Yini i-Digoxin: Ukusetshenziswa, Umthamo, Imiphumela Eceleni Nokunye

I-Digoxin iyikhambi lenhliziyo elisiza ukuqinisa ukushaya kwenhliziyo yakho nokulawula ukushaya kwenhliziyo okungajwayelekile. Itholakala esitshalweni se-foxglove futhi isetshenziswe ngokuphepha amashumi eminyaka ukwelapha izimo ezihlukahlukene zenhliziyo lapho ezinye izindlela zokwelapha zinganele.

Uma inikezwa ngemithambo yemisipha (umjovo wemisipha) noma imithambo (IV), i-digoxin isebenza ngokushesha kunezindlela zokuthatha ngomlomo. Lezi zindlela zokujova zivame ukusetshenziswa ezibhedlela uma udinga ukulawulwa kokushaya kwenhliziyo okusheshayo noma ungenakuthatha imithi ngomlomo.

Isetshenziselwani i-Digoxin?

Umjovo we-Digoxin ngokuyinhloko welapha izimo ezimbili eziyinhloko zenhliziyo: ukuhluleka kwenhliziyo kanye ne-atrial fibrillation. Udokotela wakho angase ancome lo muthi uma inhliziyo yakho idinga ukusekelwa okwengeziwe ukuze ipompe igazi ngempumelelo noma uma ukushaya kwenhliziyo yakho kungajwayelekile ngendlela eyingozi.

Ngokuhluleka kwenhliziyo, i-digoxin isiza imisipha yenhliziyo yakho ukuthi ishintshe ngamandla. Lokhu kusho ukuthi inhliziyo yakho ingapompa igazi eliningi ngokuphuma ngakunye, okunciphisa izimpawu ezinjengokuphefumula kanzima, ukuvuvukala emilenzeni yakho, nokukhathala okwenza imisebenzi yansuku zonke ibe yinselele.

Lapho welapha i-atrial fibrillation, i-digoxin yehlisa izinga lokushaya kwenhliziyo yakho libe ngendlela elawulekayo. I-Atrial fibrillation ibangela ukuthi amagumbi aphezulu enhliziyo yakho ashaye ngendlela engahlelekile, futhi i-digoxin isiza ukubuyisela isigqi esizinzile umzimba wakho ongasebenza ngaso ngempumelelo.

Ezimweni eziphuthumayo, i-digoxin ejovwayo ingasindisa ukuphila lapho othile enezinkinga ezinzima zokushaya kwenhliziyo. Amaqembu ase-Hospital ayisebenzisa lapho isenzo esisheshayo sidingeka ukuze kuzinziswe ukushaya kwenhliziyo okuyingozi okungaholela ezinkingeni ezinzima.

Ngokuvamile, imijovo ye-digoxin ingase isetshenziswe kwezinye izifo zokushaya kwenhliziyo ezinjenge-atrial flutter noma i-supraventricular tachycardia. Udokotela wakho wenhliziyo uzonquma ukuthi i-digoxin iyona yini ekufanele ngokuya ngesimo sakho senhliziyo esithile kanye nesimo sempilo yakho esiphelele.

Isebenza Kanjani i-Digoxin?

I-Digoxin ithathwa njengomuthi wenhliziyo olungileyo osebenza ngokushintsha indlela amangqamuzana enhliziyo yakho abhekana ngayo ne-calcium ne-sodium. Ivimba ipompo elithile emangqamuzaneni emisipha yenhliziyo yakho, okugcina kwenza inhliziyo yakho ishintshe ngamandla nangokuqina.

Cabanga ngenhliziyo yakho njengemisipha edinga izimpawu zikagesi ezifanele ukuze isebenze kahle. I-Digoxin ilungisa kahle lezi zimpawu ngokuthinta ipompo le-sodium-potassium, elilawula indlela amangqamuzana emisipha yenhliziyo yakho ashintsha ngayo futhi aphumule.

Lo muthi futhi uthinta imizwa yakho ye-vagus, efana nesistimu yamabhuleki emvelo enhliziyo yakho. Ngokuvuselela le mizwa, i-digoxin isiza ukunciphisa izinga lokushaya kwenhliziyo yakho, inikeze inhliziyo yakho isikhathi esiningi sokugcwaliswa ngegazi phakathi kokushaya.

