I-Colistimethate ayifanele wonke umuntu, futhi udokotela wakho uzobukeza ngokucophelela umlando wakho wezokwelapha ngaphambi kokukuyalela. Abantu abanezimo ezithile zezempilo bangase badinge ukwelashwa okuhlukile noma ukuqashwa okukhethekile.

Akufanele uthole i-colistimethate uma unokungezwani komzimba ne-colistin, ama-antibiotics e-polymyxin, noma yiziphi izithako emuthini. Tshela ithimba lakho lezempilo nganoma yiziphi izindlela zokungezwani komzimba nezinto ezithile eziye zaba khona ngaphambili kuma-antibiotics, ngisho noma zibonakala zingahlobene.

Abantu abanezinkinga zezinso ezikhona badinga ukucatshangelwa okukhethekile, njengoba i-colistimethate ingathinta ukusebenza kwezinso. Udokotela wakho uzoqaphela izinzuzo ngokumelene nezingozi futhi angase alungise umthamo wakho noma akhethe ukwelashwa okuhlukile uma izinso zakho zingasebenzi kahle.

Uma une-myasthenia gravis (isimo sokuba buthakathaka kwemisipha), izinkinga zemizwa, noma izinkinga zokuzwa, udokotela wakho uzodinga ukukuqapha ngokucophelela okwengeziwe. Lezi zimo zingase zibe zimbi kakhulu yi-colistimethate, nakuba ukwelashwa kungase kudingeke uma unokutheleleka okukhulu.

Abesifazane abakhulelwe nabancelisayo badinga ukucatshangelwa okukhethekile, njengoba kukhona ulwazi olulinganiselwe mayelana nokuphepha kwe-colistimethate ngesikhathi sokukhulelwa. Udokotela wakho uzoyala kuphela uma izinzuzo ziqeda izingozi ezingaba khona.

Amagama Omkhiqizo we-Colistimethate

I-Colistimethate itholakala ngaphansi kwamagama amaningi omkhiqizo, i-Coly-Mycin M ingesinye sezinto ezivamile e-United States. Amanye amagama omkhiqizo afaka i-Colistin ne-Promixin, nakuba ukutholakala kuhluka ngokuya ngezwe.

Igama elivamile elithi

Uma i-colistimethate ingafaneleki noma ingatholakali, udokotela wakho angase acabange ngamanye ama-antibiotics, nakuba izinketho zamagciwane angamelanayo zilinganiselwe. Ukukhetha kuncike ekutheni yimaphi amagciwane abangela ukutheleleka kwakho kanye nokuzwela kwawo emithini ehlukene.

Ezinye izindlela ezingenye zihlanganisa i-tigecycline, esebenza ngokumelene namagciwane amaningi angamelanayo, noma ukwelashwa okuhlanganisiwe kusetshenziswa ama-antibiotics amaningi ndawonye. Imithi emisha efana ne-ceftazidime-avibactam noma i-meropenem-vaborbactam ingase futhi ibe yizinketho zezinhlobo ezithile zokutheleleka.

Kwezinye izimo, udokotela wakho angase azame i-polymyxin B, ehlobene eduze ne-colistimethate futhi isebenza ngendlela efanayo. Nokho, amaphrofayili emiphumela emibi afana kakhulu, ngakho lokhu akusona ngaso sonke isikhathi esinye isisombululo esihle uma uke waba nezinkinga nge-colistimethate.

Iqiniso liwukuthi eziningi izifo ezinokumelana okuphezulu, i-colistimethate isahlala ingenye yezindlela zokwelapha eziphumelela kakhulu ezitholakalayo. Ithimba lakho lezokwelapha lizohlala lizama ukuthola inketho ephephile nephumelelayo yesimo sakho esithile.

Ingabe i-Colistimethate Ingcono Kunezinye Izibulala-magciwane?

I-Colistimethate akudingeki ukuthi “ingcono” kunezinye izibulala-magciwane - imane nje isebenza kahle kumagciwane angasabeli kwezinye izindlela zokwelapha. Cabanga ngayo njengethuluzi elikhethekile lezimo ezithile kunokuba kube umuthi ongcono ngokujwayelekile.

Ezifweni ezibangelwa amagciwane azwela kwamanye ama-antibiotics, odokotela ngokuvamile bazokhetha lezo ezinye izinketho kuqala. Lokhu kungenxa yokuthi i-colistimethate ithwala izingozi eziningi zemiphumela emibi, ikakhulukazi ezinso kanye nohlelo lwezinzwa.

Amandla e-colistimethate aqhamuka ekwazi kwayo ukulwa namagciwane amaningi amelana nemithi lapho ezinye izibulala-magciwane zehlulekile. Kulezi zimo ezisongela impilo, ingasindisa impilo ngokoqobo, okuyenza ibe yigugu naphezu kwezingozi zayo.

