Yini ama-Estrogens ahlanganisiwe kanye ne-Bazedoxifene: Ukusetshenziswa, Umthamo, Imiphumela Eceleni nokuningi

Ama-estrogens ahlanganisiwe kanye ne-bazedoxifene kuyindlela yokwelapha ngamaphilisi e-hormone ehlanganisiwe esiza ukwelapha izimpawu zokuya esikhathini kuyilapho ivikela amathambo akho. Lokhu kuhlanganiswa okuyingqayizivele kuhlanganisa ama-hormone e-estrogen ne-selective estrogen receptor modulator (SERM) ukukunikeza impumuzo ekuvutheni komzimba ebusuku nakusihlwa ngaphandle kokwandisa ingozi yakho yomdlavuza we-endometrial.

Cabanga ngale mithi njengendlela elinganiselayo yokwelapha ngama-hormone. Ingxenye ye-estrogen ibhekana nalezo zimpawu ezingakhululeki zokuya esikhathini, kuyilapho i-bazedoxifene isebenza njengendlela yokuvikela umugqa wakho wesibeletho, iqeda isidingo somuthi ohlukile we-progestin.

Yini ama-Estrogens ahlanganisiwe kanye ne-Bazedoxifene?

Le mithi ihlanganisa izithako ezimbili ezisebenzayo ezisebenza ndawonye ukuphatha izimpawu zokuya esikhathini ngokuphepha. Ama-estrogens ahlanganisiwe ayingxube yama-hormone e-estrogen atholakala emithonjeni yemvelo, kuyilapho i-bazedoxifene iwuhlobo olusha lwe-hormone modulator oluqondise ngokuqondile ama-estrogen receptors.

Le nhlanganisela yakhelwe ngqo abesifazane abasenasibeletho sabo futhi abadinga ukwelashwa ngama-hormone. Ngokungafani nokwelashwa ngama-hormone okujwayelekile okudinga ukwengeza i-progestin ukuvikela umugqa wesibeletho, le mithi ihlanganisa i-bazedoxifene ukuhlinzeka ngalokho kuvikelwa ngokwemvelo.

Ungase wazi le mithi ngegama layo lomkhiqizo elithi Duavee. Iza njengamaphilisi omlomo owathatha kanye ngosuku, okwenza kube yindlela elula yokuphatha izimpawu zokuya esikhathini ngenkathi kugcinwa impilo yamathambo.

Yini ama-Estrogens ahlanganisiwe kanye ne-Bazedoxifene Okusetshenziselwa Yona?

Le mithi ikakhulukazi iphatha ukuvutha komzimba okuphakathi nendawo kuya kokukhulu kanye nokujuluka ebusuku okuhambisana nokuya esikhathini. Uma uhlangabezana nalezi zimpawu ze-vasomotor eziphazamisa impilo yakho yansuku zonke noma ukulala, le ndlela yokwelapha ehlanganisiwe inganikeza impumuzo enkulu.

Umuthi futhi usiza ukuvimbela i-osteoporosis kwabesifazane abase-postmenopausal abasengozini yokuphuka kwamathambo. Njengoba amazinga e-estrogen ehla ngesikhathi sokuya esikhathini, amathambo akho angaba buthaka futhi athambekele ekuphukeni. Lokhu kwelashwa kusiza ukugcina ukuminyana kwamathambo namandla.

Udokotela wakho angase ancome lo muthi uma unezimpawu zokuya esikhathini eziphazamisayo futhi ufuna ukugwema ukuthatha imithi ehlukene yokukhulula izimpawu nokuvikela amathambo. Kuyasiza ikakhulukazi kwabesifazane ababa nemiphumela emibi evela ekwelashweni okujwayelekile kwe-hormone.

Isebenza Kanjani I-Conjugated Estrogens ne-Bazedoxifene?

Lo muthi usebenza ngendlela eyinkimbinkimbi yokusebenza kabili ekhuluma ngezimpawu zokuya esikhathini ngenkathi ivikela izicubu zakho zokuzala. Ingxenye ye-estrogen ithatha indawo yamanye ama-hormone umzimba wakho uyeka ukuwakhiqiza ngesikhathi sokuya esikhathini, okusiza ukulawula uhlelo lokulawula izinga lokushisa lomzimba wakho.

I-Bazedoxifene isebenza njenge-selective estrogen receptor modulator, okusho ukuthi iziphatha njenge-estrogen kwezinye izingxenye zomzimba wakho (njengamathambo) ngenkathi ivimba imiphumela ye-estrogen kwezinye (njengesisu). Lesi senzo esikhethiwe sisiza ukuvimbela ukujiya komugqa wakho wesibeletho okungaholela engozini yomdlavuza.

Inhlanganisela ithathwa njengenketho yokwelapha nge-hormone enamandla aphakathi nendawo. Inamandla ngokwanele ukuhlinzeka ngokuqeda izimpawu ezinengqondo nokuvikela amathambo, kodwa yakhelwe ukunciphisa izingozi eziningi ezihambisana nokwelashwa okujwayelekile kokufaka ama-hormone.

Kufanele Ngiyithathe Kanjani I-Conjugated Estrogens ne-Bazedoxifene?

Thatha lo muthi ngendlela enconwa ngayo udokotela wakho, ngokuvamile ithebhulethi eyodwa ngomlomo kanye ngosuku. Ungayithatha nokudla noma ngaphandle kokudla, kodwa ukuyithatha nokudla kungasiza ukunciphisa noma yikuphi ukuphatheka kwesisu ongase ukuzwe ekuqaleni.

Zama ukuthatha ithebhulethi yakho ngesikhathi esifanayo nsuku zonke ukuze ugcine amazinga e-hormone aqhubekayo emzimbeni wakho. Abesifazane abaningi bakuthola kuwusizo ukuyithatha ngesidlo sasekuseni noma sakusihlwa njengengxenye yomsebenzi wabo wansuku zonke. Lokhu kuqina kusiza umzimba wakho ukuthi ujwayele imithi ngempumelelo.

Gwinya ithebhulethi yonke ngengilazi yamanzi egcwele. Ungayichobozi, uhlafune, noma uyiphule ithebhulethi, ngoba lokhu kungathinta indlela imithi emuncwa futhi ikhishwe ngayo emzimbeni wakho. Uma unenkinga yokugwinya amaphilisi, khuluma nodokotela wakho mayelana nezinketho ezingezinye.

Kufanele Ngiyithathe Isikhathi Esingakanani I-Conjugated Estrogens kanye ne-Bazedoxifene?

Ubude bokwelashwa buyahluka ngokuya ngezimpawu zakho kanye nemigomo yezempilo. Abesifazane abaningi bathatha le mithi iminyaka eminingi ukuze baphathe izimpawu zokuya esikhathini, kanti abanye bangase bayisebenzise ikakhulukazi ukuvikela amathambo futhi baqhubeke nokuyisebenzisa isikhathi eside.

Udokotela wakho uzohlola njalo ukuthi usayidinga yini le mithi, ngokuvamile njalo emavikini angu-6 kuya kwangu-12. Lokhu kuhlolwa kusiza ukuqinisekisa ukuthi izinzuzo zisaqhubeka ukwedlula noma yiziphi izingozi ezingaba khona. Abanye besifazane bathola ukuthi banganciphisa umthamo wabo noma bayeke imithi njengoba izimpawu zabo zokuya esikhathini zithuthuka ngokwemvelo ngokuhamba kwesikhathi.

Ukuvikelwa kwamathambo, ukusetshenziswa kwesikhathi eside kungase kudingeke, ikakhulukazi uma unezinye izici eziyingozi ze-osteoporosis. Udokotela wakho uzocabangela ukuhlolwa kwakho kokuminyana kwamathambo, umlando womndeni, kanye nempilo yonke lapho enquma ubude obufanele bokwelashwa.

Yiziphi Imiphumela Eceleni Ye-Conjugated Estrogens kanye ne-Bazedoxifene?

Njengayo yonke imithi, le ndlela yokwelapha ehlanganisiwe ingabangela imiphumela emibi, nakuba abesifazane abaningi beyibekezelela kahle. Ukuqonda okukulindele kungakusiza ukuthi uzizwe ulungiselelwe kangcono futhi wazi ukuthi ungaxhumana nini nomhlinzeki wakho wezempilo.

Imiphumela emibi evame kakhulu ngokuvamile imnene futhi ivame ukuthuthuka njengoba umzimba wakho ujwayela imithi emasontweni ambalwa okuqala kokwelashwa.

Imiphumela emibi evamile ongase uyithole ihlanganisa:

• Ukugula noma ukungakhululeki esiswini, ikakhulukazi uma uqala umuthi
• Ukuzwela kwamabele noma ukuvuvukala
• Ikhanda elibuhlungu, elivame ukuba lula futhi okwesikhashana
• Ukuphuma kwegazi emithanjeni noma ukubona amachashazi, ikakhulukazi ezinyangeni ezimbalwa zokuqala
• Ukuminyana kwemilenze noma ukuqina kwemisipha
• Isiyezi noma ukukhathala

Le miphumela ejwayelekile ivamise ukwehla njengoba umzimba wakho ujwayela izinguquko zamahomoni. Ukuthatha umuthi nokudla kungasiza ekunciphiseni isicanucanu nokungakhululeki esiswini.

Imiphumela engavamile kodwa ebucayi idinga ukunakekelwa kwezokwelapha ngokushesha, yize ivela kaningi kwabesifazane abaningi.

Xhumana nodokotela wakho ngokushesha uma uhlangabezana nalokhu:

• Ubuhlungu obukhulu besisu noma isicanucanu esiqhubekayo nokuhlanza
• Ukuphuma kwegazi okungajwayelekile emithanjeni okunzima noma okuqhubeka ngaphezu kwezinyanga ezimbalwa zokuqala
• Ikhanda elibuhlungu elingaphenduli ekwelashweni okuvamile
• Ushintsho lombono noma ukulahlekelwa umbono ngokuphazima kweso
• Ubuhlungu besifuba noma ubunzima bokuphefumula
• Ubuhlungu obukhulu emlenzeni noma ukuvuvukala okungabonisa iqhubu legazi
• Ukuphuzi kwesikhumba sakho noma amehlo, okungabonisa izinkinga zesibindi

Ngenkathi imiphumela emibi engathi sína ingavamile, ukuqaphela lezi zimpawu zokuxwayisa kusiza ukuqinisekisa ukuthi uthola ukunakekelwa kwezokwelapha ngokushesha uma kudingeka.

Ubani Ongafanele Athole Ama-Estrogens Ahlanganisiwe kanye ne-Bazedoxifene?

Lo muthi awulungelwe wonke umuntu, futhi izimo ezithile zezempilo zenza kungaphephile ukuwusebenzisa. Udokotela wakho uzobuyekeza ngokucophelela umlando wakho wezokwelapha ngaphambi kokukuyalela lo muthi ukuze aqinisekise ukuthi ukufanele.

Akufanele uthathe lo muthi uma unomlando wamaqhubu egazi, unhlangothi, noma isifo senhliziyo. Ingxenye ye-estrogen ingakhuphula ingozi yakho yokuthuthukisa lezi zenzakalo ezinkulu zenhliziyo nemithambo yegazi, ikakhulukazi uma usuvele unezici eziyingozi.

Abesifazane abanomlando womdlavuza wamabele, umdlavuza we-endometrial, noma eminye imidlavuza ezwelayo kumahomoni kufanele bagweme lo muthi. Ingxenye ye-estrogen ingase ikwazi ukukhuthaza ukukhula kwama-tumor azwelayo kumahomoni, okwenza kungaphephile kwabesifazane abanezimo ezinjalo.

Ezinye izinto ezibalulekile ezingavumelekile zihlanganisa:

• Isifo sesibindi esisebenzayo noma ama-enzyme esibindi aphakanyiswe kakhulu
• Ukuphuma kwegazi okungachazeki kwesitho sangasese sowesifazane okungahlolwanga ngudokotela
• Ukukhulelwa okwaziwayo noma okusolwayo
• Isifo sezinso esibi kakhulu
• Izifo zokujiya kwegazi ezizuzwe ngofuzo
• Ikhanda elibuhlungu elibuhlungu kakhulu eline-aura

Uma unesifo sikashukela, umfutho wegazi ophezulu, noma ezinye izimo ezingamahlalakhona, udokotela wakho uzohlola izinzuzo nezingozi ngokucophelela ngaphambi kokukuyalela lo muthi.

Amakhemikhali e-Estrogens ahlanganisiwe kanye ne-Bazedoxifene Igama Lomkhiqizo

Lo muthi ohlanganisiwe utholakala ngaphansi kwegama lomkhiqizo elithi Duavee e-United States. I-Duavee iqukethe i-0.45 mg ye-estrogens ehlanganisiwe kanye ne-20 mg ye-bazedoxifene kuthebhulethi ngayinye.

Lo muthi ukhiqizwa yi-Pfizer futhi wagunyazwa yi-FDA ngo-2013. Njengamanje ukuphela kwenhlanganisela etholakalayo ye-estrogens ehlanganisiwe kanye ne-bazedoxifene emakethe, ngakho-ke azikho izinhlobo ezivamile ezitholakalayo okwamanje.

Ikhemisi lakho ngezinye izikhathi lingase libhekisele kulo ngegama lalo elivamile, kodwa uma uthatha umuthi wakho, uzothola amaphilisi e-Duavee brand. Amaphilisi anesimo esiyindilinga futhi abomvana, okwenza kube lula ukuwahlonza.

Ezinye izindlela ze-Estrogens eziHlanganisiwe kanye ne-Bazedoxifene

Uma lo muthi ungakulungele, ezinye izinketho zingasiza ekuphatheni izimpawu zokuya esikhathini futhi zivikele impilo yamathambo. Udokotela wakho angakusiza ukuthi uhlole lezi zindlela ezingezinye ngokuya ngezidingo zakho ezithile kanye nephrofayili yezempilo.

Izinhlanganisela zendabuko zokwelashwa ngamahomoni zihlanganisa i-estrogen kanye nemithi ye-progestin efana ne-Prempro noma i-Premphase. Lezi zinketho zingase zifanele uma ungenakukwazi ukuthatha i-bazedoxifene kodwa usadinga ukwelashwa ngamahomoni.

Ezinye izindlela ezingezona zamahomoni zokuphatha izimpawu zokuya esikhathini esiphelile zihlanganisa:

• Ama-selective serotonin reuptake inhibitors (SSRIs) afana ne-paroxetine (Brisdelle) ngoba ukushisa okukhulu
• I-Gabapentin yokunciphisa ukushisa okukhulu nokuthuthukisa ukulala
• I-Clonidine yokuphatha izimpawu ze-vasomotor
• Ukuguqulwa kwendlela yokuphila okuhlanganisa ukuzivocavoca njalo kanye nezinguquko zokudla

Ukuze kuvikelwe amathambo ngokuqondile, udokotela wakho angase ancome ama-bisphosphonates afana ne-alendronate (Fosamax) noma i-risedronate (Actonel), noma eminye imithi efana ne-denosumab (Prolia).

Ingabe i-Conjugated Estrogens ne-Bazedoxifene Ingcono Kunezindlela Zokwelapha Ngamahomoni Zendabuko?

Le nhlanganisela inikeza ezinye izinzuzo eziyingqayizivele ngaphezu kokwelashwa ngamahomoni kwendabuko, ikakhulukazi kwabesifazane abafuna ukugwema imiphumela emibi ehlobene ne-progestin. Ukufakwa kwe-bazedoxifene esikhundleni se-progestin kunganciphisa ukuqunjelwa, izinguquko zemizwa, nobumnene bebele abanye besifazane abahlangabezana nakho ngemithi yamahomoni yendabuko.

Umuthi ungase futhi ube nomthelela ongcono kuphrofayili yakho ye-lipid uma uqhathaniswa nezinye izinhlanganisela zamahomoni zendabuko. Ezinye izifundo zikhomba ukuthi kungasiza ukugcina noma ukuthuthukisa amazinga e-cholesterol ngenkathi kunikezwa ukukhululeka kwezimpawu zokuya esikhathini.

Nokho, ukwelashwa ngamahomoni kwendabuko kungase kufaneleke kakhulu kwabanye besifazane, ikakhulukazi labo abadinga imithamo ephezulu ye-estrogen noma abanezinkinga ezithile zempilo. Udokotela wakho angasiza ekunqumeni ukuthi iyiphi indlela evumelana kangcono nezidingo zakho zomuntu ngamunye kanye nemigomo yezempilo.

Imibuzo Evame Ukubuzwa Mayelana Ne-Conjugated Estrogens ne-Bazedoxifene

Ingabe i-Conjugated Estrogens ne-Bazedoxifene Iphephile Kwabesifazane Abane-Osteoporosis?

