Yini i-Corticotropin: Ukusetshenziswa, Umthamo, Imiphumela Eceleni Nokunye

I-Corticotropin iyisidakamizwa se-hormone esenziwe ngumuntu esilingisa i-ACTH (adrenocorticotropic hormone) yemvelo yomzimba wakho. Lesi sidakamizwa sikhuthaza amaglandla akho e-adrenal ukuthi akhiqize i-cortisol namanye ama-hormone abalulekile asiza ukuphatha ukuvuvukala nokuphendula kokucindezeleka.

Udokotela wakho angase akubhalele i-corticotropin uma umzimba wakho ungakhiqizi ama-hormone emvelo anele noma uma udinga ukuhlolwa okuthile kokuxilonga. Inikezwa njengesijovo kungaba emsipheni wakho noma ngaphansi kwesikhumba sakho, kuye ngokuthi umhlinzeki wakho wezempilo uthini okungcono kakhulu esimweni sakho.

Yini i-Corticotropin Esetshenziselwa Yona?

I-Corticotropin isiza ukwelapha izimo eziningana lapho umzimba wakho udinga ukusekelwa okwengeziwe kwe-hormone. Umuthi usebenza ngokutshela amaglandla akho e-adrenal ukuthi enze ama-hormone awo emvelo engeziwe, okungasiza ukunciphisa ukuvuvukala nokusekela ukusabela komzimba wakho ekucindezelekeni.

Udokotela wakho angase akubhalele i-corticotropin ukuze ahlolwe ukuxilonga ukuze abone ukuthi amaglandla akho e-adrenal asebenza kahle kangakanani. Lokhu kuyasiza ikakhulukazi uma kudingeka baqonde ukuthi amaglandla akho e-adrenal angaphendula kahle yini ezimpawini ze-hormone.

Umuthi futhi welapha izimo ezithile zokuvuvukala njengokuqubuka kwe-multiple sclerosis, ukusabela okukhulu komzimba, nezinye izifo ze-autoimmune. Kulezi zimo, ukukhiqizwa okwengeziwe kwe-cortisol kusiza ukuthulisa ukusabela okusebenzayo kakhulu kwamasosha akho omzimba.

Ngokuvamile, i-corticotropin ingasetshenziselwa ama-spasm ezingane, uhlobo olungavamile lokuquleka oluthinta izingane. Umuthi ungasiza ukunciphisa imvamisa nobukhulu balokhu kuquleka lapho ezinye izindlela zokwelapha zingasebenzi.

Isebenza Kanjani i-Corticotropin?

I-Corticotropin isebenza ngokulingisa i-hormone ubuchopho bakho obukhiqiza ngokwemvelo obizwa nge-ACTH. Uma uthola lo muthi, uhamba ngegazi lakho uze ufike emaglandleni akho e-adrenal, ahlala phezu kwezinso zakho.

Uma i-corticotropin ifinyelela emaglands akho e-adrenal, iwatshela ukuthi akhiqize i-cortisol eningi namanye ama-hormone e-steroid. Cabanga ngayo njengokhiye ovula ikhono lamaglands akho e-adrenal lokwenza la ma-hormone abalulekile.

Lokhu kuthathwa njengemithi enamandla amaphakathi ngoba ithinta lonke uhlelo lwakho lwe-hormone lomzimba. Imiphumela ingaba namandla kakhulu, yingakho udokotela wakho ezokuqapha eduze ngenkathi uyithatha.

Imithi ngokuvamile iqala ukusebenza kungakapheli amahora ambalwa, kodwa ungase ungazizwa imiphumela ephelele izinsuku eziningana. Umzimba wakho udinga isikhathi sokuphendula ekukhiqizweni kwama-hormone okwandayo nokuthi ukuvuvukala kunciphe.

Ngingayithatha kanjani i-Corticotropin?

I-Corticotropin inikezwa njengomjovo, kungaba emsipheni wakho (intramuscular) noma ngaphansi kwesikhumba sakho (subcutaneous). Ngeke uthathe le mithi ngomlomo, futhi ngokuvamile inikezwa uchwepheshe wezempilo endaweni yezokwelapha.