Udktela wakho uzohlala ezama ukusebenzisa i-antibiotic ethambile esebenzayo kuqala, eqhubekela ezinkethweni ezinamandla njenge-colistimethate kuphela uma kudingeka. Le ndlela isiza ukugcina ukusebenza kwale mithi enamandla uma idingeka ngempela.

Imibuzo Evame Ukubuzwa Mayelana ne-Colistimethate

Ingabe i-Colistimethate iphephile kubantu abanezifo zezinso?

I-Colistimethate ingathinta ukusebenza kwezinso, ngakho-ke abantu abanezinkinga zezinso ezikhona badinga ukunakekelwa okukhethekile nokuqapha. Udktela wakho uzolungisa umthamo wakho ngokusekelwe ekutheni izinso zakho zisebenza kahle kangakanani futhi uzohlola ukusebenza kwezinso zakho njalo ngesikhathi sokwelashwa.

Uma unezinkinga zezinso ezincane, ungase ukwazi ukuthola i-colistimethate ngomthamo omncane nokuqapha okwengeziwe. Kodwa-ke, uma ukusebenza kwezinso zakho kulimala kakhulu, udktela wakho angase adinge ukucabangela ezinye izindlela zokwelapha noma asebenzise i-colistimethate kuphela uma kudingeka ngempela.

Ngingenzani uma ngithola imiphumela emibi engathi sína?

Njengoba uzothola i-colistimethate esibhedlela noma endaweni yezokwelapha, ithimba lakho lezokwelapha lizokuqapha eduze ukuze libone imiphumela emibi. Uma uqaphela noma yiziphi izimpawu ezikhathazayo njengobunzima bokuphefumula, isiyezi esikhulu, noma izinguquko ezinkulu ekuchameni, tshela umhlengikazi wakho noma udktela ngokushesha.

Ungakhathazeki ngokukhathaza abasebenzi bezokwelapha - bafuna ukwazi nganoma yiziphi izimpawu oziphilayo. Ukutholwa kwangaphambi kwesikhathi nokwelashwa kwemiphumela emibi kungavimbela izinkinga ezingathi sína ukuthi zingenzeki.

Kwenziwani uma ngiphuthelwa umthamo we-Colistimethate?

Njengoba i-colistimethate inikezwa ochwepheshe bezempilo endaweni yezokwelapha, ngeke kudingeke ukhathazeke ngokulahlekelwa imithamo. Ithimba lakho lezokwelapha lizoqinisekisa ukuthi uthola imithi yakho ngesikhathi njengengxenye yohlelo lwakho lokwelapha.

Uma ngenxa yesizathu esithile umthamo uhlehliswa ngenxa yezinqubo zezokwelapha noma ezinye izindlela zokwelapha, ithimba lakho lezempilo lizolungisa isikhathi ngendlela efanele. Bazoqinisekisa ukuthi uthola lonke uhlelo lokwelashwa oludingekayo lokutheleleka kwakho.

Ngingayeka nini ukuthatha i-Colistimethate?

Akufanele neze uyeke ukwelashwa nge-colistimethate ngokwakho - lesi sinqumo kufanele senziwe njalo yithimba lakho lezempilo ngokusekelwe ekuphenduleni kwakho ekwelashweni kanye nemiphumela yokuhlolwa. Ukuyeka ngaphambi kwesikhathi kungavumela ukuthi ukutheleleka kubuye kube namandla kunakuqala.

Udokotela wakho uzoqoka ukuthi uyeka nini ukwelashwa ngokusekelwe ezintweni eziningana: izimpawu zakho zithuthuka, ukuhlolwa kwegazi okukhombisa ukuthi ukutheleleka kuyacaca, futhi uqinisekisa ukuthi uthole imithi eyanele ukuvimbela amagciwane ukuthi angabuyi.

Ingakwazi yini i-Colistimethate ukusebenzisana neminye imithi?

Yebo, i-colistimethate ingasebenzisana neminye imithi eminingana, yingakho ithimba lakho lezokwelapha lizobuyekeza yonke imithi yakho yamanje ngaphambi kokuqala ukwelashwa. Ukusebenzisana okubaluleke kakhulu kuneminye imithi engathinta izinso noma uhlelo lwezinzwa.

Imithi efana nama-aminoglycoside antibiotics, ama-diuretics athile, kanye neminye imithi yokubamba ubuhlungu ingandisa ingozi yezinkinga zezinso uma ihlanganiswe ne-colistimethate. Ithimba lakho lezempilo lizophatha ngokucophelela lezi zinto ezihlangene futhi lingase lilungise imithamo noma isikhathi seminye imithi njengoba kudingeka.