Ngokungafani neminye imithi yenhliziyo esebenza ngemizuzu, i-digoxin yakha ohlelweni lwakho ngokuhamba kwesikhathi. Ifomu elijovwayo liqala ukusebenza phakathi kwemizuzu engama-30 kuya emahoreni amabili, kodwa kungathatha izinsuku eziningana ukufinyelela emiphumeleni yayo ephelele emzimbeni wakho.

Kufanele Ngizithathe Kanjani Izijovo ze-Digoxin?

Izijovo ze-Digoxin zihlala zinikezwa ochwepheshe bezempilo abaqeqeshiwe ezindaweni zezokwelapha njengezibhedlela noma imitholampilo. Ngeke kudingeke ukhathazeke ngokuzijova wena lezi zijovo ekhaya, njengoba zidinga ukuqapha ngokucophelela nokulinganisa okunembile.

Ukuze kulawulwe ngomthambo, umuthi uqondiswa ngqo emgudwini wakho wegazi ngomugqa we-IV. Ithimba lezempilo lizowujova kancane kancane ngemizuzu embalwa ukuvimbela izinguquko ezingazelelwe esigqi senhliziyo yakho ezingaba yingozi.

Izijovo ze-Intramuscular ziya emsipheni omkhulu, ngokuvamile engalweni yakho engenhla noma ethangeni. Le ndlela ayivamile kodwa ingasetshenziswa lapho ukufinyelela kwe-IV kunzima noma lapho izinga lokumuncwa elincane kancane lithandwa.

Ngaphambi kokuthola i-digoxin, ithimba lakho lezokwelapha lizohlola ukusebenza kwezinso zakho namazinga e-electrolyte. Lezi zinto zithinta indlela umzimba wakho oqhubula ngayo umuthi, futhi ukulungiswa kungase kudingeke ukuze kuqinisekiswe ukuphepha kwakho.

Akudingeki ukuthi ugweme ukudla noma iziphuzo ngaphambi kokuthola imijovo ye-digoxin. Kodwa-ke, ukugcina imikhuba yokudla eqhubekayo kusiza umzimba wakho ukuthi usebenzise imithi ngendlela elindelekile uma ushintshela ezinhlotsheni zomlomo.

Kufanele Ngiyithathe Isikhathi Esingakanani I-Digoxin?

Ubude bokwelashwa nge-digoxin buhluka kakhulu kuye ngesimo senhliziyo yakho esithile nokuthi usabela kanjani emuthini. Abanye abantu bayayidinga amasonto ambalwa ngesikhathi sokuhlaselwa yinhliziyo, kanti abanye bangase badinge ukwelashwa isikhathi eside ngezimo ezingapheli.

Ngenhliziyo ekhukhumele noma izinkinga zesigqi, ungase uthole imijovo ye-digoxin izinsuku ezimbalwa nje esibhedlela. Uma isimo sakho sizinzile, udokotela wakho cishe uzokushintshela ku-digoxin yomlomo noma eminye imithi yenhliziyo ongayithatha ekhaya.

Uma une-atrial fibrillation engapheli, ungase udinge i-digoxin izinyanga noma iminyaka. Udokotela wakho wenhliziyo uzoqapha njalo ukusebenza kwenhliziyo yakho namazinga egazi ukuze aqinisekise ukuthi imithi iyaqhubeka nokusiza ngaphandle kokubangela izinkinga.

Udokotela wakho ngeke ayeke i-digoxin ngokuzumayo, ikakhulukazi uma ube uyithatha isikhathi eside. Bazokwehlisa kancane kancane umthamo wakho ngenkathi beqapha inhliziyo yakho ukuze bavimbele noma yimiphi imiphumela yokubuyela emuva engase yenze isimo sakho sibe sibi.

Yiziphi Imiphumela Eceleni Ye-Digoxin?

Imiphumela ejwayelekile ye-digoxin ngokuvamile imnene futhi iyalawuleka, nakuba kubalulekile ukuyiqaphela. Abantu abaningi baba nezinkinga ezimbalwa uma imithi inikezwa ngendlela efanele futhi iqashwe kahle.

