Yini i-Dapagliflozin ne-Metformin: Ukusetshenziswa, Umthamo, Imiphumela Eceleni nokuningi

I-Dapagliflozin ne-metformin kuyinhlanganisela yemithi esiza ukuphatha isifo sikashukela sohlobo 2 ngokusebenza ngezindlela ezimbili ezihlukene zokwehlisa amazinga kashukela egazini. Le ndlela yokusebenza kabili ingasebenza kahle kakhulu kunokusebenzisa imithi eyodwa, ikunikeza ukulawula okungcono ngesifo sikashukela sakho ngokulula kokuthatha amaphilisi ambalwa nsuku zonke.

Yini i-Dapagliflozin ne-Metformin?

Le mithi ihlanganisa ukwelashwa okubili okufakazelwe kwesifo sikashukela kuthebhulethi eyodwa. I-Dapagliflozin ingeyeqembu lezidakamizwa elibizwa ngokuthi ama-SGLT2 inhibitors, kanti i-metformin ivela emndenini wezidakamizwa ze-biguanide.

Cabanga ngale nhlanganisela njengendlela yeqembu yokuphatha ushukela wakho wegazi. Isithako ngasinye sibhekana nenkinga ngendlela ehlukile, sisebenza ndawonye ukusiza umzimba wakho ukuthi uqhubeke ne-glucose ngempumelelo. Le nhlanganisela itholakala ngaphansi kwamagama emikhiqizo afana ne-Xigduo XR e-United States.

Udokotela wakho angase akubhalele le nhlanganisela uma i-metformin yodwa inganikezi ukulawulwa okwanele kashukela wegazi, noma uma udinga izinzuzo zazo zombili izidakamizwa kodwa ukhetha ukulula kwepilisi elilodwa.

Isetshenziselwani i-Dapagliflozin ne-Metformin?

Le nhlanganisela yemithi isetshenziselwa ikakhulukazi ukwelapha isifo sikashukela sohlobo 2 kubantu abadala. Isiza ukwehlisa amazinga kashukela egazini uma ukudla nokuzivivinya kuphela kunganele ukugcina amazinga e-glucose enempilo.

Umhlinzeki wakho wezempilo angase ancome le mithi uma usuvele uthatha i-metformin kodwa udinga ukulawulwa okwengeziwe kashukela wegazi. Iphinde ibhalwe uma ungenza inzuzo ezinzuzweni eziyingqayizivele ezinikezwa yi-dapagliflozin, njengokulahlekelwa isisindo okungenzeka nokuncishiswa kwengcindezi yegazi.

Ngaphandle kokuphathwa kashukela wegazi, abanye abantu bathola izinzuzo ezengeziwe njengokulahlekelwa isisindo esincane nokuncishiswa okuncane kwengcindezi yegazi. Kodwa-ke, le miphumela iyahlukahluka kumuntu nomuntu, futhi imithi akufanele isetshenziswe ngenjongo yokulahlekelwa isisindo kuphela.

Isebenza Kanjani I-Dapagliflozin ne-Metformin?

Le nhlanganisela isebenza ngezindlela ezimbili ezihlukene ezihambisana kahle. I-Metformin ngokuyinhloko isebenza esibindini sakho, inciphisa inani le-glucose esibindi sakho esikhiqizayo futhi isize imisipha yakho ukuthi isebenzise i-insulin ngempumelelo.

I-Dapagliflozin ithatha indlela ehluke ngokuphelele ngokusebenza ezinso zakho. Ivimba iphrotheni ebizwa nge-SGLT2 evame ukusiza izinso zakho ukuthi zimunce i-glucose emuva egazini lakho. Lapho le phrotheni ivalekile, i-glucose eyeqile ikhishwa ngomchamo wakho esikhundleni sokuhlala egazini lakho.

Lesi senzo esiphindwe kabili sisho ukuthi umzimba wakho ukhiqiza i-glucose encane ngenkathi futhi uqeda i-glucose eningi, okudala inhlanganisela enamandla yokulawula ushukela wegazi. Umuthi uthathwa njengomuthi oqinile futhi osebenzayo, ngokuvamile unikeza ngcono okukhulu emazingeni kashukela wegazi kungakapheli amasonto ambalwa ukuqala ukwelashwa.

