Yini i-Daclatasvir: Ukusetshenziswa, Umthamo, Imiphumela Eceleni Nokuningi

I-Daclatasvir iyikhambi elilwa namagciwane elenzelwe ngqo ukwelapha i-hepatitis C, ukutheleleka ngegciwane okuthinta isibindi sakho. Lo muthi oqoshwe ngudokotela ungowodidi lwemithi ebizwa ngokuthi ama-antivirals aqondile, asebenza ngokuvimba igciwane ukuthi lingaphindaphindi emzimbeni wakho. Ngenkathi i-daclatasvir yayivame ukusetshenziswa ngokuhlanganyela neminye imithi ye-hepatitis C, izinketho zokwelapha ezintsha sezimshiye ngemuva kakhulu ezinhlelweni eziningi zokwelapha namuhla.

Yini i-Daclatasvir?

I-Daclatasvir iyikhambi eliqondiswe ngqo elilwa namagciwane elilwa negciwane le-hepatitis C (HCV) ngokugxambukela kuphrothini ethile edingwa yigciwane ukuze liphindaphindwe. Cabanga ngayo njengokhiye ovimba omunye wemisebenzi ebalulekile yegciwane, okuvimbela ukuthi lingazikopishi emangqamuzaneni esibindi sakho.

Lo muthi wathuthukiswa njengengxenye yoshintsho ekwelashweni kwe-hepatitis C olusuke ezindleleni zokwelapha ezindala, ezinzima. I-Daclatasvir iqondise ngqo iphrothini ye-NS5A, ebalulekile ekwazi kwegciwane lokuziphindaphinda nokuhlanganisa izinhlayiya ezintsha zegciwane.

Lo muthi uhlala usetshenziswa ngokuhlanganyela neminye imithi ye-hepatitis C ngoba ukusebenzisa imithi eminingi ngasikhathi sinye kuphumelela kakhulu kunokusebenzisa umuthi owodwa kuphela. Le ndlela yokuhlanganisa isiza ekuqinisekiseni ukuthi igciwane alithuthukisi ukumelana nokwelashwa.

Yini i-Daclatasvir Esetshenziselwa Yona?

I-Daclatasvir isetshenziselwa ukwelapha ukutheleleka okuqhubekayo ngegciwane le-hepatitis C kubantu abadala. Udokotela wakho angakubhala uma unezinhlobo ezithile ze-hepatitis C, ikakhulukazi uhlobo 3, yize lungasebenza kahle nakwezinye izinhlobo.

Lo muthi uvame ukunconywa kubantu abangakaze belashwe i-hepatitis C ngaphambili, kanye nalabo abazame ezinye izindlela zokwelapha ezingasebenzanga. Isetshenziselwa futhi iziguli ezinomdlavuza wesibindi (ukushwabana) obangelwa yi-hepatitis C, yize lokhu kudinga ukuqapha ngokucophelela.

Kwezinye izimo, odokotela banikeza i-daclatasvir ezigulini ezinombili i-hepatitis C kanye nezifo ze-HIV. Indlela yokwelapha ehlanganisiwe isiza ukuphatha zombili izimo ngasikhathi sinye ngenkathi kunciphisa ubungozi bokuxhumana kwemithi.

Isebenza Kanjani I-Daclatasvir?

I-Daclatasvir isebenza ngokugxila nokuvimba iphrotheni ye-NS5A, okudingwa yi-hepatitis C virus ukuze iphindaphindeke futhi isabalale esibindini sakho. Lapho le phrotheni ivalekile, igciwane alikwazi ukuqeda umjikelezo walo wokuphila futhi ekugcineni liyashona.

Lo muthi ubhekwa njengomuthi onamandla ngokulinganisela uwedwa, yingakho uhlala uhlanganiswa neminye imithi elwa namagciwane. Le nhlanganisela idala ukwelashwa okunamandla okuhlasela igciwane lisuka ezindaweni eziningi, okwenza kungabi nokwenzeka ukuthi igciwane lisinde noma likwazi ukumelana.

Umuthi usebenza ngokushesha, neziguli eziningi zibona ukwehla okukhulu emthwalweni wazo wegciwane emasontweni ambalwa okuqala okwelashwa. Kodwa-ke, ukuqeda inkambo ephelele yokwelashwa kubalulekile ukuqinisekisa ukuthi igciwane liqedwe ngokuphelele ohlelweni lwakho.

Kufanele Ngiyithathe Kanjani I-Daclatasvir?

Thatha i-daclatasvir ngendlela eqondile udokotela wakho ayalela ngayo, ngokuvamile kanye ngosuku ngaphandle kokudla. Umthamo ojwayelekile uvamise ukuba ngu-60mg ngosuku, nakuba udokotela wakho engase alungise lokhu ngokuya ngeminye imithi oyithathayo noma isimo sakho sezempilo esithile.

