Yini i-Dasabuvir-Ombitasvir-Paritaprevir-and-Ritonavir: Ukusetshenziswa, Umthamo, Imiphumela Eceleni nokuningi

I-Dasabuvir-ombitasvir-paritaprevir-and-ritonavir iyinhlanganisela yemithi esetshenziselwa ukwelapha ukutheleleka okungamahlalakhona ngegciwane le-hepatitis C (HCV). Le nhlanganisela enamandla yemithi emine isebenza ndawonye ukuvimbela igciwane le-hepatitis C ukuthi lingaphindaphani emzimbeni wakho, inikeze amasosha akho omzimba ithuba lokususa ukutheleleka ngokuphelele.

Ungase uyazi le mithi ngegama layo lomkhiqizo elithi Viekira Pak, eliqukethe yonke imithi emine ephusheni elilodwa lokwelashwa. Le nhlanganisela imelela ukuqhubeka okukhulu ekwelashweni kwe-hepatitis C, inikeza amazinga aphezulu okuphulukiswa ngemiphumela emincane eceleni kunokwelashwa okudala.

Yini i-Dasabuvir-Ombitasvir-Paritaprevir-and-Ritonavir?

Le mithi ihlanganisa imithi emine ehlukene elwa namagciwane ngalinye eliqondise igciwane le-hepatitis C ngezindlela ezihlukile. Cabanga ngayo njengendlela yeqembu elihleliwe lapho imithi ngayinye inomsebenzi othile wokuvimbela igciwane ukuthi lingasindi futhi liphindaphane.

I-Dasabuvir ivimba i-enzyme ebizwa nge-NS5B polymerase edingwa igciwane ukuze lizikopishe. I-Ombitasvir iqondise enye iphrotheni yegciwane ebizwa nge-NS5A esiza igciwane ukuthi lihlangane nezinhlayiya ezintsha. I-Paritaprevir ivimbela i-NS3/4A protease, esetshenziswa igciwane ukucubungula amaphrotheni alo ngendlela efanele.

I-Ritonavir ayilwi ngokuqondile negciwane le-hepatitis C kodwa isebenza njenge-booster. Yehlisa ngokushesha isibindi sakho siqeda i-paritaprevir, sigcina amazinga aphezulu emithi esebenzayo ohlelweni lwakho isikhathi eside.

Isetshenziselwa Ukuthini i-Dasabuvir-Ombitasvir-Paritaprevir-and-Ritonavir?

Le nhlanganisela yemithi iphatha ukutheleleka okungamahlalakhona nge-hepatitis C, ikakhulukazi i-genotype 1, okuyiluphi uhlobo oluvamile lwe-hepatitis C e-United States. Udokotela wakho uzohlola igazi lakho ukuze anqume ukuthi yiluphi uhlobo olunalo ngaphambi kokubhala lo muthi.

Umuthi usebenza kubantu abane noma ngaphandle kwe-cirrhosis, isimo lapho izicubu ezinamathambo zithatha indawo yezicubu zesibindi ezinempilo. Kodwa-ke, kufaneleka kuphela kubantu abane-cirrhosis ekhokhelwayo, okusho ukuthi isibindi sakho sisebenza kahle naphezu kokulimala.

Ngezinye izikhathi odokotela banikeza le nhlanganisela kanye ne-ribavirin, omunye umuthi oqeda amagciwane, kuye ngesimo sakho esithile. Umhlinzeki wakho wezempilo uzonquma uhlelo olungcono kakhulu lokwelapha olususelwe esimweni sesibindi sakho, ukwelashwa kwangaphambilini, nempilo yonke.

Isebenza Kanjani I-Dasabuvir-Ombitasvir-Paritaprevir-and-Ritonavir?

Lo muthi uthathwa njengokwelashwa okuqinile nokusebenza kahle kwe-hepatitis C. Usebenza ngokugxila ezindaweni eziningi emjikelezweni wokuphila wegciwane, okwenza kube nzima kakhulu ukuthi igciwane lisinde noma lithuthukise ukumelana.

Isici ngasinye sihlasela igciwane ngendlela ehlukile, sidale lokho odokotela abakubiza ngokuthi

I-Viekira Pak iqukethe amaphilisi anemibala ehlukene ozowathatha ndawonye. Thatha wonke amaphilisi ngesikhathi esisodwa, uwagwinye wonke ngamanzi. Ungawachobozi, uwahlafune, noma uwaphule amaphilisi ngoba lokhu kungathinta indlela umuthi okhishwa ngayo emzimbeni wakho.