Kufanele Ngiyithathe Kanjani I-Dapagliflozin ne-Metformin?

Thatha lo muthi ngendlela udokotela wakho ayala ngayo, ngokuvamile kanye ngosuku ngokudla kwakho kwasekuseni. Ukuwuthatha nokudla kusiza ukunciphisa isisu esibuhlungu, okungaba yinkinga nge-metformin, futhi kusiza umzimba wakho ukuthi umunce umuthi ngendlela efanele.

Gwinya ithebhulethi yonke ngengilazi yamanzi egcwele. Ungagxobi, ungaqhekezi, noma uhlafune amaphilisi akhishwe isikhathi eside, ngoba lokhu kungathinta indlela umuthi okhishwa ngayo emzimbeni wakho. Uma uthatha inguqulo ekhishwe isikhathi eside, ungase uqaphele igobolondo lethebhulethi elingenalutho esitulweni sakho, okuyinto evamile.

Ngaphambi kokuthatha umuthi wakho, yidla ukudla okulinganiselayo okuhlanganisa ama-carbohydrate athile. Lokhu kusiza ukuvimbela ushukela wakho wegazi ukuthi wehle kakhulu futhi kunciphisa ithuba lokucasuka kwesisu. Gwema ukuthatha umuthi ngesisu esingenalutho, ikakhulukazi uma uqala ukwelashwa.

Hlala uhlanzekile emini yonke ngokuphuza amanzi amaningi. Lokhu kubaluleke kakhulu ngoba i-dapagliflozin yandisa ukuchama, futhi ukuhlanza okufanele kusiza ekuvikeleni izinkinga ezinjengokuphelelwa amanzi emzimbeni noma izifo zomgudu womchamo.

Kufanele ngiyithathe isikhathi esingakanani i-Dapagliflozin ne-Metformin?

Lo muthi ngokuvamile ungumuthi wesikhathi eside wokuphatha isifo sikashukela sohlobo 2. Abantu abaningi baqhubeka bewuthatha uma nje usebenza kahle futhi wamukeleka kahle, okusho iminyaka eminingi noma unomphela.

Udokotela wakho uzoqapha ukuthi umzimba wakho usabela kanjani emuthini ngokuhlolwa kwegazi njalo, ngokuvamile ehlola amazinga akho e-A1C njalo ezinyangeni ezintathu kuya kweziyisithupha. Lokhu kuhlolwa kusiza ukunquma ukuthi umuthi usebenza ngempumelelo yini nokuthi ngabe kudingeka yini ukulungiswa komthamo.

Ungayeki ukuthatha lo muthi ngokuzumayo ngaphandle kokubonisana nomhlinzeki wakho wezempilo. Ukuyeka ngokuphazima kungabangela amazinga akho kashukela egazini ukuthi anyuke, okungaholela ezinkingeni ezingathi sína. Uma udinga ukuyeka umuthi, udokotela wakho uzokwenza uhlelo lokukudlulisa ekwelashweni okuhlukile ngokuphepha.

Yiziphi Imiphumela Eceleni ye-Dapagliflozin ne-Metformin?

Njengayo yonke imithi, le nhlanganisela ingabangela imiphumela emibi, yize abantu abaningi beyibekezelela kahle. Ukuqonda ukuthi okulindelekile kungakusiza ukuthi uzizwe uqiniseka ngokwengeziwe ngomuthi wakho futhi wazi ukuthi ungaxhumana nini nomhlinzeki wakho wezempilo.

Imiphumela emibi ejwayelekile ongase uyithole ihlanganisa:

• Ukuchama okwandayo nokoma (ngenxa yendlela i-dapagliflozin esebenza ngayo)
• Isicanucanu esincane noma isisu esicasukile, ikakhulukazi lapho kuqala ukwelashwa
• Ukuqunjelwa noma izitulo ezixekile (ngokuvamile zesikhashana futhi zithuthuka ngokuhamba kwesikhathi)
• Ukunambitheka kwensimbi emlonyeni wakho (kusuka ku-metformin)
• Izifo zomgudu womchamo (zivamile kwabesifazane)
• Izifo zemvubelo, ikakhulukazi kwabesifazane

Lezi zimo ezivamile ezithinta umzimba zivame ukuthuthuka njengoba umzimba wakho ujwayela imithi, ngokuvamile emasontweni ambalwa okuqala okwelashwa.