Indawo yokujova ngokuvamile izoba engalweni yakho engenhla, ethangeni, noma ezinqeni zakho ngemijovo ye-intramuscular. Ngemijovo ye-subcutaneous, ngokuvamile inikezwa ethisshini elinamanzi lengalo yakho noma ithanga. Umhlinzeki wakho wezempilo uzokhetha indawo engcono kakhulu ngokusekelwe ezidingweni zakho ezithile.

Akudingeki ukuthi uthathe i-corticotropin nokudla noma ubisi ngoba kungumjovo. Nokho, kuyasiza ukudla ukudla okulinganiselayo ngaphambi kokuqokwa kwakho ukuze ugcine amazinga akho wamandla ezinzile, ikakhulukazi uma wenza ukuhlolwa kokuxilonga.

Abanye abantu bazizwa bekhululekile ngokuba nesnakhi esilula ngemuva komjovo, ikakhulukazi uma benovalo mayelana nezinqubo zezokwelapha. Umhlinzeki wakho wezempilo angase futhi ancome ukuphuza amanzi amaningi ukusiza umzimba wakho ukuthi usebenzise imithi ngempumelelo.

Ngingayithatha isikhathi esingakanani i-Corticotropin?

Ubude bokwelashwa kwe-corticotropin buhlukahluka kakhulu kuye ngokuthi uyithatheleni. Ukuze uthole ukuhlolwa kokuxilonga, ungase udinge imijovo emibili kuphela ukuze uhlole ukusebenza kwegland yakho ye-adrenal.

Uma welapha isimo sokuvuvukala njengokusha kwe-multiple sclerosis, ukwelashwa kuvame ukuthatha noma yikuphi kusuka ezinsukwini ezimbalwa kuya emavikini ambalwa. Udokotela wakho uzonquma isikhathi esiqondile ngokusekelwe ekutheni usabela kahle kangakanani emuthini.

Ngezinhlungu zezingane, ukwelashwa kungase kuqhubeke izinyanga eziningana, udokotela wakho enciphisa kancane kancane umthamo njengoba isimo sengane yakho sithuthuka. Lokhu kwelashwa okude kudinga ukuqapha ngokucophelela ukuqaphela imiphumela emibi.

Umhlinzeki wakho wokunakekelwa kwezempilo uzohlola njalo ukuthi usawudinga yini umuthi futhi alungise uhlelo lwakho lokwelashwa ngokufanele. Ungalokothi uyeke ukuthatha i-corticotropin ngokuzumayo ngaphandle kokukhuluma nodokotela wakho kuqala, ngoba lokhu kungabangela izimpawu zokuhoxisa.

Yini Imiphumela Emibi ye-Corticotropin?

Njengemithi eminingi ethinta uhlelo lwakho lwamahomoni, i-corticotropin ingabangela imiphumela eminingi emibi. Ukuqonda okufanele ukulindele kungakusiza ukuthi uzizwe ulungiselelwe kangcono futhi wazi ukuthi ungaxhumana nini nomhlinzeki wakho wokunakekelwa kwezempilo.

Imiphumela emibi ejwayelekile abantu abaningi abayitholayo ihlanganisa ukwanda kwesifiso sokudla, ukukhuluphala, kanye nezinguquko zemizwa njengokuzizwa unamandla noma ungaphumuli. Ungase futhi uqaphele ukwanda komzwelo wokoma nokuchama njengoba umzimba wakho uzivumela emuthini.

Nawa amanye imiphumela emibi ebikwa njalo okufanele uyazi ngayo:

• Ukwanda kwesifiso sokudla nokukhuluphala
• Ushintsho lwemizwa oluhlanganisa ukungaphumuli noma injabulo
• Ubunzima bokulala
• Ukwanda komzwelo wokoma nokuchama
• Ukwenyuka okwesikhashana kwengcindezi yegazi
• Isicanucanu esincane noma isisu esicasukile
• Ukuphendula kwendawo yokujova njengobubomvu noma ukuvuvukala

Le miphumela emibi ejwayelekile ivamise ukuthuthuka njengoba umzimba wakho uzivumela emuthini noma lapho ukwelashwa kuphela. Abantu abaningi bayayibekezelela i-corticotropin kahle, ikakhulukazi ekusetshenzisweni kwesikhashana.

