Yini i-Cyclophosphamide: Ukusetshenziswa, Umthamo, Imiphumela Eceleni Nokunye

I-Cyclophosphamide iyikhambi elinamandla le-chemotherapy elisetshenziswa odokotela ukwelapha izinhlobo ezahlukene zomdlavuza kanye nezimo ezithile ze-autoimmune. Ingaphansi kohlu lwemithi ebizwa ngokuthi ama-ejenti e-alkylating, asebenza ngokugxambukela ne-DNA ngaphakathi kwamaseli ahlukanisa ngokushesha njengamaseli omdlavuza. Ngenkathi le mithi ingasebenza kakhulu ezimweni ezinzima, idinga ukuqapha ngokucophelela futhi iza nezinto ezibalulekile okuzoxoxwa ngazo ngokucophelela ithimba lakho lezempilo.

Yini i-Cyclophosphamide?

I-Cyclophosphamide iyikhambi elinikezwa ngudokotela elicindezela amasosha akho omzimba futhi limise amaseli athile ekukhuleni nasekuhlukaniseni. Yilokho odokotela abakubiza ngokuthi umuthi ocindezela amasosha omzimba kanye ne-cytotoxic, okusho ukuthi inganciphisa ukusabela komzimba wakho emasosheni omzimba ngenkathi futhi inobuthi ezinhlotsheni ezithile zamaseli. Lesi senzo esiphindwe kabili senza ukuthi sibe usizo ikakhulukazi ekwelapheni imidlavuza lapho amaseli ehlukanisa ngokushesha, kanye nezifo ze-autoimmune lapho amasosha akho omzimba esebenza ngokweqile.

Lo muthi usetshenziswe emithini amashumi eminyaka futhi uthathwa njengenye yezindlela zokwelapha eziyisisekelo ku-oncology kanye ne-rheumatology. Udokotela wakho angase futhi amazi ngamagama awo omkhiqizo, okuhlanganisa i-Cytoxan ne-Procytox, nakuba izinhlobo ezivamile zitholakala kabanzi.

Yini i-Cyclophosphamide Esetshenziselwa Yona?

I-Cyclophosphamide iphatha izinhlobo eziningi zezimo zezokwelapha ezinzima, ikakhulukazi imidlavuza nezifo ze-autoimmune. Udokotela wakho angase akubhalele yona uma ezinye izindlela zokwelapha zingasebenzanga noma uma udinga umuthi oqinile ikakhulukazi ukuze ulawule isimo sakho.

Ukwelashwa komdlavuza, ivame ukusetshenziselwa imidlavuza yegazi efana ne-leukemia ne-lymphoma, kanye nezimila eziqinile ezihlanganisa umdlavuza webele, umdlavuza wamaphaphu, nomdlavuza wama-ovari. Izikhathi eziningi, uzoyithola njengengxenye yokwelashwa okuhlanganisiwe neminye imithi ye-chemotherapy, njengoba le ndlela ivame ukusebenza kangcono kunokusebenzisa umuthi owodwa kuphela.

Ezimweni ze-autoimmune, i-cyclophosphamide iyasiza lapho amasosha akho omzimba ehlasela ngokungaqondile izicubu zakho ezinempilo. Odokotela bavame ukuyinika ezimweni ezinzima ze-lupus, ikakhulu uma lesi sifo sithinta izinso zakho noma ezinye izitho ezibalulekile. Isetshenziselwa futhi izimo ezinjenge-rheumatoid arthritis, i-multiple sclerosis, nezinhlobo ezithile ze-vasculitis lapho ezinye izindlela zokwelapha zingazange zinikeze ukulawula okwanele.

Ngokuvamile, udokotela wakho angase ancome i-cyclophosphamide ezimweni ezingavamile ezinjengezimo ezinzima ze-nephrotic syndrome ezinganeni, noma njengengxenye yokulungiselela ukufakelwa komnkantsha wamathambo. Isinqumo sokusebenzisa lo muthi sihlala sihlanganisa ukulinganisa izinzuzo zawo ezingaba khona nezingozi zawo, okuzoxoxwa ngeqembu lakho lezempilo ngemininingwane.

Isebenza Kanjani I-Cyclophosphamide?

