Yini Ukwelashwa Kwe-Dimethyl Sulfoxide (DMSO) Intravesical: Ukusetshenziswa, Umthamo, Imiphumela Eceleni Nokunye

Ukwelashwa kwe-Dimethyl sulfoxide (DMSO) intravesical kuyindlela yokwelapha ekhethekile lapho isixazululo se-DMSO esincishisiwe sibekwa ngqo esinyeni sakho ngesikhathi se-catheter. Lokhu kwelashwa kusetshenziswa ikakhulukazi esimweni esibuhlungu sesinye esibizwa ngokuthi i-interstitial cystitis, eyaziwa nangokuthi i-painful bladder syndrome. Umuthi usebenza ngokunciphisa ukuvuvukala nobuhlungu odongeni lwesinye, unikeze impumuzo lapho ezinye izindlela zokwelapha zingasebenzi ngokwanele.

Yini i-Dimethyl Sulfoxide (DMSO)?

I-DMSO iyincwadi ecacile, engenambala enezakhiwo eziyingqayizivele eziyivumela ukuthi ingene ezicutshini futhi inciphise ukuvuvukala. Uma isetshenziswa ngaphakathi, kusho ukuthi umuthi ulethwa ngqo esinyeni sakho kunokuba uthathwe ngomlomo noma ngomjovo. Le ndlela eqondiwe ivumela umuthi ukuthi usebenze ngqo lapho udingeka kakhulu.

Isixazululo esisetshenziswa esinyeni sakho ngokuvamile singama-50% okugxila kwe-DMSO okuxutshwe namanzi ahlanzekile. Lokhu kunciphisa kwenza kuphephe ukusetshenziswa esinyeni ngenkathi kugcina imiphumela yayo yokwelapha. Umhlinzeki wakho wezempilo uzosebenzisa i-catheter ehlanzekile ukuze abeke ngobumnene isixazululo esinyeni sakho ngesikhathi sokwelashwa.

Yini Ukwelashwa Kwe-DMSO Intravesical Okusetshenziselwa Yona?

Ukwelashwa kwe-DMSO intravesical kuvunywe yi-FDA ngokuqondile i-interstitial cystitis (IC), isimo esingamahlalakhona esibangela ubuhlungu besinye nokuchama njalo. Uma une-IC, udonga lwakho lwesinye luvuvukala futhi luyacasuka, okuholela ekungakhulumeni okuqhubekayo okungathinta kakhulu impilo yakho yansuku zonke.

Udokotela wakho angase ancome lokhu kwelashwa uma uhlangabezana nokuchama njalo, izidingo eziphuthumayo zokuchama, noma ubuhlungu obungamahlalakhona be-pelvic obungaphendulanga kahle kwezinye izindlela zokwelapha. Ukwelashwa kuwusizo ikakhulukazi kubantu abaye bazama izinguquko zokudla, imithi yomlomo, nezinye izindlela zokwelapha zesinye ngaphandle kwempumuzo eyanele.

Ngenkathi i-DMSO isetshenziswa kakhulu ku-interstitial cystitis, ezinye izinyanga zingase zicabange ukuyisebenzisa kwezinye izimo zomchamo ezingapheli lapho ukwelashwa okujwayelekile kungasebenzi. Kodwa-ke, lokhu kungaba ukusetshenziswa okungajwayelekile okudinga ukuhlolwa ngokucophelela nguchwepheshe.

Isebenza Kanjani Ukwelashwa Nge-DMSO Intravesical?

I-DMSO isebenza ngezindlela eziningana ukusiza ukwelapha umchamo wakho. Isebenza njenge-ejenti elwa nokuvuvukala, inciphisa ukuvuvukala nokucasuka odongeni lomchamo wakho okubangela ubuhlungu nokuchama njalo. Umuthi futhi usiza ukuncibilikisa izicubu ezinamanxeba ezingase zakheke ngenxa yokuvuvukala okungapheli.

