Yini i-Dantrolene: Ukusetshenziswa, Umthamo, Imiphumela Eceleni Nokunye

I-Dantrolene iyikhambi elithambisa imisipha elisebenza ngqo emicu yakho yemisipha ukunciphisa ukuncipha kwemisipha okungafuneki kanye nokuhlaselwa. Ngokungafani nezinye izithambisi zemisipha ezisebenza ngohlelo lwakho lwezinzwa, i-dantrolene iqondisa imisipha ngokwayo, okuyenza isebenze ngendlela eyingqayizivele ezimweni ezithile lapho imisipha iba qinile ngendlela eyingozi noma isebenza ngokweqile.

Lo muthi udlala indima ebalulekile ekwelapheni izimo ezinzima ezihlobene nemisipha futhi kungashintsha umdlalo kubantu ababhekene ne-spasticity yemisipha engapheli. Ake sihlolisise ukuthi i-dantrolene isebenza kanjani nokuthi ingase ibe usizo yini esimweni sakho esithile.

Yini i-Dantrolene Esetshenziselwa Yona?

I-Dantrolene iphatha izimo eziningana ezinzima ezihlobene nemisipha lapho imisipha yakho incipha ngamandla amakhulu noma njalo. Umuthi unqunyelwe ikakhulukazi i-spasticity engapheli, okusho ukuthi imisipha yakho ihlala iqine futhi iqina, okwenza ukunyakaza kube nzima futhi ngezinye izikhathi kube buhlungu.

Udokotela wakho angase anqume i-dantrolene uma une-spasticity evela ezimweni ezinjenge-multiple sclerosis, cerebral palsy, ukulimala komgogodla, noma unhlangothi. Lezi zimo zingabangela ukuthi imisipha yakho inciphe ngokuzenzakalela, okwenza imisebenzi yansuku zonke ibe yinselele futhi ingakhululeki.

I-Dantrolene futhi isebenza njengokwelashwa okusindisa impilo ye-malignant hyperthermia, ukusabela okungavamile kodwa okuyingozi kuma-anesthetics athile ngesikhathi sokuhlinzwa. Kulesi simo esiphuthumayo, umuthi ungangavimbela ukuqina kwemisipha okungase kube yingozi nokushisa ngokweqile.

Isebenza Kanjani I-Dantrolene?

I-Dantrolene isebenza ngokuvimba ukukhishwa kwe-calcium ngaphakathi kwamaseli akho emisipha, okubalulekile ekunciphiseni imisipha. Cabanga nge-calcium njengokhiye oqala inqubo yokuncipha kwemisipha - i-dantrolene empeleni isusa lowo khiye, ivumela imisipha yakho ukuthi iphumule kalula.

Lokhu kwenza i-dantrolene ibe yinto ephumuzayo yemisipha enamandla ngokulinganisela, kodwa ihluke kwezinye izinto eziphumuzayo imisipha ngoba isebenza ngqo emsipheni kunokuthi isebenze ngobuchopho bakho noma umgogodla wakho. Le ndlela eqondiswe ngqo isho ukuthi ingasebenza kahle kakhulu ezinhlotsheni ezithile zezinkinga zemisipha ngenkathi ibangela imiphumela emibi embalwa yezinzwa eziphakathi.

Umuthi ngokuvamile uthatha amasonto amaningana ukufinyelela ekusebenzeni kwawo okuphelele, ngakho ungase ungaboni ukukhululeka ngokushesha. Imisipha yakho izokhululeka kancane kancane futhi ilawuleke kalula njengoba umuthi wakha emzimbeni wakho.

Ngingayithatha kanjani i-Dantrolene?

Thatha i-dantrolene ngendlela eqondile udokotela wakho ayalela ngayo, ngokuvamile uqala ngomthamo ophansi okhula kancane kancane ngokuhamba kwesikhathi. Abantu abaningi baqala ngo-25 mg kanye ngosuku bese beqhubeka kancane kancane umthamo wabo osebenzayo, ongase ube noma yikuphi kusuka ku-100 kuya ku-400 mg ngosuku ohlukaniswe ngemithamo eminingi.