I-Cyclophosphamide isebenza ngokungenelela nge-DNA ngaphakathi kwamaseli, ikakhulukazi lawo ahlukanisa ngokushesha. Lapho umuthi ungena emzimbeni wakho, isibindi sakho siwuguqula sibe yizinhlanganisela ezisebenzayo ezingaxhuma imicu ye-DNA, empeleni zivimbela amaseli ukuthi akopishe izinto zawo zofuzo ngendlela efanele. Lesi senzo sisebenza kahle kakhulu kumangqamuzana omdlavuza, avame ukuhlukanisa ngokushesha kakhulu kunamaseli ajwayelekile anempilo.

Lokhu kuthathwa njengomuthi oqinile onemiphumela enamandla emzimbeni wakho wonke. Ngokungafani nokwelashwa okuthambile, i-cyclophosphamide ayihloseli amaprotheni athile noma izindlela kodwa ithinta inqubo eyisisekelo yokuhlukaniswa kwamaseli. Le ndlela ebanzi yokusebenza yenza isebenze ezinhlotsheni eziningi ezahlukene zomdlavuza namaseli omzimba, kodwa futhi kusho ukuthi ingathinta amaseli anempilo ahlukanisa njalo, njengalawo atholakala emnkantshweni wamathambo akho, ama-follicles ezinwele, kanye nethrekhi yokugaya ukudla.

Umuthi futhi ucindezela amasosha akho omzimba ngokunciphisa inani lamaseli amhlophe egazi umzimba wakho awenzayo. Ngenkathi lokhu kucindezelwa kwamasosha omzimba kusiza ekwelapheni izifo ze-autoimmune, futhi kusho ukuthi uzoba sengozini enkulu yokutheleleka ngenkathi usebenzisa umuthi. Ithimba lakho lokunakekelwa kwezempilo lizohlola njalo ukubalwa kwegazi lakho ukuze liqinisekise ukuthi amasosha akho omzimba awacindezelwa kakhulu.

Kufanele Ngiwuthathaphi I-Cyclophosphamide?

Indlela othatha ngayo i-cyclophosphamide incike ekutheni udokotela wakho unquma amaphilisi omlomo noma uhlobo lwe-intravenous. Ngamaphilisi omlomo, ngokuvamile uzozithatha ekuseni ngenkomishi yamanzi egcwele, futhi kubalulekile ukuphuza uketshezi oluningi usuku lonke ukusiza ukuvikela izinso zakho nomchamo. Udokotela wakho ngokuvamile uzoncoma ukuphuza okungenani izinkomishi zamanzi eziyi-8-10 nsuku zonke ngenkathi usebenzisa lo muthi.

Uma uthatha uhlobo lomlomo, ungaluthatha ngokudla noma ngaphandle kokudla, nakuba ukuluthatha ngokudla kungasiza ukunciphisa isisu esicasulayo. Kodwa-ke, gwema ukuphuza ijusi le-grapefruit, njengoba lingaphazamisa indlela umzimba wakho osebenza ngayo ngomuthi. Abanye abantu bakuthola kuwusizo ukuthatha umuthi ngesikhathi esifanayo nsuku zonke ukuze bagcine amazinga aqhubekayo ohlelweni lwabo.

Ukwelashwa kwe-intravenous, uzothola umuthi ngomthambo, ngokuvamile esibhedlela noma ekliniki. Le nqubo ngokuvamile ithatha imizuzu engama-30 emahoreni amaningana, kuye ngohlelo lwakho oluthile lokwelapha. Ithimba lakho lokunakekelwa kwezempilo lizokuqapha eduze ngesikhathi nangemva kokufakwa ngakunye ukuze libheke noma yiziphi izindlela eziphendulayo ngokushesha.

Ungalokothi uchoboze, uhlafune, noma uphule amaphilisi, njengoba lokhu kungaholela ekumuncweni okungalingani kanye nemiphumela emibi engaba yingozi. Uma unenkinga yokugwinya amaphilisi, khuluma nomphathi wakho wamaphilisi mayelana nezinketho ezingezinye. Njalo phatha umuthi ngokucophelela futhi ugeze izandla zakho kahle ngemva kokuthinta amaphilisi, njengoba umuthi ungasetshenziswa ngokuthintana nesikhumba.

Kufanele Ngiyithathe Isikhathi Esingakanani I-Cyclophosphamide?

