Yini i-Danazol: Ukusetshenziswa, Umthamo, Imiphumela Eceleni Nokunye

I-Danazol iyimithi ye-hormone eyenziwe ngumuntu esiza ukwelapha izimo eziningana ezihlobene nempilo yokuzala kanye nezifo zegazi. Le mithi isebenza ngokucindezela ama-hormone athile emzimbeni wakho, okungasiza ukunciphisa izimpawu ze-endometriosis, isifo sebele se-fibrocystic, kanye nesifo esingavamile sokopha esibizwa ngokuthi i-hereditary angioedema.

Ungase uzibuze ukuthi le mithi ingena kanjani ohlelweni lwakho lokwelashwa. I-Danazol isetshenziswe amashumi eminyaka ukusiza abantu ukuthi balawule izimo eziyinselele ezithinta izinga lempilo yabo. Nakuba kungahlali kuyindlela yokuqala yokwelashwa, ingasebenza kahle kakhulu uma ezinye izinketho zingasebenzanga kahle.

Yini i-Danazol?

I-Danazol iyi-hormone eyenziwe ngumuntu eyingxenye yeqembu lemithi ebizwa ngokuthi ama-androgens. Ilingisa eminye imiphumela yama-hormone esilisa emzimbeni wakho, kodwa ungakhathazeki - lokhu akusho ukuthi kuzobangela izinguquko ezinkulu endleleni obukeka ngayo noma ozizwa ngayo.

Umuthi usebenza ngokunciphisa ukukhiqizwa kwama-hormone athile avela endleni yakho ye-pituitary. Cabanga ngayo njengokwehlisa ivolumu yezimpawu ze-hormone ezingabangela izinkinga ezimweni ezinjenge-endometriosis. Lesi senzo sokucindezela ama-hormone sisiza ukunciphisa ukuvuvukala nokukhula kwezicubu okungajwayelekile.

I-Danazol iza ngesimo samaphilisi futhi ithathwa ngomlomo. Udokotela wakho uzoyibhala ngokuya ngesimo sakho esithile nokuthi umzimba wakho usabela kanjani ekwelashweni. Umuthi ukhona kusukela ngeminyaka yawo-1970, ngakho odokotela banolwazi oluningi lokuyisebenzisa ngokuphepha.

Yini i-Danazol Esetshenziselwa Yona?

I-Danazol iphatha izimo ezintathu eziyinhloko, ngasinye sidinga izindlela ezihlukene kanye nemithamo. Udokotela wakho uzoqoka ukuthi yisiphi isimo esisebenza kuwe futhi alungise ukwelashwa kwakho ngokufanele.

Ukusetshenziswa okuvamile kakhulu kungokwe-endometriosis, isimo esibuhlungu lapho izicubu ezifana nokuvundisa kwakho kwesibeletho zikhula ngaphandle kwesibeletho. Lokhu kungabangela ukuqaqamba okukhulu kwesikhathi, ukuphuma kwegazi okuningi, nobuhlungu besinqe. I-Danazol isiza ngokunciphisa amazinga e-estrogen, okunciphisa lokhu kukhula kwezicubu ezingavamile futhi kunciphise ukuvuvukala.

Lo muthi futhi welapha isifo sebele se-fibrocystic, esibangela amabele aqinile, athambile avame ukuzizwa embi ngaphambi kwesikhathi sakho. Ngokulinganisa amazinga e-hormone, i-danazol inganciphisa ubuhlungu besifuba futhi inciphise ukwakheka kwama-cysts amasha.

Nge-hereditary angioedema, isimo esingavamile se-genetic, i-danazol isebenza ngenjongo ehlukile. Lesi simo sibangela ukuvuvukala okungazelelwe ebusweni bakho, emqaleni, ezandleni, noma ezingxenyeni zakho zangasese ngenxa yokuntuleka kwamaprotheni. I-Danazol isiza ukuvimbela lezi ziqephu ezivuvukala eziyingozi ngokukhulisa ukukhiqizwa komzimba wakho kwamaprotheni alahlekile.

Isebenza Kanjani I-Danazol?