Ungayithatha i-dantrolene ngaphandle noma ngaphandle kokudla, kodwa ukuyithatha nokudla kungasiza ukunciphisa isisu uma uhlangabezana nanoma yini. Gwinya amaphilisi wonke ngengilazi yamanzi egcwele - ungawachobozi, uwahlafune, noma uwavule ngaphandle uma udokotela wakho ekutshela ngqo ukuthi wenze kanjalo.

Zama ukuthatha imithamo yakho ngesikhathi esifanayo nsuku zonke ukuze ugcine amazinga aqhubekayo emzimbeni wakho. Uma uthatha imithamo eminingi nsuku zonke, yihlukanise ngokulinganayo usuku lonke njengoba kuqondiswe ngumhlinzeki wakho wezempilo.

Ngingayithatha isikhathi esingakanani i-Dantrolene?

Ubude bokwelashwa kwe-dantrolene busekelwe esimweni sakho esithile nokuthi usabela kahle kangakanani emuthini. Ukuze uthole i-spasticity engapheli, abantu abaningi bathatha i-dantrolene izinyanga noma iminyaka njengesu lokuphatha isikhathi eside.

Udokotela wakho cishe uzoqala ngesikhathi sokuhlola samasonto amaningana ukuze abone ukuthi umuthi usebenza kahle kangakanani kuwe. Uma ungaboni ngcono okukhulu ngemuva kwamasonto angu-6-8 ngomthamo wakho oqondiwe, udokotela wakho angase alungise umthamo noma acabange ezinye izindlela zokwelapha.

Kwabanye abantu, i-dantrolene iba yingxenye ehlala njalo yohlelo lwabo lokwelashwa, kanti abanye bangayisebenzisa okwesikhashana ngesikhathi sokwanda kwezimpawu noma izikhathi zokwanda kokuqina kwemisipha. Ungayeki ukuthatha i-dantrolene ngokuzumayo ngaphandle kokuxhumana nodokotela wakho, ngoba lokhu kungabangela ukuthi izimpawu zakho zibuye ngokushesha.

Ziyini Imiphumela Eceleni ye-Dantrolene?

Abantu abaningi bahlangabezana nemiphumela ethile engemihle lapho beqala i-dantrolene, kodwa eminingi yalezi iyathuthuka njengoba umzimba wakho ujwayela umuthi. Imiphumela engemihle evame kakhulu ongase uyibone ihlanganisa ukozela, isiyezi, ubuthakathaka, nokukhathala, ikakhulukazi emasontweni ambalwa okuqala kokwelashwa.

Nansi imiphumela engemihle ongase ube nethuba elikhulu lokuyithola, ikakhulukazi lapho uqala umuthi:

• Ukozela nokukhathala okungase kuthinte imisebenzi yakho yansuku zonke
• Isiyezi, ikakhulukazi lapho usukuma ngokushesha
• Ubuthakathaka obujwayelekile bemisipha emzimbeni wakho wonke
• Isicanucanu noma isisu esibuhlungu
• Ukuqunjelwa noma izinguquko emikhubeni yamathumbu
• Ikhanda elibuhlungu elivame ukuba lincane noma liphakathi nendawo

Le miphumela engemihle evamile ivame ukuba ngaphansi kokuphazamisa njengoba umzimba wakho ujwayela umuthi emasontweni ambalwa okuqala okwelashwa.