Imiphumela emibi engathi sína ingenzeka, ikakhulukazi ngezikhathi zokwelashwa ezinde. Lokhu kudinga ukunakekelwa kwezempilo ngokushesha futhi akufanele kungashaywa mthetho.

Xhumana nodokotela wakho ngokushesha uma uhlangabezana nanoma yiziphi zalezi zimpawu ezikhathazayo:

• Ushintsho olukhulu lwemizwa noma ukucindezeleka
• Izimpawu zokutheleleka njengomkhuhlane noma ukukhwehlela okuqhubekayo
• Ikhanda elibuhlungu elibuhlungu noma izinguquko embonweni
• Ukulimala okungavamile noma ukuphuma kwegazi
• Ubuhlungu obukhulu besisu noma izitulo ezimnyama, ezinamathelayo
• Ukuvuvukala emilenzeni yakho, amaqakala, noma izinyawo
• Ubuhlungu besifuba noma ubunzima bokuphefumula

Imiphumela emibi engavamile kodwa engathi sína ingabandakanya ukucindezelwa kwegland ye-adrenal, ukusabela okukhulu komzimba, noma ukwanda kokuzwela ezifweni. Udokotela wakho uzokugada eduze ukuze abambe noma yiziphi zalezi zinkinga ekuqaleni.

Ubani Ongafanele Athathe I-Corticotropin?

Abantu abathile kufanele bagweme i-corticotropin noma bayisebenzise ngokuqapha okukhulu. Udokotela wakho uzobukeza ngokucophelela umlando wakho wezokwelapha ngaphambi kokukuyalela lo muthi ukuze aqinisekise ukuthi uphephile kuwe.

Akufanele uthathe i-corticotropin uma unokutheleleka okusebenzayo okungelashwa ngama-antibiotics. Umuthi ungacindezela amasosha akho omzimba, okwenza izifo zibe nzima emzimbeni wakho ukuzilwa.

Abantu abanezimo ezithile zezokwelapha badinga ukucatshangelwa okukhethekile ngaphambi kokuqala i-corticotropin. Udokotela wakho uzokala izinzuzo ngokumelene nezingozi uma unanoma yiziphi zalezi zimo.

Izimo ezingase zikuvimbele ukuthi ungathathi i-corticotropin zihlanganisa:

• Ukutheleleka okusebenzayo noma kwakamuva
• Imithi yokugoma yamagciwane aphilayo (yakamuva noma ehleliwe)
• Ukungezwani komzimba okwaziwayo ne-corticotropin noma imithi efanayo
• Ezinye izifo zokukhunta
• Ukwehluleka kwenhliziyo okukhulu
• Umfutho wegazi ophezulu ongagadiwe
• Isifo se-peptic ulcer esisebenzayo

Udokotela wakho uzodinga ukukugada ngokucophelela okwengeziwe uma unesifo sikashukela, i-osteoporosis, noma izimo zempilo yengqondo. Umuthi ungathinta amazinga kashukela egazini, ukuminyana kwamathambo, nokuzinza kwemizwa.

Uma ukhulelwe noma uncelisa, udokotela wakho uzonquma kuphela i-corticotropin uma izinzuzo zicacile ukuthi zidlula izingozi ezingaba khona. Umuthi ungangena ngaphakathi kwe-placenta futhi ubonakale e-breast milk, ngakho-ke ukucatshangelwa ngokucophelela kuyadingeka.

Amagama Omkhiqizo we-Corticotropin

I-Corticotropin itholakala ngaphansi kwamagama amaningi omkhiqizo, i-H.P. Acthar Gel iyona eyanqunywa kakhulu e-United States. Le fomula ethile iyinhlobo esebenza isikhathi eside enikeza ukukhishwa kwamahomoni okuqhubekayo.

Amanye amagama omkhiqizo ongahlangana nawo afaka i-Acthar kanye namafomula ahlukahlukene ajwayelekile. Umkhiqizo othile odokotela bakho abawunqumayo ungancika esimweni sakho, umshwalense wakho, kanye nohlobo lokwelashwa oludingayo.