I-Danazol ithathwa njengomuthi onamandla ngokulinganisela odala izinguquko ezinkulu ekulinganiseni kwakho ama-hormone. Isebenza ngokucindezela ukukhululwa kwama-hormone avela endleni yakho ye-pituitary, ikakhulukazi i-luteinizing hormone (LH) ne-follicle-stimulating hormone (FSH).

Lapho la ma-hormone encishisiwe, ama-ovari akho akhiqiza i-estrogen ne-progesterone encane. Lokhu kushintsha kwama-hormone kusiza ukunciphisa izicubu ze-endometrial futhi kunciphisa izinqubo zokuvuvukala ezibangela ubuhlungu nokukhula okungavamile. Ezimweni zamabele, lokhu kuncishiswa okufanayo kwama-hormone kunciphisa izinguquko eziqhubekayo ezenza ama-lumps abuhlungu.

Ku-hereditary angioedema, i-danazol isebenza ngendlela ehlukile ngokwandisa ukukhiqizwa kwesibindi sakho se-C1 esterase inhibitor. Leli phrotheni lisiza ukulawula ukuvuvukala futhi livimbele iziqephu zokuvuvukala ezingazelelwe, ezinzima eziqaphela lesi simo.

Imiphumela yomuthi iyaguquleka, okusho ukuthi amazinga akho e-hormone azobuyela kokujwayelekile ngemva kokuyeka ukuwuthatha. Nokho, kungase kuthathe izinyanga eziningana ukuthi umzimba wakho uzilungise ngokugcwele.

Kufanele Ngiyithathe Kanjani I-Danazol?

Thatha i-danazol ngendlela eqondile udokotela wakho ayalela ngayo, ngokuvamile kabili ngosuku ngokudla ukusiza ukunciphisa isisu esicasulayo. Isikhathi sokuthatha imithamo yakho kufanele sisabalaliswe ngokulinganayo usuku lonke, njengasekuseni nakusihlwa.

Ungathatha i-danazol ngaphandle kokudla, kodwa ukuyithatha ngokudla noma ukudla okulula kuvame ukusiza ekuvikeleni isicanucanu. Abanye abantu bathola ukuthi ukuyithatha nobisi noma ukudla okulula kusebenza kahle. Gwema ukuyithatha esiswini esingenalutho uma uthambekele ekucasukeni kwesisu.

Gwinya amaphilisi wonke ngenkomishi yamanzi egcwele. Ungagxobi, uhlafune, noma uvule amaphilisi, ngoba lokhu kungathinta indlela umuthi omuncwa ngayo. Uma unenkinga yokugwinya amaphilisi, khuluma nodokotela wakho mayelana nezinye izindlela.

Zama ukuthatha imithamo yakho ngezikhathi ezifanayo nsuku zonke ukuze ugcine amazinga aqhubekayo emzimbeni wakho. Ukusetha izikhumbuzi zocingo noma ukuxhuma imithamo emisebenzini yansuku zonke efana nokudla kungakusiza ukuthi ukhumbule. Ukuqina kubalulekile ukuthi umuthi usebenze ngempumelelo.

Kufanele Ngiyithathe Isikhathi Esingakanani I-Danazol?

Ubude bokwelashwa nge-danazol buhlukahluka kakhulu kuye ngesimo sakho nokuthi usabela kahle kangakanani. Abantu abaningi bayayithatha izinyanga ezi-3 kuya kwezi-6 ekuqaleni, kodwa abanye bangase badinge izikhathi zokwelashwa ezinde.

Ngokuqondene ne-endometriosis, ukwelashwa kuvame ukuthatha izinyanga ezi-3 kuya kwezi-6. Udokotela wakho uzoqapha izimpawu zakho futhi angase andise ukwelashwa uma ubona imiphumela emihle ngaphandle kwemiphumela emibi ekhathazayo. Abantu abaningi bathola ukuthuthuka okukhulu ezinyangeni ezimbalwa zokuqala.

Isifo samabele se-Fibrocystic sivame ukudinga izinyanga ezi-2 kuya kwezi-6 zokwelashwa. Udokotela wakho angase akuqale ngomthamo ophezulu ekuqaleni, bese ewunciphisa njengoba izimpawu zakho zithuthuka. Abanye abantu badinga izinyanga ezimbalwa kuphela, kanti abanye bazuza ekwelashweni okude.