Ngaphezu kwalokho, i-DMSO inezindawo ezincane zokunciphisa ubuhlungu futhi ingasiza ekuphumuleni imisipha ebushelelezi odongeni lomchamo wakho. Le nhlanganisela yemiphumela isiza ukubuyisela ukusebenza komchamo okujwayelekile futhi inciphisa ukungakhululeki okuqhubekayo ongase ukuzwe.

Ukwelashwa kuthathwa njengokunamandla ngokulinganisela ezimweni zomchamo. Ngenkathi kungewona umuthi wokuqala odokotela abajwayele ukuwuzama, kungasebenza kahle kakhulu kubantu abangatholanga ukukhululeka ngezindlela ezinobumnene njengokuguqulwa kokudla noma imithi yomlomo.

Kufanele Ngilungiselele Kanjani Ukwelashwa Nge-DMSO Intravesical?

Ngaphambi kokwelashwa kwakho, uzodinga ukukhipha umchamo wakho ngokuphelele. Umhlinzeki wakho wezempilo ngokuvamile uzokucela ukuthi ufike nomchamo ogcwele ngokulinganisela, bese ekucela ukuthi uchame ngaphambi nje kokuqala kwenqubo. Lokhu kuqinisekisa ukuthi umchamo wakho usesimweni esifanele sokuthola umuthi.

Akudingeki ukuthi uzile noma ugweme ukudla ngaphambi kokwelashwa, kodwa ezinye izinyanga zincoma ukugwema i-caffeine nokudla okune-asidi ngosuku lokwelashwa ngoba lokhu kungacasula umchamo wakho. Ukugqoka izingubo ezikhululekile, ezixekile kungenza inqubo ikhululeke kuwe.

Qiniseka ukuthi utshela umhlinzeki wakho wezempilo ngayo yonke imithi oyithathayo, okuhlanganisa imithi etholakala ngaphandle kwemvume kadokotela kanye nezithasiselo. Nakuba kungekho ukusebenzisana okuningi kwemithi ne-DMSO, udokotela wakho udinga isithombe esiphelele sokwelashwa kwakho kwamanje.

Kufanele Ngiyithathe Isikhathi Esingakanani Ukwelashwa Nge-DMSO Intravesical?

Ukwelashwa okujwayelekile kwe-DMSO kuhilela ukuthola umuthi kanye njalo ngesonto elilodwa kuya kwamabili cishe izikhathi eziyisithupha kuya kweziyisishiyagalombili sezizonke zokwelashwa. Iseshini ngayinye yokwelashwa ivame ukuthatha imizuzu engaba ngu-15 kuya kwengama-30, lapho uzogcina khona isixazululo esesinyeni sakho.

Udokotela wakho uzoqapha impendulo yakho ekwelashweni futhi angase alungise imvamisa noma inani lokwelashwa ngokusekelwe endleleni ozizwa ngayo. Abanye abantu baqaphela ukuthuthuka ngemva kokwelashwa okumbalwa nje, kanti abanye bangase badinge inkambo ephelele ukuze bathole ukukhululeka okukhulu.

Ngemva kokuqeda uchungechunge lokuqala, ungase ungadingi okunye ukwelashwa, noma udokotela wakho angase ancome ukwelashwa okuthile kokugcinwa uma izimpawu zakho zibuyela. Umgomo uwukuthola inani elincane lokwelashwa elidingekayo ukuze izimpawu zakho ziqhubeke zilawuleka.

Yiziphi Imiphumela Eceleni Yokwelashwa Nge-DMSO Intravesical?

Abantu abaningi bayakubekezelela kahle ukwelashwa nge-DMSO intravesical, kodwa kufanele wazi ngemiphumela engaba khona eceleni. Umphumela ovamile eceleni ukunambitheka okufana negalikhi emlonyeni wakho nephunga elifana negalikhi emoyeni wakho nasesikhumbeni, okungahlala amahora ambalwa kuya ezinsukwini ezimbalwa ngemva kokwelashwa.

