Yini i-Edaravone: Ukusetshenziswa, Umthamo, Imiphumela Eceleni nokuningi

I-Edaravone iyimithi enikezwa ngomugqa we-IV (intravenous) ukusiza ukunciphisa ukuqhubeka kwe-ALS, eyaziwa nangokuthi isifo sikaLou Gehrig. Le mithi isebenza njenge-antioxidant enamandla, okusho ukuthi isiza ukuvikela amaseli akho ezinzwa ekulimaleni okubangelwa ngama-molecule ayingozi abizwa ngokuthi ama-radicals amahhala.

Uma wena noma othile omkhathalelayo etholiwe ukuthi une-ALS, ukufunda nge-edaravone kungazizwa kukukhathaza. Izindaba ezinhle ukuthi le mithi imelela ithemba - yakhelwe ngqo ukusiza ukugcina ukusebenza kwama-motor neurons, amaseli ezinzwa alawula imisipha yakho.

Yini i-Edaravone?

I-Edaravone iyimithi evikela imizwa eyingxenye yeqembu lezidakamizwa elibizwa ngokuthi ama-free radical scavengers. Cabanga ngayo njengesihlangu esisiza ukuvikela amaseli akho ezinzwa ekucindezelekeni kwe-oxidative - uhlobo lokulimala kwamaselula oludlala indima enkulu ekuqhubekeni kwe-ALS.

Imithi yaqala yathuthukiswa eJapane ukwelapha iziguli ezinomdlavuza. Abacwaningi bathola ukuthi imiphumela efanayo yokuvikela eyayinayo emangqamuzaneni obuchopho ingazuza nakubantu abane-ALS. I-FDA yavuma i-edaravone yokwelashwa kwe-ALS ngo-2017, okuyenza ibe yimithi yesibili eyake yavunywa ngqo ngalesi simo.

Lokhu akuyona ikhambi le-ALS, kodwa kungasiza ukunciphisa ukuqhubeka kwalesi sifo ezigulini ezithile. Udokotela wakho uzoqaphela ukuthi ungumuntu ofanelekayo yini ngokuya ngesimo sakho esithile nokuthi usekuphi ekuqaleni kwenqubo yesifo.

Yini i-Edaravone Esetshenziselwa Yona?

I-Edaravone ivunywe ngqo ukwelapha i-amyotrophic lateral sclerosis (ALS), isifo esiqhubekayo se-neurodegenerative esithinta amaseli ezinzwa ebuchosheni bakho nasemgogodleni. I-ALS ngokuqhubekayo ibuthakathisa imisipha emzimbeni wakho wonke, ithinte ikhono lakho lokuhamba, ukukhuluma, ukudla, futhi ekugcineni ukuphefumula.

Umuthi usebenza kahle kakhulu uma uqala ekuqaleni kwenqubo yesifo. Udokotela wakho ngokuvamile uzoncoma i-edaravone uma une-ALS eqinisekile noma engase ibe khona futhi usesezigabeni zokuqala. Izifundo zibonisa ukuthi ingasiza ekulondolozeni amakhono akho okusebenza kwansuku zonke isikhathi eside uma kuqhathaniswa nokungelashwa.

Akubona bonke abantu abane-ALS abazozuza ku-edaravone. Ithimba lakho lokunakekelwa kwezempilo lizohlola izinto ezinjengokuthi isifo sakho siqhubeka kanjani, impilo yakho yonke, kanye nekhono lokubekezelela ukwelashwa nge-IV ngaphambi kokuncoma lo muthi.

Isebenza Kanjani I-Edaravone?

I-Edaravone isebenza ngokubamba nokungathathi hlangothi ama-radicals amahhala - ama-molecule angazinzile angalimaza amaseli akho ezinzwa. Ku-ALS, la ma-radicals amahhala ayakha futhi anegalelo ekufeni kwama-motor neurons, amaseli akhethekile alawula imisipha yakho.

Lo muthi ubhekwa njenge-ejenti evikela imizwa enamandla aphakathi nendawo. Ayimisi i-ALS ngokuphelele, kodwa inganciphisa ukulimala kwamaselula okuqhubela phambili isifo. Cabanga ngayo njengokusebenzisa i-sunscreen - ayivimbeli konke ukulimala kwelanga, kodwa iyanciphisa kakhulu.

Umuthi futhi usiza ukunciphisa ukuvuvukala ohlelweni lwakho lwezinzwa futhi ungathuthukisa ukusebenza kwe-mitochondria, ama-powerhouses amancane ngaphakathi kwamaseli akho. Ngokuvikela lezi zakhiwo zamaselula, i-edaravone isiza ama-motor neurons akho ukuthi ahlale enempilo isikhathi eside.

Kufanele Ngiyithathe Kanjani I-Edaravone?

I-Edaravone inikezwa kuphela nge-IV infusion endaweni yezokwelapha - awukwazi ukuthatha lo muthi ekhaya ngomlomo. Ukwelashwa kulandela iphethini ethile yomjikelezo eshintshana phakathi kwezikhathi zokwelashwa nezikhathi zokuphumula.

Nakhu ukuthi isimiso esivamile sokwelashwa sibukeka kanjani:

• Umjikelezo wokuqala: Ukufakwa kwe-IV kwansuku zonke izinsuku eziyi-14, bese kuba izinsuku eziyi-14 zokuphumula
• Imijikelezo elandelayo: Ukufakwa kwe-IV kwansuku zonke izinsuku eziyi-10 ngaphandle kwesikhathi sezinsuku eziyi-14, bese kuba izinsuku eziyi-14 zokuphumula
• Ukufakwa ngakunye kuthatha cishe imizuzu engama-60 ukuqeda
• Uzodinga ukuvakashela indawo yezokwelapha noma isikhungo sokufakwa ngakunye kokwelashwa

Akudingeki ukuthi udle noma yini ekhethekile ngaphambi kokufakwa kwakho, kodwa ukuhlala unamanzi kahle kusiza umzimba wakho ukuthi usebenze imithi ngempumelelo. Abanye abantu bakuthola kuwusizo ukuletha incwadi noma ithebhulethi ukudlulisa isikhathi ngesikhathi sokufakwa okuthatha ihora elilodwa.

Ithimba lakho lezempilo lizokuqapha ngesikhathi sokufakwa ngakunye ukuze libheke noma yimaphi imiphumela emibi. Bazophinda balandelele izimpawu zakho ze-ALS ngokuhamba kwesikhathi ukuze babone ukuthi imithi isebenza kahle kangakanani kuwe.

Kufanele Ngiyithathe Isikhathi Esingakanani I-Edaravone?

Ubude bokwelashwa nge-edaravone buyahluka kumuntu nomuntu futhi kuncike ekutheni usabela kahle kangakanani emuthini. Abantu abaningi baqhubeka nokwelashwa uma nje bezuza kukho futhi bekubekezelela imiphumela emibi.

Udokotela wakho uzohlola intuthuko yakho njalo ezinyangeni ezimbalwa esebenzisa izikali ezijwayelekile zokulinganisa i-ALS. Lokhu kuhlola kusiza ukunquma ukuthi imithi iyehla ngempumelelo yini ukuqhubeka kwesifo sakho. Uma ukhombisa izinzuzo ezicacile, ithimba lakho lezempilo cishe lizokuncoma ukuthi uqhubeke nokwelashwa.

Abanye abantu bathatha i-edaravone izinyanga eziningi noma iminyaka, kanti abanye bangase badinge ukuyeka ngokushesha ngenxa yemiphumela emibi noma ukuqhubeka kwesifo. Isinqumo sokuqhubeka noma sokuyeka ukwelashwa kufanele senziwe ngaso sonke isikhathi kanye nethimba lakho lezempilo, kucatshangelwa izinga lakho jikelele lempilo kanye nemigomo yokwelashwa.