Ngokuqondene ne-hereditary angioedema, ukwelashwa kuvame ukuba isikhathi eside futhi kungase kuqhubeke iminyaka. Umgomo ukuvimbela izigameko zokuvuvukala, ngakho udokotela wakho uzosebenza nawe ukuthola umthamo ophansi osebenzayo wokuvikela okuqhubekayo.

Ziyini Imiphumela Eceleni ye-Danazol?

Njenganoma imuphi umuthi othinta ama-hormone, i-danazol ingabangela imiphumela eceleni ehlukahlukene, nakuba kungewona wonke umuntu oyitholayo. Ukuqonda ukuthi okulindeleke kungakusiza ukuthi uzizwe ulungile futhi wazi ukuthi ungaxhumana nini nodokotela wakho.

Imiphumela ejwayelekile eceleni abantu abaningi abayitholayo ihlanganisa ukukhuluphala, ukuqunjelwa, kanye nezinguquko emjikelezweni wakho wokuya esikhathini. Ungase uqaphele ukuthi izikhathi zakho ziba lula, azivamile, noma ziyeka ngokuphelele ngenkathi uthatha i-danazol. Lokhu empeleni kuyingxenye yendlela umuthi osebenza ngayo futhi ngokuvamile kuyahlehla ngemva kokuyeka ukwelashwa.

Nawa imiphumela eceleni ebikwa kaningi:

• Ukukhuluphala ngamakhilogremu angu-5-10
• Ukuqunjelwa nokugcinwa kwamanzi
• Ukushisa okukhulu noma ukujuluka ebusuku
• Ushintsho lwemizwa noma ukucasuka
• Izinduna noma isikhumba esinamafutha
• Ukuncipha kosayizi wamabele
• Ukuminyana kwemisipha

Imiphumela eceleni engavamile kodwa ekhathazayo ihlanganisa izinguquko zezwi, ukukhula kwezinwele ngokweqile, kanye nezinguquko ezinkulu zemizwa. Ukujula kwezwi kungaba unomphela, ngakho xhumana nodokotela wakho ngokushesha uma uqaphela ukuthi izwi lakho liba libi noma lijula.

Imiphumela eceleni engavamile kodwa ebucayi idinga ukunakekelwa kwezokwelapha ngokushesha. Lokhu kuhlanganisa ubuhlungu obukhulu besisu, ukuphuzi kwesikhumba noma amehlo, ikhanda elibuhlungu kakhulu, noma izimpawu zamahlule egazi njengobuhlungu bomlenze obuzumayo noma ukuphefumula kanzima. Nakuba lokhu kungavamile, kudinga ukuhlolwa ngokushesha.

Ubani Ongafanele Athole I-Danazol?

Amaqembu amaningana abantu kufanele agweme i-danazol ngenxa yokukhathazeka ngokuphepha. Udokotela wakho uzobuyekeza ngokucophelela umlando wakho wezokwelapha ngaphambi kokukuyalela lo muthi.

Abesifazane abakhulelwe akufanele neze bathathe i-danazol, njengoba ingabangela ukukhubazeka okukhulu kokuzalwa, ikakhulukazi okuthinta ukuthuthukiswa kwezinsana zabesifazane. Uma uzama ukukhulelwa noma kunethuba lokuthi ungase ukhulelwe, xoxa ngalokhu nodokotela wakho ngokushesha.

Abantu abanezimo ezithile zezokwelapha kufanele bagweme i-danazol noma bayisebenzise ngokuqapha okukhulu. Lezi zimo zenza izingozi ezengeziwe uma zihlanganiswe nemiphumela ye-hormonal yomuthi:

• Isifo senhliziyo esibi noma ukuhluleka kwenhliziyo
• Isifo sesibindi noma ama-enzyme esibindi aphakeme
• Isifo sezinso
• Umlando wamagazi amagazi
• Umfutho wegazi ophezulu ongagadiwe
• Isifo sikashukela esibi
• Umlando wokushaywa unhlangothi

Uma unomlando womdlavuza wamabele noma eminye imidlavuza ezwelayo kuma-hormone, udokotela wakho uzodinga ukukala izingozi nezinzuzo ngokucophelela okukhulu. Imiphumela ye-hormonal yomuthi ingase ithinte ukukhula komdlavuza kwezinye izimo.