Imiphumela emibi engathi sína edinga ukunakekelwa kwezempilo ngokushesha ihlanganisa:

• Izimpawu ze-diabetic ketoacidosis (isicanucanu, ukuhlanza, ubuhlungu besisu, ubunzima bokuphefumula)
• Ukuphelelwa amanzi emzimbeni okukhulu (isiyezi, umlomo owomile, ukuncipha komchamo)
• Izinkinga zezinso (ukuqubuka, izinguquko emchamweni, ukukhathala)
• Izifo ezinzima zangasese (ukukhipha okungavamile, ukuluma okukhulu, ubuhlungu)
• I-lactic acidosis (ayivamile kodwa ingathi sína - ubuhlungu bemisipha, ubunzima bokuphefumula, ubuhlungu besisu)

Xhumana nomhlinzeki wakho wezempilo ngokushesha uma uhlangabezana nanoma yiziphi zalezi zimpawu ezingathi sína, njengoba zingase zidinge ukungenelela kwezokwelapha ngokushesha.

Abanye abantu bangase babe nemiphumela emibi engavamile kodwa engathi sína efana ne-Fournier's gangrene (isifo esibi sendawo yangasese) noma ukusabela okukhulu komzimba. Nakuba lokhu kungavamile, kubalulekile ukuqaphela izimpawu ezingavamile futhi ufune usizo lwezokwelapha uma unokukhathazeka.

Ubani Ongafanele Athathwe I-Dapagliflozin ne-Metformin?

Lo muthi awufaneleki kuwo wonke umuntu, futhi udokotela wakho uzohlola ngokucophelela ukuthi ulungele yini. Izimo ezithile zezempilo nezimo zenza le nhlanganisela ingaphephile noma ingafaneleki.

Akufanele uthathe lo muthi uma une:

• Uhlobo 1 lukashukela (umzimba wakho udinga i-insulin, hhayi ukuqedwa kwe-glucose)
• Isifo sezinso esibi (umuthi ungenza umsebenzi wezinso ube mubi)
• I-diabetic ketoacidosis (inkinga engathi sína edinga ukwelashwa ngokushesha)
• Ukungezwani okwaziwayo ne-dapagliflozin, metformin, noma yiziphi izithako emuthini
• Isifo sesibindi esibi (sithinta indlela umzimba wakho osebenzisa ngayo i-metformin)
• Ukuhluleka kwenhliziyo okudinga ukulaliswa esibhedlela (kungase kwandise ingozi yezinkinga)

Udktela wakho uzosebenzisa ukuqapha uma unezimo ezenyusa ingozi yakho yezinkinga, njengokutheleleka kwamathumbu okuvame ukwenzeka, umlando wokucindezelwa kwegazi eliphansi, noma uma usumdala futhi unengozi enkulu yokuphelelwa amanzi emzimbeni.

Izimo ezithile zidinga ukuyekiswa okwesikhashana komuthi, njengaphambi kokuhlinzwa, ngesikhathi sokugula ngomkhuhlane nokuphelelwa amanzi emzimbeni, noma uma udinga umbala wokwenza izithombe zezokwelapha.

Amagama Omkhiqizo we-Dapagliflozin kanye ne-Metformin

Lo muthi ohlanganisiwe uyatholakala ngaphansi kwamagama amaningi omkhiqizo, i-Xigduo XR iyilena evame ukunqunywa e-United States. Elithi "XR" limele ukukhishwa okweluliwe, okusho ukuthi umuthi ulungiselelwe ukukhishwa kancane usuku lonke.

Amanye amagama omkhiqizo angase atholakale emazweni ahlukene, futhi izinguqulo ezivamile zalolu hlobo oluhlanganisiwe zingase zitholakale ngokuhamba kwesikhathi. Umkhemisi wakho angakusiza ukuthi uqonde ukuthi yiluphi uhlobo olutholayo nokuthi ngabe yinguqulo yokukhishwa ngokushesha noma yokukhishwa okweluliwe.

