Yini ama-Estrogen aHlanganisiwe: Ukusetshenziswa, Umthamo, Imiphumela Eceleni nokuningi

Ama-estrogen ahlanganisiwe ayindlela yokwelashwa kokushintshwa kwamahomoni equkethe ingxube yamahomoni e-estrogen. Le mithi isiza ukufaka esikhundleni se-estrogen umzimba wakho oyeka ukuyenza ngokwemvelo, ikakhulukazi ngesikhathi sokuyeka ukuya esikhathini. Ungase wazi lo muthi ngegama lawo elivamile lomkhiqizo, i-Premarin, ebelisiza abesifazane ukulawula izimpawu ezihlobene namahomoni amashumi eminyaka.

Yini ama-Estrogen aHlanganisiwe?

Ama-estrogen ahlanganisiwe yinhlanganisela yamahomoni e-estrogen avela ngokwemvelo, ikakhulukazi atholakala emchamweni wamahhashi akhulelwe. Lo muthi uqukethe izinhlobo eziningi ze-estrogen ezisebenza ngokubambisana ukuze zilingise lokho umzimba wakho ongakwenza ngokwemvelo. Ingxenye ethi

Ngesikhathi esingavamile, odokotela banikeza ama-estrogen ahlanganisiwe ezinhlotsheni ezithile zomdlavuza webele emadodeni nabesifazane, nakuba lokhu kusetshenziswa kudinga ukuqapha ngokucophelela. Abanye abahlinzeki bezempilo bayawasebenzisa futhi ukwelapha umdlavuza wendlala yesinye emadodeni, nakuba lokhu sekuncipha njengoba imithi emisha itholakala.

Isebenza Kanjani I-Conjugated Estrogens?

I-Conjugated estrogens isebenza ngokufaka esikhundleni se-estrogen umzimba wakho ongawenzi ngamanani anele. Uma usuwuthathile umuthi, uhamba ngegazi lakho futhi unamathele kuma-estrogen receptors emzimbeni wakho wonke. Lawa ma-receptor afana nokhiye abakhethekile abavulwa yi-estrogen kuphela, futhi uma esetshenzisiwe, asiza ukulawula imisebenzi eminingi ebalulekile yomzimba.

Lo muthi uthathwa njenge-hormone replacement therapy enamandla aphakathi nendawo. Inamandla ngokwanele ukwelapha ngempumelelo izimpawu eziningi zokuya esikhathini, kodwa ithambile ngokwanele ukusetshenziswa isikhathi eside uma inikezwe ngendlela efanele. Izinhlobo eziningi ze-estrogen kuma-estrogen ahlanganisiwe zisebenza ndawonye ukuhlinzeka ngokufaka esikhundleni se-hormone okubanzi kunezithako ze-hormone eyodwa.

Umzimba wakho ucubungula ama-estrogen ahlanganisiwe ikakhulukazi ngesibindi sakho, lapho ehlukaniswa khona futhi ekugcineni aqedwe. Le nqubo isiza ukugcina amazinga e-hormone aqinile usuku lonke, yingakho abantu abaningi bethatha lo muthi kanye ngosuku.

Kufanele Ngizithathe Kanjani I-Conjugated Estrogens?

Thatha ama-estrogen ahlanganisiwe ngendlela eqondile udokotela wakho ayalela ngayo, ngokuvamile kanye ngosuku ngesikhathi esifanayo nsuku zonke. Ungawuthatha lo muthi ngaphandle noma ngaphandle kokudla, kodwa ukuwuthatha nokudla kungasiza ukunciphisa ukuphazamiseka kwesisu uma uhlangabezana nanoma yini. Abantu abaningi bakuthola kuwusizo ukuthatha umthamo wabo ekuseni ukuze bagcine isimiso esiqhubekayo.

Gwinya ithebhulethi yonke ngengilazi yamanzi egcwele. Ungayichobozi, uhlafune, noma uyiphule ithebhulethi, njengoba lokhu kungathinta indlela umuthi ogxilwa ngayo. Uma uthatha eminye imithi, yihlukanise okungenani ngehora ngaphandle uma udokotela wakho ekutshela ngenye indlela.

Ukuze uthole imiphumela engcono kakhulu, zama ukuthatha umthamo wakho ngesikhathi esifanayo nsuku zonke. Lokhu kusiza ukugcina amazinga e-hormone aqinile emzimbeni wakho. Uma uqala lo muthi, udokotela wakho cishe uzoqala ngomthamo ophansi bese ewulungisa kancane kancane ngokuya ngokuthi usabela kanjani nokuthi yiziphi izimpawu oziphilayo.