Amagama Omkhiqizo we-Danazol

I-Danazol itholakala ngaphansi kwamagama amaningi omkhiqizo, nakuba inguqulo ejwayelekile ivame ukunqunywa namuhla. Igama lomkhiqizo wokuqala lalingu-Danocrine, okungenzeka usalibona linqunywe kwezinye izindawo.

Amanye amagama omkhiqizo afaka i-Danol ne-Azol, nakuba ukutholakala kuhluka ngokuya ngezwe nesifunda. Amakhemisi amaningi agcina inguqulo ejwayelekile, esebenza kahle njengezinketho zegama lomkhiqizo futhi ngokuvamile ibiza kancane.

Lapho uthatha umuthi wakho, ilebula lizokhombisa "i-danazol" noma igama lomkhiqizo elithile elinqunywe udokotela wakho. Zonke izinguqulo ziqukethe isithako esifanayo esisebenzayo futhi zisebenza ngendlela efanayo emzimbeni wakho.

Ezinye Izindlela Zokwelapha ze-Danazol

Kukhona ezinye izindlela zokwelapha zezimo eziphathwa yi-danazol, nakuba ukukhetha okungcono kuncike esimweni sakho esithile nomlando wezokwelapha. Udokotela wakho angakusiza ukuthi uhlole lezi zinketho uma i-danazol ingakulungele.

Nge-endometriosis, ezinye izindlela zokwelapha zifaka amaphilisi okulawula inzalo ama-hormonal, imithi ye-progestin-only, noma ama-GnRH agonists afana ne-leuprolide. Lezi zisebenza ngendlela ehlukile kune-danazol kodwa zingasebenza ngokulinganayo ekulawuleni izimpawu.

Isifo sebele le-fibrocystic singase siphendule kahle ezithakweni zikavithamini E, amafutha e-evening primrose, noma ukunciphisa ukuthatha i-caffeine. Abanye abantu bathola ukukhululeka ngokulawulwa kokuzalwa ngamahomoni noma imithi elwa nokuvuvukala.

Nge-hereditary angioedema, imithi emisha efana ne-icatibant noma i-ecallantide ingelapha ukuhlaselwa okukhulu, kuyilapho imithi efana ne-lanadelumab ingavimbela iziqephu. Lezi zinketho ezintsha zivame ukuba nemiphumela emincane kuno-danazol.

Ingabe i-Danazol Ingcono Kunezinye Izindlela Zokwelapha Ngamahomoni?

I-Danazol akudingeki ukuthi ingcono noma imbi kunezinye izindlela zokwelapha ngamahomoni - ihlukile, inezinzuzo nobubi obuyingqayizivele. Ukukhetha okungcono kuncike esimweni sakho esithile, ezinye izinto zempilo, nokuthi usabela kanjani ekwelashweni.

Uma kuqhathaniswa namaphilisi okulawula ukuzalwa noma ezinye izindlela zokwelapha ngamahomoni, i-danazol ivame ukusebenza ngokushesha futhi ngendlela emangalisayo. Abantu abaningi babona ngcono phakathi nezinyanga ezi-2-3, kuyilapho ezinye izindlela zokwelapha zingase zithathe isikhathi eside ukukhombisa imiphumela.

Nokho, i-danazol ngokuvamile ibangela imiphumela esecacile kunezinye izindlela zokwelapha ngamahomoni. Ukuhwebelana kuvame ukuba ukukhululeka kwezimpawu okusheshayo, okuphelele ngokumelene nemiphumela engalawuleki kalula nezinye izinketho.

Udokotela wakho uzocabangela iminyaka yakho, isifiso sokukhulelwa, ubukhulu bezimpawu, nokubekezelelana nemiphumela emibi lapho encoma indlela yokwelapha engcono kakhulu kuwe.