Njalo hlola nodokotela wakho noma umkhemisi ngaphambi kokushintsha phakathi kwamagama omkhiqizo noma izinguqulo ezivamile, njengoba izinhlobo ezihlukene zingase zibe nokuhlukahluka okuncane kwemithamo noma izidingo zesikhathi.

Ezinye izindlela ze-Dapagliflozin kanye ne-Metformin

Uma le nhlanganisela ingakulungele, ezinye izindlela ezingasiza ukuphatha isifo sakho sikashukela sohlobo 2 ngempumelelo. Udokotela wakho angase acabangele eminye imithi ehlanganisiwe noma alungise uhlelo lwakho lokwelashwa ngokusekelwe ezidingweni zakho ezithile kanye nezimo zempilo.

Imithi ehlanganisiwe enye ihlanganisa i-empagliflozin nge-metformin (Synjardy), i-canagliflozin nge-metformin (Invokamet), noma i-sitagliptin nge-metformin (Janumet). Inhlanganisela ngayinye inezinzuzo ezihlukene kancane kanye namaphrofayili emiphumela emibi.

Umhlinzeki wakho wokunakekelwa kwezempilo angase futhi ancome ukuthatha imithi ngokuhlukana, esebenzisa i-metformin yodwa ngomunye umuthi wesifo sikashukela, noma ukuhlola amanye amakilasi ahlukene emithi yesifo sikashukela afana ne-GLP-1 receptor agonists noma i-insulin uma kudingeka.

Ukukhetha okunye kuncike ezimweni zakho, okuhlanganisa ukusebenza kwezinso zakho, impilo yenhliziyo, imigomo yokulawula isisindo, nokuthi uyibekezelela kangakanani imithi ehlukene.

Ingabe i-Dapagliflozin ne-Metformin Ingcono Kune-Metformin Yodwa?

Kubantu abaningi abanesifo sikashukela sohlobo 2, inhlanganisela ye-dapagliflozin ne-metformin inikeza ukulawulwa okungcono ushukela wegazi kune-metformin yodwa. Izifundo zibonisa ukuthi ukwengeza i-dapagliflozin ku-metformin ngokuvamile kuholela ekunciphiseni okwengeziwe kwe-A1C ngamaphuzu angama-0.5 kuya ku-1.0 ekhulwini.

Inhlanganisela inikeza izinzuzo ezingaphezu kokulawulwa ushukela wegazi okungeke kunikezwe yi-metformin yodwa. Lokhu kufaka phakathi ukulahlekelwa isisindo okungenzeka (ngokuvamile amakhilogremu ama-2-5), ukuncipha okuncane komfutho wegazi, kanye nezinzuzo zenhliziyo nemithambo yegazi ezingase zibe khona abacwaningi basazifunda.

Nokho, inhlanganisela iza nemiphumela emibi eyengeziwe nezindleko ezinganayo i-metformin yodwa. Ukwanda kokuchama, ingozi enkulu yokutheleleka ngamathumbu omchamo, kanye nokwenzeka kokuphelelwa amanzi emzimbeni kuqondene nengxenye ye-dapagliflozin.

Udokotela wakho uzohlola lezi zinzuzo nezingozi ngokusekelwe esimweni sakho, ukulawulwa kwamanje ushukela wegazi, nemigomo yonke yezempilo ukuze anqume ukuthi inhlanganisela ifanele yini ukuzama icala lakho elithile.

Imibuzo Evame Ukubuzwa Mayelana ne-Dapagliflozin ne-Metformin

Ingabe i-Dapagliflozin ne-Metformin Iphephile Esimeni Senhliziyo?

Le nhlanganisela ingaba usizo ngempela kubantu abanezinhlobo ezithile zesifo senhliziyo. Izifundo zikhomba ukuthi ama-SGLT2 inhibitors afana ne-dapagliflozin angasiza ekunciphiseni ingozi yokulaliswa esibhedlela ngenxa yokuhluleka kwenhliziyo kanye nokufa kwenhliziyo nemithambo yegazi kubantu abanesifo sikashukela sohlobo 2.

Kodwa-ke, uma unomlando wokuhluleka kwenhliziyo, udokotela wakho uzokuqapha ngokucophelela lapho uqala lo muthi. Ezimweni ezingavamile, abanye abantu bangase bahlangabezane nezimpawu zokwanda kokuhluleka kwenhliziyo, ngakho-ke ukuqokwa okuvamile kokulandela kubalulekile ukuqinisekisa ukuthi umuthi uyasiza kunokulimaza impilo yenhliziyo yakho.

