Yini i-Dalfampridine: Ukusetshenziswa, Umthamo, Imiphumela Eceleni nokuningi

I-Dalfampridine iyikhambi elenzelwe ngqo ukusiza abantu abanezifo ze-multiple sclerosis (MS) ukuthi bahambe kangcono futhi bahambe kalula. Yilona kuphela kanye nokwelashwa okuvunyelwe yi-FDA okungathuthukisa ikhono lokuhamba kubantu abaphila ne-MS, okuhlinzeka ngethemba kulabo abahlushwa izinselelo zokuhamba.

Lo muthi usebenza ngokuqinisa amasignali kagesi emithanjeni yezinzwa elimele, usiza ubuchopho bakho ukuthi buxhumane ngempumelelo nemisipha yakho. Cabanga ngakho njengokusiza ukubuyisela ezinye zezindlela zokuxhumana i-MS eziphazamise ngazo ohlelweni lwakho lwezinzwa.

Yini i-Dalfampridine?

I-Dalfampridine iyikhambi lomlomo elingelika-class lemithi ebizwa ngokuthi ama-potassium channel blockers. Yenzelwe ngqo abantu abane-multiple sclerosis abanezinkinga zokuhamba ngenxa yesimo sabo.

Umuthi uza njengamaphilisi akhishwe isikhathi eside owathatha kabili ngosuku. Kubalulekile ukuqonda ukuthi i-dalfampridine ayikwelaphi i-MS noma imise ukuthuthuka kwalesi sifo. Kunalokho, igxila ekuthuthukiseni isinye isimpawu esithinta abantu abaningi abane-MS - ubunzima bokuhamba.

Ungase futhi uzwe lo muthi ubizwa ngegama lawo lomkhiqizo, i-Ampyra. Womabili la magama abhekisela emuthini ofanayo, ngakho-ke ungakhathazeki uma ubona noma yikuphi okukodwa emiyalelweni yakho noma ezingxoxweni zezokwelapha.

Yini i-Dalfampridine Esetshenziselwa Yona?

I-Dalfampridine ivunyelwe ngokuqondile ukuthuthukisa ikhono lokuhamba kubantu abadala abane-multiple sclerosis. Uma une-MS futhi uthola ukuthi ukuhamba sekunzima kakhulu, kuhamba kancane, noma kudinga umzamo omkhulu kunakuqala, lo muthi ungase usize.

Umuthi ungasiza abantu banoma yiluphi uhlobo lwe-MS - kungakhathaliseki ukuthi une-relapsing-remitting, secondary progressive, noma primary progressive forms of the condition. Okubaluleke kakhulu ukuthi uhlangabezana nobunzima bokuhamba obuhlobene ne-MS yakho.

Kufanele kuqashelwe ukuthi akubona bonke abantu abane-MS abazozuza ku-dalfampridine. Ucwaningo lubonisa ukuthi cishe ama-35-40% abantu abayithathayo bathola ukuthuthuka okukhulu ekusheshiseni kwabo ukuhamba kanye nekhono. Udokotela wakho angakusiza ukuthi unqume ukuthi ungumuntu ofanelekayo yini kulolu hlobo lokwelashwa.

Isebenza Kanjani I-Dalfampridine?

I-Dalfampridine isebenza ngokuvimba iziteshi ze-potassium emithanjeni yakho yezinzwa, okusiza ukuqinisa amasignali kagesi ahamba ngemithambo yezinzwa ezilimele. Ku-MS, isembozo esivikelayo esizungeze imithambo yezinzwa (esibizwa nge-myelin) silimala, okwenza kube nzima ukuthi amasignali kagesi ahambe kahle.

Uma uthatha i-dalfampridine, isiza la masignali kagesi abuthakathaka ukuthi ahambe kahle kakhulu ebuchosheni bakho aya emsipheni wakho. Lokhu kuxhumana okuthuthukisiwe kungasho ukuthi ukuhamba kungathuthuka, ukusheshisa ukuhamba kwenyuke, futhi amandla emisipha emilenzeni yakho athuthuke.

Umuthi ubhekwa njengosebenza kahle ngokulinganisela kunokuba kube ukwelashwa okuqinile. Ngenkathi inganikeza izinzuzo ezibalulekile kulabo abayiphendulayo, ukuthuthuka kuvame ukuba kuncane kodwa kusabalulekile ngokwanele ukwenza umehluko wangempela ekuphileni kwansuku zonke.

