Yini i-Crisaborole: Ukusetshenziswa, Umthamo, Imiphumela Eceleni nokuningi

I-Crisaborole iyimithi esetshenziswa ngaphandle esiza ukwelapha i-eczema elula kuya kweliphakathi (i-atopic dermatitis) ngokunciphisa ukuvuvukala nokuluma. Le khilimu ethambile, engena-steroidal isebenza ngendlela ehlukile kunezinye izindlela zokwelapha ze-steroid, okuyenza ibe yindlela ebalulekile kubantu abadinga ukuphathwa kwe-eczema kwesikhathi eside ngaphandle kokukhathazeka okuthile okuhambisana nokusetshenziswa kwe-steroid okude.

Yini i-Crisaborole?

I-Crisaborole iyi-phosphodiesterase-4 (PDE-4) inhibitor eza njenge-oyintimenti esetshenziswa ngaphandle. Yenzelwe ngokuqondile ukwelapha i-eczema ngokugxila kwinqubo yokuvuvukala ebangela izindawo zesikhumba ezibomvu, ezilumayo, nezicasukile eziyisici salesi simo.

Ngokungafani nama-steroid asetshenziswa ngaphandle, i-crisaborole ayicindezeli amasosha akho omzimba ngendlela ebanzi. Kunalokho, isebenza ngokukhethekile ngokuvimba ama-enzyme athile anegalelo ekuvuvukeni esikhumbeni sakho. Le ndlela eqondiwe iyenza ibe wusizo ikakhulukazi ezindaweni ezizwelayo njengobuso nentamo, lapho ukusetshenziswa kwe-steroid kwesikhathi eside kungase kubangele ukuncipha noma ezinye izinguquko zesikhumba.

Lo muthi wagunyazwa yi-FDA ngonyaka ka-2016 futhi usuye waba yindlela ebalulekile yokwelapha kokubili izingane nabantu abadala abane-eczema. Itholakala ngemiyalelo kadokotela kuphela futhi ngokuvamile incomwa uma ezinye izindlela zokwelapha zingazange zinikeze ukukhululeka okwanele noma uma udinga inketho engena-steroidal yokuphathwa okuqhubekayo.

Isetshenziselwani i-Crisaborole?

I-Crisaborole isetshenziswa ikakhulukazi ukwelapha i-atopic dermatitis elula kuya kweliphakathi, eyaziwa ngokuthi i-eczema. Lesi simo sesikhumba esingamahlala-mandla sibangela ukuthi izindawo zesikhumba zivuvukale, zilume, zibe bomvu, futhi ngezinye izikhathi ziqhekeke noma zibe nesikali.

Udktela wakho angase ancome i-crisaborole uma uhlangabezana nezimpawu ezivamile ze-eczema njengokuluma okuqhubekayo, izindawo ezibomvu noma ezinsundu zesikhumba, izigaxa ezincane eziphakanyisiwe ezingase zikhiphe uketshezi uma zikhiwe, noma isikhumba esijiyile, esiqhekekile, noma esinesikali. Ilusizo ikakhulukazi ekwelapheni i-eczema ezindaweni ezizwelayo zomzimba wakho, okuhlanganisa ubuso bakho, izinkophe, intamo, kanye nemibimbi yesikhumba.

Umuthi futhi ulusizo ekwelapheni isikhathi eside. Ngenxa yokuthi awuthwali izingozi ezifanayo njengokusetshenziswa kwama-steroid isikhathi eside, odokotela abaningi bawuncoma kubantu abadinga ukwelashwa okuqhubekayo ukuvimbela ukuqubuka kwe-eczema. Ingasetshenziswa ngokuphepha isikhathi eside ngaphandle kokukhathazeka ngokuncipha kwesikhumba noma eminye imiphumela emibi ehlobene nama-steroid.

Isebenza Kanjani I-Crisaborole?

I-Crisaborole isebenza ngokuvimba i-enzyme ebizwa ngokuthi i-phosphodiesterase-4 (PDE-4) emangqamuzaneni esikhumba sakho. Le enzyme ngokuvamile ichitha into ebizwa ngokuthi i-cyclic adenosine monophosphate (cAMP), esiza ukulawula ukuvuvukala.