Kufanele Ngithathe Isikhathi Esingakanani Ama-Conjugated Estrogens?

Ubude besikhathi ozothatha ngaso ama-conjugated estrogens buxhomeke ekutheni uwasebenziselani nokuthi asebenza kahle kangakanani kuwe. Ngezimpawu zokuya esikhathini, abesifazane abaningi basebenzisa ukwelashwa nge-hormone iminyaka embalwa ngesikhathi sokushintsha okunzima kakhulu. Udokotela wakho uzobuyekeza njalo ukuthi usawudinga yini umuthi nokuthi ngamuphi umthamo.

Iziqondiso zamanje zezokwelapha ziphakamisa ukusebenzisa umthamo ophansi osebenzayo isikhathi esifushane esidingekayo ukuze kulawulwe izimpawu zakho. Le ndlela isiza ukukhulisa izinzuzo ngenkathi kunciphisa izingozi ezingaba khona. Abanye besifazane badinga ukufakwa kwe-hormone unyaka owodwa noma emibili nje, kanti abanye bangazuza ekusebenziseni isikhathi eside, ikakhulukazi uma besengozini enkulu ye-osteoporosis.

Umhlinzeki wakho wezempilo uzohlela ukuhlolwa okujwayelekile ukuze aqaphe ukuthi usabela kanjani emuthini. Lokhu kuvakasha kuyithuba elibalulekile lokuxoxa nganoma yiziphi izinguquko ezimpawini zakho, ukubuyekeza noma yimaphi imiphumela emibi, nokulungisa uhlelo lwakho lokwelashwa njengoba kudingeka. Ungayeki ukuthatha ama-conjugated estrogens kungazelelwe ngaphandle kokukhuluma nodokotela wakho kuqala, ngoba lokhu kungabangela ukuthi izimpawu zibuye.

Yiziphi Imiphumela Emibi Yama-Conjugated Estrogens?

Abantu abaningi bayawamukela kahle ama-conjugated estrogens, kodwa njengayo yonke imithi, ingabangela imiphumela emibi. Izindaba ezinhle ukuthi imiphumela eminingi emibi imnene futhi ivame ukuthuthuka njengoba umzimba wakho uzivumela emuthini. Ukuqonda ukuthi okulindelekile kungakusiza ukuthi uzizwe uqiniseka ngokwengeziwe ngokuphathwa kwakho.

Imiphumela ejwayelekile esemqoka abesifazane abaningi abahlangabezana nayo ihlanganisa ubuhlungu bebele, ukuqaqamba kwekhanda, nokucasuka okuncane. Lezi zimpawu zivame ukuvela uma uqala umuthi okokuqala noma uma umthamo wakho ulungiswa. Ungase futhi uqaphele ukuqunjelwa okuthile, izinguquko zemizwa, noma izinguquko emjikelezweni wakho wokuya esikhathini uma usaya esikhathini.

Nawa imiphumela esemqoka ebikwa kaningi evame ukuzixazulula yodwa:

• Ubuhlungu bebele noma ukuvuvukala
• Ukuqaqamba kwekhanda noma ama-migraines
• Ukucasuka noma isisu esicasukile
• Ukuqunjelwa noma izinguquko zesibalo somzimba
• Ukuguquguquka kwemizwa noma ukucasuka
• Ukuphuma kwegazi esithweni sangasese noma ukubona amachashaza

Le miphumela esemqoka ejwayelekile ivame ukungabonakali ngemva kwamasonto ambalwa okuqala ukwelashwa njengoba umzimba wakho ujwayela izinguquko zamahomoni.

Imiphumela esemqoka engathi sína ayivamile kodwa idinga ukunakekelwa kwezokwelapha ngokushesha. Xhumana nodokotela wakho ngokushesha uma uhlangabezana nokuqaqamba kwekhanda okukhulu, izinguquko zombono, ubuhlungu besifuba, noma ukuphefumula okungavamile. Izimpawu zamahlule egazi, njengobuhlungu emlenzeni noma ukuvuvukala, nazo zidinga ukuhlolwa kwezokwelapha ngokushesha.