Zama ukuthatha imithamo yakho ngezikhathi ezifanayo nsuku zonke ukuze ugcine amazinga aqhubekayo omuthi ohlelweni lwakho. Ukusetha ama-alamu ocingweni kungakusiza ukuthi ukhumbule, ikakhulukazi emasontweni ambalwa okuqala okwelashwa.

Kufanele Ngithathe Isikhathi Esingakanani I-Dasabuvir-Ombitasvir-Paritaprevir-and-Ritonavir?

Abantu abaningi bathatha lo muthi amasonto angu-12, nakuba abanye bengase badinge amasonto angu-24 kuye ngesimo sabo esithile. Udokotela wakho uzoqoka ubude obufanele ngokuya ngohlobo lwakho lwe-genotype, isimo sesibindi sakho, kanye nomlando wokwelashwa kwangaphambilini.

Abantu abangakaze belashwe i-hepatitis C ngaphambili ngokuvamile badinga amasonto angu-12 okwelashwa. Labo abaye bazama ezinye izindlela zokwelapha ezingasebenzanga, noma abanezinhlobo ezithile zokulimala kwesibindi, bangase badinge inkambo ende yamasonto angu-24.

Kubalulekile ukuqeda inkambo ephelele yokwelashwa ngisho noma uqala ukuzizwa ungcono. Ukuyeka ngaphambi kwesikhathi kungavumela igciwane ukuthi libuye futhi libe nokumelana nemithi, okwenza ukwelashwa okuzayo kube nzima.

Yiziphi Imiphumela Eceleni Ye-Dasabuvir-Ombitasvir-Paritaprevir-and-Ritonavir?

Abantu abaningi bawuthatha kahle lo muthi, nemiphumela emibi ngokuvamile iba milde kuya phakathi nendawo. Imiphumela emibi evame kakhulu ihlanganisa ukukhathala, isicanucanu, ukulala kahle, kanye nekhanda.

Nawa amanye amiphumela emibi ongase uyithole ngesikhathi sokwelashwa:

• Ukukhathala nokuzizwa ukhathele kunokujwayelekile
• Isicanucanu futhi ngezinye izikhathi ukuhlanza
• Ikhanda
• Ubunzima bokulala noma ukuqwasha
• Ukuqunjelwa
• Ukuqina kwesikhumba
• Ukuqaqamba kwemisipha
• Ukucasuka noma izinguquko zemizwa

Lezi zimpawu zivame ukuthuthuka njengoba umzimba wakho ujwayela imithi emasontweni ambalwa okuqala. Abantu abaningi bathola ukuthi bangaqhubeka nemisebenzi yabo ejwayelekile ngenkathi bethatha lokhu kwelashwa.

Kunezinye izimo ezingavamile kodwa ezinzima kakhulu ezingase zidinge ukunakekelwa kwezempilo ngokushesha. Lokhu kufaka phakathi ukukhathala okukhulu, ukuphuzi kwesikhumba sakho noma amehlo, umchamo omnyama, noma ukuphuma kwegazi okungavamile noma ukulimala.

Ngokungavamile kakhulu, abanye abantu bangase babe nokusabela okukhulu kwesikhumba, izinguquko ezinkulu zemizwa, noma izimpawu zezinkinga zesibindi ezingaphezu kwalokho obekulindelekile ekuthelelekeni nge-hepatitis C ngokwayo. Xhumana nodokotela wakho ngokushesha uma ubona noma yiziphi izimpawu ezikhathazayo.

Ubani Ongafanele Athole I-Dasabuvir-Ombitasvir-Paritaprevir-and-Ritonavir?

Lo muthi awulungelwe wonke umuntu one-hepatitis C. Abantu abanezinkinga zesibindi eziphakathi nendawo kuya kwezinkulu, ezaziwa ngokuthi i-decompensated cirrhosis, akufanele bathathe le nhlanganisela ngoba ingenza umsebenzi wesibindi ube mubi.

Kufanele ukugweme lokhu kwelashwa uma unokungezwani komzimba kunoma iyiphi yezingxenye ezine. Abantu abathatha imithi ethile esebenzisana ngendlela eyingozi nale mithi nabo abakwazi ukusebenzisa le nhlanganisela ngokuphepha.

