Eculizumab-aeeb (indlela ye-intravenous)
Imikhiqizo etholakalayo
Bkemv
Mayelana naleli khambi
Isikhubekiso se-Eculizumab-aeeb sisetshenziswa ekwelapheni uhlobo lwesifo segxagxa oluthiwa yi-paroxysmal nocturnal hemoglobinuria (PNH). Le mishini iyasiza ekunciphiseni ukuwohloka kwamaseli egazi ebomvu noma ukuwohloka (hemolysis) kubantu abane-PNH. Le mishini isetshenziswa futhi ekwelapheni isifo esibi sesiqiniso sokuthiwa yi-atypical hemolytic uremic syndrome (aHUS). Isikhubekiso se-Eculizumab-aeeb yisigqebhezana esiyinhlanganisela yokuqina esebenza ohlelweni lokuvikela umzimba. Le mishini itholakala kuphela ngaphansi kohlelo lokusabalalisa oluqediwe oluthiwa yi-BKEMV™ REMS (Risk Evaluation and Mitigation Strategy) Program.
Ngaphambi kokusebenzisa leli khambi
Umakuqondisa ekusebenziseni imithi, kufanele kuqhathaniswe ingozi yokuthatha imithi nezinzuzo ezizoletha. Lo ngumqondo owenzayo wena nodokotela wakho. Kule mithi, kufanele kucabangelwe okulandelayo: Tshela udokotela wakho uma uke waba nanoma yiluphi uhlobo oluhlukile noma oluhambelanayo lokulimala kule mithi noma kunoma iyiphi enye imithi. Tshela futhi ochwepheshe bakho bezempilo uma unezinye izinhlobo zokungezwani, njengokudla, izidakamizwa, izigcini, noma izilwane. Ngomkhiqizo ongenamibhalo, funda ilebula noma izithako zephakheji ngokucophelela. Izifundo ezifanele azikwenzelwanga ukuhlola ubudlelwano phakathi nobudala nemiphumela yokuthombisa i-eculizumab-aeeb yokwelapha i-PNH kubantwana. Ukuphepha nokuphumelela akukaqiniswa. Izifundo ezifanele ezenziwe kuze kube manje azibonisi izinkinga ezikhethekile zabantwana ezingalinda ukusetshenziswa kwe-eculizumab-aeeb injection yokwelapha i-aHUS kubantwana. Ukuphepha nokuphumelela kuye kwaqinisekiswa. Izifundo ezifanele ezenziwe kuze kube manje azibonisi izinkinga ezikhethekile zabantu abadala ezingalinda ukusetshenziswa kwe-eculizumab-aeeb injection kubantu abadala. Ayikho izifundo ezifanele kubesifazane zokunquma ingozi yengane uma usebenzisa le mithi ngesikhathi sokuncelisa. Linganisa izinzuzo ezingaba khona nezingozi ezingaba khona ngaphambi kokuthatha le mithi ngesikhathi sokuncelisa. Nakuba ezinye izidakamizwa kufanele zingasetshenziswa ndawonye, kwezinye izimo imithi emibili ehlukene ingasetshenziswa ndawonye ngisho noma kungenzeka ukuthi kube khona ukusebenzisana. Kulezi zimo, udokotela wakho angase afune ukushintsha umthamo, noma ezinye izinyathelo zokuphepha zingadingeka. Uma uthola le mithi, kubalulekile kakhulu ukuthi ochwepheshe bakho bezempilo bazi uma uthatha noma iyiphi imithi ehlaliswe ngezansi. Ukusebenzisana okulandelayo kukhethwe ngokusekelwe ekubalulekeni kwabo okungenzeka futhi akuyona yonke into. Ukusebenzisa le mithi nanoma iyiphi imithi elandelayo ngokuvamile akusikholisi, kodwa kungadingeka kwezinye izimo. Uma kokubili imithi ilotshiwe ndawonye, udokotela wakho angase ashintshe umthamo noma ukuthi uyayisebenzisa kangakanani enye noma zombili imithi. Ezinye izidakamizwa akufanele zisetshenziswe ngesikhathi sokudla noma ngesikhathi sokudla izinhlobo ezithile zokudla ngoba ukusebenzisana kungase kwenzeke. Ukusebenzisa utshwala noma utshaba ngezinye izidakamizwa kungase futhi kubangele ukusebenzisana. Xoxa nochwepheshe bakho bezempilo ngokusetshenziswa kwemithi yakho ngokudla, utshwala, noma utshaba. Ukuba khona kwezinye izinkinga zezokwelapha kungathinta ukusetshenziswa kwale mithi. Qiniseka ukuthi utshela udokotela wakho uma unezinye izinkinga zezokwelapha, ikakhulukazi:
Indlela yokusebenzisa leli khambi
Udokotela noma omunye ochwepheshe bezempilo oqeqeshwe uzohlinzeka ngale miyeke. Lolu lwemiyeke lunikezwa nge-IV catheter ebekwe kwenye yezinsizi zakho. Kumele luhlanganiswe kancane, ngakho-ke i-IV yakho izohlala ibekwe okungenani imizuzu engama-35 kubantu abadala namahora angu-1 kuya kwangu-4 kubantwana. Kubalulekile kakhulu ukuqonda izidingo ze-BKEMV™ REMS program, futhi uqonde incwajana yemithi ye-BKEMV™. Funda futhi ulandele le miyalo ngokucophelela. Buza udokotela wakho uma unemibuzo. Cela umthengisi wemithi incwajana yemithi uma ungenayo. Shaya udokotela wakho noma umthengisi wemithi ukuze uthole imiyalo.
Umshwana wokuzihlangula: I-August iyinkundla yolwazi lwezempilo futhi izimpendulo zayo azihlanganisi iseluleko sezokwelapha. Njalo thintana nochwepheshe bezokwelapha onelayisensi eduze nawe ngaphambi kokwenza noma yiluphi ushintsho.