Imiphumela evame kakhulu ongase uyibone ihlanganisa isicanucanu, ukulahlekelwa isifiso sokudla, nokuzizwa ungaphilile. Lezi zimpawu zivame ukwenzeka lapho amazinga e-digoxin egazini lakho eba phezulu kakhulu, yingakho ukuhlolwa kwegazi okuvamile kubalulekile.

Nansi imiphumela ejwayelekile eceleni ethinta abantu abaningi abathatha i-digoxin:

• Ukugula nokuhlanza
• Ukulahlekelwa isifiso sokudla
• Ukuphuma isifo sohudo
• Ukuqaqamba kwekhanda
• Isiyezi
• Ukukhathala noma ubuthakathaka
• Ukubona okungacacile noma okushintshe umbala kube ophuzi

Lezi zimpawu zivame ukuthuthuka njengoba umzimba wakho ujwayela umuthi noma lapho umthamo wakho ulungiswa kahle. Ithimba lakho lezempilo lizosebenza nawe ukuthola ibhalansi efanele phakathi kokusebenza kahle nokunethezeka.

Imiphumela emibi engathi sína ayivamile kodwa idinga ukunakekelwa kwezempilo ngokushesha. Lokhu kuvame ukwenzeka lapho amazinga e-digoxin eba phezulu kakhulu egazini lakho, isimo esibizwa ngokuthi i-digoxin toxicity.

Imiphumela emibi engathi sína edinga ukunakekelwa kwezempilo okuphuthumayo ihlanganisa:

• Ukugula okukhulu nokuhlanza
• Ukudideka noma izinguquko zengqondo
• Ukushaya kwenhliziyo okungajwayelekile noma ukushaya kwenhliziyo okusheshayo
• Isiyezi esikhulu noma ukuquleka
• Ubuhlungu besifuba
• Ukuphazamiseka okukhulu kokubona

Uma uhlangabezana nanoma yiziphi zalezi zimpawu, xhumana nomhlinzeki wakho wezempilo ngokushesha noma funa ukunakekelwa okuphuthumayo. Isenzo esisheshayo singavimbela izinkinga ezingathi sína ezivela ku-digoxin toxicity.

Imiphumela emibi engavamile kodwa engathi sína ihlanganisa ukungajwayeleki okukhulu kwesigqi senhliziyo okungaba yingozi ekuphileni. Lokhu kwenzeka kubantu abangaphansi kuka-1% abathatha i-digoxin kodwa kungenzeka kakhulu lapho umsebenzi wezinso ungaphelele noma lapho eminye imithi iphazamisa ukucutshungulwa kwe-digoxin.

Ubani Ongafanele Athole I-Digoxin?

Abanye abantu abakwazi ukuthatha i-digoxin ngokuphepha ngenxa yobungozi obandisiwe bezinkinga ezingathi sína. Udokotela wakho uzobuyekeza ngokucophelela umlando wakho wezokwelapha nesimo sakho sempilo yamanje ngaphambi kokukuyala lo muthi.

Akufanele uthole i-digoxin uma une-ventricular fibrillation, isigqi senhliziyo esibeka ukuphila engozini lapho amagumbi aphansi enhliziyo yakho ethuthumela esikhundleni sokumpompa. I-Digoxin ingenza lesi simo sibe sibi futhi senze kube nzima ukusiphatha.

Abantu abanezimo ezithile zenhliziyo badinga ukuqapha okukhethekile noma abakwazi ukuthatha i-digoxin nakancane. Lokhu kuhlanganisa labo abanokuvinjwa kwenhliziyo, lapho amasignali kagesi engahambi kahle enhliziyweni, noma labo abanokugula kwemisipha yenhliziyo eyandisiwe, lapho imisipha yenhliziyo iba makhulu ngokungavamile.

Izinkinga zezinso zithinta kakhulu indlela umzimba wakho oqhubula ngayo i-digoxin. Uma unezifo ezinzima zezinso, udokotela wakho angase agweme i-digoxin ngokuphelele noma asebenzise imithamo ephansi kakhulu ngokuqapha okucophelelayo, njengoba umuthi ungakha amazinga ayingozi.