Nawa amasignali okuxwayisa adinga ukunakekelwa kwezokwelapha ngokushesha:

• Ukuqaqamba kwekhanda okukhulu noma okuqhubekayo
• Ushintsho lombono noma izinkinga zamehlo
• Ubuhlungu besifuba noma ukuphefumula okuncane
• Ubuhlungu emlenzeni, ukuvuvukala, noma ukufudumala
• Ukuphuma kwegazi okungavamile esithweni sangasese
• Ubuhlungu obukhulu besisu
• Ukuphuzi kwesikhumba noma amehlo

Ngenkathi le miphumela esemqoka engathi sína ingavamile, ukuyazi kukusiza ukuthi ufune usizo ngokushesha uma kudingeka, okungavimbela izinkinga.

Ubani Ongafanele Athathwe Ama-Estrogens Ahlanganisiwe?

Ama-estrogens ahlanganisiwe awaphephile kuwo wonke umuntu, futhi izimo ezithile zezempilo zenza lo muthi ungafaneleki noma uyingozi. Udokotela wakho uzobuyekeza ngokucophelela umlando wakho wezokwelapha ngaphambi kokukuyalela lo muthi ukuze aqinisekise ukuthi uphephile kuwe. Ukwethembeka ngomlando wakho wezempilo kusiza umhlinzeki wakho wezempilo ukuthi enze isinqumo esingcono kakhulu sokunakekelwa kwakho.

Akufanele uthathe ama-estrogens ahlanganisiwe uma unomlando wamagazi, unhlangothi, noma isifo senhliziyo. Umuthi ungakhuphula ingozi yakho yalezi zimo ezinzima, ikakhulukazi uma uke wazithola ngaphambili. Isifo sesibindi esisebenzayo noma umlando wezinkinga zesibindi nazo zenza lo muthi ungafaneleki.

Nawa amakhondishini amakhulu avamile ukuvimbela ukusetshenziswa okuphephile kwama-estrogens ahlanganisiwe:

• Umlando wamagazi noma unhlangothi
• Isifo sesibindi esisebenzayo
• Umlando womdlavuza wamabele noma we-endometrial
• Ukuphuma kwegazi okungachazeki kwesitho sangasese sowesifazane
• Ukukhulelwa noma ukusolwa ngokukhulelwa
• Isifo senhliziyo esisebenzayo

Udokotela wakho uzokala lezi zinto eziyingozi ngokumelene nezinzuzo ezingaba khona ukuze anqume ukuthi ama-estrogens ahlanganisiwe akulungele yini.

Ezinye izimo zidinga ukuqapha okwengeziwe kodwa azikhiphi ngokuzenzakalelayo lo muthi. Uma unesifo sikashukela, umfutho wegazi ophezulu, noma umlando womndeni womdlavuza wamabele, udokotela wakho usengakwazi ukukuyala ama-estrogens ahlanganisiwe kodwa uzokuqapha eduze. Okubalulekile ukuxhumana okuvulekile nomhlinzeki wakho wezempilo mayelana nazo zonke izinkinga zakho zempilo.

Amagama e-Brand e-Conjugated Estrogens

I-Premarin yigama elaziwa kakhulu le-brand lama-estrogens ahlanganisiwe futhi selitholakala amashumi eminyaka amaningi. Lolu hlobo luqukethe ama-estrogens ahlanganisiwe atholakala emchamweni wamahhashi akhulelwe, yilapho igama elithi "Premarin" livela khona. Itholakala ngamandla ahlukahlukene ukuze ihambisane nezidingo ezihlukene zokulinganisa.

Amanye amagama e-brand afaka i-Cenestin ne-Enjuvia, equkethe ama-estrogens ahlanganisiwe okwenziwa e-laboratories kunokuba avela emithonjeni yezilwane. Lezi zindlela ezingezinye zisebenza ngendlela efanayo ne-Premarin kodwa zingase zithandwe ngabantu abafuna izinketho ze-hormone ezisekelwe ezitshalweni noma ezenziwe. Udokotela wakho angakusiza ukhethe uhlobo olungcono kakhulu olususelwe ezintweni ozikhethayo nezidingo zakho zezokwelapha.

Ezinye izindlela zokwelapha i-Conjugated Estrogens

Ezinye izindlela zokwelapha ngama-estrogen ahlanganisiwe ziyatholakala uma lo muthi ungakulungele. Ama-hormone afana nama-estradiol, afana namakhemikhali afana nama-hormone omzimba wakho owakhiqiza ngokwemvelo. Lokhu kuza ngezinhlobo ezahlukene ezihlanganisa iziqeshana, ama-gel, namathebhulethi, okunikeza ukuguquguquka endleleni ozothola ngayo ukushintshwa kwama-hormone.

Ezinye izindlela ezingezona ezama-hormone nazo zingasiza ekuphatheni izimpawu zokuya esikhathini. Ama-selective serotonin reuptake inhibitors (SSRIs) afana ne-paroxetine anganciphisa ukushisa, kuyilapho i-gabapentin ingasiza kokubili ukushisa kanye nokuphazamiseka kokulala. Ushintsho lwendlela yokuphila, okuhlanganisa ukuzivocavoca njalo, ukuphatha ingcindezi, kanye nokuguqulwa kokudla, kungahlinzeka ngokuqeda izimpawu ezibalulekile.

Ukuze uthole impilo yamathambo ngokuqondile, imithi efana nama-bisphosphonates (njenge-alendronate) ingavimbela i-osteoporosis ngaphandle kokushintshwa kwama-hormone. Udokotela wakho angakusiza ukuthi uhlole lezi zinketho uma ama-estrogen ahlanganisiwe engalungile noma uma ukhetha izindlela ezingezona ezama-hormone zokuphatha izimpawu zakho.

Ingabe ama-Conjugated Estrogens angcono kune-Estradiol?

Kokubili ama-estrogen ahlanganisiwe kanye ne-estradiol ziyizinketho ezisebenzayo zokushintshwa kwama-hormone, kodwa zisebenza ngendlela ehlukile emzimbeni wakho. Ama-estrogen ahlanganisiwe aqukethe izinhlobo eziningi ze-estrogen, kuyilapho i-estradiol iyi-hormone eyodwa, i-bioidentical. Ukukhetha phakathi kwazo kuvame ukuncika ezimpawini zakho ngazinye, okuthandayo, nokuthi umzimba wakho usabela kanjani emuthini ngamunye.

Ama-estrogen ahlanganisiwe angahlinzeka ngokushintshwa kwama-hormone okuphelele ngoba aqukethe ama-estrogen ahlukene amaningana esebenza ndawonye. Kodwa-ke, i-estradiol iyafana nalokho ama-ovari akho akukhiqiza ngokwemvelo, okuyinto abanye abantu abayithandayo. I-Estradiol nayo iza ngezindlela eziningi zokulethwa, okuhlanganisa iziqeshana nama-gel, okudlula isibindi futhi kunganciphisa izingozi ezithile.

Udktela wakho uzocabangela izinto ezifana neminyaka yakho, umlando wezempilo, nobukhulu bezimpawu lapho ekhetha phakathi kwalezi zinketho. Abanye besifazane benza ngcono ngomunye kunomunye, futhi kungase kuthatha isikhathi ukuthola okusebenzela wena. Inketho "engcono" ngempela yileyo elawula ngempumelelo izimpawu zakho ngemiphumela emincane.

Imibuzo Evame Ukubuzwa Mayelana Nama-Estrogens Ahlanganisiwe

Ingabe Ama-Estrogens Ahlanganisiwe Aphephile Ezigulini Zezinhliziyo?

Ama-estrogens ahlanganisiwe adinga ukucatshangelwa ngokucophelela uma unezifo zenhliziyo noma izici eziyingozi zenhliziyo nemithambo yegazi. Ucwaningo lwakamuva lubonisa ukuthi ukuqala ukwelashwa ngamaphilisi e-hormone kungakapheli iminyaka eyi-10 yokuya esikhathini kungase kube nezinzuzo enhliziyweni, kodwa ukuqala kamuva noma kwabesifazane abanezifo zenhliziyo ekhona kungakhuphula izingozi zenhliziyo nemithambo yegazi. Udktela wakho wenhliziyo nodktela wakho wezifo zabesifazane kufanele basebenzisane ukuze bahlole isimo sakho esithile.

Uma unezifo zenhliziyo ezithambile noma izici eziyingozi ezinjengokukhuphuka kwe-cholesterol, udktela wakho angase akwazi ukukuchazela ama-estrogens ahlanganisiwe kodwa uzokugada eduze. Kodwa-ke, uma uke wahlaselwa yinhliziyo, washaywa unhlangothi, noma unezifo zenhliziyo ezinzima, lo muthi ngokuvamile awunconyelwe ngenxa yengozi eyengeziwe yama-clots egazi nezigameko zenhliziyo nemithambo yegazi.

Ngingenzani Uma Ngiphuthelwa Ngokusebenzisa Ama-Estrogens Ahlanganisiwe Amaningi Kakhulu?

