Danicopan (indlela yokumathisa ngomlomo)
Imikhiqizo etholakalayo
Voydeya
Mayelana naleli khambi
I-Danicopan isetshenziswa kanye nezinye izidakamizwa (um., iravulizumab noma i-eculizumab) ukuze ikwelaphe i-hemolysis engaphandle kwe-vascular (ukubhidlika kwamaseli ebomvu egazi okwenzeka ngaphandle kwezithelo zegazi) kubantu abanehlobo lesifo segazi elibizwa ngokuthi yi-paroxysmal nocturnal hemoglobinuria (PNH). Lolu dokotela lutholakala kuphela ngaphansi kohlelo lokusabalalisa oluqediwe oluthi Voydeya™ REMS (Uhlelo Lokuhlola Ubungozi Nokunciphisa). Lo mkhiqizo utholakala ngezindlela zokulinganisa ezilandelayo:
Ngaphambi kokusebenzisa leli khambi
Uma kunqunywe ukusebenzisa imithi, kufanele kuqhathaniswe ingozi yokuthatha imithi nezinzuzo ezizoletha. Lo ngumqondo owenzayo wena nodokotela wakho. Kule mithi, kufanele kucabangelwe okulandelayo: Tshela udokotela wakho uma uke waba nanoma iyiphi impendulo engaqondakali noma ebangelwa uketshezi kule mithi noma kwezinye izidakamizwa. Tshela futhi ochwepheshe bakho bezempilo uma unezinye izinhlobo zoketshezi, njengokudla, izibenge, izigcini, noma izilwane. Ngomkhiqizo ongenayo iresiphi, funda ilebula noma izithako zephakheji ngokucophelela. Izifundo ezifanele azikwenzelwanga ubudlelwano bokuphila nokuthinta kwe-danicopan kubantu abancane. Ukuphepha nokuphumelela akukaqiniswa. Izifundo ezifanele ezenziwe kuze kube manje azibonisi izinkinga ezikhethekile zabantu abadala ezingakhawuleli ukusetshenziswa kwe-danicopan kubantu abadala. Ayikho izifundo ezifanele kubesifazane zokunquma ingozi yengane uma usebenzisa le mithi ngesikhathi sokuncelisa. Linganisa izinzuzo ezingaba khona nezingozi ezingaba khona ngaphambi kokuthatha le mithi ngesikhathi sokuncelisa. Nakuba ezinye izidakamizwa kufanele zingasetshenziswa ndawonye nhlobo, kwezinye izimo izidakamizwa ezimbili ezahlukene zingasetshenziswa ndawonye ngisho noma kungenzeka ukuhlangana. Kulezi zimo, udokotela wakho angafuna ukushintsha umthamo, noma ezinye izinyathelo zokuphepha zingadingeka. Uma uthatha le mithi, kubaluleke kakhulu ukuthi ochwepheshe bakho bezempilo bazi uma uthatha noma iyiphi imithi ehlaliswe ngezansi. Ukuhlangana okulandelayo kukhethwe ngokusekelwe ekubalulekeni kwabo okungenzeka futhi akuyona yonke into ehlanganisiwe. Ukusebenzisa le mithi nanoma iyiphi imithi elandelayo ngokuvamile akuyona into enconywayo, kodwa kungadingeka kwezinye izimo. Uma kokubili imithi ilotshiwe ndawonye, udokotela wakho angashintsha umthamo noma ukuthi uyayisebenzisa kangakanani enye noma kokubili imithi. Ezinye izidakamizwa akufanele zisetshenziswe ngesikhathi sokudla noma ngesikhathi sokudla izinhlobo ezithile zokudla njengoba kungenzeka ukuhlangana. Ukusebenzisa utshwala noma utshaba nezinye izidakamizwa kungabangela ukuhlangana. Xoxa nochwepheshe bakho bezempilo ngokusetshenziswa kwemithi yakho ngokudla, utshwala, noma utshaba. Ukuba khona kwezinye izinkinga zezokwelapha kungathinta ukusetshenziswa kwale mithi. Qiniseka ukuthi utshela udokotela wakho uma unezinye izinkinga zezokwelapha, ikakhulukazi:
Indlela yokusebenzisa leli khambi
Thatha leli leyeza kuphela njengoba kunconywe udokotela wakho. Ungalithathi ngokweqile, ungalithathi njalo, futhi ungalithathi isikhathi eside kunalokho udokotela wakho akuyalile. Kubalulekile kakhulu ukuthi uqonde izidingo ze-Voydeya™ REMS program, futhi uqonde incwadi yemiyalo ye-Voydeya™. Funda futhi ulandele le miyalo ngokucophelela. Buza udokotela wakho uma unemibuzo. Cela umthengisi wezidakamizwa incwadi yemiyalo uma ungenayo. Ungathatha leli leyeza ngokudla noma ngaphandle kokudla. Lithathe ngesikhathi esifanayo nsuku zonke. Inani leli leyeza lizohlukahluka kubantu abahlukene. Landela imiyalo yodokotela wakho noma imiyalo esembile. Ulwazi olulandelayo luhlanganisa kuphela amanani ajwayelekile aleli leyeza. Uma inani lakho lihlukile, ungalishintshi ngaphandle kokuthi udokotela wakho akuyale ukuba wenze njalo. Inani leyeza olithathayo lixhomeke emandleni eleyeza. Futhi, inani lezinani olithathayo nsuku zonke, isikhathi esivunyelwe phakathi kwezinani, nobude besikhathi olithatha leli leyeza kuya ngenkinga yezokwelapha oyisebenzisela leli leyeza. Uma uphuthelwa yisilinganiso saleli leyeza, lithathe ngokushesha okukhulu. Noma kunjalo, uma sekusondele isikhathi sesilinganiso sakho esilandelayo, susa isilinganiso esiphuthelwe bese ubuyela esimweni sakho esivamile sokudla. Ungawandisi ama-doses. Uma uphuthelwa yisilinganiso, lithathe ngokushesha okukhulu. Uma uphuthelwa yisilinganiso futhi kusukela emahoreni angu-3 ngaphambi kwesilinganiso sakho esilandelayo, susa isilinganiso esiphuthelwe bese uthatha isilinganiso sakho esilandelayo ngesikhathi esivamile. Gcina leli leyeza esitsheni esivalekile ekushiseni kweqembu, kude nokushisa, ukufuma, nokukhanya okuqondile. Gcina ungalwi. Gcina ungafinyeleleki kubantwana. Ungagcini leyeza eliphelile noma leyeza elingasasetshenziswa. Buza ochwepheshe bakho bezempilo ukuthi kufanele ulahle kanjani noma yiliphi leyeza ongeke ulisetshenzise.
Umshwana wokuzihlangula: I-August iyinkundla yolwazi lwezempilo futhi izimpendulo zayo azihlanganisi iseluleko sezokwelapha. Njalo thintana nochwepheshe bezokwelapha onelayisensi eduze nawe ngaphambi kokwenza noma yiluphi ushintsho.