Ngokuvamile, abanye abantu bahlangabezana nemiphumela engemihle ebaluleke kakhulu edinga ukunakekelwa kwezokwelapha. Nakuba lokhu kungavamile, kubalulekile ukukwazi:

• Ubuthakathaka obukhulu bemisipha obuphazamisa ukuhamba noma imisebenzi yansuku zonke
• Ukuphefumula kanzima noma ukuphelelwa umoya
• Ubuhlungu besifuba noma ukushaya kwenhliziyo okusheshayo
• Ukuqunjelwa okukhulu okuholela ekuphelelwe amanzi emzimbeni
• Ukulimala noma ukopha okungavamile
• Ukuphuzi kwesikhumba noma amehlo (i-jaundice)

Ngokungavamile, i-dantrolene ingabangela izinkinga ezinzima zesibindi, yingakho udokotela wakho ezoqapha ukusebenza kwesibindi sakho ngezivivinyo zegazi ezivamile. Izimpawu zezinkinga zesibindi zihlanganisa isicanucanu esiqhubekayo, ukukhathala okungavamile, umchamo omnyama, noma ukuphuzi kwesikhumba sakho noma amehlo akho.

Xhumana nomhlinzeki wakho wezempilo uma uhlangabezana nanoma yimaphi imiphumela emibi ekhathazayo, ikakhulukazi uma iba yimbi ngokuhamba kwesikhathi noma iphazamisa impilo yakho yansuku zonke.

Obani okungafanele basebenzise i-Dantrolene?

I-Dantrolene ayifanele wonke umuntu, futhi izimo ezithile zezempilo zenza kungaphephile ukuyisebenzisa. Akufanele usebenzise i-dantrolene uma unezifo zesibindi ezisebenzayo noma uma uke waba nezinkinga zesibindi ngenxa yokuthatha i-dantrolene esikhathini esidlule.

Abantu abanezimo ezithile zenhliziyo, ikakhulukazi lezo ezithinta isigqi senhliziyo, kungenzeka bangabi ngabakhethekile be-dantrolene. Udokotela wakho uzohlola ngokucophelela impilo yenhliziyo yakho ngaphambi kokukuyala lo muthi.

Kufanele futhi ugweme i-dantrolene uma ukhulelwe noma uncelisa, njengoba umuthi ungangena enganeni yakho futhi ungase ulimaze. Uma uhlela ukukhulelwa noma uthola ukuthi ukhulelwe ngenkathi usebenzisa i-dantrolene, xhumana nodokotela wakho ngokushesha ukuze uxoxe ngezindlela ezingezinye.

Ngaphezu kwalokho, abantu abanezifo ezinzima zamaphaphu noma izinkinga zokuphefumula kungenzeka bangakwazi ukuthatha i-dantrolene ngokuphepha, njengoba umuthi ngezinye izikhathi ungabangela izinkinga zokuphefumula.

Amagama e-Brand e-Dantrolene

I-Dantrolene iyatholakala ngaphansi kwegama le-brand elithi Dantrium, okuyindlela yomlomo evame ukuyalelwa yalo muthi. Kokubili i-dantrolene ejwayelekile kanye ne-brand-name Dantrium ziqukethe isithako esifanayo esisebenzayo futhi zisebenza ngokufanayo emzimbeni wakho.

Ikhemisi lakho lingase linikeze inguqulo ejwayelekile noma yegama le-brand ngokuya ngomshwalense wakho nokutholakala. Zombili izinhlobo zisebenza ngendlela efanayo, nakuba abanye abantu bekhetha ukunamathela ohlotsheni olulodwa ukuze kuvumelane.

Kukhona futhi uhlobo olujovwayo lwe-dantrolene olubizwa nge-Ryanodex, kodwa lokhu kusetshenziswa kuphela ezindaweni zasemtholampilo zokwelapha izimo eziphuthumayo ze-malignant hyperthermia.

Ezinye izindlela ze-Dantrolene

Eminye imithi eminingi ingelapha i-muscle spasticity uma i-dantrolene ingakulungele noma inganikezi ukukhululeka okwanele. I-Baclofen ivame ukuthathwa njengokwelashwa kokuqala kwe-spasticity futhi isebenza ngomgogodla wakho ukunciphisa ukuncipha kwemisipha.

