Dabrafenib (indlela yokumathisa ngomlomo)
Imikhiqizo etholakalayo
Tafinlar
Mayelana naleli khambi
UDabrafenib isetshenziswa yodwa noma ngokuhlanganiswa neTrametinib ukuze kuphathwe i-melanoma (umdlavuza wesikhumba) esiyile noma esingeke sisuswe ngokuthunga. Isetshenziswa futhi kanye neTrametinib ukusiza ukuvimbela i-melanoma ekubuyeni ngemuva kokuthunga. Isetshenziswa kuphela uma amaseli e-melanoma enama-mutations e-BRAF V600E noma i-V600K. UDabrafenib usetshenziswa futhi kanye neTrametinib ukuze kuphathwe umdlavuza we-lungu ongaxhunyiwe (NSCLC) osukwandisiwe nomdlavuza we-thyroid ongaqondakali (ATC) osukwandisiwe futhi ongenazo izinketho zokwelashwa ezanele. Isetshenziswa kuphela uma amaseli e-NSCLC namaseli e-ATC enama-mutations e-BRAF V6000E. UDabrafenib usetshenziswa futhi ngokuhlanganiswa neTrametinib ukuze kuphathwe izicubu eziqinile ezisuselwe, ezingasuswa ngokuthunga, noma ezibi kakhulu (ezithuthukile) futhi ongenazo izinketho zokwelashwa ezanele. Isetshenziswa kuphela uma izicubu eziqinile zine-mutations e-BRAF V600E. UDabrafenib usetshenziswa futhi ngokuhlanganiswa neTrametinib ukuze kuphathwe i-glioma ephansi (LGG) kubantu abadinga ezinye izindlela zokwelashwa. Isetshenziswa kuphela uma umdlavuza wobuchopho une-mutations e-BRAF V600E. Udokotela wakho uzosebenzisa ukuhlolwa okukhethekile ukubheka le mi-mutations. UDabrafenib uyingxenye yeqembu lemithi, ebizwa ngokuthi yi-antineoplastics (imithi yomdlavuza). Lolu lwemi lulawuleka kuphela ngomyalelo wodokotela. Lo mkhiqizo utholakala ngezindlela zokulinganisa ezilandelayo:
Ngaphambi kokusebenzisa leli khambi
Uma ukhetha ukusebenzisa imithi, kufanele kuqhathaniswe ingozi yokuthatha imithi nezinzuzo ezizoletha. Lo ngumqondo owenzayo wena nodokotela wakho. Kule mithi, kufanele kucabangelwe okulandelayo: Tshela udokotela wakho uma uke waba nanoma yiluphi uhlobo oluhlukile noma ukusabela okungokwe-alerji kule mithi noma kunoma iyiphi enye imithi. Tshela futhi ochwepheshe bakho bezempilo uma unezinye izinhlobo zokungezwani, njengokudla, izidakamizwa, izigcini, noma izilwane. Ngomkhiqizo ongenayo iresiphi, funda ilebula noma izithako zephakheji ngokucophelela. Izifundo ezifanele azikwenzelwanga ubudlelwano bobudala nemiphumela ye-dabrafenib yokwelapha i-melanoma, umdlavuza we-lung ongaxhunyiwe, nomdlavuza we-thyroid ongaqondakali kubantwana, ukwelapha iziphumo ezilukhuni kubantwana abaneminyaka engaphansi kwengu-6, nokwelapha i-glioma kubantwana abaneminyaka engaphansi konyaka. Ukuphepha nokuphumelela akukaqiniswa. Izifundo ezifanele ezenziwe kuze kube manje azibonisi izinkinga ezikhethekile zabantu abadala ezingalinda ukusetshenziswa kwe-dabrafenib kubantu abadala. Ayikho izifundo ezifanele kubesifazane zokunquma ingozi yengane uma usebenzisa le mithi ngesikhathi sokuncelisa. Linganisa izinzuzo ezingaba khona nezingozi ezingaba khona ngaphambi kokuthatha le mithi ngesikhathi sokuncelisa. Nakuba ezinye izidakamizwa kufanele zingasetshenziswa ndawonye, kwezinye izimo imithi emibili ehlukene ingasetshenziswa ndawonye ngisho noma kungenzeka ukuthi kube khona ukusebenzisana. Kulezi zimo, udokotela wakho angase afune ukushintsha umthamo, noma ezinye izinyathelo zokuphepha zingadingeka. Uma uthatha le mithi, kubalulekile kakhulu ukuthi ochwepheshe bakho bezempilo bazi uma uthatha noma iyiphi imithi ehlu lwezansi. Ukusebenzisana okulandelayo kukhethwe ngokusekelwe ekubalulekeni kwabo okungenzeka futhi akuyona yonke into. Ukusebenzisa le mithi nanoma iyiphi imithi elandelayo ayikhuthazwa. Udokotela wakho angase anqume ukungakwelaphi