Uma ngengozi uthatha ama-estrogens ahlanganisiwe amaningi kunalawo abekiwe, ungangeni ekuqeqeshweni, kodwa xhumana nomhlinzeki wakho wezempilo noma isikhungo sokulawula ubuthi ukuze uthole isiqondiso. Ukuthatha umthamo owengeziwe ngezikhathi ezithile akunakwenzeka ukuthi kubangele ukulimala okukhulu, kodwa kungase kwandise ingozi yakho yemiphumela emibi efana nesicanucanu, ububele besifuba, noma ukuphuma kwegazi.

Qaphela izimpawu ezinjengokugula okukhulu, ukuhlanza, ubuhlungu bebele, noma ukuphuma kwegazi okungavamile, futhi funa ukwelashwa uma lokhu kwenzeka. Ngemithamo yesikhathi esizayo, buyela esimisweni sakho esivamile futhi ungazami "ukulungisa" umthamo owengeziwe ngokususa olandelayo. Uma uvame ukukhohlwa imithamo noma uthatha imithi eyengeziwe, cabangela ukusebenzisa umhleli wamaphilisi noma ukusetha izikhumbuzi zocingo.

Kufanele Ngenzeni Uma Ngiqeda Umthamo We-Conjugated Estrogens?

Uma uqeda umthamo we-conjugated estrogens, yithathe ngokushesha lapho ukhumbula, ngaphandle kokuthi sekuyisikhathi esiseduze somthamo wakho olandelayo. Kulokho, weqa umthamo oqediwe bese uqhubeka nesimiso sakho esivamile. Ungalokothi uthathe imithamo emibili ngesikhathi esisodwa ukuze ulungise umthamo oqediwe, ngoba lokhu kungakhuphula ingozi yakho yemiphumela emibi.

Ukuqeda umthamo ngezikhathi ezithile akuyingozi, kodwa zama ukugcina ukuqina ukuze uthole ukulawulwa okungcono kakhulu kwezimpawu. Uma uvame ukukhohlwa imithamo, izimpawu zakho zingase zibuye noma zibe zimbi. Ukusetha i-alamu yansuku zonke noma ukusebenzisa umhleli wamaphilisi kungakusiza ukuthi uhlale emgwaqeni ngesimiso sakho semithi.

Ngingayeka Nini Ukuthatha I-Conjugated Estrogens?

Isinqumo sokuyeka i-conjugated estrogens kufanele senziwe ngaso sonke isikhathi ngesiqondiso sikadokotela wakho. Abesifazane abaningi banganciphisa kancane kancane umthamo wabo futhi ekugcineni bayeke imithi uma izimpawu zabo eziphazamisayo kakhulu zokuya esikhathini sezizinzile. Lokhu kuvame ukwenzeka eminyakeni embalwa ngemuva kokuqala kokuya esikhathini, kodwa umugqa wesikhathi uyahlukahluka kumuntu ngamunye.

Udkt wakho cishe uzoncoma ukunciphisa umthamo kancane kancane kunokuyeka kungazelelwe. Le ndlela enqekayo isiza ukunciphisa ukubuya kwezimpawu futhi inciphisa ingozi yemiphumela yokubuyela emuva. Abanye besifazane bathola ukuthi bangayeka ngokuphelele, kanti abanye badinga ukuqhubeka nomthamo ophansi wokuvikela amathambo noma izimpawu eziqhubekayo. Ukuhlolwa okuvamile kusiza ukunquma isikhathi esifanele sakho.

Ngingathatha I-Conjugated Estrogens Ngeminye Imithi?

Ama-estrogens ahlanganisiwe angasebenzisana neminye imithi eminingi, ngakho-ke kubalulekile ukutshela udokotela wakho ngakho konke okuthathayo, okuhlanganisa imithi etholakala ngaphandle kwemvume kadokotela kanye nezithasiselo. Eminye imithi inganciphisa ukusebenza kahle kwama-estrogens ahlanganisiwe, kanti eminye ingase ikhuphule ingozi yakho yemiphumela emibi.

Izinciphisi zegazi ezinjenge-warfarin zidinga ukuqashwa ngokucophelela uma zithathwa nama-estrogens ahlanganisiwe, njengoba le hormone ingathinta ukuthi inciphisi yegazi isebenza kahle kangakanani. Ezinye izibulala-magciwane kanye nemithi yokulwa nokuthuthumela nayo inganciphisa ukusebenza kahle kokwelashwa ngama-hormone. Udokotela wakho noma usokhemisi angabuyekeza yonke imithi yakho ukuze ahlole ukuthi kukhona yini ukusebenzisana okungase kube khona futhi alungise imithamo uma kudingeka.