Yini i-Dalbavancin: Ukusetshenziswa, Umthamo, Imiphumela Eceleni nokuningi

I-Dalbavancin iyisibulala-magciwane esinamandla odokotela abasinika ngomjovo ukuze belaphe izifo zesikhumba ezinzima ezibangelwa amagciwane. Lo muthi ungoweqembu elibizwa ngokuthi ama-antibiotics e-lipoglycopeptide, asebenza ngokuvimbela amagciwane ayingozi ekwakheni izindonga zawo zokuzivikela zamaseli.

Okuhlukanisa i-dalbavancin ukuthi ihlala emzimbeni wakho isikhathi eside kakhulu. Lokhu kusho ukuthi ngokuvamile udinga umthamo owodwa noma emibili kuphela esikhundleni sokuthatha ama-antibiotics nsuku zonke amasonto amaningi. Yenzelwe ngqo abantu abadala abanezifo zesikhumba nezicubu ezithambile eziyinkimbinkimbi ezingaphendulanga kahle kwezinye izindlela zokwelapha.

Isetshenziselwani i-Dalbavancin?

I-Dalbavancin ilapha izifo zesikhumba nezakhiwo zesikhumba ezibangelwa amagciwane (ABSSSI) kubantu abadala. Lezi yizifo ezinzima ezingena ngaphansi nje kobuso besikhumba sakho futhi ngokuvamile zihilela izendlalelo ezingaphansi, okuhlanganisa amafutha, imisipha, noma izicubu ezixhumene.

Udokotela wakho angase akubhalele i-dalbavancin uma unezifo ezinjenge-cellulitis, ama-abscesses amakhulu, noma izifo zamanxeba. Isebenza kahle ikakhulukazi emagciwaneni e-gram-positive, okuhlanganisa amanye alwa namanye ama-antibiotics. Lawa magciwane ahlanganisa i-Staphylococcus aureus (kuhlanganisa i-MRSA), izinhlobo ze-Streptococcus, ne-Enterococcus faecalis.

Lo muthi ugcinelwe izifo ezingathi sína ngoba iyi-antibiotic enamandla kakhulu. Umhlinzeki wakho wezempilo ngokuvamile uzokhetha i-dalbavancin lapho amanye ama-antibiotics engasebenzanga noma lapho ukutheleleka kungathi sína ngokwanele ukudinga ukulaliswa esibhedlela.

Isebenza Kanjani i-Dalbavancin?

I-Dalbavancin iyi-antibiotic enamandla kakhulu esebenza ngokuhlasela izindonga zamaseli amagciwane. Cabanga ngezindonga zamaseli amagciwane njengogobolondo elivikelayo elizungeze iqanda - ngaphandle kwalo, amagciwane awazi ukuthi angasinda kanjani.

Umuthi uqondiswe ngqo ku-enzyme ebizwa ngokuthi i-transglycosylase, okuyinto amagciwane ayidingayo ukuze akhe futhi alondoloze izindonga zawo zamaseli. Uma i-dalbavancin ivimba le enzyme, amagciwane aqala ukuwohloka futhi afe. Lokhu kwenza kube yilokho odokotela abakubiza ngokuthi i-antibiotic "bactericidal", okusho ukuthi ibulala amagciwane kunokumane iwamise ukuthi angakhuli.

Okumangalisayo nge-dalbavancin ukuthi inesikhathi eside sokuphila, okusho ukuthi ihlala isebenza emzimbeni wakho cishe izinsuku eziyi-8-9 ngemva komthamo owodwa. Lokhu kuba khona isikhathi eside kuyenza iqhubeke nokulwa nokutheleleka ngisho nangemva kokuthi uthole ukumnika kwe-IV.

Kufanele Ngiyithathe Kanjani I-Dalbavancin?

I-Dalbavancin inikezwa kuphela ngokumnika nge-IV esibhedlela noma emtholampilo. Awukwazi ukuthatha lo muthi ngomlomo ekhaya. Uchwepheshe wezempilo uzohlala ewunika ukuze aqinisekise ukuthi umthamo ulungile futhi akuqaphele nganoma yiziphi izindlela ozosabela ngazo.