Lapho i-PDE-4 ivalekile, amazinga e-cAMP ayanda emangqamuzaneni esikhumba sakho. Amazinga aphezulu e-cAMP asiza ukunciphisa ukukhiqizwa kwezinto ezivuvukalisayo ezibangela ububomvu, ukuvuvukala, nokuluma okuhambisana ne-eczema. Cabanga ngakho njengokwehlisa ivolumu ekuphenduleni ukuvuvukala kwesikhumba sakho kunokuyivala ngokuphelele.

Le ndlela yenza i-crisaborole ibe umuthi olwa nokuvuvukala olunamandla amancane. Ayinamandla ngokushesha njengama-steroid aphezulu, kodwa inikeza ukukhululeka okuqhubekayo, okungaguquki ngaphandle kokuba khona kokuncipha kwesikhumba noma ezinye izinkinga ezihlobene ne-steroid. Umuthi ngokuvamile uqala ukusebenza phakathi nezinsuku ezimbalwa kuya evikini lokusetshenziswa njalo, ngemiphumela egcwele evame ukubonakala ngemva kwamasonto angu-2-4 okusetshenziswa njalo.

Kufanele Ngiyithathe Kanjani I-Crisaborole?

Sebenzisa i-crisaborole ngendlela eqondile udokotela wakho ayalela ngayo, ngokuvamile kabili ngosuku ezindaweni zesikhumba ezithintekile. Ungayisebenzisa ngaphandle noma ngaphandle kokudla, njengoba kuyimithi esetshenziswa ngaphandle engasebenzisani nalokho okudlayo.

Qala ngokuwasha izandla zakho kahle ngaphambi kokuyisebenzisa. Hlanza isikhumba esithintekile ngensipho namanzi amancane, bese usomisa. Faka ungqimba oluncane lwegrisi ezindaweni ezithintekile bese ulugcoba kancane kuze kube yilapho lunyamalala. Umuthi kufanele usetshenziswe esikhumbeni sakho, hhayi ezindaweni ezinama-mucous membrane njengaphakathi komlomo wakho noma ekhaleni.

Ngemuva kokusebenzisa i-crisaborole, phinda ugeze izandla zakho ngaphandle uma welapha izandla zakho uqobo. Akudingeki ukuthi umboze izindawo eziphathwayo ngamabhandishi noma izingubo ngaphandle uma udokotela wakho ekuncoma ngqo. Ungafaka i-moisturizer ngaphezu komuthi uma kudingeka, kodwa linda imizuzu embalwa ukuze i-crisaborole imunce kuqala.

Gwema ukuthola umuthi emehlweni akho, emlonyeni, noma ngaphakathi ekhaleni lakho. Uma lokhu kwenzeka ngengozi, geza indawo kahle ngamanzi. Ungageza noma ushawa ngokujwayelekile ngenkathi usebenzisa i-crisaborole, kodwa zama ukusebenzisa umuthi esikhumbeni esihlanzekile, esomile ukuze umunce kangcono.

Kufanele Ngiyithathe Isikhathi Esingakanani I-Crisaborole?

Ubude bokwelashwa nge-crisaborole buyahluka ngokuya ngempendulo yakho kanye nobukhulu be-eczema yakho. Abantu abaningi baqala ukubona ngcono ngesonto lokuqala lokusebenzisa, ngemiphumela ebalulekile ngokuvamile evela ngemuva kwamasonto angu-2-4 okusetshenziswa okuqhubekayo.

Ukuqubuka okukhulu, ungasebenzisa i-crisaborole amasonto amaningana kuze kube yilapho izimpawu zakho zilawulwa kahle. Uma i-eczema yakho ithuthuka, udokotela wakho angase ancome ukuqhubeka nomuthi njengokwelashwa kokugcinwa ukuvimbela ukuqubuka okuzayo. Lokhu kungenye yezinzuzo ze-crisaborole - ingasetshenziswa ngokuphepha isikhathi eside ngaphandle kokukhathazeka okuhambisana nokusetshenziswa kwama-steroid isikhathi eside.

Abanye abantu basebenzisa i-crisaborole izinyanga eziningi noma iminyaka njengengxenye yohlelo lwabo oluqhubekayo lokuphatha i-eczema. Udokotela wakho uzoqapha inqubekela phambili yakho futhi angase alungise uhlelo lwakho lokwelapha ngokusekelwe ekutheni isikhumba sakho siphendula kanjani nokuthi ngabe uhlangabezana nemiphumela emibi. Ungayeki ukusebenzisa umuthi kungazelelwe ngaphandle kokubonisana nomhlinzeki wakho wezempilo, ngoba lokhu kungaholela ekubuyeni kwezimpawu zakho.