Ngesikhathi nangemva nje kokwelashwa, ungase uzwe ukungakhululeki okuthile esinyeni, ukusha, noma ukwanda okwesikhashana kwezimpawu zakho ezivamile. Le miphumela ngokuvamile ixazululwa emahoreni ambalwa njengoba umzimba wakho uqhubekisa umuthi.

Nawa amanye imiphumela ejwayelekile eceleni ongase uyithole:

• Ukunambitheka okufana negalikhi nomoya oqhamuka emlonyeni
• Ukuphatheka kabi kwesikhashana emchamweni noma ukusha
• Ukwanda kwesidingo sokuya ngokushesha ngemva kokwelashwa
• Ukuqina okuncane komchamo
• Ukwanda kwesikhashana kobuhlungu besinqe

Le miphumela evamile ngokuvamile imnene futhi yesikhashana, izixazulula yona njengoba imithi isuswa emzimbeni wakho.

Imiphumela engavamile kodwa ebucayi kakhulu ingenzeka, nakuba ingavamile. Lokhu kungabandakanya ukusabela okukhulu komzimba, ukucasuka okukhulu komchamo okungathuthuki, noma ukusha kwamakhemikhali odongeni lomchamo uma ikhambi ligxilile kakhulu.

Ngokuvamile kakhulu, abanye abantu bangase bahlangabezane:

• Ukusabela okukhulu komzimba okunzima ngokuphefumula noma ukuvuvukala
• Ubuhlungu obuqhubekayo obukhulu bomchamo obuhlala ngaphezu kwamahora angama-48
• Igazi emchamweni elingaxazululeki ngokushesha
• Izimpawu zokutheleleka komchamo njengomkhuhlane nokubanda

Uma uhlangabezana nanoma iyiphi yale miphumela emibi, xhumana nomhlinzeki wakho wezempilo ngokushesha noma funa usizo oluphuthumayo lwezokwelapha.

Ubani Ongafanele Athole Ukwelashwa Nge-DMSO Intravesical?

Ukwelashwa nge-DMSO intravesical akulungelwe wonke umuntu. Akufanele uthole lokhu kwelashwa uma unokutheleleka okusebenzayo emgudwini womchamo, njengoba imithi ingase yenze ukutheleleka kube kubi kakhulu noma iphazamise ikhono lomzimba wakho lokulwa nayo.

Abantu abanezimo ezithile zomchamo kufanele bagweme ukwelashwa nge-DMSO. Uma unomdlavuza womchamo noma umlando womdlavuza womchamo, lokhu kwelashwa ngokuvamile akukhuthazwa njengoba kungase kuphazamise ukutholwa komdlavuza noma ukwelashwa.

Udokotela wakho uzoqapha ngokucophelela ukuthi i-DMSO ilungile yini kuwe uma unanoma yiziphi zalezi zimo:

• Ukunyuka kwamathumbu okusebenzayo
• Umlando noma umlando womdlavuza wesinye
• Isifo esibi sezinso
• Ukungezwani okwaziwayo ne-DMSO noma izinhlanganisela zesulfure
• Ukukhulelwa noma ukuncelisa
• Isifo esibi sesibindi

Uma ukhulelwe noma uhlela ukukhulelwa, xoxa ngalokhu nodokotela wakho njengoba ukuphepha kwe-DMSO ngesikhathi sokukhulelwa kungakahlolisiswa ngokugcwele. Ngokufanayo, uma uncelisa, ukwelashwa okuhlukile kuvame ukukhethwa.

Amagama Omkhiqizo we-DMSO

Igama lomkhiqizo elivame ukusetshenziswa kakhulu ekwelashweni kwe-DMSO intravesical yi-Rimso-50. Lena yifomula evunywe yi-FDA eyenzelwe ngqo ukufakwa esinyeni futhi iqukethe i-50% ye-DMSO emanzini ahlanzekile.