Yini Imiphumela Emibi Ye-Edaravone?

Njengayo yonke imithi, i-edaravone ingabangela imiphumela emibi, nakuba kungewona wonke umuntu oyitholayo. Ukuqonda ukuthi okulindelekile kungakusiza ukuthi uzizwe ulungiseleleke futhi uqiniseke ngokwelashwa kwakho.

Imiphumela emibi evame kakhulu ngokuvamile imnene futhi iyalawuleka:

• Ukuqaqamba noma ukuvuvukala endaweni ye-IV
• Ukuqaqamba kwekhanda
• Ukuqubuka kwesikhumba noma ukuluma
• Isicanucanu noma ukuphathwa yisisu
• Isiyezi noma ukuzwa ukukhathala
• Ukukhathala ngemuva kokwelashwa

Le miphumela emibi ejwayelekile ivamise ukuthuthuka njengoba umzimba wakho ujwayela umuthi. Ithimba lakho lezempilo lingase lincoma izindlela zokuphatha lezi zimo, njengokusebenzisa iqhwa endaweni ye-IV noma ukuthatha imithi yesicanucanu.

Imiphumela emibi engathi sína ayivamile kodwa idinga ukunakekelwa kwezempilo ngokushesha:

• Ukuphendula okukhulu komzimba (ubunzima bokuphefumula, ukuvuvukala kobuso noma umphimbo)
• Ushintsho olukhulu ekusebenzeni kwezinso
• Ukuphendula okukhulu kwesikhumba noma ukuqubuka okusabalalele
• Ukuphuma kwegazi okungajwayelekile noma ukuqaqamba
• Izimpawu zokutheleleka endaweni ye-IV (ukubomvu okukhulu, ukufudumala, noma i-pus)

Ithimba lakho lezokwelapha lizokuqapha ngokucophelela ukuze libone lezi zimo ezingathi sína. Bazohlola ukusebenza kwezinso zakho njalo ngemithombo yegazi futhi baqaphele noma yiziphi izimpawu zokuphendula komzimba ngesikhathi sokufakwa kwemithi.

Ubani Ongafanele Athole i-Edaravone?

I-Edaravone ayifanele wonke umuntu one-ALS. Udokotela wakho uzohlola ngokucophelela ukuthi lo muthi ukufanele yini ngokuya ngezinto eziningana ezibalulekile.

Akufanele uthathe i-edaravone uma une:

• Ukungezwani okwaziwayo ne-edaravone noma yiziphi izithako zayo
• Isifo sezinso esibi noma ukwehluleka kwezinso
• Umlando wokuphendula okukhulu komzimba emithini ye-IV
• I-ALS ethuthukile lapho umuthi kungenzeka unganikezi inzuzo
• Izinhlobo ezithile ze-ALS ezingazange zithuthuke kahle ku-edaravone ocwaningweni

Udokotela wakho uzobheka nesimo sakho sempilo esiphelele, okuhlanganisa ukusebenza kwenhliziyo yakho, impilo yesibindi, kanye nekhono lokubekezelela ukwelashwa kwe-IV okuvamile. Uma ukhulelwe noma uncelisa, izingozi nezinzuzo zizodinga ukuxoxwa ngokucophelela nethimba lakho lezempilo.

Ubudala bodwa abukukhiphi ekwelashweni nge-edaravone, kodwa abadala bangase badinge ukuqashwa ngokucophelela ngenxa yokwanda kokuzwela emithini kanye nengozi enkulu yemiphumela emibi.

Igama Lomkhiqizo le-Edaravone

I-Edaravone ithengiswa ngaphansi kwegama lomkhiqizo elithi Radicava e-United States. Umuthi ukhiqizwa yi-Mitsubishi Tanabe Pharma futhi wawuyindlela yokuqala yokwelapha i-ALS entsha eyavunywa yi-FDA eminyakeni engaphezu kwama-20.