Nazi izimo ezithile lapho lo muthi unganconyelwe khona:

• Isifo sesibindi esiphakathi nendawo kuya kwesikhulu (Ikilasi le-Child-Pugh B noma C)
• Ukungezwani komzimba okwaziwayo kunoma iyiphi ingxenye yomuthi
• Ukuthatha imithi ethile esebenzisana ngendlela eyingozi
• Ukukhulelwa noma ukuhlela ukukhulelwa
• Omama abancelisa
• Izinhlobo ezithile ze-hepatitis C genotypes ngaphandle kwe-genotype 1

Udokotela wakho uzobuyekeza umlando wakho wezokwelapha ophelele kanye nemithi yamanje ngaphambi kokukuyalela lokhu kwelashwa ukuze aqinisekise ukuthi kuphephile kuwe.

Amagama Omkhiqizo we-Dasabuvir-Ombitasvir-Paritaprevir-and-Ritonavir

Igama eliyinhloko lomkhiqizo lale nhlanganisela yemithi emine yi-Viekira Pak, ekhiqizwa yi-AbbVie. Le phakheji yomkhiqizo iqukethe yonke imithi emine ngemithamo yayo efanele ukuze kube lula ukuyisebenzisa.

Emazweni athile, ungase ukubone kuthengiswa ngamanye amagama, kodwa i-Viekira Pak isahlala iyigama lomkhiqizo elaziwa kakhulu. Umuthi ngezinye izikhathi ubizwa nangokuthi igama lawo elifushanisiwe elithi "3D" kanye ne-ritonavir emibhalweni yezokwelapha.

Izinhlobo ezivamile zalolu hlobo oluqondile lwemithi emine azitholakali kabanzi okwamanje, nakuba izingxenye ngazinye zingase zitholakale ngokuhlukana ngezinhlobo ezivamile kwezinye izifunda.

Ezinye izindlela ze-Dasabuvir-Ombitasvir-Paritaprevir-and-Ritonavir

Ezinye izindlela zokwelapha i-hepatitis C eziphumelela kakhulu ziyatholakala uma le nhlanganisela ingakulungeli. Imithi emisha efana ne-sofosbuvir-velpatasvir (Epclusa) isebenza ngokumelene nazo zonke izinhlobo ze-hepatitis C.

Ezinye izindlela zihlanganisa i-glecaprevir-pibrentasvir (Mavyret), nayo ephatha zonke izinhlobo ze-hepatitis C futhi inokuxhumana okuncane kwemithi. Izinhlanganisela ezisekelwe ku-sofosbuvir njenge-Harvoni (sofosbuvir-ledipasvir) zinikeza enye inketho enhle kakhulu.

Udokotela wakho uzokusiza ukhethe inketho engcono kakhulu ngokusekelwe ohlotsheni lwakho oluthile, isimo sesibindi sakho, eminye imithi oyithathayo, kanye nomshwalense wakho. Zonke lezi zindlela zokwelapha zesimanje zinamazinga okuphulukisa aphezulu ngokufanayo.

Ingabe i-Dasabuvir-Ombitasvir-Paritaprevir-and-Ritonavir ingcono kune-Sofosbuvir-Ledipasvir?

Yomibili le mithi iphumelela kakhulu ekwelapheni i-hepatitis C genotype 1, ngamazinga okuphulukisa angaphezu kuka-95%. Ukukhetha phakathi kwazo kuvame ukwehla esimweni sakho esithile kunokuthi enye ibe ngcono ngokucacile kunenye.

I-Sofosbuvir-ledipasvir (Harvoni) inokuxhumana okuncane kwemithi futhi kungase kube lula ukuyithatha kubantu abathatha imithi eminingi. Iphinde ithathwe njithebhulethi eyodwa kanye ngosuku, okuthile abanye abantu bakuthola kulula kunokulinganisa kabili ngosuku kwe-Viekira Pak.

Noma kunjalo, i-Viekira Pak ingase ithandwe kubantu abake bazama ukwelashwa okusekelwe ku-sofosbuvir ngaphambili, noma ezimweni lapho izindleko zikwenza kube lula ukufinyelela. Zombili lezi zindlela zokwelapha zinezinhlobo ezifanayo zemiphumela emibi nokusebenza kahle.

Udokotela wakho uzocabangela izinto ezinjengeminye imithi yakho, ukusebenza kwezinso, umshwalense, nezintandokazi zakho siqu lapho ekusiza ukuthi ukhethe phakathi kwalezi zinketho ezinhle kakhulu.