Isikhathi sokwelashwa nge-cyclophosphamide siyahluka kakhulu kuye ngesimo sakho esithile nokuthi usabela kanjani emuthini. Ukuze welashwe umdlavuza, ungase uwuthole ngemijikelezo ezingxenyeni eziningi zenyanga, ngamagebe phakathi kokwelashwa ukuvumela umzimba wakho ukuthi ululame. Inkambo ejwayelekile ingase ihlanganise ukwelashwa njalo ngemva kwamasonto angu-3-4 imijikelezo engu-4-6, nakuba lokhu kungahluka kakhulu kuye ngohlelo lwakho lokwelashwa.

Ezimweni ze-autoimmune, isikhathi sokwelashwa sivame ukuba sifushane kodwa siqine ekuqaleni. Ungase uthole imithamo yansuku zonke izinyanga eziningana, kulandelwe ukuncishiswa kancane kancane kwemvamisa. Abanye abantu abanezimo ezinjenge-lupus bangayithatha izinyanga ezingu-3-6 njengengxenye yokwelashwa kokungeniswa, bese beshintshela emuthini wokugcina ohlukile.

Udokotela wakho uzohlola njalo ukuthi usabela kanjani ekwelashweni ngokuhlolwa kwegazi, izifundo zokuthwebula izithombe, nokuhlolwa komzimba. Lokhu kuhlola kusiza ukunquma ukuthi uzoqhubeka yini, uguqule, noma umise umuthi. Kubalulekile ukungayeki ukuthatha i-cyclophosphamide ngokuzumayo ngaphandle kokubonisana nethimba lakho lezempilo, njengoba lokhu kungaholela ekuqubukeni kwesimo sakho esingaphansi.

Umthamo ophelele oqongelelwe owuthola ekuphileni kwakho nawo uyinto ebalulekile okufanele icatshangelwe, njengoba kunemingcele yokuthi kungakanani i-cyclophosphamide umuntu angayithola ngokuphepha ngenxa yemiphumela engaba khona yesikhathi eside ezithweni ezinjenge-bladder nenhliziyo.

Yiziphi Izimo Ezingezinhle ze-Cyclophosphamide?

I-Cyclophosphamide ingabangela uhla lwemiphumela engemihle, kusukela kokulula nokulawulekayo kuya kokubaluleke kakhulu okudinga ukunakekelwa kwezempilo ngokushesha. Ukuqonda le miphumela engaba khona kukusiza ukuthi wazi okulindelekile nokuthi uzoxhumana nini nethimba lakho lezempilo.

Imiphumela eseceleni evame kakhulu ongase uhlangabezane nayo ihlanganisa isicanucanu, ukuhlanza, nokulahlekelwa isifiso sokudla, okuvame ukwenzeka kungakapheli amahora ngemuva kokuthatha umuthi. Abantu abaningi futhi bahlangabezana nokukhathala, ukulahlekelwa izinwele, nokwanda kokuba sengozini yokutheleleka ngenxa yokwehla kwenani lemaseli egazi elimhlophe. Le miphumela ngokuvamile yesikhashana futhi iyathuthuka ngemuva kokuphela kokwelashwa, nakuba ukukhula kabusha kwezinwele kungathatha izinyanga eziningana.

Imiphumela eseceleni engathi sína kodwa engavamile ihlanganisa izinkinga zomchamo, ezingahluka kusukela ekwandeni kwemvamisa yokuchama kuya egazini emchamweni noma ukuvuvukala okukhulu komchamo okubizwa ngokuthi i-hemorrhagic cystitis. Yingakho ukuphuza amanzi amaningi kubaluleke kangaka ngenkathi usebenzisa lo muthi. Izinkinga zenhliziyo nazo zingenzeka, ikakhulu ngemithamo ephezulu noma izikhathi zokwelashwa ezinde, nakuba lokhu kungavamile.

Abanye abantu bangase bahlangabezane nokuvuvukala kwamaphaphu, izinkinga zesibindi, noma ukwehla okukhulu kwenani lamaseli egazi okudinga ukunakekelwa kwezempilo ngokushesha. Umdlavuza wesibili, nakuba ungavamile kakhulu, ungenza iminyaka ngemuva kokwelashwa, ikakhulukazi umdlavuza womchamo noma umdlavuza wegazi. Udokotela wakho uzoxoxa ngalezi zingozi nawe futhi achaze ukuthi zilinganiswa kanjani nezinzuzo zokwelapha isimo sakho samanje.