Yiziphi Imiphumela Emibi ye-Crisaborole?

Abantu abaningi bayayibekezelela kahle i-crisaborole, kodwa njengayo yonke imithi, ingabangela imiphumela emibi. Izindaba ezinhle ukuthi imiphumela emibi engathi sína ayivamile, futhi iningi lezimpawu zithambile futhi zesikhashana.

Imiphumela emibi evamile ethinta kufika ku-10% yabantu ihlanganisa:

• Umuzwa wokusha noma wokugwaza endaweni yokusebenzisa (ngokuvamile othambile futhi wesikhashana)
• Ukuvuvukala kwesikhumba noma ububomvu lapho usebenzisa umuthi khona
• Ukuluma endaweni yokusebenzisa (okungase kubonakale kungahambisani ngoba umuthi welapha ukuluma)
• Ubuhlungu besikhumba noma ukuzwela
• I-allergic contact dermatitis (ukusabela kwesikhumba emuthini ngokwawo)

Lezi zimpawu ezivamile zivame ukwenzeka uma uqala ukusebenzisa umuthi futhi zivame ukuthuthuka njengoba isikhumba sakho sizivumela ekwelashweni. Umuzwa wokusha noma wokugwaza uvame ukubonakala kakhulu ngesikhathi sokusetshenziswa kokuqala futhi uthambekele ekunciphiseni ngokuqhubeka nokusetshenziswa.

Imiphumela emibi engavamile kodwa ekhathazayo ihlanganisa:

• Ukungezwani komzimba okukhulu (ukuqubuka, imihuzuko, ubunzima bokuphefumula, ukuvuvukala kobuso, izindebe, noma umphimbo)
• Izimpawu zokutheleleka kwesikhumba (ukwanda kobubomvu, ukufudumala, amanyala, noma umkhuhlane)
• Ukwanda kwezimpawu zakho ze-eczema
• Ushintsho olungavamile esikhumbeni noma ukushintsha kombala

Uma uhlangabezana nanoma yiziphi izimpawu ezinzima noma uma imiphumela emibi ethambile ingathuthuki ngemva kwesonto lokusebenzisa, xhumana nomhlinzeki wakho wezempilo. Bangasiza ekutholeni ukuthi kufanele uqhubeke yini nomuthi noma uzame indlela yokwelapha ehlukile.

Obani okungafanele bathathe i-Crisaborole?

I-Crisaborole ayifanele wonke umuntu, futhi abanye abantu kufanele bagweme ukusebenzisa lo muthi. Udokotela wakho uzobukeza umlando wakho wezokwelapha kanye nesimo sakho sempilo yamanje ngaphambi kokuwubhala.

Akufanele usebenzise i-crisaborole uma unokungezwani nawo noma yiziphi izithako zawo. Izimpawu zokungezwani komzimba zihlanganisa ukuqubuka okukhulu, izinduna, ubunzima bokuphefumula, noma ukuvuvukala kobuso bakho, izindebe, ulimi, noma umphimbo. Uma uke waba nokungezwani komzimba emithini efanayo yendawo esikhumbeni esikhathini esidlule, qiniseka ukutshela udokotela wakho.

Abantu abanezimo ezithile zesikhumba kufanele basebenzise i-crisaborole ngokucophelela:

• Izifo zesikhumba ezisebenzayo (ezibangelwa amagciwane, amagciwane, noma isikhunta) endaweni yokwelashwa
• Amanxeba avulekile noma isikhumba esilimele kakhulu
• Izimo zesikhumba ngaphandle kwe-eczema ezingase zibe zimbi ngumuthi
• Umlando wokungezwani komzimba okukhulu emithini yendawo

Izinto ezikhethekile zisebenza kubantu abakhulelwe nabancelisa. Ngenkathi izifundo zingakakhombisi imiphumela eyingozi ezinganeni ezingakazalwa, i-crisaborole kufanele isetshenziswe ngesikhathi sokukhulelwa kuphela uma izinzuzo ezingaba khona zidlula izingozi. Uma uncelisa, gwema ukusebenzisa umuthi ezindaweni lapho ingane yakho ingase ithintane nawo, njengesifuba noma indawo yezinwele.