Yebo, lo muthi uvunyelwe ngokuqondile ukuvimbela i-osteoporosis kubantu besifazane abase-postmenopausal futhi kungaba yindlela enhle uma usengozini yokuphuka kwamathambo. Ingxenye ye-estrogen isiza ukugcina ubukhulu bamathambo, kuyilapho i-bazedoxifene inikeza imiphumela eyengeziwe yokuvikela amathambo.

Udokotela wakho uzoqapha ubukhulu bamathambo akho ngama-DEXA scans avamile ukuqinisekisa ukuthi umuthi uvikela amathambo akho ngempumelelo. Abesifazane abaningi babona ngcono izimpawu zabo zobukhulu bamathambo ngonyaka wokuqala wokwelashwa.

Kufanele Ngenzeni Uma Ngisebenzisa Ngengozi I-Conjugated Estrogens ne-Bazedoxifene Eningi Kakhulu?

Uma ngengozi uthatha ngaphezu komthamo wakho obekiwe, xhumana nodokotela wakho noma isikhungo sokulawula ubuthi ngokushesha. Ukuthatha okuningi kakhulu kungakhuphula ingozi yakho yemiphumela emibi engathi sína njengama-clots egazi, isicanucanu esibi, noma ukuphuma kwegazi okungajwayelekile.

Ungazami ukuthi "ukulungisa" ukweqisa ngokweqa umthamo wakho olandelayo. Kunalokho, buyela esimisweni sakho somthamo ovamile njengoba uqondiswe ngumhlinzeki wakho wokunakekelwa kwezempilo. Gcina umkhondo wokuthi ukweqisa kwenzeke nini ukuze unikeze imininingwane enembile ochwepheshe bezokwelapha.

Kufanele Ngenzeni Uma Ngiphuthelwa Umthamo we-Conjugated Estrogens ne-Bazedoxifene?

Uma uphuthelwa umthamo, wuthatha ngokushesha lapho ukhumbula, ngaphandle uma sekuseduze isikhathi somthamo wakho olandelayo ohleliwe. Kulokho, weqa umthamo ophuthelwe bese ubuyela esimisweni sakho somthamo ovamile.

Ungalokothi uthathe imithamo emibili ngesikhathi esisodwa ukuze ulungise umthamo ophuthelwe, ngoba lokhu kungakhuphula ingozi yakho yemiphumela emibi. Uma uvame ukukhohlwa imithamo, cabangela ukusetha i-alamu yansuku zonke noma usebenzise umhleli wamaphilisi ukukusiza ukuthi ukhumbule.

Ngingayeka nini Ukuthatha i-Conjugated Estrogens ne-Bazedoxifene?

Kufanele uyeke kuphela ukuthatha lo muthi ngaphansi kokuqondisa kukadokotela wakho. Ukuyeka kungazelelwe kungabangela ukuthi izimpawu zakho zokuya esikhathini zibuye ngokushesha futhi kungase kuthinte impilo yamathambo akho uma uwuthatha ukuze uvimbele i-osteoporosis.

Udktela wakho angase anciphise kancane kancane umthamo wakho ngaphambi kokuyeka ngokuphelele, ikakhulukazi uma ubuthathe umuthi isikhathi eside. Le ndlela yokunciphisa ingasiza ekunciphiseni ukubuya kwezimpawu futhi yenze ushintsho luzizwe lukhululekile.

Ngingawathatha yini ama-Conjugated Estrogens kanye ne-Bazedoxifene neminye imithi?

Lo muthi ungasebenzisana neminye imithi eminingi, ngakho-ke kubalulekile ukutshela udktela wakho ngayo yonke imithi, izithasiselo, kanye nemikhiqizo yezitshalo oyithathayo. Eminye imithi ingakhuphula noma yehlise ukusebenza kahle kokwelashwa ngamahomoni.

Ama-antibiotics athile, imithi elwa nesikhunta, kanye nemithi yokulwa nokuthuthumela ingathinta indlela umzimba wakho osebenza ngayo ngalo muthi. Udktela wakho kungadingeka ukuthi alungise umthamo wakho noma akuqaphele eduze uma uthatha lezi zinhlobo zemithi ndawonye.