Ukumnika ngokuvamile kuthatha imizuzu engaba ngu-30 ukuze kuqedwe. Umhlengikazi wakho uzokunika kancane nge-vein engalweni yakho. Ngaphambi kokumnika, awudingi ukuzila ukudla noma ukugwema ukudla okuthile, nakuba kuhlale kuhle ukuhlala unamanzi kahle.

Abantu abaningi bathola umthamo owodwa ongu-1500 mg noma imithamo emibili enikezwa ngesonto elilodwa (1000 mg ekuqaleni, bese kuba ngu-500 mg ngemva kwezinsuku eziyisikhombisa). Udokotela wakho uzonquma ukuthi yiluphi uhlelo olusebenza kangcono ekuthelelekeni kwakho okuthile kanye nesimo sempilo yakho esiphelele.

Kufanele Ngiyithathe Isikhathi Esingakanani I-Dalbavancin?

Ubuhle be-dalbavancin ukuthi ngokuvamile udinga kuphela umthamo owodwa noma emibili. Ngokungafani nama-antibiotics endabuko adinga amaphilisi nsuku zonke izinsuku eziyi-7-14, umphumela ohlala isikhathi eside we-dalbavancin usho ukuthi ukwelashwa kuvame ukuqeda ngemva kokuvakashelwa okukodwa noma okubili esibhedlela.

Uma uthola umuthi owodwa, uzothola i-1500 mg kanye futhi yilokho kuphela. Ngesimiso semithamo emibili, uzothola umthamo wesibili ngqo ezinsukwini eziyisikhombisa ngemuva kowokuqala. Udokotela wakho uzochaza indlela ngokusekelwe ezintweni ezinjengobunzima bokutheleleka kwakho nokuthi usabela kanjani emuthini.

Noma ungathathi imithi yansuku zonke, i-antibiotic iyaqhubeka nokusebenza emzimbeni wakho amasonto ngemuva kokufakwa. Lokhu kusebenza okwandisiwe yikho okwenza inkambo yokwelashwa emfushane isebenze kahle ekuthelelekeni kwesikhumba okungathi sína.

Yiziphi Imiphumela Eceleni ye-Dalbavancin?

Njengayo yonke imithi, i-dalbavancin ingabangela imiphumela emibi, nakuba abantu abaningi beyibekezelela kahle. Imiphumela emibi evame kakhulu ngokuvamile imnene futhi yesikhashana.

Nansi imiphumela emibi ongase uyithole, iqala ngaleyo evame kakhulu:

• Isicanucanu nokuhlanza
• Ukuqunjelwa
• Ukukhathazeka
• Isiyezi
• Ukuqubuka noma ukuluma
• Ubuhlungu, ububomvu, noma ukuvuvukala endaweni ye-IV

Lezi zimpawu zivame ukuthuthuka phakathi nosuku olulodwa noma ezimbili futhi akuvamile ukuthi zidinge ukuyeka umuthi. Kodwa-ke, kufanele ngaso sonke isikhathi wazise ithimba lakho lezempilo uma uhlangabezana nanoma yikuphi ukungakhululeki.

Imiphumela emibi engathi sína ayivamile kodwa ingabandakanya ukusabela okukhulu komzimba, ukushaya kwenhliziyo okungajwayelekile, noma isimo esiyingozi esibizwa ngokuthi i-C. diff colitis (ukuqubuka kwamathumbu okukhulu). Uma uhlangabezana nobunzima bokuphefumula, ubuhlungu obukhulu besisu, noma ukuqunjelwa okuqhubekayo, funa usizo lwezokwelapha ngokushesha.

Ubani Ongafanele Athole i-Dalbavancin?

I-Dalbavancin ayifanele wonke umuntu, futhi udokotela wakho uzobuyekeza ngokucophelela umlando wakho wezokwelapha ngaphambi kokuyinika. Akufanele uthole lo muthi uma uke waba nokusabela komzimba ku-dalbavancin noma ama-antibiotics afanayo esikhathini esidlule.