Ukuzala kungathinteka yi-cyclophosphamide, nengozi iphakeme ezigulini ezindala kanye nalezo ezithola imithamo ephezulu. Uma uhlela ukuba nezingane esikhathini esizayo, xoxa ngezinketho zokulondoloza ukuzala nodokotela wakho ngaphambi kokuqala ukwelashwa.

Ubani Ongafanele Athole I-Cyclophosphamide?

I-Cyclophosphamide ayifanele wonke umuntu, futhi udokotela wakho uzohlola ngokucophelela ukuthi iphephile yini kuwe ngokusekelwe emlandweni wakho wezempilo kanye nesimo sakho samanje sempilo. Abantu abanezinhlelo zokuzivikela ezithuthukiswe kakhulu noma izifo ezisebenzayo ngokuvamile akufanele bathathe lo muthi, njengoba ungaqhubeka ucindezela ukuzivikela futhi uqhubekise izifo.

Uma unezifo ezinzima zezinso noma isibindi, udokotela wakho angase adinge ukulungisa umthamo wakho kakhulu noma akhethe olunye uhlobo lokwelashwa ngokuphelele. Umuthi ucubungulwa yisibindi sakho futhi ukhishwe ngezinso zakho, ngakho izinkinga ngalezi zitho zingaholela ekunqwabelaneni okuyingozi komuthi emzimbeni wakho.

Abesifazane abakhulelwe akufanele bathathe i-cyclophosphamide, njengoba ingabangela ukukhubazeka okukhulu kokuzalwa kanye nezinkinga zokukhulelwa. Uma uncelisa, kuzodingeka uyeke, njengoba umuthi udlulela obisini futhi ungalimaza ingane yakho. Abesifazane abaneminyaka yokuzala ngokuvamile badinga ukusebenzisa izindlela zokuvimbela inzalo ezisebenzayo ngesikhathi sokwelashwa kanye nangezinyanga ezimbalwa ngemva kwalokho.

Abantu abanomlando wokungezwani komzimba okukhulu ne-cyclophosphamide noma imithi efanayo kufanele bagweme lokhu kwelashwa. Ngaphezu kwalokho, uma usuvele uthole umthamo omkhulu wokuphila kwe-cyclophosphamide, udokotela wakho ngeke aphinde awubhale ngenxa yengozi eyengeziwe yezinkinga ezinkulu zesikhathi eside.

Amagama Omkhiqizo we-Cyclophosphamide

I-Cyclophosphamide itholakala ngaphansi kwamagama amaningi omkhiqizo, nakuba inguqulo ejwayelekile isetshenziswa kakhulu futhi isebenza kahle. Amagama omkhiqizo ajwayelekile afaka i-Cytoxan, okungenzeka ukuthi yaziwa kakhulu, kanye ne-Procytox, esetshenziswa kwamanye amazwe. Ungase futhi uhlangane ne-Endoxan ezindaweni ezithile.

Lawa magama omkhiqizo wonke aqukethe isithako esifanayo esisebenzayo futhi asebenza ngendlela efanayo, nakuba kungase kube khona umehluko omncane ezithakweni ezingasebenzi noma ekwakhekeni kwamaphilisi. Ikhemisi lakho lingase lishintshe phakathi kwezinhlobo ezijwayelekile nezomkhiqizo, okujwayelekile ukuthi kuphephile futhi kwamukelekile. Kodwa-ke, uma unezinto ezithile ezingezwani nazo ezithakweni ezingasebenzi, qiniseka ukuthi uxoxa ngalokhu nosokhemisi wakho.

Ifomu le-intravenous livame ukubizwa ngokuthi "i-cyclophosphamide yokujova" kungakhathaliseki ukuthi umenzi. Noma ngabe uthola igama lomkhiqizo noma inguqulo ejwayelekile ngokuvamile kuncike ekuhlinzekweni komshwalense wakho kanye nezintandokazi zesibhedlela noma zomtholampilo, kodwa ukusebenza kahle kufanele kube okulinganayo.

Ezinye izindlela ze-Cyclophosphamide

Imithi eminingana ehlukile ingasetshenziswa uma i-cyclophosphamide ingafaneleki noma ingasebenzi kahle esimweni sakho. Ukuze kulashwe umdlavuza, ezinye izidakamizwa ze-chemotherapy ezinjenge-carboplatin, cisplatin, noma i-doxorubicin zingaba izinketho, kuye ngohlobo oluthile lomdlavuza onaso. Ukwelashwa okusha okuhloswe ngakho kanye nemithi ye-immunotherapy nayo iyatholakala ngokuqhubekayo ezinhlotsheni eziningi zomdlavuza.