Ungathatha lo muthi ngamanzi, ubisi, noma ijusi, futhi akunandaba ukuthi uyithatha nokudla noma esiswini esingenalutho. Kodwa-ke, zama ukuyithatha ngesikhathi esifanayo nsuku zonke ukuze ugcine amazinga aqhubekayo egazini lakho.

Uma uthatha eminye imithi ethile, ikakhulukazi eminye imithi ye-HIV, udokotela wakho angase anciphise umthamo wakho we-daclatasvir ube ngu-30mg ngosuku. Ungalokothi ulungise umthamo wakho wedwa, ngoba lokhu kungase kuthinte ukuthi ukwelashwa kusebenza kahle kangakanani.

Gwinya ithebhulethi yonke ngaphandle kokuyichoboza, ukuyihlafuna, noma ukuyiqhekeza. Uma unzima ukugwinya amaphilisi, khuluma nodokotela wakho ngezinketho ezingenye noma amasu angase akusize.

Kufanele Ngiyithathe Isikhathi Eside Kangakanani I-Daclatasvir?

Abantu abaningi bathatha i-daclatasvir amasonto angu-12 (cishe izinyanga ezi-3) njengengxenye yohlelo lwabo lokwelapha i-hepatitis C. Kodwa-ke, ubude bokwelashwa kwakho bungahluka kuye ngesimo sakho esithile, okuhlanganisa ukuthi yiluphi uhlobo lwe-hepatitis C onalo nokuthi ngabe unayo yini i-cirrhosis.

Ezinye iziguli zingase zidinge amasonto angu-24 okwelashwa, ikakhulukazi uma zinesifo sesibindi esithuthuke kakhulu noma zizame ezinye izindlela zokwelapha i-hepatitis C ngaphambili. Udokotela wakho uzoqoka ubude bokwelashwa obufanele ngokuya ngomlando wakho wezokwelapha kanye nokuphendula ekwelashweni.

Kubalulekile ukuqeda lonke uhlelo lokwelashwa, ngisho noma uqala ukuzizwa ungcono noma izivivinyo zakho zaselabhu zikhombisa ukuthi igciwane alitholakali. Ukuyeka ukwelashwa ngaphambi kwesikhathi kwandisa kakhulu ingozi yokuthi igciwane lizobuya futhi lingase lenze ukwelashwa okuzayo kungasebenzi kahle.

Yiziphi Imiphumela Eceleni ye-Daclatasvir?

Abantu abaningi bayayibekezelela kahle i-daclatasvir, kodwa njengayo yonke imithi, ingabangela imiphumela emibi. Izindaba ezinhle ukuthi imiphumela emibi engathi sína ayivamile, futhi abantu abaningi bangaqeda ukwelashwa kwabo ngaphandle kwezinkinga ezinkulu.

Nawa imiphumela emibi ejwayelekile ongase uyithole ngenkathi uthatha i-daclatasvir:

• Ikhanda nokukhathala
• Isicanucanu nokuhlanza ngezikhathi ezithile
• Ukuqunjelwa noma ukuqunjelwa
• Isiyezi noma ukuzwa sengathi uyakhanya
• Ubunzima bokulala
• Ukuqubuka kwesikhumba okuncane noma ukuluma

Le miphumela emibi ejwayelekile ivame ukuthuthuka njengoba umzimba wakho ujwayela umuthi futhi akuvamile ukuthi idinge ukuyeka ukwelashwa.

Imiphumela emibi engathi sína ayivamile kodwa idinga ukunakekelwa ngokushesha kwezokwelapha. Lokhu kufaka phakathi:

• Ukusabela okukhulu komzimba okunzima ngokuphefumula noma ukuvuvukala
• Ushintsho olungajwayelekile ekushayeni kwenhliziyo
• Izimpawu zezinkinga zesibindi njengokuba mthubi kwesikhumba noma umchamo omnyama
• Ukucindezeleka okukhulu noma imicabango yokuzilimaza
• Isicanucanu esiqhubekayo esiqinile esivimbela ukudla

Uma uhlangabezana nanoma yiziphi zalezi zimpawu ezinzima, xhumana nomhlinzeki wakho wezempilo ngokushesha noma funa ukunakekelwa kwezimo eziphuthumayo.

Ubani Ongafanele Athathe I-Daclatasvir?

I-Daclatasvir ayifanele wonke umuntu, futhi udokotela wakho uzobuyekeza ngokucophelela umlando wakho wezokwelapha ngaphambi kokuyinika. Akufanele uthathe lo muthi uma unokungezwani komzimba ne-daclatasvir noma yiziphi izithako zawo.