Izingane ezingaphansi kweminyaka emi-2 ubudala akufanele zisebenzise i-crisaborole ngaphandle uma kunconywe ngqo yi-dermatologist yezingane. Ukuphepha nokusebenza ezinganeni ezincane kakhulu akukamiswanga ngokugcwele.

Amagama Omkhiqizo we-Crisaborole

I-Crisaborole itholakala ngaphansi kwegama lomkhiqizo elithi Eucrisa e-United States. Leli njengamanje igama eliyinhloko lomkhiqizo lapho umuthi uthengiswa futhi ubhalwa khona.

I-Eucrisa yenziwa yi-Pfizer futhi iza njenge-2% ye-ointment yendawo. Umuthi utholakala ngamashubhu osayizi abahlukene, ngokuvamile ama-gramu angama-60 noma ama-gramu ayi-100, kuye ngokuthi incwadi yakho kadokotela kanye nezidingo zokwelashwa.

Njengamanje, azikho izinhlobo ezivamile ze-crisaborole ezitholakala e-United States. Lokhu kusho ukuthi i-Eucrisa iyona kuphela inketho yomkhiqizo, engenza imithi ibize kakhulu kunezindlela ezingezona eziqondile. Kodwa-ke, izinhlelo eziningi zomshuwalense zihlanganisa i-crisaborole, futhi umenzi unikeza izinhlelo zokusiza iziguli ukusiza ukunciphisa izindleko zabantu abafanelekile.

Ezinye izindlela ze-Crisaborole

Uma i-crisaborole ingakulungele noma inganikezi ukukhululeka okwanele, kukhona izindlela eziningi zokwelapha ezingenye ezitholakalayo zokuphatha i-eczema. Udokotela wakho angakusiza ukuthi uhlole lezi zinketho ngokusekelwe ezidingweni zakho ezithile kanye nomlando wakho wezokwelapha.

Ama-corticosteroids asezindaweni ahlala eyizindlela ezivame kakhulu zokwelapha. Lokhu kufaka phakathi izinketho ezithambile njenge-hydrocortisone ezindaweni ezizwelayo, ama-steroid anamandla aphakathi njenge-triamcinolone ezindaweni zomzimba, nezinketho ezinamandla njenge-clobetasol ekuqhumeni okukhulu. Ngenkathi le mithi isebenza kahle, idinga ukuqapha ngokucophelela ukusetshenziswa kwesikhathi eside ukuvimbela imiphumela emibi efana nokuncipha kwesikhumba.

Ezinye izindlela ezingezona ze-steroidal zifaka:

• Ama-calcineurin inhibitors asezindaweni (tacrolimus, pimecrolimus) - awusizo ikakhulukazi ekwelapheni ubuso nentamo
• Ama-JAK inhibitors asezindaweni njenge-ruxolitinib - inketho entsha ye-eczema elula kuya ephakathi
• Ama-creams okulungisa umgoqo kanye nezithambisi eziqokiwe
• Ama-antihistamines okukhulula ukuluma

Nge-eczema enkulu engaphenduli ekwelashweni okusezindaweni, izinketho zesistimu zingase zicatshangelwe. Lokhu kufaka phakathi imithi yomlomo efana nemijovo ye-dupilumab, i-methotrexate, noma i-cyclosporine, nakuba lezi zivame ukugcinelwa amacala amakhulu ngenxa yamandla abo emiphumeleni emibi ebaluleke kakhulu.

Ingabe i-Crisaborole ingcono kune-Tacrolimus?

Kokubili i-crisaborole ne-tacrolimus ziyizindlela zokwelapha ezingewona ama-steroidal e-eczema, kodwa zisebenza ngendlela ehlukile futhi zinezinzuzo ezihlukile. Ukukhetha phakathi kwazo kuncike esimweni sakho esithile, ukuzwela kwesikhumba, kanye nemigomo yokwelapha.