Ukungalingani kwama-electrolyte, ikakhulukazi amazinga aphansi e-potassium noma e-magnesium, kwenza ubuthi be-digoxin bube maningi. Ithimba lakho lezokwelapha lizohlola futhi lilungise lawa mazinga ngaphambi kokuqala ukwelashwa nge-digoxin.

Ukukhulelwa kudinga ukucatshangelwa okukhethekile, njengoba i-digoxin ingawela i-placenta ukuze ifinyelele ingane yakho. Ngenkathi ngezinye izikhathi kudingeka ngesikhathi sokukhulelwa, udokotela wakho wezifo zabesifazane nodokotela wenhliziyo bazosebenzisana ukuze bahlole izinzuzo ngokumelene nezingozi ezingaba khona.

Amagama Omkhiqizo we-Digoxin

I-Digoxin itholakala ngaphansi kwamagama amaningi omkhiqizo, nakuba ifomu elivamile lisetshenziswa kakhulu ezibhedlela nasemitholampilo. Igama lomkhiqizo elaziwa kakhulu yi-Lanoxin, ebelitholakala amashumi eminyaka futhi lithenjwa abahlinzeki bezempilo emhlabeni wonke.

Amanye amagama omkhiqizo afaka i-Digitek ne-Digox, nakuba lawo engasetshenziswa kakhulu ngamafomu ajovwayo. Izikhungo eziningi zezempilo zisebenzisa i-digoxin ejwayelekile yokujova ngoba isebenza ngendlela efanayo futhi ishibhile kunezinguqulo zamagama omkhiqizo.

Noma ngabe uthola i-digoxin yegama lomkhiqizo noma ejwayelekile, umuthi usebenza ngendlela efanayo. Isithako esisebenzayo kanye nokulinganisa kufana, ngakho ungalindela izinzuzo ezifanayo nemiphumela emibi kungakhathaliseki ukuthi iyiphi inguqulo oyitholayo.

Ezinye Izindlela Zokwelapha ze-Digoxin

Imithi eminingi ehlukile ingelapha ukuhluleka kwenhliziyo kanye ne-atrial fibrillation lapho i-digoxin ingafaneleki noma ingasebenzi. Udokotela wakho wenhliziyo uzokhetha inketho engcono kakhulu ngokusekelwe esimweni sakho senhliziyo esithile, ezinye izinkinga zempilo, nokuthi uzithwala kanjani kahle imithi ehlukene.

Ngokuhluleka kwenhliziyo, ama-ACE inhibitors afana ne-lisinopril noma ama-beta-blockers afana ne-metoprolol avame ukukhethwa njengemithi yomugqa wokuqala. Le mithi ikhombise ukuthuthukisa amazinga okusinda futhi ngokuvamile kulula ukuphatha kuno-digoxin.

Imithi emisha yokuhluleka kwenhliziyo ihlanganisa i-sacubitril/valsartan (Entresto) kanye ne-SGLT2 inhibitors efana ne-dapagliflozin. Le mithi inikeza izinzuzo ezinhle kakhulu kubantu abaningi abanokuhluleka kwenhliziyo futhi ingasetshenziswa esikhundleni se-digoxin noma ngasohlangothini lwayo.

Ukuze kulawulwe izinga le-atrial fibrillation, ama-beta-blockers kanye nama-calcium channel blockers afana ne-diltiazem avame ukusetshenziswa njengezinye izindlela. Le mithi ivame ukuba lula ukuyilinganisa nokuyiqapha kuno-digoxin ngenkathi inikeza ukulawulwa okusebenzayo kwesilinganiso senhliziyo.

Kwezinye izimo, udokotela wakho angase ancome izinqubo ezinjenge-cardioversion noma i-ablation esikhundleni semithi. Lezi zindlela zokwelapha zingabuyisela isigqi senhliziyo esijwayelekile ngaphandle kwesidingo sokwelashwa ngemithi yesikhathi eside.

Ingabe i-Digoxin Ingcono Kune-Metoprolol?