Ezinye izimo zezokwelapha zidinga ukucatshangelwa okukhethekile noma zingakuvimbela ukuthi ungathathi i-daclatasvir ngokuphepha. Lokhu kufaka phakathi:

• Isifo sesibindi esibi ngaphandle kwe-hepatitis C
• Izifo ezithile zokushaya kwenhliziyo
• Isifo sezinso esibi esidinga i-dialysis
• Ukusetshenziswa kabi kwezinto ezingase zithinte ukwelashwa
• Ukukhulelwa noma ukuhlela ukukhulelwa

Abantu abathatha imithi ethile kungenzeka futhi badinge ukugwema i-daclatasvir noma ukuthi imithamo yabo ilungiswe ngokucophelela ukuvimbela ukusebenzisana okuyingozi.

Uma ukhulelwe noma uncelisa, xoxa ngezingozi nezinzuzo nodokotela wakho. Ngenkathi i-daclatasvir ngokwayo ingase ingalimazi ingane esakhula, ivame ukuhlanganiswa neminye imithi engaba yinkinga ngesikhathi sokukhulelwa.

Amagama Omkhiqizo we-Daclatasvir

I-Daclatasvir itholakala ngaphansi kwegama lomkhiqizo elithi Daklinza emazweni amaningi, okuhlanganisa ne-United States. Leli yigama lomkhiqizo elaziwa kakhulu ngalo muthi emhlabeni wonke.

Kwezinye izifunda, ungase uthole i-daclatasvir ithengiswa ngaphansi kwamagama omkhiqizo ahlukene noma njengengxenye yamaphilisi ahlanganisiwe afaka eminye imithi ye-hepatitis C. Njalo hlola nomunye wemithi yakho ukuze uqinisekise ukuthi uthola umuthi ofanele namandla.

Izinhlobo ezijwayelekile ze-daclatasvir zingase zitholakale kwamanye amazwe, okungasiza ukunciphisa izindleko zokwelashwa. Kodwa-ke, njalo sebenzisa uhlobo oluqondile noma uhlobo olujwayelekile olubhalwe ngudokotela wakho, njengoba abakhiqizi abahlukene bengase babe namafomula ahlukile kancane.

Ezinye izindlela zokwelapha i-Daclatasvir

Ukwelashwa okusha kwe-hepatitis C sekutholakala okungase kube lula noma kuphumelele kunezinqubo ezisekelwe ku-daclatasvir. Lezi ezinye izindlela zokwelapha zihlanganisa amaphilisi ahlanganisiwe aqukethe imithi eminingi kuthebhulethi eyodwa, okwenza ukwelashwa kube lula.

Ezinye izindlela ezivamile udokotela wakho angazicabangela zihlanganisa:

• Sofosbuvir/velpatasvir (Epclusa)
• Glecaprevir/pibrentasvir (Mavyret)
• Sofosbuvir/ledipasvir (Harvoni)
• Elbasvir/grazoprevir (Zepatier)

Lokhu kwelashwa okusha kuvame ukuba nemiphumela emibi embalwa, izikhathi zokwelashwa ezimfushane, noma amazinga okusebenza kahle angcono kunezinhlanganisela ezindala ezisekelwe ku-daclatasvir.

Udokotela wakho uzokhetha inketho engcono kakhulu yokwelashwa ngokusekelwe ohlotsheni lwakho oluqondile lwe-hepatitis C, umlando wakho wezokwelapha, eminye imithi oyithathayo, kanye nezimo zakho ngazinye. Izindleko nokukhokhelwa komshuwalense kungase futhi kuthonye ukukhethwa kokwelashwa.

Ingabe i-Daclatasvir ingcono kune-Sofosbuvir?

I-Daclatasvir ne-sofosbuvir zisebenza ngendlela ehlukile futhi ngokuvamile zisetshenziswa ndawonye kunokuba ziqhathaniswe njengezinketho eziqhudelanayo. I-Sofosbuvir ivimba ingxenye ehlukile yomjikelezo wempilo we-hepatitis C virus, okwenza le mithi emibili ibe yisithasiselo kunokuba iqhudelane.

Uma isetshenziswa ndawonye, i-daclatasvir ne-sofosbuvir zakha inhlanganisela enamandla esebenza kahle kakhulu ngokumelene ne-hepatitis C. Le nhlanganisela inamazinga okuphulukisa angama-90% noma ngaphezulu ezigulini eziningi, okuyinto enhle kakhulu ekwelashweni kwe-hepatitis C.

Noma kunjalo, ukwelashwa okusha okuhlanganisiwe okuhlanganisa imithi eminingi emaphilisi amanye sekuthandwa kakhulu ngoba kulula futhi ngezinye izikhathi kuphumelela kakhulu. Lezi zinketho ezintsha zingase zibe yizinqumo ezingcono ezigulini eziningi kunezinhlanganisela ze-daclatasvir-sofosbuvir.