Noma ngabe igama lomkhiqizo linjani, yonke imithi ye-corticotropin isebenza ngendlela efanayo. Umuthi wakho ungakunikeza imininingwane ethile mayelana nomkhiqizo owutholayo kanye nanoma yiziphi iziyalezo ezithile zokugcina noma zokuphatha.

Ezinye Izindlela ze-Corticotropin

Imithi eminingi ehlukile inganikeza izinzuzo ezifanayo ne-corticotropin, kuye ngesimo sakho esithile. Udokotela wakho angase acabangele lezi zinketho uma i-corticotropin ingakulungele noma uma uhlangabezana nemiphumela emibi.

Ama-corticosteroids omlomo afana ne-prednisone noma i-prednisolone ayizindlela ezivamile zokwelapha izimo ezivuthayo. Le mithi kulula ukuyithatha ngoba amaphilisi, kodwa asebenza ngendlela ehlukile ngokunikeza ngokuqondile amahomoni e-steroid kunokuvuselela amaglands akho e-adrenal.

Ukuqubuka kwe-multiple sclerosis, udokotela wakho angase ancome i-methylprednisolone ephezulu ye-intravenous esikhundleni se-corticotropin. Lokhu kwelashwa kuvame ukunikezwa esibhedlela noma esikhungweni sokufaka imithi izinsuku eziningana.

Ezinye izindlela zihlanganisa imithi ecindezela amasosha omzimba, ukwelashwa okuguqula isifo, noma amanye amakhambi amasha e-biologic, kuye ngesimo sakho esithile. Umhlinzeki wakho wezempilo uzoxoxa ukuthi iyiphi inketho engasebenza kangcono esimweni sakho.

Ingabe i-Corticotropin ingcono kune-Prednisone?

I-Corticotropin ne-prednisone zisebenza ngendlela ehlukile, ngakho ukuqhathanisa akuhlali kuqondile. I-Corticotropin ikhuthaza umzimba wakho ukuthi ukhiqize amahomoni awo, kuyilapho i-prednisone inikeza ngokuqondile ama-steroid okwenziwa.

Ezimweni ezithile njengokuqubuka kwe-multiple sclerosis, womabili lawo makhambi angasebenza. Kodwa-ke, i-corticotropin ingase ithandwe ngoba ikhuthaza ukukhiqizwa kwama-hormone emvelo futhi ingase ibe nemiphumela emincane yesikhathi eside ekusebenzeni kwegland ye-adrenal.

I-Prednisone ivame ukuba lula ngoba ithathwa ngomlomo futhi ingasetshenziswa ekhaya. I-Corticotropin idinga imijovo futhi ivame ukudinga ukunikezwa endaweni yokunakekelwa kwezempilo, okwenza kungasebenzi kahle ekusetshenzisweni kwesikhathi eside.

Udokotela wakho uzocabangela izinto ezifana nesimo sakho esithile, ukuthi udinga ukwelashwa ngokushesha kangakanani, ikhono lakho lokuvakashela isikhungo sokunakekelwa kwezempilo ukuze uthole imijovo, kanye nomshwalense wakho lapho unquma phakathi kwalawo makhambi.

Imibuzo Evame Ukubuzwa Nge-Corticotropin

Ingabe i-Corticotropin iphephile kubantu abanesifo sikashukela?

I-Corticotropin ingasetshenziswa kubantu abanesifo sikashukela, kodwa idinga ukuqapha ngokucophelela. Umuthi ungakhuphula amazinga kashukela egazini ngokukhuthaza ukukhiqizwa kwe-cortisol, okuthinta indlela umzimba wakho oqhubula ngayo i-glucose.

Udokotela wakho cishe uzofuna ukuhlola ushukela wakho wegazi kaningi ngenkathi uthatha i-corticotropin. Ungase udinge ukulungiswa okwesikhashana emithini yakho yesifo sikashukela noma imithamo ye-insulin ukuze ugcine ukulawulwa okuhle kashukela egazini.

Abantu abaningi abanesifo sikashukela esilawulwa kahle bangathatha i-corticotropin ngokuphepha isikhathi esifushane. Ithimba lakho lokunakekelwa kwezempilo lizosebenza nawe ukuze lilawule kokubili isifo sakho sikashukela kanye nesimo eselashwa nge-corticotropin.