Abantu abanezimo zenhliziyo ezithile badinga ukuqapha okwengeziwe ngoba i-dalbavancin ingathinta ukushaya kwenhliziyo. Udokotela wakho cishe uzohlola i-EKG ngaphambi kokwelashwa uma unomlando wezinkinga zenhliziyo noma usebenzisa imithi ethinta izinga lokushaya kwenhliziyo yakho.

Lo muthi awuvunyelwe ezinganeni ezingaphansi kweminyaka engu-18 ubudala, njengoba ukuphepha nokusebenza kungakahlolwa ezigulini ze-pediatric. Ngaphezu kwalokho, uma ukhulelwe noma uncelisa, udokotela wakho uzohlola izinzuzo ngokumelene nezingozi ezingaba khona ngaphambi kokuncoma i-dalbavancin.

Igama Lomkhiqizo le-Dalbavancin

I-Dalbavancin ithengiswa ngaphansi kwegama lomkhiqizo elithi Dalvance e-United States. Leli yigama elivamile ozolibona emarekhodini esibhedlela nakumalabhuli emithi.

Lo muthi ukhiqizwa yi-Allergan (manje eyingxenye ye-AbbVie) futhi utholakala kusukela ngo-2014. Uma ukhuluma ngokwelashwa kwakho nabahlinzeki bezempilo, bangase babhekisele kuyo nganoma yiliphi igama - i-dalbavancin noma i-Dalvance.

Ezinye Izindlela Zokwelapha ze-Dalbavancin

Ezinye izibulala-magciwane eziningi zingelapha izifo zesikhumba ezinzima, nakuba ngasinye sinokuhle okuhlukile nezinhlelo zokulinganisa. Udokotela wakho angase acabangele ezinye izindlela ezisekelwe kumagciwane akho athile, umlando wezokwelapha, nezintandokazi zokwelashwa.

Ezinye izindlela ezivamile zihlanganisa i-vancomycin, edinga ukufakwa kwe-IV nsuku zonke izinsuku ezingu-7-10, noma i-linezolid, eza ngesimo se-IV nesomlomo. I-Telavancin ingenye inketho esebenza isikhathi eside, nakuba idinga ukufakwa nsuku zonke izinsuku ezingu-7-10 kunokuba i-dalbavancin inezilinganiso ezilodwa noma ezimbili.

Izinketho ezintsha zihlanganisa i-oritavancin, nayo eyindlela yokwelapha ngomthamo owodwa, kanye ne-tedizolid, engathathwa izinsuku ezi-6 nge-IV noma ngomlomo. Umhlinzeki wakho wezempilo uzokhetha inketho engcono kakhulu ngokusekelwe ezimweni zesifo sakho kanye nesimo sakho sempilo esiphelele.

Ingabe i-Dalbavancin Ingcono Kune-Vancomycin?

I-Dalbavancin ne-vancomycin yomibili imithi elwa namagciwane emihle kakhulu yezifo zesikhumba ezinzima, kodwa isebenza ngezindlela ezehlukene futhi inezinzuzo ezihlukile. Inzuzo enkulu ye-dalbavancin ukulula - udinga umthamo owodwa noma emibili kuphela esikhundleni sokwelashwa kwansuku zonke kwe-IV isonto lonke.

I-Vancomycin ibilokhu iyizinga legolide amashumi eminyaka futhi inocwaningo oluningi olusekela ukusebenza kwayo. Kodwa-ke, idinga ukuqapha kwansuku zonke kwamazinga egazi futhi ingabangela izinkinga zezinso uma isetshenziswa isikhathi eside. I-Dalbavancin ayidingi lokhu kuqapha okukhulu.

Ngokuqondene nokusebenza, izifundo zibonisa ukuthi yomibili imithi isebenza kahle ngokulinganayo ekwelapheni izifo zesikhumba eziyinkimbinkimbi. Udokotela wakho uzokhetha ngokusekelwe ezintweni ezinjengokusebenza kwezinso zakho, amagciwane athile abangela ukutheleleka kwakho, nokuthi ngabe ukhetha ukuvakashela esibhedlela okuncane.

Imibuzo Evame Ukubuzwa Mayelana ne-Dalbavancin

Ingabe i-Dalbavancin iphephile ezigulini ezinokugula kwezinso?

I-Dalbavancin ingasetshenziswa kubantu abanezifo zezinso, kodwa udokotela wakho uzolungisa umthamo ngokusekelwe ekutheni izinso zakho zisebenza kahle kangakanani. Uma unezinkinga ezinzima zezinso, ungase uthole umthamo omncane noma ube nokuqapha okwengeziwe ngesikhathi sokwelashwa.

Umuthi ngokuyinhloko ukhishwa ngezinso zakho, ngakho ukuncipha komsebenzi wezinso kusho ukuthi umuthi uhlala emzimbeni wakho isikhathi eside. Lokhu akudingeki ukuthi kube yingozi, kodwa kudinga ukugadwa kwezokwelapha ngokucophelela ukuze kuqinisekiswe ukuthi uthola inani elifanele.

Ngingenzani uma ngiba nokusabela komzimba ku-Dalbavancin?

Uma uhlangabezana nezimpawu zokusabela komzimba ngesikhathi noma ngemva kokufakwa komuthi, yazisa ithimba lakho lezempilo ngokushesha. Izimpawu zingabandakanya ubunzima bokuphefumula, ukuvuvukala kobuso bakho noma umphimbo, ukuqubuka okukhulu, noma ukuzwa ukuthi uyakhathala.

Njengoba i-dalbavancin inikezwa endaweni yezokwelapha, abasebenzi abaqeqeshiwe bangaphendula ngokushesha ekuphenduleni komzimba. Banemithi nemishini elungele ukwelapha ukusabela okukhulu. Ukusabela okuningi komzimba ku-dalbavancin kulula, kodwa ngaso sonke isikhathi kungcono ukuqapha futhi ukhulume uma kukhona okungahambi kahle.

Kufanele Ngenzeni Uma Ngingaphuthelwa Umthamo We-Dalbavancin?

Uma uhlelelwe ukuthola umthamo omibili futhi uphuthelwa ukuqokwa kwakho kwesibili, xhumana nomhlinzeki wakho wezempilo ngokushesha okukhulu. Umthamo wesibili kufanele unikezwe ngqo ezinsukwini eziyisikhombisa ngemuva kowokuqala, kodwa ngokuvamile kukhona ukuguquguquka kwesikhathi.

Udokotela wakho angase akuqokelele ukuqokwa okulandelayo okutholakalayo noma alungise uhlelo lwakho lokwelapha ngokusekelwe endleleni ozabela ngayo emthomeni wokuqala. Ungazami ukubala noma ukuhlela kabusha ngokwakho - ngaso sonke isikhathi xhumana nethimba lakho lezempilo.

Ngingayeka Nini Ukuthatha I-Dalbavancin?

Ngokungafani nama-antibiotics endabuko, awuyeki ukuthatha i-dalbavancin ngoba ngokuvamile ukwelashwa komthamo owodwa noma emibili. Uma usutholile umthamo wakho obekiwe, ukwelashwa kuqediwe.

Umuthi uqhubeka usebenza emzimbeni wakho amasonto amaningana ngemuva kokufakwa, ngakho akudingeki wenze okunye. Udokotela wakho uzoqapha ukuqhubeka kokutheleleka kwakho ngokuqokwa okulandelayo futhi angase ayale ukuhlolwa okwengeziwe ukuqinisekisa ukuthi ukwelashwa kusebenza ngempumelelo.

Ngingakwazi Yini Ukuphuza Utshwala Ngenkathi Ngelashwa Nge-Dalbavancin?

Akukho ukusebenzisana okuthile phakathi kwe-dalbavancin notshwala, kodwa ngokuvamile kuhle ukugwema ukuphuza ngenkathi ulwa nokutheleleka okukhulu. Utshwala bungaphazamisa amasosha akho omzimba futhi bunganciphisa inqubo yakho yokululama.

Ngaphezu kwalokho, uma uhlangabezana nemiphumela emibi efana nesicanucanu noma isiyezi emuthini, utshwala bungenza lezi zimpawu zibe zimbi kakhulu. Kungcono ukugxila ekuphumuleni, ekudleni okunempilo, nokuhlala unamanzi ngenkathi umzimba wakho ulwa nokutheleleka.