Ezinye izikhungo zezokwelapha zingase zilungiselele izixazululo zazo ze-DMSO zisebenzisa i-DMSO yezinga lezemithi, kodwa i-Rimso-50 iyindlela ejwayelekile, evunywe yi-FDA esetshenziswa ochwepheshe bezempilo abaningi. Njalo qiniseka ukuthi uthola ukwelashwa kumhlinzeki wezempilo oqeqeshiwe esebenzisa i-DMSO efanele yezinga lezokwelapha.

Ezinye izindlela ze-DMSO

Uma i-DMSO ingakulungele noma inganikezi ukukhululeka okwanele, kukhona ezinye izindlela zokwelapha i-cystitis interstitial nobuhlungu besinye obungapheli. I-Pentosan polysulfate (Elmiron) iyimithi yomlomo engasiza ekwakheni kabusha umugqa ovikelayo wesinye sakho.

Ezinye izindlela zokwelapha ze-intravesical zihlanganisa i-heparin, i-lidocaine, noma ama-cocktails ahlanganisiwe angathuthukiswa udokotela wakho esinyeni sakho. Lezi zindlela ezingezinye zingase zibe namaphrofayili ahlukene emiphumeleni kanye namanani okusebenza uma kuqhathaniswa ne-DMSO.

Ezinye izinketho zokwelapha udokotela wakho angazicabangela zihlanganisa:

• Imithi yomlomo efana nama-antidepressants e-tricyclic noma ama-antihistamines
• Izinqubo zokunweba isinye
• Ukwelashwa kokuvuselela imizwa
• Ukuguqulwa kokudla kanye nezinguquko zokuphila
• Ukwelashwa ngokomzimba kokungasebenzi kahle komgogodla we-pelvic

Umhlinzeki wakho wezempilo uzosebenza nawe ukuthola indlela yokwelapha ekufanela kahle izimpawu zakho nezidingo zokuphila kwakho.

Ingabe i-DMSO ingcono kune-Pentosan Polysulfate (Elmiron)?

Kokubili i-DMSO ne-pentosan polysulfate (Elmiron) kuyizindlela zokwelapha ezisebenzayo ze-interstitial cystitis, kodwa zisebenza ngezindlela ezihlukene futhi zinezinzuzo ezihlukene. I-DMSO inikezwa ngqo esinyeni futhi ivame ukunikeza ukukhululeka okusheshayo, kuyilapho i-Elmiron ithathwa ngomlomo futhi kungathatha izinyanga eziningana ukukhombisa izinzuzo ezigcwele.

Ukwelashwa kwe-DMSO kuvame ukuqedwa emasontweni ambalwa kuya ezinyangeni, kuyilapho i-Elmiron idinga imithi yomlomo yansuku zonke okungenzeka idinge ukuqhubeka isikhathi eside. Abanye abantu bakhetha indlela eqondiwe ye-DMSO, kuyilapho abanye bethola imithi yomlomo yansuku zonke ilula.

Ukukhetha phakathi kwalezi zindlela zokwelapha kuvame ukuncika ezimpawini zakho ezithile, okuthandayo ukuphila kwakho, nokuthi usabele kanjani kwezinye izindlela zokwelapha. Udokotela wakho uzokusiza ukuthi ulinganise izinzuzo nobubi benketho ngayinye ngokuya ngesimo sakho.

Imibuzo Evame Ukubuzwa Mayelana Nokwelashwa kwe-DMSO Intravesical

Ingabe i-DMSO iphephile kubantu abanesifo sikashukela?

Ukwelashwa kwe-DMSO intravesical ngokuvamile kubhekwa njengokuphephile kubantu abanesifo sikashukela, njengoba imithi isetshenziswa ngqo esinyeni futhi ayithinti kakhulu amazinga kashukela egazini. Kodwa-ke, abantu abanesifo sikashukela bangase babe nengozi enkulu yokutheleleka ngamathumbu omchamo, ngakho udokotela wakho uzokugada eduze ngesikhathi sokwelashwa.