Imibuzo Evame Ukubuzwa Mayelana ne-Dasabuvir-Ombitasvir-Paritaprevir-and-Ritonavir

Ingabe i-Dasabuvir-Ombitasvir-Paritaprevir-and-Ritonavir iphephile kubantu abanezifo zezinso?

Lo muthi ngokuvamile uphephile kubantu abanezinkinga zezinso eziphakathi nendawo, njengoba imithi icutshungulwa ikakhulukazi yisibindi sakho kunokuba izinso zakho. Noma kunjalo, udokotela wakho uzoqapha ukusebenza kwezinso zakho ngesikhathi sokwelashwa.

Abantu abanezifo ezinzima zezinso noma labo abakwi-dialysis bangase badinge ukulungiswa kwemithamo noma ezinye izindlela zokwelapha. Umhlinzeki wakho wokunakekelwa kwezempilo uzohlola ukusebenza kwezinso zakho ngezivivinyo zegazi ngaphambi nangemva kokwelashwa ukuze aqinisekise ukuphepha.

Ngingenzani uma ngiphuthelwa ngengozi ukuthatha i-Dasabuvir-Ombitasvir-Paritaprevir-and-Ritonavir eningi kakhulu?

Uma ngengozi uthatha okungaphezu komthamo wakho obekiwe, xhumana nodokotela wakho noma isikhungo sokulawula ubuthi ngokushesha. Ngenkathi ukweqisa okukhulu kungavamile, ukuthatha okuningi kakhulu kungakhuphula ingozi yakho yemiphumela emibi.

Ungazami ukwenza umthamo owengeziwe ngokuqaqa umthamo wakho olandelayo ohleliwe. Kunalokho, buyela esimisweni sakho esijwayelekile sokulinganisa futhi wazise umhlinzeki wakho wokunakekelwa kwezempilo ukuthi kwenzekeni ukuze bakwazi ukukuqapha ngendlela efanele.

Ngingenzani uma ngiphuthelwa umthamo we-Dasabuvir-Ombitasvir-Paritaprevir-and-Ritonavir?

Uma uphuthelwa umthamo futhi kungaphakathi kwamahora angu-12 ukusuka ngesikhathi okufanele ngabe uwuthathile ngaso, thatha umthamo ophuthelwe ngokushesha nje ngokudla. Uma sekudlule amahora angaphezu kwangu-12, weqa umthamo ophuthelwe bese uthatha umthamo wakho olandelayo ohleliwe.

Ungalokothi uthathe imithamo emibili ngesikhathi esisodwa ukuze ubuyisele umthamo owuphuthelwe, ngoba lokhu kungakhuphula ingozi yakho yemiphumela emibi. Zama ukugcina isimiso esiqhubekayo ngangokunokwenzeka, kodwa ungakhathazeki uma ngezinye izikhathi uphuthelwa umthamo.

Ngingayeka nini ukuthatha i-Dasabuvir-Ombitasvir-Paritaprevir-and-Ritonavir?

Yeka kuphela ukuthatha lo muthi uma udokotela wakho ekutshela ukuthi wenze njalo, ngokuvamile ngemva kokuqeda inkambo yakho ephelele ebekiwe yamasonto angu-12 noma angu-24. Ukuyeka ngaphambi kwesikhathi kungavumela igciwane le-hepatitis C ukuthi libuye futhi mhlawumbe likhule ukumelana.

Udokotela wakho uzoqhuba ukuhlolwa kwegazi ngesikhathi nangemva kokwelashwa ukuze aqaphele ukuthi umuthi usebenza kahle kangakanani. Noma ngabe uzizwa ungcono ngokuphelele, kubalulekile ukuqeda inkambo ephelele ukuze kuqinisekiswe ukuthi igciwane liqedwe ngokuphelele.

Ngingakwazi yini ukuphuza utshwala ngenkathi ngithatha lo muthi?

Kungcono ukugwema utshwala ngokuphelele ngenkathi uthatha lo muthi kanye nezinyanga eziningana ngemva kokwelashwa. Utshwala bungasebenzisa kabi isibindi futhi buphazamise ikhono lesibindi sakho lokwelapha ukutheleleka kwe-hepatitis C.

Njengoba lo muthi ngezinye izikhathi ungabangela imiphumela emibi ehlobene nesibindi, ukwengeza utshwala kwandisa ingozi yezinkinga. Udokotela wakho uzokweluleka ngokuthi kungaba nini kuphephile ukuphuza utshwala futhi ngemva kokuqeda ukwelashwa.