I-Tizanidine enye inketho esebenza ohlelweni lwakho lwezinzwa oluphakathi nendawo ukunciphisa ithoni yemisipha. Ivame ukubangela ukozela okuningi kune-dantrolene kodwa ingasebenza kahle kakhulu kwezinye izinhlobo ze-spasticity.

Ezinye izindlela ezingezinye zihlanganisa i-diazepam, enezindawo zokuphumuza imisipha kanye nemiphumela yayo yokulwa nokukhathazeka, kanye nemijovo ye-botulinum toxin ye-localized muscle spasticity. Udokotela wakho angasiza ekunqumeni ukuthi iyiphi inketho engasebenza kangcono esimweni sakho esithile.

Ingabe i-Dantrolene Ingcono Kune-Baclofen?

I-Dantrolene ne-baclofen zisebenza ngendlela ehlukile futhi ngasinye sinokuhle okuncike esimweni sakho esithile nokuthi umzimba wakho usabela kanjani. I-Baclofen ivame ukuzanywa kuqala ngoba isetshenziswe isikhathi eside futhi inemiphumela engabikezelwa kakhulu kubantu abaningi.

I-Dantrolene ingase ikulungele uma i-baclofen ibangela ukozela okuningi noma imiphumela engemihle yokuqonda, ngoba i-dantrolene isebenza ngqo emisipheni kunokuba isebenze ngobuchopho bakho nomgogodla. Abanye abantu bathola i-dantrolene ithandeka kakhulu ekusetshenzisweni kwesikhathi eside.

Nokho, i-baclofen ingasebenza kahle kakhulu ezinhlotsheni ezithile ze-spasticity, ikakhulukazi lezo ezibangelwa ukulimala komgogodla. Ukukhetha phakathi kwale mithi kuncike ekuphenduleni kwakho ngakunye, ukubekezelelana nemiphumela emibi, kanye nembangela eyinhloko ye-muscle spasticity yakho.

Udokotela wakho angase aze ancome ukuzama kokubili imithi ngezikhathi ezihlukene ukuze abone ukuthi iyiphi esebenza kangcono esimweni sakho esithile.

Imibuzo Evame Ukubuzwa Mayelana ne-Dantrolene

Ingabe i-Dantrolene Iphephile Ezigulini Zezinso?

I-Dantrolene ngokuvamile ithathwa njengephephile kubantu abanezifo zezinso uma iqhathaniswa neminye imithi eminingi ngoba ngokuyinhloko icutshungulwa yisibindi sakho kunokuba izinso zakho. Kodwa-ke, kufanele usazise udokotela wakho nganoma yiziphi izinkinga zezinso onazo.

Udokotela wakho angase afune ukuqapha ukusebenza kwezinso zakho eduze ngenkathi uthatha i-dantrolene, ikakhulukazi uma unezifo zezinso eziphakathi nendawo kuya kwezinkulu. Umthamo womuthi ngokuvamile awudingi ukulungiswa ngenxa yezinkinga zezinso, kodwa isimo sakho sempilo esiphelele sizothonya isinqumo.

Kufanele Ngenzeni Uma Ngithatha I-Dantrolene Eningi Ngengozi?

Uma ngengozi uthatha i-dantrolene eningi kunaleyo ebekiwe, xhumana nodokotela wakho noma isikhungo sokulawula ubuthi ngokushesha, ngisho noma uzizwa ulungile. Ukuthatha i-dantrolene eningi kungabangela ubuthakathaka bemisipha obuyingozi, ubunzima bokuphefumula, nezinkinga zenhliziyo.

Ungalindi ukubona ukuthi ngabe izimpawu ziyavela yini - funa ukunakekelwa kwezokwelapha ngokushesha. Letha ibhodlela lomuthi nawe egumbini eliphuthumayo ukuze abahlinzeki bezempilo bazi kahle ukuthi yini nokuthi ungakanani okuthathile.