I-Digoxin ne-metoprolol zisebenza ngendlela ehlukile futhi azikwazi ukuqhathaniswa ngokuqondile, njengoba zivame ukusetshenziselwa izinjongo ezihlukene noma ngisho ndawonye. Ukukhetha phakathi kwazo kuncike esimweni sakho senhliziyo esithile, ezinye izici zempilo, kanye nemigomo yokwelashwa.

Ngokuhluleka kwenhliziyo, i-metoprolol ngokuvamile ikhethwa njengemithi yomugqa wokuqala ngoba kufakazelwe ukuthi isiza abantu ukuthi baphile isikhathi eside. Ama-beta-blockers afana ne-metoprolol avikela inhliziyo kuma-hormone okucindezeleka futhi empeleni angathuthukisa ukusebenza kwenhliziyo ngokuhamba kwesikhathi.

I-Digoxin ngokuvamile ingezwa uma i-metoprolol yodwa inganele ukulawula izimpawu noma uma ungenakukwazi ukubekezelela imithamo ephezulu yama-beta-blockers. Ilusizo ikakhulukazi kubantu abaqhubeka nokuba nezimpawu ngaphandle kokwelashwa okungcono ngeminye imithi.

Ukuze kulawulwe izinga le-atrial fibrillation, yomibili imithi ingasebenza, kodwa i-metoprolol ivame ukulawuleka kalula. Ayidingi ukuqapha njalo amazinga egazi njengoba i-digoxin idinga, okwenza kube lula ukuyisebenzisa isikhathi eside.

Abantu abaningi empeleni bathatha yomibili imithi ndawonye, njengoba zigcwalisana kahle. Udokotela wakho wenhliziyo uzonquma ukuhlanganiswa okungcono kakhulu ngokusekelwe ezidingweni zakho ngazinye kanye nokuphendula ekwelashweni.

Imibuzo Evame Ukubuzwa Mayelana ne-Digoxin

Ingabe i-Digoxin iphephile kubantu abanezifo zezinso?

I-Digoxin idinga ukucatshangelwa ngokucophelela kubantu abanezifo zezinso ngoba izinso zakho zinesibopho sokukhipha imithi emzimbeni wakho. Lapho umsebenzi wezinso ukhubazekile, i-digoxin ingakha emazingeni ayingozi, okwandisa ingozi yobuthi.

Uma unezifo zezinso eziphakathi nendawo, udokotela wakho usengakwazi ukukuyala i-digoxin kodwa uzosebenzisa imithamo ephansi futhi aqaphe amazinga egazi lakho kaningi. Bazophinda bahlole umsebenzi wezinso zakho njalo ukuze baqinisekise ukuthi akubi ngaphezulu.

Abantu abanezifo zezinso ezinzima noma labo abase-dialysis badinga ukulungiswa okukhethekile kwemithamo. Udokotela wakho wezinso kanye nodokotela wenhliziyo bazosebenzisana ukuze banqume ukuthi i-digoxin iphephile yini kuwe nokuthi iyiphi umthamo ozofaneleka.

Ngingenzani uma ngithola i-Digoxin eningi ngengozi?

Ukweqisa kwe-Digoxin kuyisimo esiphuthumayo sezokwelapha esidinga ukwelashwa ngokushesha esibhedlela. Njengoba ochwepheshe bezempilo beqoka imijovo ye-digoxin ngaso sonke isikhathi, ukweqisa ngengozi akuvamile, kodwa kungenzeka ngenxa yamaphutha emithamo noma ukuzwela komuntu ngamunye.

Izimpawu zokweqisa umthamo we-digoxin zihlanganisa isicanucanu esibi, ukuhlanza, ukudideka, ukuphazamiseka kokubona, kanye nezinguquko eziyingozi zesigqi senhliziyo. Uma uhlangabezana nanoma yiziphi zalezi zimpawu ngemva kokuthola i-digoxin, yazisa ithimba lakho lezempilo ngokushesha.

Ukwelashwa kokweqisa umthamo we-digoxin kungase kuhlanganise imithi yokulwa nemiphumela yayo, ukunakekelwa okusekelayo kwezimpawu, futhi ezimweni ezinzima, umuthi okhethekile obizwa ngokuthi i-digoxin immune fab. Ithimba lezokwelapha lizobheka isigqi senhliziyo yakho ngokuqhubekayo futhi linikeze ukwelashwa okufanele.