Ungase futhi uyibone ibizwa ngegama layo elivamile, i-edaravone, emibhalweni yezokwelapha noma emadokumenti omshwalense. Womabili la magama abhekisela emuthini ofanayo onesithako esisebenzayo esifanayo.

Igama lomkhiqizo elithi Radicava livela egameni elithi

Ingabe i-Edaravone Ingcono Kune-Riluzole?

I-Edaravone ne-riluzole zisebenza ngezindlela ezihlukene, ngakho azikwazi ukuqhathaniswa ngokuqondile - zicabange njengamathuluzi ahlukene ekhithi yakho yokwelapha kunokuba izinketho eziqhudelanayo. Odokotela abaningi batusa ukusebenzisa zombili lezi zithako ndawonye uma kufanelekile.

I-Riluzole isikhona isikhathi eside futhi inemininingwane eminingi yocwaningo. Ithathwa njengepilisi kabili ngosuku, okwenza kube lula kune-edaravone's IV infusions. Kodwa-ke, i-edaravone ingase inikeze izinzuzo ezinganikezwa yi-riluzole ngenxa yendlela yayo yokusebenza ehlukile.

Ucwaningo luphakamisa ukuthi i-edaravone ingase isebenze kahle ekulondolozeni amakhono okusebenza kwansuku zonke, kuyilapho i-riluzole ingase ibe ngcono ekunwebeni isikhathi sokusinda esiphelele. Udokotela wakho uzokusiza ukuthi uqonde ukuthi yisiphi isithako noma inhlanganisela yezithako enengqondo kakhulu esimweni sakho esithile.

Ukukhetha phakathi kwale mithi kuncike ezintweni ezinjengesigaba sesifo sakho, ikhono lokubekezelela ukwelashwa nge-IV, umshwalense, nezintandokazi zomuntu siqu mayelana nokulula kokwelashwa vs izinzuzo ezingaba khona.

Imibuzo Evame Ukubuzwa Mayelana ne-Edaravone

Ingabe i-Edaravone Iphephile Kubantu Abanezifo Zenhliziyo?

I-Edaravone ngokuvamile ingasetshenziswa ngokuphepha kubantu abanezifo zenhliziyo, kodwa udokotela wakho wenhliziyo kanye nodokotela wezinzwa kuzodingeka basebenze ndawonye ukuze bakuqaphele ngokucophelela. Umuthi awuthinti ngokuqondile ukusebenza kwenhliziyo, kodwa ukufakwa kwe-IV kungeza uketshezi ohlelweni lwakho.

Uma unesifo senhliziyo noma ezinye izimo lapho uketshezi olwengeziwe lungaba yinkinga, ithimba lakho lezempilo lizokuqapha eduze ngesikhathi sokufakwa. Bangase balungise izinga lokufakwa noma batusa eminye imithi ukusiza umzimba wakho ukuthi ubhekane noketshezi olwengeziwe.

Ngaphambi kokuqala i-edaravone, qiniseka ukuthi udokotela wakho uyazi nganoma yiziphi izimo zenhliziyo, imithi yokwehlisa umfutho wegazi, noma umlando wezinkinga zenhliziyo. Lolu lwazi lubasiza ukuthi banikeze ukunakekelwa okuphephe kakhulu.

Kufanele ngenzeni uma ngiphuthelwa ngengozi umthamo we-Edaravone?

Uma uphuthelwa ukufakwa kwe-edaravone okuhleliwe, xhumana nethimba lakho lezempilo ngokushesha ngangokunokwenzeka ukuze lihlehlise. Ungazami "ukubamba" ngokuhlela ukufakwa okwengeziwe - lokhu kungandisa ingozi yakho yemiphumela emibi ngaphandle kokuhlinzeka ngezinzuzo ezengeziwe.

Ithimba lakho lezokwelapha lizokusiza ukuthi unqume indlela engcono kakhulu yokubuyela emkhondweni ngohlelo lwakho lokwelashwa. Ezimweni eziningi, bazomane baqhubeke nomjikelezo wakho ovamile lapho ugcine khona.