Kufanele Ngiyithathe Kanjani I-Dalfampridine?

I-Dalfampridine kufanele ithathwe ngendlela eqondile njengoba inqatshelwe udokotela wakho, ngokuvamile kabili ngosuku cishe ngamahora ayi-12 ngaphandle. Umthamo ojwayelekile ungu-10 mg kabili ngosuku, futhi kubalulekile ukungadluli leli nani njengoba imithamo ephezulu ingandisa ingozi yokuhlaselwa yizithuthwane.

Ungayithatha i-dalfampridine ngaphandle noma ngaphandle kokudla, kodwa zama ukungaguquguquki ngendlela yakho. Uma ukhetha ukuyithatha nokudla, yenza njalo, futhi uma ukhetha ukuyithatha esiswini esingenalutho, namathela kulowo mkhuba.

Ngaso sonke isikhathi gwinya amaphilisi wonke - ungaligayi, ulihlafune, noma uliqhekeze. Ifomula yokukhishwa okweluliwe yenzelwe ukukhipha umuthi kancane usuku lonke, futhi ukuqhekeza ithebhulethi kungabangela ukuthi umuthi omningi ukhishwe ngesikhathi esisodwa.

Thatha imithamo yakho cishe ngesikhathi esifanayo nsuku zonke ukuze ugcine amazinga aqhubekayo omuthi emzimbeni wakho. Abantu abaningi bakuthola kuwusizo ukusetha izikhumbuzi noma bathathe imithamo yabo neminye imisebenzi yansuku zonke efana nesidlo sasekuseni nesidlo sakusihlwa.

Kufanele Ngiyithathe Isikhathi Esingakanani I-Dalfampridine?

Ubude bokwelashwa nge-dalfampridine buhlukahluka kumuntu nomuntu futhi buxhomeke ekutheni usabela kanjani kahle emuthini. Udokotela wakho ngokuvamile uzokwenza uzame umuthi cishe amasonto angu-2-4 ukuze abone ukuthi uqaphela noma yikuphi ukuthuthuka ekuhambeni kwakho.

Uma uhlangabezana nezinzuzo eziqondakalayo, ungaqhubeka nokuthatha i-dalfampridine uma nje isaqhubeka nokusiza futhi ungaqali ukuzwa imiphumela engathandeki. Abanye abantu bayayithatha izinyanga noma iminyaka njengengxenye yokuqhubeka kwabo ukuphatha i-MS.

Nokho, uma ungaqapheli noma yikuphi ukuthuthuka ekuhambeni kwakho ngemva kwamasonto amaningana okwelashwa, udokotela wakho cishe uzoncoma ukuyeka umuthi. Akukho nzuzo ekuqhubekeni ne-dalfampridine uma ingasizi izimpawu zakho.

Ukuqokwa okuvamile kokulandela udokotela wakho kubalulekile ukuqapha ukusabela kwakho emuthini futhi uhlole noma yimiphi imiphumela emibi. Udokotela wakho angase futhi ahlolisise ngezikhathi ezithile ukuthi ngabe umuthi usahlinzeka ngezinzuzo.

Yiziphi Imiphumela Emiqoka Ye-Dalfampridine?

Njengayo yonke imithi, i-dalfampridine ingabangela imiphumela emibi, nakuba kungewona wonke umuntu oyitholayo. Imiphumela emibi evame kakhulu ngokuvamile ithambile futhi iyalawuleka, kodwa kubalulekile ukwazi ukuthi yini okufanele uyibheke.

Imiphumela emibi ebikwa kaningi ihlanganisa izifo zomgudu womchamo, ukungalali, isiyezi, ikhanda, isicanucanu, ubuthakathaka, ubuhlungu emhlane, nezinkinga zokulinganisela. Lezi zimpawu zivame ukuba mncane futhi zingase zithuthuke njengoba umzimba wakho ujwayela umuthi.

Nawa imiphumela emibi evamile ongase uyithole:

• Izifo zamathumbu omchamo
• Ukuhluleka ukulala noma ukuqwasha
• Isiyezi noma ukuzizwa unovalo
• Ukukhathazeka
• Ukucasuka kwesisu noma isicanucanu
• Ukuzizwa ubuthakathaka noma ukhathele
• Ubuhlungu emhlane
• Izinkinga zokulinganisela

Abantu abaningi bathola ukuthi le miphumela emibi iyalawuleka, futhi ivame ukungabonakali ngokuhamba kwesikhathi njengoba umzimba wakho ujwayela imithi.

Kukhona neminye imiphumela emibi engavamile kodwa ebucayi edinga ukunakekelwa kwezokwelapha ngokushesha. Okukhathaza kakhulu yingozi yokuhlaselwa, yingakho kubaluleke kakhulu ukungadluli umthamo obekiwe.

Xhumana nodokotela wakho ngokushesha uma uhlangabezana nanoma iyiphi yale miphumela emibi ebucayi:

• Ukuhlaselwa noma ukugcwala
• Isiyezi esikhulu noma ukuquleka
• Ukuphefumula kanzima
• Ukuphendula okukhulu komzimba (ukuqubuka, ukuvuvukala, ubunzima bokuphefumula)
• Ukudideka okukhulu noma ukulahlekelwa yisikhundla

Le miphumela emibi ebucayi ayivamile uma imithi ithathwa njengoba inikeziwe, kodwa kubalulekile ukufuna usizo lwezokwelapha ngokushesha uma kwenzeka.

Ubani Ongafanele Athathwe i-Dalfampridine?

I-Dalfampridine ayiphephile kuwo wonke umuntu, futhi zikhona izimo nezimo lapho le mithi ingafanele isetshenziswe. Udokotela wakho uzobuyekeza ngokucophelela umlando wakho wezokwelapha ngaphambi kokukuyalela le mithi.

Akufanele uthathe i-dalfampridine uma unezinkinga eziphakathi nendawo kuya kwezinkulu zezinso, njengoba izinso zakho zidinga ukukwazi ukucubungula nokususa imithi ngendlela efanele. Abantu abanomlando wokuhlaselwa kufanele futhi bagweme le mithi ngenxa yengozi eyengeziwe yokuhlaselwa.

Nawa amanye amakhondishini amakhulu enza i-dalfampridine ingafaneleki:

• Isifo sezinso esiphakathi nendawo kuya kwesikhulu
• Umlando wokuhlaselwa noma isithuthwane
• Ukungezwani ne-dalfampridine noma yiziphi izithako zayo
• Izinkinga ezinkulu zesibindi
• Njengamanje uthatha eminye imithi equkethe i-dalfampridine

Udaktela wakho uzophinda aqaphele mayelana nokunikeza i-dalfampridine uma usumdala, njengoba abadala bangase babe sensitive kakhulu emiphumeleni yomuthi.

Izinto okufanele zicatshangelwe ngesikhathi sokukhulelwa nokuncelisa nazo zibalulekile. Nakuba kungekho ucwaningo olwanele lokusho ngokuqinisekile ukuthi i-dalfampridine iphephile yini ngesikhathi sokukhulelwa, udokotela wakho uzoqaphela izinzuzo ezingaba khona uma ziqhathaniswa nanoma yiziphi izingozi ezingenzeka uma ukhulelwe noma uhlela ukukhulelwa.

Amagama Omkhiqizo we-Dalfampridine

I-Dalfampridine ivame ukwaziwa ngegama lomkhiqizo wayo i-Ampyra e-United States. Leli yigama lomkhiqizo wokuqala lapho umuthi waqala ukuvunywa yi-FDA.

Kwamanye amazwe, ungase ubone i-dalfampridine ithengiswa ngaphansi kwamagama ahlukene omkhiqizo, kodwa isithako esisebenzayo sihlala sifana. Ezinye izinhlobo ze-generic ze-dalfampridine nazo zingase zitholakale, nakuba kufanele zihlangabezane nezindinganiso eziqinile ezifanayo njengohlobo lomkhiqizo.

Noma ngabe uthola i-Ampyra yegama lomkhiqizo noma inguqulo ye-generic ye-dalfampridine, umuthi kufanele usebenze ngendlela efanayo. Umkhemisi wakho angasiza ukucacisa ukuthi iyiphi inguqulo oyitholayo futhi aphendule noma yimiphi imibuzo mayelana nokuhlukahluka phakathi kwezinketho zomkhiqizo ne-generic.

Ezinye izindlela ze-Dalfampridine

Njengamanje, i-dalfampridine iyona kuphela umuthi ovunywe yi-FDA oklanyelwe ngqo ukuthuthukisa ikhono lokuhamba kubantu abane-MS. Lokhu kuyenza ihluke phakathi kokwelashwa kwe-MS, njengoba eminye imithi igxila ekuvikeleni ukuphindeka noma ukunciphisa ukuqhubeka kwesifo.

Nokho, zikhona ezinye izindlela ezingasiza ngezinkinga zokuhamba ku-MS. Ukwelashwa ngokomzimba kuvame ukunconywa kanye noma esikhundleni somuthi, njengoba kungasiza ukuthuthukisa amandla, ibhalansi, nokuxhumana ngemithambo eqondiwe.

Ithimba lakho lokunakekelwa kwezempilo lingase liphinde lincomise izinsiza zokuhamba njengezinduku zokuhamba, abahambi, noma ama-braces ukusiza ngezinselelo zokuhamba. Ukwelashwa komsebenzi kungahlinzeka ngamasu okulondoloza amandla nokuhamba kahle usuku lonke.

Abanye abantu bathola inzuzo ezindleleni zokwelapha ezingeziwe njengokwelashwa ngamanzi, i-yoga eyenzelwe abantu abane-MS, noma izinhlelo zokuzivivinya ezithile ezenzelwe izimo zemizwa. Lezi akuzona ezinye izindlela eziqondile ze-dalfampridine, kodwa zingaba izithasiselo eziwusizo ohlelweni lwakho lokwelapha.

Ingabe i-Dalfampridine Ingcono Kunezinye Izidakamizwa ze-MS?

I-Dalfampridine isebenza ngenjongo ehlukile kunezidakamizwa eziningi ze-MS, ngakho akuyona ngempela indaba yokuthi "ingcono" kodwa kunalokho ukubhekana nezici ezihlukene zesimo. Izidakamizwa eziningi ze-MS zigxila ekuvikeleni ukuphindeka noma ukunciphisa ukuqhubeka kwesifo, kuyilapho i-dalfampridine iqondise ngqo ubunzima bokuhamba.

Ungase uthathe i-dalfampridine kanye nezinye izindlela zokwelapha ze-MS njengokwelashwa okuguqula isifo (ama-DMT) njenge-interferon beta, i-glatiramer acetate, noma imithi emisha yomlomo. Lezi zisebenza ndawonye kunokuncintisana.

Inzuzo ye-dalfampridine ukuthi iyona kuphela imithi efakazelwe ngokuqondile ukuthuthukisa ikhono lokuhamba ku-MS. Uma ubunzima bokuhamba bunomthelela omkhulu ekhwalithi yakho yempilo, i-dalfampridine inikeza indlela eqondiwe engahlinzekwa eminye imithi.

Udokotela wakho uzokusiza ukuthi uqonde ukuthi i-dalfampridine ingangena kanjani ohlelweni lwakho lokwelapha i-MS lonke nokuthi ngabe kunengqondo yini ukuyithatha kanye neminye imithi yakho.

Imibuzo Evame Ukubuzwa Mayelana ne-Dalfampridine

Ingabe i-Dalfampridine Iphephile Kubantu Abanezinkinga Zenhliziyo?

I-Dalfampridine ingasetshenziswa ngabantu abanezimo zenhliziyo, kodwa udokotela wakho uzofuna ukukuqapha eduze. Imithi ngezinye izikhathi ingabangela izinguquko esigqi senhliziyo, nakuba lokhu kungavamile uma kuthathwa ngomthamo obekiwe.

Uma unomlando wezinkinga zenhliziyo, udokotela wakho angase ancome i-electrocardiogram (EKG) ngaphambi kokuqala i-dalfampridine nokuqapha ngezikhathi ezithile ngemva kwalokho. Qiniseka ukuthi utshela udokotela wakho nganoma yiziphi izimo zenhliziyo, okuhlanganisa ukushaya kwenhliziyo okungajwayelekile, ukuhluleka kwenhliziyo, noma ukuhlaselwa yinhliziyo kwangaphambilini.

Abantu abaningi abanezimo zenhliziyo ezinzile bangayithatha ngokuphepha i-dalfampridine, kodwa udokotela wakho uzokwenza lesi sinqumo ngokusekelwe emlandweni wakho wezokwelapha othile kanye nesimo sakho sempilo yamanje.

Kufanele ngenzeni uma ngithatha i-Dalfampridine eningi ngengozi?

Uma ngengozi uthatha i-dalfampridine eningi kunaleyo ebekiwe, funa usizo lwezokwelapha ngokushesha. Ukuthatha i-dalfampridine eningi kakhulu kwandisa kakhulu ingozi yokuhlaselwa yizithuthwane, okungaba yingozi.

Shayela udokotela wakho, iya egumbini eliphuthumayo, noma ushayele ukulawulwa kwezinto ezinobuthi ngokushesha uma uthathe ngaphezu komthamo wakho obekiwe. Ungalindi ukubona ukuthi izimpawu ziyavela yini, njengoba ukuhlaselwa yizithuthwane kungenzeka ngaphandle kwesixwayiso lapho amazinga e-dalfampridine ekhuphuka kakhulu.

Ukuvimbela ukweqisa ngengozi, ungalokothi uthathe imithamo eyengeziwe ukuze ulungise lezo eziphuthelwe, futhi njalo hlola kabili ukuthi uthatha inani elilungile. Cabangela ukusebenzisa umhleli wamaphilisi ukusiza ukulandela imithamo yakho.

Kufanele ngenzeni uma ngiphuthelwa umthamo we-Dalfampridine?

Uma uphuthelwa umthamo we-dalfampridine, yithathe ngokushesha lapho ukhumbula, kodwa kuphela uma sekudlule amahora angaphezu kuka-6 kuze kube umthamo wakho olandelayo ohleliwe. Uma kungaphansi kwamahora angu-6 kuze kube umthamo wakho olandelayo, weqa umthamo ophuthelwe bese uthatha umthamo wakho olandelayo ngesikhathi esijwayelekile.

Ungalokothi uthathe imithamo emibili ngesikhathi esisodwa noma uthathe imithi eyengeziwe ukuze ulungise umthamo ophuthelwe. Lokhu kungandisa ingozi yakho yemiphumela emibi, ikakhulukazi ukuhlaselwa yizithuthwane.

Uma uvame ukukhohlwa imithamo, cabangela ukusetha izikhumbuzi zocingo noma ukusebenzisa umhleli wamaphilisi ukukusiza ukuthi uhlale emgqeni. Ukuthatha imithi ngokuqhubekayo kubalulekile ekugcineni amazinga aqhubekayo emithi ohlelweni lwakho.

Ngingayeka nini ukuthatha i-Dalfampridine?

Ungayeka ukuthatha i-dalfampridine nganoma yisiphi isikhathi, njengoba kungekho ingozi yezimpawu zokuhoxisa. Kodwa-ke, noma yikuphi ukuthuthuka emandleni okuhamba cishe kuzobuyela ezingeni eliyisisekelo ezinsukwini ezimbalwa ngemva kokuyeka umuthi.

Odokotela abaningi batusa ukuzama i-dalfampridine okungenani amasonto angu-2-4 ngaphambi kokunquma ukuthi uzoqhubeka yini. Uma ungaboni noma yikuphi ukuthuthuka ekuhambeni kwakho ngalesi sikhathi, udokotela wakho cishe uzosikisela ukuyeka.

Uma uthola izinzuzo kodwa ufuna ukuyeka ukuthatha i-dalfampridine nganoma yisiphi isizathu, xoxa ngalokhu nodokotela wakho. Bangakusiza ukuthi ulinganise izinzuzo ozitholayo ngokumelene nanoma yikuphi ukukhathazeka ongase ube nakho mayelana nokuqhubeka nomuthi.

Ngingashayela Ngenkathi Ngithatha I-Dalfampridine?

Abantu abaningi bangashayela ngokuphepha ngenkathi bethatha i-dalfampridine, kodwa kufanele uqaphele, ikakhulukazi uma uqala umuthi. I-Dalfampridine ingabangela isiyezi, izinkinga zokulinganisela, noma eminye imiphumela engase ithinte ikhono lakho lokushayela ngokuphepha.

Qala ngokubona ukuthi umuthi ukuthinta kanjani ngaphambi kokungena ngemuva kwesondo. Uma uzwa isiyezi, ukudideka, noma izinkinga zokulinganisela, gwema ukushayela kuze kube yilapho lezi zimpawu zithuthuka noma zixazululeka.

Xoxa nodokotela wakho ngokuphepha ekushayeleni, ikakhulukazi uma uhlangabezana nanoma yimiphumela engase iphazamise ikhono lakho lokusebenzisa imoto ngokuphepha. Ukuphepha kwakho nokuphepha kwabanye emgwaqweni kufanele kube yinto eza kuqala njalo.