Kufanele Ngenzeni Uma Ngingaphuthelwa Umthamo We-Digoxin?

Njengoba imijovo ye-digoxin inikezwa ochwepheshe bezempilo ezindaweni zezokwelapha, ukuphuthelwa umthamo ngokuvamile akuyona into okudingeka ukhathazeke ngayo. Ithimba lakho lezokwelapha lizoqinisekisa ukuthi uthola imithi yakho njengoba kunqunywe ngesikhathi sokuhlala kwakho esibhedlela noma ukuvakashelwa emtholampilo.

Uma ushintshela ku-digoxin yomlomo ekhaya futhi uphuthelwa umthamo, yithathe ngokushesha lapho ukhumbula, ngaphandle uma sekuseduze isikhathi somthamo wakho olandelayo. Ungalokothi uthathe imithamo emibili ngesikhathi esisodwa ukuze ulungise umthamo ophuthelwe, ngoba lokhu kungabangela imiphumela emibi.

Xhumana nomhlinzeki wakho wezempilo uma ungaqiniseki ukuthi yini okufanele uyenze ngomthamo ophuthelwe. Bangakunikeza isiqondiso esiqondile esisekelwe esimisweni sakho sokulinganisa kanye nesimo sakho samanje.

Ngingayeka Nini Ukuthatha I-Digoxin?

Isinqumo sokuyeka i-digoxin sincike esimweni senhliziyo yakho esiyisisekelo nokuthi usabela kahle kangakanani ekwelashweni. Udokotela wakho wenhliziyo uzohlola njalo ukuthi usayidinga yini imithi nokuthi ngabe izinzuzo zisaqhubeka zidlula noma yiziphi izingozi.

Kwabanye abantu abanenhliziyo ehlulekayo, i-digoxin ingase idingeke kuphela ngesikhathi seziqephu ezinzima noma izikhathi zokwanda kwezimpawu. Uma isimo sakho sizinzile ngeminye imithi, udokotela wakho angase anciphise kancane kancane futhi ekugcineni ayeke i-digoxin.

Uma une-atrial fibrillation engapheli, ungase udinge i-digoxin isikhathi eside. Nokho, udokotela wakho uzobuyekeza njalo uhlelo lwakho lokwelashwa futhi angase akushintshele kweminye imithi noma alungise uhlelo lwakho ngokususelwa ekuphenduleni kwakho kanye nanoma yimaphi imiphumela emibi.

Ungayeki ukuthatha i-digoxin ngokuzumayo ngaphandle kokugadwa kwezokwelapha, ngoba lokhu kungabangela ukuthi isimo senhliziyo yakho sibe sibi ngokushesha. Udokotela wakho uzokwenza isimiso esiphephile sokunciphisa uma ukuyeka kufanelekile.

Ngingayithatha Eminye Imithi Ngesikhathi Ngithola I-Digoxin?

Imithi eminingi ingasebenzisana ne-digoxin, ngakho-ke kubalulekile ukwazisa ithimba lakho lezempilo ngayo yonke imithi, izithasiselo, kanye nemikhiqizo yezitshalo oyithathayo. Ezinye izindlela zokusebenzisana zingakhuphula amazinga e-digoxin abe maningi ayingozi, kanti ezinye zinganciphisa ukusebenza kwayo.

Imithi ejwayelekile engakhuphula amazinga e-digoxin ihlanganisa ama-antibiotics athile, imithi elwa nesikhunta, kanye neminye imithi yokwehlisa umfutho wegazi. Ithimba lakho lezokwelapha lizobuyekeza ngokucophelela yonke imithi yakho futhi lilungise imithamo njengoba kudingeka ukuvimbela ukusebenzisana.

Imithi etholakala ngaphandle kwemvume kadokotela efana nama-antacid ingathinta ukumuncwa kwe-digoxin, ngakho-ke isikhathi sokuphathwa kuba ngesibalulekile. Abahlinzeki bakho bezempilo bazoxhumanisa uhlelo lwakho lwemithi ukuze banciphise ukusebenzisana ngenkathi beqinisekisa ukuthi zonke izindlela zakho zokwelapha zihlala zisebenza.