Imibuzo Evame Ukubuzwa Mayelana ne-Danazol

Q1. Ingabe i-Danazol iphephile kubantu abanezifo zenhliziyo?

I-Danazol idinga ukucatshangelwa ngokucophelela uma unesifo senhliziyo, njengoba singathinta amazinga e-cholesterol futhi singase sandise izingozi zenhliziyo nemithambo yegazi. Udokotela wakho cishe uzofuna ukuqapha impilo yakho yenhliziyo ngokucophelela uma uthatha i-danazol ngezimo zenhliziyo ezikhona.

Umuthi ungakhuphula i-LDL (embi) cholesterol futhi wehlise i-HDL (enhle) cholesterol, okungafaneleki empilweni yenhliziyo. Nokho, kwezinye izimo ezinjenge-endometriosis enzima, izinzuzo zingase zidlule lezi zingozi ngokuqapha okufanele.

Umbuzo 2. Kufanele Ngenzeni Uma Ngithatha I-Danazol Eningi Ngengozi?

Uma ngengozi uthatha i-danazol eningi kunaleyo ebekiwe, xhumana nodokotela wakho noma isikhungo sokulawula ubuthi ngokushesha. Ukuthatha okuningi kungaqinisa imiphumela emibi futhi kubangele izinkinga ezingathi sína.

Ungalindi ukubona ukuthi ngabe izimpawu ziyavela yini - thola iseluleko sezokwelapha ngokushesha. Letha ibhodlela lemithi nawe uma udinga ukuya esibhedlela, ukuze abasebenzi bezokwelapha bakwazi ukubona kahle ukuthi uthathe ini nokuthi uthathe okungakanani.

Umbuzo 3. Kufanele Ngenzeni Uma Ngeqa Umthamo We-Danazol?

Uma weqa umthamo, wuthatha ngokushesha lapho ukhumbula, ngaphandle uma sekuseduze isikhathi somthamo wakho olandelayo. Kuleso simo, weqa umthamo owuqeqile bese uqhubeka neshejuli yakho ejwayelekile.

Ungalokothi uthathe imithamo emibili ngesikhathi esisodwa ukuze ulungise umthamo owuqeqile, ngoba lokhu kungandisa ingozi yakho yemiphumela emibi. Uma uvame ukukhohlwa imithamo, cabangela ukusetha izikhumbuzi zocingo noma ukusebenzisa umhleli wamaphilisi.

Umbuzo 4. Ngingayeka Nini Ukuthatha I-Danazol?

Yeka kuphela ukuthatha i-danazol uma udokotela wakho ekutshela ukuthi wenze njalo, ngisho noma uzizwa ungcono. Ukuyeka ngaphambi kwesikhathi kungavumela izimpawu zakho ukuthi zibuye ngaphambi kokuthi uzuze inzuzo enkulu.

Udkt wakho cishe uzofuna ukunciphisa umthamo wakho kancane kancane kunokuyeka kungazelelwe. Lokhu kusiza umzimba wakho ukuthi uzivumelanise ngokushelela emazingeni ajwayelekile ama-hormone futhi kunciphisa ithuba lokuthi izimpawu zibuye ngokushesha.

Umbuzo 5. Ingabe Izikhathi Zami Zizobuyela Esimeni Esijwayelekile Ngemuva Kokuyeka I-Danazol?

Yebo, imijikelezo yakho yokuya esikhathini kufanele ibuyele esimweni esijwayelekile kungakapheli izinyanga ezi-2-3 ngemuva kokuyeka i-danazol. Abantu abaningi bathola ukuthi izikhathi zabo zibuyela kancane kancane ephethini yabo yangaphambilini, yize kungathatha imijikelezo embalwa ukuthi ijwayeleke ngokugcwele.

Uma izikhathi zakho zingabuyi kungakapheli izinyanga ezi-3, noma uma unokukhathazeka mayelana nezinguquko emjikelezweni wakho, xhumana nodokotela wakho. Kwesinye isikhathi ukuhlolwa okwengeziwe kuyadingeka ukuqinisekisa ukuthi konke kubuyela esimweni esijwayelekile njengoba kulindelekile.