Kufanele Ngenzeni Uma Ngisebenzisa I-Corticotropin Eningi Ngengozi?

Njengoba i-corticotropin inikezwa ochwepheshe bezempilo, ukweqisa ngengozi akuvamile. Kodwa-ke, uma usola ukuthi uthole imithi eningi kakhulu, xhumana nomhlinzeki wakho wokunakekelwa kwezempilo noma funa usizo lwezempilo oluphuthumayo ngokushesha.

Izimpawu ze-corticotropin eningi kakhulu zingabandakanya izinguquko ezinzima zemizwa, umfutho wegazi ophezulu kakhulu, ikhanda elibuhlungu kakhulu, noma izimpawu zikashukela ophezulu oyingozi. Lezi zimpawu zidinga ukuhlolwa kwezokwelapha ngokushesha.

Ungazami ukwelapha ukweqisa okusolwayo wedwa. Ochwepheshe bezokwelapha badinga ukuhlola izimpawu zakho futhi bangase badinge ukuhlinzeka ngokunakekelwa okusekelayo noma imithi yokulwa nemiphumela.

Kufanele Ngenzeni Uma Ngeqa Umthamo We-Corticotropin?

Uma weqa umjovo we-corticotropin ohleliwe, xhumana nomhlinzeki wakho wokunakekelwa kwezempilo ngokushesha ukuze uxoxe ngokuhlela kabusha. Ungazami ukwenza ngaphezu kwemithamo eqediwe ngokuthatha imithi eyengeziwe kamuva.

Ukuze uthole ukuhlolwa kokuxilonga, ukuqa umthamo kungase kusho ukuthi udinga ukuqala kabusha inqubo yokuhlola. Udokotela wakho uzokweluleka ngendlela engcono kakhulu yokuqhubeka ngayo ngokusekelwe esimweni sakho esithile.

Uma welapha isimo esiqhubekayo, umhlinzeki wakho wokunakekelwa kwezempilo angase alungise isimiso sakho sokwelapha noma ancome izindlela ezingezinye ukuze aqinisekise ukuthi uqhubeka nokuthola izinzuzo ozidingayo.

Ngingayeka Nini Ukuthatha I-Corticotropin?

Isikhathi sokuyeka i-corticotropin sincike ngokuphelele ekutheni uyithathani nokuthi usabela kanjani ekwelashweni. Ungalokothi uyeke ukuthatha lo muthi ngaphandle kokubonisana nomhlinzeki wakho wokunakekelwa kwezempilo kuqala.

Ukuze kutholwe ukuhlolwa kokuxilonga, ngokuvamile uzoyeka ngemva kokuba ukuhlolwa kuqediwe. Ukuze welaphe izimo ezinjengokugqashuka kwe-multiple sclerosis, udokotela wakho uzolinciphisa kancane kancane umthamo njengoba izimpawu zakho zithuthuka.

Umhlinzeki wakho wezempilo uzoqapha inqubekela phambili yakho futhi anqume ukuthi kuphephile nini ukuyeka imithi. Bangase badinge ukunciphisa umthamo wakho kancane ukuze bavimbele izimpawu zokuhoxisa noma ukucindezelwa kwegland ye-adrenal.

Ngingayithatha i-Corticotropin neminye imithi?

I-Corticotropin ingasebenzisana neminye imithi eminingi, ngakho kubalulekile ukutshela umhlinzeki wakho wezempilo ngakho konke okuthathayo. Lokhu kuhlanganisa imithi kadokotela, imithi etholakala ngaphandle kwekhawunta, kanye nezithasiselo.

Eminye imithi engasebenzisana ne-corticotropin ihlanganisa izinciphisi zegazi, imithi yesifo sikashukela, ama-antibiotics athile, kanye neminye imithi yamahomoni. Udokotela wakho uzobuyekeza lezi zinto ezihlangene futhi alungise uhlelo lwakho lokwelapha uma kudingeka.

Njalo yazisa bonke abahlinzeki bakho bezempilo ukuthi uthatha i-corticotropin, ikakhulukazi uma udinga ukunakekelwa kwezempilo okuphuthumayo noma ubona udokotela omusha. Lolu lwazi lubasiza ukuthi benze izinqumo eziphephile mayelana nokunakekelwa kwakho.