Kufanele ngenzeni uma ngisebenzisa ngengozi i-Dapagliflozin ne-Metformin eningi kakhulu?

Uma ngengozi uthatha ngaphezu komthamo wakho obekiwe, xhumana nomhlinzeki wakho wezempilo noma isikhungo sokulawula ubuthi ngokushesha. Ukuthatha okuningi kungakhuphula ingozi yakho yemiphumela emibi engathi sína efana ne-lactic acidosis evela engxenyeni ye-metformin noma ukoma okukhulu okuvela ku-dapagliflozin.

Qaphela izimpawu ezinjengokugula okukhulu, ukuhlanza, ubuhlungu besisu, ubunzima bokuphefumula, ukozela okungavamile, noma izimpawu zokoma okukhulu. Ungalindi ukuthi izimpawu zivele ngaphambi kokufuna usizo, njengoba ezinye izinkinga zingase zithuthuke ngokushesha futhi zidinga ukunakekelwa kwezempilo ngokushesha.

Kufanele ngenzeni uma ngiphuthelwa umthamo we-Dapagliflozin ne-Metformin?

Uma uphuthelwa umthamo, wuthatha ngokushesha lapho ukhumbula, kodwa kuphela uma kusekuseni futhi ungawuthatha nokudla. Uma sekusihlwa noma kusihlwa, weqa umthamo ophuthelwe bese uthatha umthamo wakho olandelayo ngesikhathi esivamile ekuseni ngakusasa.

Ungalokothi uthathe imithamo emibili ngesikhathi esisodwa ukuze ulungise umthamo ophuthelwe, ngoba lokhu kungakhuphula ingozi yakho yemiphumela emibi. Uma uvame ukukhohlwa imithamo, cabangela ukusetha i-alamu yansuku zonke noma usebenzise umhleli wamaphilisi ukukusiza ukuthi ukhumbule umkhuba wakho wemithi.

Ngingayeka nini ukuthatha i-Dapagliflozin ne-Metformin?

Yeka kuphela ukuthatha lo muthi ngaphansi kwesiqondiso sikadokotela wakho. Noma ngabe amazinga akho kashukela egazi ethuthuka kakhulu, ukuyeka umuthi kungazelelwe cishe kuzobangela ukuthi amazinga akho aphinde anyuke, njengoba isifo sikashukela sohlobo 2 siyisimo esingamahlalakhona esidinga ukuphathwa okuqhubekayo.

Udktela wakho angase acabange ukunciphisa umthamo wakho noma ashintshele emuthini ohlukile uma uhlangabezana nemiphumela emibi ebalulekile, uma ukusebenza kwezinso zakho kushintsha, noma uma ukuphathwa kwesifo sikashukela sakho kudinga ukuguquka ngokuhamba kwesikhathi. Noma yiziphi izinguquko emithini yakho yesifo sikashukela kufanele ngaso sonke isikhathi zibe yingxenye yamasu okwelapha ahlelwe ngokucophelela.

Ngingakwazi yini ukuphuza utshwala ngenkathi ngithatha i-Dapagliflozin ne-Metformin?

Ungaphuza utshwala ngokulinganisela ngenkathi uthatha lo muthi, kodwa udinga ukuqapha kakhulu ushukela wakho wegazi futhi uhlale unamanzi. Utshwala bungakhuphula ingozi ye-lactic acidosis uma ihlanganiswe ne-metformin, ikakhulukazi uma uphuza kakhulu noma ungadli njalo.

Nciphisa ukusetshenziswa kotshwala kungabi ngaphezu kwesisodwa ngosuku kwabesifazane kanye neziphuzo ezimbili ngosuku kwabesilisa, futhi ngaso sonke isikhathi uphuze nokudla ukusiza ukuvimbela ushukela ophansi wegazi. Uma unomlando wokuhlukunyezwa kotshwala noma izinkinga zesibindi, xoxa ngokusebenzisa utshwala nomhlinzeki wakho wezempilo, njengoba kungase kube ngcono ukukugwema ngokuphelele.