Ezimweni ze-autoimmune, ezinye izindlela zihlanganisa i-methotrexate, evame ukusetshenziselwa i-rheumatoid arthritis kanye ne-lupus, noma i-mycophenolate mofetil, ewusizo ikakhulukazi ekuhilelekeni kwezinso ze-lupus. I-Rituximab, i-monoclonal antibody, ingasebenza kahle ezimweni ezithile ze-autoimmune kanye nezinhlobo ezithile zomdlavuza.

Ukwelashwa okungokwemvelo okufana ne-adalimumab, infliximab, noma i-tocilizumab kungase kufaneleke ezimweni ezithile ze-autoimmune, ikakhulukazi i-rheumatoid arthritis noma izinhlobo ezithile ze-vasculitis. Le mithi isebenza ngendlela ehlukile kune-cyclophosphamide ngokuhlosela izingxenye ezithile zesimiso somzimba sokuzivikela kunokusicindezela ngokuphana.

Ukukhetha okunye kuncike ezintweni eziningi ezihlanganisa isimo sakho esithile, ukwelashwa kwangaphambilini okuzamile, iminyaka yakho, ezinye izimo zempilo, nezintandokazi zomuntu siqu. Udokotela wakho uzosebenza nawe ukuthola ukwelashwa okufanele kakhulu uma i-cyclophosphamide ingakulungele.

Ingabe i-Cyclophosphamide ingcono kune-Methotrexate?

Ukuqhathanisa i-cyclophosphamide ne-methotrexate akulula ngoba zisetshenziselwa izimo ezingafani futhi zisebenza ngezindlela ezingafani. I-Cyclophosphamide ngokuvamile ithathwa njengeqina futhi ivame ukugcinelwa izimo ezinzima kakhulu noma uma ezinye izindlela zokwelapha zingasebenzanga. I-Methotrexate ivame ukusetshenziswa njengendlela yokuqala yokwelapha izimo eziningi ze-autoimmune ngoba ineziphumela ezingezinhle ezingcono.

Ezimweni ezinjenge-rheumatoid arthritis, i-methotrexate ivame ukuzanywa kuqala ngoba iyasebenza kubantu abaningi futhi ineziphumela ezingezinhle ezingalawuleka kalula. I-Cyclophosphamide ingase icatshangelwe uma i-methotrexate ingasebenzi noma uma unezinkinga ezinzima zezitho ezidinga ukwelashwa okunobudlova obukhulu.

Ekwelashweni kwe-lupus, ukukhetha kuncike ekutheni yiziphi izitho ezithintekile nokuthi isifo sinzima kangakanani. I-Methotrexate ingase yanele izimpawu zamalunga nokubandakanyeka kwesikhumba, kuyilapho i-cyclophosphamide ivame ukudingeka ekubandakanyekeni okukhulu kwezinso noma kobuchopho. Ngezinye izikhathi odokotela bazisebenzisa ngokulandelana, beqala nge-cyclophosphamide yesifo esinzima bese beshintshela ku-methotrexate ukuze banakekele.

Umuthi

Ubungozi obukhulu bokutheleleka obubangelwa yi-cyclophosphamide bungase bukhathaze ikakhulukazi abantu abanesifo sikashukela, njengoba amazinga kashukela aphezulu egazini nawo angalimaza ukusebenza komzimba. Lokhu kusho ukuthi uzodinga ukuqapha kakhulu ukulawulwa kukashukela egazini, ukunakekelwa kahle kwamanxeba, nokubheka izimpawu zokutheleleka. Ithimba lakho lezempilo cishe lizofuna ukukubona njalo ukuze liqaphe kokubili isifo sakho sikashukela nokuphendula kwakho ku-cyclophosphamide.

Ngingenzani Uma Ngithatha I-Cyclophosphamide Eningi Ngengozi?

Uma ngengozi uthatha i-cyclophosphamide eningi kunaleyo ebekiwe, xhumana nodokotela wakho noma isikhungo sokulawula ubuthi ngokushesha, ngisho noma ungezwa ugula ngokushesha. Ukweqisa kungabangela izinkinga ezinkulu ezihlanganisa ukwehla okukhulu kwenani lamaseli egazi, isicanucanu esikhulu nokuhlanza, kanye nezinkinga ezingase zibe yingozi empilweni.