Udokotela wakho uzokusiza ukuthi uqonde ukuthi iyiphi inketho yokwelashwa engcono kakhulu esimweni sakho esithile, ecabangela izinto ezinjengohlobo lwakho lwe-hepatitis C, umlando wezokwelapha, nezintandokazi zokwelashwa.

Imibuzo Evame Ukubuzwa Mayelana ne-Daclatasvir

Q1. Ingabe i-Daclatasvir iphephile kubantu abanezifo zezinso?

I-Daclatasvir ngokuvamile ingasetshenziswa ngokuphepha kubantu abanezifo zezinso eziphansi kuya kweziphakathi, njengoba izinso zingayikhiphi kakhulu le mithi emzimbeni wakho. Kodwa-ke, abantu abanezifo zezinso ezinzima noma labo abasebenzisa i-dialysis badinga ukuqashwa ngokucophelela futhi mhlawumbe ezinye izinketho zokwelashwa.

Udokotela wakho uzohlola ukusebenza kwezinso zakho ngaphambi kokuqala ukwelashwa futhi angase akubheke ngesikhathi sokwelashwa. Uma unezinkinga zezinso, qiniseka ukuthi wazisa umhlinzeki wakho wezempilo ukuze akwazi ukulungisa uhlelo lwakho lokwelashwa ngokufanele.

Q2. Kufanele ngenzeni uma ngiphuzile i-Daclatasvir eningi ngengozi?

Uma ngengozi uphuze i-daclatasvir eningi kunaleyo ebekiwe, xhumana nodokotela wakho noma isikhungo sokulawula ubuthi ngokushesha. Ngenkathi ukweqisa okukhulu kungavamile, ukuphuza okuningi kungakhuphula ingozi yakho yemiphumela emibi noma izinkinga zesigqi senhliziyo.

Ungazami ukulungisa ukweqisa ngokweqa umthamo wakho olandelayo. Kunalokho, landela imiyalelo kadokotela wakho mayelana nokuthi ungaluqala nini kabusha uhlelo lwakho lokulinganisa olujwayelekile. Gcina umkhondo wokuthi uyiphuze nini umthamo owengeziwe ukuze usize umhlinzeki wakho wezempilo ukuthi ahlulele noma yiziphi izingozi.

Q3. Kufanele ngenzeni uma ngiphuthelwa umthamo we-Daclatasvir?

Uma uphuthelwa umthamo we-daclatasvir, yiphuze ngokushesha lapho ukhumbula, ngaphandle kwalapho sekuseduze isikhathi somthamo wakho olandelayo obekiwe. Kuleso simo, weqa umthamo ophuthelwe bese uqhubeka nohlelo lwakho olujwayelekile.

Ungalokothi uthathe imithamo emibili ngesikhathi esisodwa ukuze ulungise umthamo owuphuthelwe, ngoba lokhu kungakhuphula ingozi yakho yemiphumela emibi. Uma uphuthelwa imithamo njalo, cabangela ukusetha izikhumbuzi zocingo noma ukusebenzisa umhleli wamaphilisi ukukusiza ukuthi uhlale emgqeni.

Q4. Ngingayeka nini ukuthatha i-Daclatasvir?

Yeka kuphela ukuthatha i-daclatasvir uma udokotela wakho ekutshela ukuthi wenze njalo, ngokuvamile ngemva kokuqeda inkambo yakho ephelele yokwelashwa. Abantu abaningi bayayithatha amasonto angu-12 kuya kwangu-24, kuye ngesimo sabo esithile.

Udokotela wakho uzoqapha intuthuko yakho ngezivivinyo zegazi futhi akwazise uma kuphephile ukuyeka ukwelashwa. Ukuyeka ngaphambi kwesikhathi, ngisho noma uzizwa ungcono, kungavumela igciwane le-hepatitis C ukuthi libuye futhi kungenza ukwelashwa okuzayo kungasebenzi kahle.

Q5. Ngingakwazi yini ukuphuza utshwala ngenkathi ngithatha i-Daclatasvir?

Kungcono ukugwema utshwala ngokuphelele ngenkathi uthatha i-daclatasvir ukuze uthole ukwelashwa kwe-hepatitis C. Utshwala bungalimaza isibindi sakho, esivele sicindezelekile ngenxa yokutheleleka nge-hepatitis C, futhi kungaphazamisa ikhono lomzimba wakho lokuphola.

Ngaphezu kwalokho, utshwala bungenza eminye imiphumela emibi ye-daclatasvir ibe yimbi, njengokucasuka kwesisu nokukhathala. Isibindi sakho sidinga ukugxila ekupholiseni ekuthelelekeni nge-hepatitis C, ngakho ukusinika ikhefu ekucubunguleni utshwala kuzosiza ukusekela ukululama kwakho.