Izimpawu zokweqisa kwe-dantrolene zifaka ubuthakathaka obukhulu bemisipha, ubunzima bokuphefumula, izinga lenhliziyo elihamba kancane, nokulahlekelwa ukwazi. Lezi zimpawu zidinga ukunakekelwa kwezokwelapha okuphuthumayo ngokushesha.

Kufanele Ngenzeni Uma Ngiphuthelwa Umthamo We-Dantrolene?

Uma uphuthelwa umthamo we-dantrolene, yithathe ngokushesha lapho ukhumbula, ngaphandle uma sekuseduze nesikhathi somthamo wakho olandelayo ohleliwe. Kulokho, weqa umthamo ophuthelwe futhi uqhubeke nohlelo lwakho lokulinganisa olujwayelekile.

Ungalokothi uthathe imithamo emibili ngasikhathi sinye ukuze ulungise umthamo ophuthelwe, ngoba lokhu kungabangela imiphumela emibi eyingozi. Uma uvame ukukhohlwa imithamo, cabanga ukusetha izikhumbuzi ocingweni lwakho noma usebenzise umhleli wamaphilisi.

Ukuphuthelwa imithamo ngezikhathi ezithile ngeke kubangele ukulimala ngokushesha, kodwa zama ukugcina ukuqina ukuze uthole umphumela omuhle kakhulu wokwelapha. Uma uphuthelwa imithamo eminingi ilandelana, xhumana nodokotela wakho ukuze uthole isiqondiso sokuthi ungaqala kanjani kabusha ngokuphepha.

Ngingayeka nini ukuthatha i-Dantrolene?

Kufanele uyeke ukuthatha i-dantrolene ngaphansi kokugadwa ngudokotela wakho, ngoba ukuyeka kungazelelwe kungabangela ukuthi imisipha yakho ekhubazekile ibuye ngokuphazima kweso futhi kungenzeka ukuthi ibe yimbi. Udokotela wakho ngokuvamile uzoncoma ukunciphisa kancane kancane umthamo wakho emasontweni amaningana.

Isikhathi sokuyeka i-dantrolene sincike esimweni sakho esiyisisekelo kanye nemigomo yokwelashwa. Abanye abantu abanezimo eziqhubekayo bangase badinge ukuyithatha unomphela, kanti abanye bangase bayeke ngemva kokululama ekulimaleni noma ngezikhathi ezinzile.

Udokotela wakho uzosebenza nawe ukuze anqume isikhathi esifanele sokucabangela ukuyeka umuthi ngokusekelwe ezimpawini zakho, impilo yonke, kanye nokuphendula kokwelashwa.

Ngingashayela ngesikhathi ngithatha i-Dantrolene?

I-Dantrolene ingabangela ukozela, isiyezi, nobuthakathaka bemisipha, okungase kuphazamise ikhono lakho lokushayela ngokuphepha, ikakhulukazi uma uqala ukuyithatha. Kufanele ugweme ukushayela uze wazi ukuthi umuthi ukuthinta kanjani wena mathupha.

Abantu abaningi bathola ukuthi le miphumela emibi iyathuthuka ngemva kwamasonto ambalwa okuqala ukwelashwa, futhi bangakwazi ukuqhubeka nokushayela okujwayelekile uma sebezinzile emthozini wabo. Nokho, abanye abantu baqhubeka nokuzwa ukozela noma ubuthakathaka obenza ukushayela kungaphephile.

Yiba oqotho kuwe mayelana nokuqapha kwakho nesikhathi sokusabela ngenkathi uthatha i-dantrolene. Uma uzizwa ukhubazekile ngisho nangokuncane, kungcono ukuhlela ezinye izindlela zokuthutha uze ukwazi ukuxoxa ngesimo nodokotela wakho.