I-Crisaborole ivame ukuba mnene futhi ibangela ukusha okuncane noma ukuluma lapho isetshenziswa uma iqhathaniswa ne-tacrolimus. Lokhu kuyenza ibe yindlela engcono kubantu abanesikhumba esizwelayo kakhulu noma labo ababengakwazi ukubekezelela i-tacrolimus ngenxa yokucasuka kokuqala. I-Crisaborole nayo ayithwali isixwayiso sebhokisi elimnyama le-FDA ukuthi i-tacrolimus inalo mayelana nengozi yomdlavuza engaba khona ekusetshenzisweni kwesikhathi eside.

Kodwa-ke, i-tacrolimus ngokuvamile ithathwa njengeqinile futhi ingase isebenze kahle kakhulu ku-eczema ephakathi nendawo kuya kokukhulu. Sekutholakala isikhathi eside futhi inocwaningo oluningi olusekela ukusetshenziswa kwayo. I-Tacrolimus nayo ivame ukusebenza ngokushesha kune-crisaborole, nabanye abantu bebona ngcono ezinsukwini kunamaviki.

Nge-eczema yobuso, yomibili imithi iyizinketho ezinhle ngoba ayibangeli ukuncipha kwesikhumba njengama-steroid. Udokotela wakho angase aqale nge-crisaborole uma unesikhumba esizwelayo noma ukukhathazeka ngokubekezeleleka, bese ecabangela i-tacrolimus uma udinga imiphumela eqinile yokulwa nokuvuvukala. Abanye abantu basebenzisa ngisho nemithi yomibili ngezikhathi ezihlukene noma ezindaweni ezihlukene zomzimba njengengxenye yohlelo lwabo lokwelapha.

Imibuzo Evame Ukubuzwa Mayelana ne-Crisaborole

Ingabe i-Crisaborole iphephile ku-Diabetes?

Yebo, i-crisaborole ngokuvamile iphephile kubantu abanesifo sikashukela. Njengoba kuyimithi esetshenziswa ngaphandle esebenza endaweni esikhumbeni, ayithinti amazinga kashukela egazini noma iphazamise imithi yesifo sikashukela.

Noma kunjalo, abantu abanesifo sikashukela kudingeka baqaphele kakhulu ukunakekelwa kwesikhumba ngoba bathambekele kakhulu ezifweni zesikhumba nasekupholiseni amanxeba okuhamba kancane. Uma unesifo sikashukela futhi uqala noma yiziphi izimpawu zokutheleleka kwesikhumba ngenkathi usebenzisa i-crisaborole, njengokubomvu okukhulu, ukufudumala, i-pus, noma umkhuhlane, xhumana nodokotela wakho ngokushesha. Umhlinzeki wakho wezempilo angase afune ukuqapha isikhumba sakho eduze ngesikhathi sokwelashwa ukuze aqinisekise ukuphola okufanele.

Kufanele Ngenzeni Uma Ngisebenzisa Ngengozi I-Crisaborole Eningi Kakhulu?

Ukusetshenziswa kwe-crisaborole eningi kakhulu ngezikhathi ezithile akunakwenzeka ukuthi kubangele izinkinga ezinkulu ngoba kungumuthi osetshenziswa ngaphandle. Kodwa-ke, ukusebenzisa amanani amaningi kakhulu kungakhuphula ingozi yakho yemiphumela emibi efana nokucasuka kwesikhumba, ukusha, noma ukusabela komzimba ngaphandle.

Uma ngengozi usebenzisa okuningi kakhulu, sula ngokucophelela okweqile ngendwangu ehlanzekile, emanzi. Ungahlikihli noma uhlikihle ngamandla, ngoba lokhu kungacasula isikhumba sakho ngaphezulu. Qapha indawo ephathwayo ukuze ubone ukubomvu okukhulu, ukusha, noma ezinye izimpawu zokucasuka emahoreni ambalwa alandelayo.

Uma uhlangabezana nokusha okukhulu, ukuqubuka okusabalale kabanzi, noma izimpawu zokusabela komzimba ngaphandle ngemuva kokusebenzisa i-crisaborole eningi kakhulu, geza indawo kahle ngensipho namanzi athambile bese uthintana nomhlinzeki wakho wezempilo. Esikhathini esizayo, khumbula ukuthi ungqimba oluncane lwanele - imithi eningi ayisho imiphumela engcono.

Kufanele Ngenzeni Uma Ngiphuthelwa Umthamo We-Crisaborole?