ngale mithi noma ashintshe ezinye izidakamizwa ozithathayo. Ukusebenzisa le mithi nanoma iyiphi imithi elandelayo ngokuvamile ayikhuthazwa, kodwa kungadingeka kwezinye izimo. Uma kokubili imithi ilotshiwe ndawonye, udokotela wakho angase ashintshe umthamo noma ukuthi uyayisebenzisa kangakanani enye noma kokubili imithi. Ezinye izidakamizwa akufanele zisetshenziswe ngesikhathi sokudla noma eduze kwesikhathi sokudla noma ukudla izinhlobo ezithile zokudla ngoba ukusebenzisana kungase kwenzeke. Ukusebenzisa utshwala noma utshaba nezinye izidakamizwa kungase futhi kubangele ukusebenzisana. Xoxa nochwepheshe bakho bezempilo ngokusetshenziswa kwemithi yakho ngokudla, utshwala, noma utshaba. Ukuba khona kwezinye izinkinga zezokwelapha kungathinta ukusetshenziswa kwale mithi. Qiniseka ukuthi utshela udokotela wakho uma unezinye izinkinga zezokwelapha, ikakhulukazi:
Indlela yokusebenzisa leli khambi
Imithi esetshenziswa ekwelapheni umdlavuza inamandla kakhulu futhi ingaba nemiphumela eminingi emibi. Ngaphambi kokusebenzisa le mithi, qiniseka ukuthi uyayiqonda yonke imingcipheko nezinzuzo. Kubalulekile ukuthi usebenzisane eduze nodokotela wakho phakathi nokwelashwa kwakho. Thatha le mithi ngokuqondile njengoba uqondiswe yidokotela wakho. Ungayithathi ngaphezulu, ungayithathi kaningi, futhi ungayithathi isikhathi eside kunalokho oqondiswe yidokotela wakho. Ukwenza kanjalo kungandisa amathuba emiphumela emibi. Le mithi ivame ukufika ne-Medication Guide nemiyalo yokuqondisa iziguli. Funda futhi ulandele le miyalo ngokucophelela. Buza udokotela wakho noma umthengisi wemithi uma unemibuzo. Thatha le mithi okungenani ihora elilodwa ngaphambi noma amahora amabili ngemva kokudla. Gwinya ikhaphsuli yonke. Ungayivuli, ungayicwili, noma ungayaphula. Ukusebenzisa ithebulethi yokuxuba: Inani lemithi lizoba lehlukile kubantu abahlukene. Landela imiyalo yodokotela wakho noma imiyalo esemthethweni. Ulwazi olulandelayo luhlanganisa kuphela amanani aphakathi ale mithi. Uma inani lakho lihlukile, ungalishintshi ngaphandle kokuthi udokotela wakho akuqondise ukuba wenze njalo. Inani lemithi oyithatha lixhomeke emandleni emithi. Futhi, inani lemithi oyithatha nsuku zonke, isikhathi esivunyelwe phakathi kwemithi, nobude besikhathi oyithatha imithi kuxhomeke enkingeni yezokwelapha oyisebenzisela imithi. Uma uphuthelwa yidosi yale mithi, yithatha ngokushesha okukhulu. Noma kunjalo, uma sekusondele isikhathi sedosi yakho elandelayo, susa idosi ephuthelwe bese ubuyela esikhathini sakho sokuthatha imithi. Ungawandisi amadosini. Uma uphuthelwa yidosi futhi kungaphansi kwamahora ayisithupha kuze kube yidosi yakho elandelayo evamile, susa idosi ephuthelwe bese ubuyela esikhathini sakho sokuthatha imithi. Uma uphuthelwa yidosi futhi kungaphezu kwamahora ayisithupha kuze kube yidosi yakho elandelayo, yithatha ngokushesha okukhulu bese ubuyela esikhathini sakho sokuthatha imithi. Uma uhlanza, susa idosi ephuthelwe bese ubuyela esikhathini sakho sokuthatha imithi. Gcina imithi esitsheni esivaliwe emazingeni okushisa kwegumbi, kude nokushisa, ukufuma, nokukhanya okulungile. Gcina ungayivumeli ukuba iqhwabe. Gcina ingafinyeleleki ezinganeni. Ungagcini imithi esidala noma imithi engasasetshenziswa. Buza ochwepheshe bakho bezempilo ukuthi kufanele uyilahla kanjani noma iyiphi imithi ongayisebenzisi.
Umshwana wokuzihlangula: I-August iyinkundla yolwazi lwezempilo futhi izimpendulo zayo azihlanganisi iseluleko sezokwelapha. Njalo thintana nochwepheshe bezokwelapha onelayisensi eduze nawe ngaphambi kokwenza noma yiluphi ushintsho.