Ungazami ukuzihlanza ngaphandle uma uqondiswe ngqo ukuthi wenze kanjalo nguchwepheshe wezempilo. Uma kungenzeka, letha ibhodlela lomuthi nawe egumbini labezimo eziphuthumayo ukuze abasebenzi bezokwelapha bakwazi ukubona kahle ukuthi uthathe ini nokuthi kungakanani. Isikhathi sibalulekile ngokuqeda i-cyclophosphamide, ngakho-ke ungalindi ukubona ukuthi izimpawu ziyavela ngaphambi kokufuna usizo.

Ngingenzani Uma Ngiphuthelwa Umthamo We-Cyclophosphamide?

Uma uphuthelwa umthamo we-cyclophosphamide yomlomo, yithathe ngokushesha lapho ukhumbula, ngaphandle uma sekuyisikhathi esicishe sibe sesikhathini sakho esilandelayo esihleliwe. Kulokho, weqa umthamo ophuthelwe bese uthatha umthamo wakho olandelayo ngesikhathi esijwayelekile. Ungalokothi uphinde umthamo ukuze ulungise lowo ophuthelwe, ngoba lokhu kungandisa ingozi yakho yemiphumela emibi engathí sina.

Ukwelashwa ngemithambo, xhumana nethimba lakho lezempilo ngokushesha uma uphuthelwa i-aphoyintimenti. Bazodinga ukukuhlela kabusha ngokushesha okukhulu futhi bangase badinge ukulungisa uhlelo lwakho lokwelashwa. Ukuphuthelwa imithamo kungathinta ukuthi ukwelashwa kwakho kusebenza kahle kangakanani, ngakho-ke kubalulekile ukuxhumana nethimba lakho lezokwelapha mayelana nanoma yiziphi izinkinga zokuhlela.

Ngingayeka Nini Ukuthatha I-Cyclophosphamide?

Kufanele uyeke kuphela ukuthatha i-cyclophosphamide uma udokotela wakho ekutshela ukuthi wenze njalo. Ukuyeka ngaphambi kwesikhathi kungavumela isimo sakho ukuthi sibuyele noma sibe sibi kakhulu, kanti ukuyeka kungazelelwe kungase kubangele imiphumela efana nokuhoxiswa noma ukuqubuka kwesifo. Udokotela wakho uzoqoka isikhathi esifanele sokuyeka ngokusekelwe ekutheni usabela kanjani emithini kanye nemiphumela yokuhlolwa kwegazi lakho.

Ukwelashwa komdlavuza, ngokuvamile uzoqeda inani elinqunywe ngaphambilini lemijikelezo ngaphandle uma kwenzeka imiphumela emibi. Ezimweni ze-autoimmune, udokotela wakho angase anciphise kancane kancane umthamo wakho ngokuhamba kwesikhathi kunokuyeka kungazelelwe. Njalo xoxa nganoma yikuphi ukukhathazeka mayelana nokuqhubeka nokwelashwa nethimba lakho lezempilo kunokwenza isinqumo sokuyeka wedwa.

Ngingakhulelwa Ngenkathi Ngithatha I-Cyclophosphamide?

Akufanele ukhulelwe ngenkathi uthatha i-cyclophosphamide, njengoba ingabangela ukukhubazeka okukhulu kokuzalwa kanye nezinkinga zokukhulelwa. Umuthi ungalimaza ingane ekhulayo ngesikhathi sokukhulelwa, ngakho-ke ukulawulwa kokuzala okusebenzayo kubalulekile kubo bobabili abesilisa nabesifazane ngesikhathi sokwelashwa. Abesifazane kufanele basebenzise ukulawulwa kokuzala okuthembekile ngesikhathi sokwelashwa kanye nasezinyangeni ezimbalwa ngemva kokuyeka umuthi.

Uma uhlela ukuba nezingane esikhathini esizayo, xoxa ngezinketho zokulondoloza inzalo nodokotela wakho ngaphambi kokuqala ukwelashwa. I-Cyclophosphamide ingathinta inzalo kubo bobabili abesilisa nabesifazane, futhi le miphumela ingase ibe unomphela. Kodwa-ke, abantu abaningi bayaphumelela ngempela ukuba nezingane ngemva kokwelashwa nge-cyclophosphamide, ikakhulukazi uma besebancane lapho belashwa noma bethola imithamo ephansi.