Uma uphuthelwa umthamo we-crisaborole, uyisebenzise ngokushesha lapho ukhumbula. Kodwa-ke, uma sekuseduze nesikhathi somthamo wakho olandelayo ohleliwe, weqa umthamo ophuthelwe bese uqhubeka nohlelo lwakho lokusebenzisa olujwayelekile.

Ungasebenzisi imithi eyengeziwe ukuze ulungise umthamo ophuthelwe, ngoba lokhu kungakhuphula ingozi yakho yemiphumela emibi. Ukuqina kubalulekile nge-crisaborole, ngakho zama ukuyisebenzisa ngezikhathi ezifanayo nsuku zonke ukuze ugcine amazinga aqinile esikhumbeni sakho.

Uma ukhohlwa njalo imithamo, cabangela ukusetha izikhumbuzi zocingo noma ukusebenzisa umuthi njengengxenye yomsebenzi wakho wansuku zonke, njengemva kokuxubha amazinyo ekuseni nakusihlwa. Ukweqa imithamo ngezikhathi ezithile ngeke kukulimaze, kodwa ukungawusebenzisi njalo kunganciphisa ukusebenza komuthi ekulawuleni i-eczema yakho.

Ngingayeka nini ukuthatha i-Crisaborole?

Ngokuvamile ungaqeda ukusebenzisa i-crisaborole lapho izimpawu zakho ze-eczema sezinyamalele futhi zihlale zizinzile isikhathi esinqunywe udokotela wakho. Kodwa-ke, ungaqedi umuthi ngokuzumayo ngaphandle kokubonisana nodokotela wakho kuqala.

Odokotela abaningi batusa ukunciphisa kancane kancane imvamisa yokusebenzisa kunokuyeka kungazelelwe. Isibonelo, ungasuka ekusebenziseni kabili ngosuku uye kanye ngosuku, bese uya ngosuku olulodwa, ngaphambi kokuyeka ngokuphelele. Le ndlela isiza ekuvikeleni ukuqubuka kabusha futhi ikuvumela ukuthi uqaphele ukuthi isikhumba sakho siphendula kanjani.

Abanye abantu badinga ukuqhubeka ne-crisaborole njengokwelashwa kwesikhathi eside ukuvimbela ukuqubuka kwe-eczema. Njengoba iphephile ukusetshenziswa isikhathi eside, udokotela wakho angase ancome ukwelashwa okuqhubekayo uma une-eczema engapheli evame ukubuyela uma ukwelashwa kuyekwa. Isinqumo sokuqhubeka noma sokuyeka kufanele senziwe ngaso sonke isikhathi ngokubonisana nodokotela wakho ngokusekelwe ekuphenduleni kwakho ngakunye nezidingo zakho.

Ngingayisebenzisa i-Crisaborole neminye imithi ye-Eczema?

Yebo, i-crisaborole ingasetshenziswa ngokuvamile kanye nezinye izindlela zokwelapha i-eczema, kodwa kufanele uhlale uhlola nodokotela wakho ngaphambi kokuhlanganisa imithi. Umhlinzeki wakho wokunakekelwa kwezempilo angasiza ekudaleni uhlelo lokwelapha olubanzi olwandisa izinzuzo ngenkathi kunciphisa ukusebenzisana okungenzeka.

I-Crisaborole isebenza kahle ngama-moisturizers nama-creams okulungisa isithiyo, okuyizinto ezibalulekile zokuphathwa kwe-eczema. Sebenzisa i-crisaborole kuqala, linda imizuzu embalwa ukuze imunceke, bese usebenzisa i-moisturizer yakho. Ungayisebenzisa futhi ngama-antihistamines omlomo ukuze uthole ukukhululeka okwengeziwe kokuluma.

Uma usebenzisa ezinye izindlela zokwelapha ezigcotshwayo, udokotela wakho angase ancome ukuzisebenzisa ngezikhathi ezahlukene zosuku noma azishintshane ukuze kugwenywe ukuxhumana okungenzeka. Ezinye izinhlanganisela, njengokusebenzisa i-crisaborole kanye nama-steroid agcotshwayo, zingase zinikezwe ngezikhathi zokuvuvukala okukhulu, kodwa lokhu kudinga ukugadwa ngokucophelela kwezokwelapha ukuze kuqinisekiswe ukuphepha nokusebenza kahle.