Eculizumab (indlela ye-intravenous)

Bkemv, Epysqli, Soliris

Isikhubekiso se-Eculizumab sisetshenziswa ekwelapheni uhlobo lwesifo segazi oluthiwa yi-paroxysmal nocturnal hemoglobinuria (PNH). Le mishini iyasiza ekunciphiseni ukuwohloka kwamaseli egazi ebomvu noma ukuwohloka (hemolysis) kubantu abane-PNH. Le mishini isetshenziswa futhi ekwelapheni isifo esibi sesiqiniso sokuthiwa yi-atypical hemolytic uremic syndrome (aHUS). Isikhubekiso se-Eculizumab sisetshenziswa futhi ekwelapheni isifo samithambo nemisipha okuthiwa yi-generalized myasthenia gravis (gMG) kubantu abane-anti-acetylcholine receptor (AchR) antibody positive. Isikhubekiso se-Eculizumab sisetshenziswa futhi ekwelapheni isifo esingavamile esibangela ukuvuvukala kwamithambo yamehlo ne-spinal cord okuthiwa yi-neuromyelitis optica spectrum disorder (NMOSD). Sisetshenziswa kubantu abane-anti-aquaporin-4 (AQP4) antibody positive. Isikhubekiso se-Eculizumab yisigqebhezana esiyinhlanganisela yamasosha omzimba esebenza ohlelweni lokuvikela umzimba. Le mishini itholakala kuphela ngaphansi kohlelo lokusabalalisa oluqediwe okuthiwa yi-Ultomiris® ne-Soliris® REMS (Risk Evaluation and Mitigation Strategy) Program. Lo mkhiqizo utholakala ngezindlela zokwelapha ezilandelayo:

Uma ukhetha ukusebenzisa le mishini, kufanele kuqhathaniswe ingozi yokuyisebenzisa nezinzuzo ezizotholakala. Lo ngumqondo owenzayo wena nodokotela wakho. Ngale mishini, kufanele kucabangelwe okulandelayo: Tshela udokotela wakho uma uke waba nanoma yiluphi uhlobo oluqakathekile noma oluhambelana ne-alergi kule mishini noma kwezinye izidakamizwa. Tshela futhi ochwepheshe bakho bezempilo uma unezinye izinhlobo ze-alergi, njengokudla, izidakamizwa, izigcini, noma izilwane. Ngomkhiqizo ongenaso iresiphi, funda ilebula noma izithako zephakheji ngokucophelela. Izifundo ezifanele ezenziwe kuze kube yimanje azibonisi izinkinga ezikhethekile zezingane ezingawunciphisa ukusebenzisa kwe-eculizumab injection ekwelapheni i-atypical hemolytic uremic syndrome ezinganeni. Kodwa-ke, ukuphepha nokuphumelela kwe-eculizumab injection ekwelapheni ezinye izimo akukaqiniswa ezinganeni. Izifundo ezifanele ezenziwe kuze kube yimanje azibonisi izinkinga ezikhethekile zabantu abadala ezingawunciphisa ukusebenzisa kwe-eculizumab injection kubantu abadala. Ayikho izifundo ezifanele kubesifazane zokunquma ingozi yengane uma usebenzisa le mishini ngesikhathi sokuncelisa. Linganisa izinzuzo ezingaba khona nezingozi ezingaba khona ngaphambi kokuthatha le mishini ngesikhathi sokuncelisa. Nakuba ezinye izidakamizwa kufanele zingasetshenziswa ndawonye, kwezinye izimo imishini emibili ehlukene ingasetshenziswa ndawonye ngisho noma kungenzeka ukuthi kube khona ukusebenzisana. Kulezi zimo, udokotela wakho angafuna ukushintsha umthamo, noma ezinye izinyathelo zokuphepha zingadingeka. Uma uthola le mishini, kubaluleke kakhulu ukuthi ochwepheshe bakho bezempilo bazi uma uthatha noma yimiphi imishini ehlaliswe ngezansi. Ukusebenzisana okulandelayo kukhethwe ngesisekelo sokubaluleka kwabo okungenzeka futhi akuyona yonke into. Ukusebenzisa le mishini nanoma yimiphi imishini elandelayo ngokuvamile akusikholisiwe, kodwa kungadingeka kwezinye izimo. Uma kokubili imishini ilotshiwe ndawonye, udokotela wakho angashintsha umthamo noma ukuthi uyayisebenzisa kangakanani enye noma zombili imishini. Ezinye izidakamizwa akufanele zisetshenziswe ngesikhathi sokudla noma eduze kwesikhathi sokudla noma ukudla izinhlobo ezithile zokudla ngoba ukusebenzisana kungase kwenzeke. Ukusebenzisa utshwala noma utshaba nezinye izidakamizwa kungabangela ukusebenzisana. Xoxa nochwepheshe bakho bezempilo ngokusetshenziswa kwemishini yakho ngokudla, utshwala, noma utshaba. Ukuba khona kwezinye izinkinga zezokwelapha kungathinta ukusetshenziswa kwale mishini. Qiniseka ukuthi utshela udokotela wakho uma unezinye izinkinga zezokwelapha, ikakhulukazi: