Dacarbazine (indlela ye-intravenous, indlela yokugcoba)
Imikhiqizo etholakalayo
Dtic-Dome, Dacarbazine
Mayelana naleli khambi
UDacarbazine iyingxenye yeqembu lemithi ebizwa ngokuthi yi-alkylating agents. Isetshenziswa ekwelapheni umdlavuza wesimiso le-lymph kanye ne-malignant melanoma (uhlobo lomdlavuza wesikhumba). Ingasetshenziswa futhi ekwelapheni ezinye izinhlobo zomdlavuza, njengoba kunqunywe ngudokotela wakho. UDacarbazine uhlanganisa ekukhuleni kwamaseli omdlavuza, awohloka ekugcineni. Njengoba ukukhula kwamaseli emizimba evamile kungase kuthonyeke yi-dacarbazine, eminye imiphumela izophinde ibonakale. Eminye yale miphumela ingaba nzima futhi kufanele uyibeke umbiko kudokotela wakho. Eminye imiphumela, njengokuwa kwezinwele, ingase ingabi nzima kodwa ingase ikhathaze. Eminye imiphumela ingase ingabonakali izinyanga noma iminyaka ngemuva kokusetshenziswa kwale mithi. Ngaphambi kokuba uqale ukwelashwa nge-dacarbazine, wena nodokotela wakho kufanele nixoxe ngezinzuzo zalemithi kanye nezingozi zokuyisebenzisa. UDacarbazine kufanele unikezwe kuphela ngudokotela wakho noma ngaphansi kokunakekelwa kwakhe okuqondile. Lo mkhiqizo utholakala ngezindlela zokulinganisa ezilandelayo:
Ngaphambi kokusebenzisa leli khambi
Uma kunquma ukusebenzisa imithi, kufanele kuqhathaniswe ingozi yokuthatha imithi nezinzuzo ezizoletha. Lo ngumqulu ozowenza wena nodokotela wakho. Kule mithi, kufanele kucabangelwe okulandelayo: Tshela udokotela wakho uma uke waba nanoma yiluphi uhlobo oluhlukile noma ukusabela okungokwe-alerji kule mithi noma kwezinye izidakamizwa. Tshela futhi ochwepheshe bakho bezempilo uma unezinye izinhlobo zokungezwani, njengokudla, izidakamizwa, izigcini, noma izilwane. Ngomkhiqizo ongenayo iresiphi, funda ilebula noma izithako zephakheji ngokucophelela. Izifundo kule mithi zenziwe kuphela kubantu abadala futhi alukho ulwazi oluqondile oluqhathanisa ukusetshenziswa kwe-dacarbazine kubantwana nokusetshenziswa kwezinye izigaba zobulili. Imithi eminingi ayifundwanga ngokukhethekile kubantu abadala. Ngakho-ke, kungenzeka kungaziwa ukuthi isebenza ngendlela efanayo njengoba isebenza kubantu abadala abasebancane noma uma ibangela imiphumela emibi noma izinkinga kubantu abadala. Alikho ulwazi oluqondile mayelana nokusetshenziswa kwe-dacarbazine kubantu abadala. Azikho izifundo ezifanele kubesifazane zokunquma ingozi yengane uma usebenzisa le mithi ngesikhathi sokuncelisa. Linganisa izinzuzo ezingaba khona nezingozi ezingaba khona ngaphambi kokuthatha le mithi ngesikhathi sokuncelisa. Nakuba imithi ethile ingafanele isetshenziswe ndawonye nhlobo, kwezinye izimo imithi emibili ehlukene ingasetshenziswa ndawonye ngisho noma kungenzeka ukuthi kube khona ukusebenzisana. Kulezi zimo, udokotela wakho angafuna ukushintsha umthamo, noma ezinye izinyathelo zokuphepha kungadingeka. Uma uthatha le mithi, kubalulekile ngokukhethekile ukuthi ochwepheshe bakho bezempilo bazi uma uthatha noma yimiphi imithi ehlongozwayo