Uma unezinkinga zesifo sikashukela ezithinta izinso zakho noma umsebenzi wesinye, udokotela wakho uzodinga ukuhlola ukuthi i-DMSO ifanele yini isimo sakho esithile. Njalo yazisa umhlinzeki wakho wezempilo ngokuphathwa kwakho isifo sikashukela kanye nanoma yiziphi izinkinga ongase ube nazo.

Ngingenzani uma ngithola i-DMSO eningi ngengozi?

Uma usola ukuthi uthole i-DMSO eningi ngesikhathi sokwelashwa, xhumana nodokotela wakho ngokushesha. Ukweqisa nge-DMSO ye-intravesical akuvamile ngoba umuthi ulinganiswa ngokucophelela futhi unikezwa ochwepheshe bezokwelapha, kodwa amanani amaningi angase abangele ukucasuka okukhulu kwesinye.

Izimpawu ze-DMSO eningi zingabandakanya ubuhlungu obukhulu besinye, ukusha okuqhubekayo, noma ukungakwazi ukuchama ngokunethezeka. Udokotela wakho angase ancome ukuphuza uketshezi olwengeziwe ukusiza ukukhipha umuthi ohlelweni lwakho futhi angase anikeze imithi yokunciphisa ukucasuka kwesinye.

Kufanele Ngenzeni Uma Ngiphuthelwa Ukwelashwa Kwe-DMSO Okuhleliwe?

Uma uphuthelwa ukwelashwa kwe-DMSO okuhleliwe, xhumana nodokotela wakho ukuze uhlele kabusha ngokushesha ngangokunokwenzeka. Ukuphuthelwa ukwelashwa okukodwa ngokuvamile ngeke kube nomthelela omkhulu emiphumeleni yakho yokwelashwa iyonke, kodwa ukugcina isimiso esiqhubekayo kusiza ukuqinisekisa imiphumela engcono kakhulu.

Udokotela wakho angase alungise isimiso sakho sokwelashwa kancane ukuze kulungiswe ukuqokwa okungaphuthelwanga, kodwa ngokuvamile, uzoqhubeka nokwelashwa okuhleliwe okusele. Ungazami ukwenza ukwelashwa okungaphuthelwanga ngokuwahlela eduze ngaphandle uma uqondiswe ngokuqondile ngudokotela wakho.

Ngingayeka Nini Ukuthatha Ukwelashwa Kwe-DMSO?

Ngokuvamile ungaqeda ukwelashwa kwe-DMSO uma usuqedile inkambo ebekiwe, evame ukuba ukwelashwa okuyisithupha kuya kwayisishiyagalombili. Udokotela wakho uzohlola impendulo yakho futhi anqume ukuthi ngabe udinga ukwelashwa okwengeziwe noma ngabe ungaqeda ngaleso sikhathi.

Abanye abantu bathola ukukhululeka okuhlala isikhathi eside ngemuva kokuqeda inkambo yabo yokuqala yokwelashwa, kanti abanye bangase badinge ukwelashwa okuthile kokulondoloza. Udokotela wakho uzosebenza nawe ukuthuthukisa uhlelo lokuphatha isikhathi eside olusekelwe ekutheni usabela kahle kangakanani ekwelashweni.

Ngingashayela Ngemuva Kokwelashwa Nge-DMSO?

Abantu abaningi bangashayela ngemva kokwelashwa nge-DMSO, njengoba imithi ngokuvamile ingabangeli ukozela noma iphazamise ikhono lakho lokushayela imoto ngokuphepha. Kodwa-ke, uma uhlangabezana nokungakhululeki okukhulu emchameni noma ukuchama njalo ngemva nje kokwelashwa, ungase ufune ukuhlela ukuthi othile akuqhubele ekhaya.

Iphunga elifana negalikhi elivela ku-DMSO ngeke lithinte ikhono lakho lokushayela, nakuba ungase ukhethe ukuthi omunye umuntu ashayele uma uzizwa unamahloni ngephunga. Lo mphumela ohlangothini ungowesikhashana futhi uzonyamalala phakathi nosuku olulodwa noma ezimbili ngemva kokwelashwa.