ngezansi. Ukusebenzisana okulandelayo kukhethwe ngesisekelo sokubaluleka kwabo okungenzeka futhi akuyona yonke into. Ukusebenzisa le mithi nanoma yimiphi imithi elandelayo ayinconywa. Udokotela wakho anganquma ukungakwelaphi ngale mithi noma ashintshe ezinye zezidakamizwa ozithathayo. Ukusebenzisa le mithi nanoma yimiphi imithi elandelayo ngokuvamile akunconywa, kodwa kungadingeka kwezinye izimo. Uma kokubili imithi ilotshiwe ndawonye, udokotela wakho angashintsha umthamo noma ukuthi uyayisebenzisa kangakanani enye noma zombili imithi. Ukusebenzisa le mithi nanoma yimiphi imithi elandelayo kungabangela ukwanda kengozi yemiphumela emibi ethile, kodwa ukusebenzisa kokubili izidakamizwa kungaba ukwelashwa okuhle kuwe. Uma kokubili imithi ilotshiwe ndawonye, udokotela wakho angashintsha umthamo noma ukuthi uyayisebenzisa kangakanani enye noma zombili imithi. Imithi ethile akufanele isetshenziswe ngesikhathi sokudla noma eduze kwesikhathi sokudla noma ukudla izinhlobo ezithile zokudla ngoba ukusebenzisana kungase kwenzeke. Ukusebenzisa utshwala noma utshaba nanoma yimiphi imithi kungabangela ukusebenzisana. Xoxa nochwepheshe bakho bezempilo ngokusetshenziswa kwemithi yakho ngokudla, utshwala, noma utshaba. Ukuba khona kwezinye izinkinga zezokwelapha kungathinta ukusetshenziswa kwale mithi. Qiniseka ukuthi utshela udokotela wakho uma unezinye izinkinga zezokwelapha, ikakhulukazi:
Indlela yokusebenzisa leli khambi
IDacarbazine ngezinye izikhathi inikezwa kanye nezinye izidakamizwa. Uma usebenzisa ukuxuba kwezidakamizwa, kubalulekile ukuthi uthole ngayinye ngesikhathi esifanele. Uma uthatha ezinye zezidakamizwa ngomlomo, cela ochwepheshe bakho bezempilo bakusize uhlela indlela yokukhumbula ukuzithatha ngezikhathi ezifanele. Leli yona imithi ivame ukubangela isicanucanu, ukugabha, nokulahlekelwa ukudla. Ukuhlungwa kungase futhi kubangele umuzwa wokushisa noma ubuhlungu. Noma kunjalo, kubalulekile kakhulu ukuthi uqhubeke uthola imithi, ngisho noma unezinkinga noma uqale ukuzizwa ungaphili kahle. Ngemuva kwezinsuku eziyi-1 noma ezi-2, ukuphazamiseka kwesisu kufanele kunciphe. Cela ochwepheshe bakho bezempilo izindlela zokunciphisa le miphumela. Inani leli yona imithi lizohluka kubantu abahlukene. Landela imiyalo yodokotela wakho noma imiyalo esemibhalweni. Ulwazi olulandelayo luhlanganisa kuphela amanani ajwayelekile aleli yona imithi. Uma inani lakho lihlukile, ungalishintshi ngaphandle kokuthi udokotela wakho akuyale ukuba wenze njalo. Inani lemithi oyithatha lixhomeke emandleni emithi. Futhi, inani lezinye zezidakamizwa ozithatha nsuku zonke, isikhathi esivunyelwe phakathi kwezidakamizwa, nobude besikhathi othatha imithi kuya ngenkinga yezokwelapha oyisebenzisela imithi.
Umshwana wokuzihlangula: I-August iyinkundla yolwazi lwezempilo futhi izimpendulo zayo azihlanganisi iseluleko sezokwelapha. Njalo thintana nochwepheshe bezokwelapha onelayisensi eduze nawe ngaphambi kokwenza noma yiluphi ushintsho.