Ukuphuthelwa ukufakwa okukodwa noma okubili ngezikhathi ezithile ngeke kube nomthelela omkhulu ekusebenzeni kokwelashwa kwakho. Kodwa-ke, ukuphuthelwa njalo ukwelashwa kunganciphisa ikhono lomuthi lokunciphisa ukuqhubeka kwesifo, ngakho-ke kubalulekile ukugcina ukwelashwa okuqhubekayo uma kungenzeka.

Kufanele ngenzeni uma ngithola imiphumela emibi ngesikhathi sokufakwa?

Uma uhlangabezana nanoma yiziphi izimpawu ezingakhululekile ngesikhathi sokufakwa kwakho kwe-edaravone, tshela ithimba lakho lezempilo ngokushesha. Baqeqeshwe ukubona nokuphatha imiphumela emibi ehlobene nokufakwa ngokushesha nangempumelelo.

Izimpawu ezivamile ezinjengokucasuka okuncane, ikhanda elibuhlungu, noma isiyezi ngokuvamile zingalawulwa ngokunciphisa izinga lokufakwa noma ukukunikeza imithi yokusiza ngezimpawu. Ithimba lakho lezokwelapha lingase futhi linikeze uketshezi lwe-IV ukukusiza ukuthi uzizwe ungcono.

Ukuze uthole ukusabela okungathi sína njengobunzima bokuphefumula, ukuqubuka okukhulu, noma ubuhlungu besifuba, ithimba lakho lezempilo lizoyeka ukufakwa ngokushesha futhi linikeze ukwelashwa okufanele kwezokwelapha. Bazosebenza nodokotela wakho ukunquma ukuthi kuphephile yini ukuqhubeka nokwelashwa kwe-edaravone esikhathini esizayo.

Ngingayeka nini ukuthatha i-Edaravone?

Isinqumo sokuyeka i-edaravone kufanele senziwe ngaso sonke isikhathi kanye nethimba lakho lezempilo ngemva kokucabangela ngokucophelela isimo sakho ngasinye. Akukho sikhathi esinqunywe ngaphambilini lapho kufanele uyeke ukwelashwa uma ukubekezelela kahle futhi ukhombisa izinzuzo.

Ungase ucabange ukuyeka i-edaravone uma uba nemiphumela engathandeki, uma i-ALS yakho iqhubeka ize ifike ezingeni lapho imithi ingasanikezi inzuzo enkulu, noma uma isimo sakho sempilo yonke sishintsha kakhulu.

Abanye abantu bakhetha ukuyeka ukwelashwa ngenxa yomthwalo wokuvakashela njalo ezikhungweni zezokwelapha, ikakhulu uma ukuhamba kwabo kuba nomkhawulo omkhulu. Ithimba lakho lokunakekelwa kwezempilo lingakusiza ukuthi ulinganise izinzuzo zokuqhubeka nokwelashwa ngokumelene nezinselelo ezingokoqobo ezilethayo.

Ngingahamba Ngesikhathi Ngithatha I-Edaravone?

Ukuhamba ngenkathi uthatha i-edaravone kudinga ukuhlelwa kusengaphambili, kodwa kuvame ukwenzeka ngokuhleleka okufanele. Uzodinga ukuhlela ukwelashwa esikhungweni sokufaka imithi noma esibhedlela endaweni oya kuyo.

Ithimba lakho lokunakekelwa kwezempilo lingakusiza ukuthi uthole izikhungo zezokwelapha ezifanelekayo kwamanye amadolobha futhi lihlele ukunakekelwa kwakho. Bangakunikeza futhi ngemibhalo ebalulekile yezokwelapha kanye nolwazi lokuxhumana uma kwenzeka izimo eziphuthumayo ngenkathi ungekho.

Ohambweni olude, ungase udinge ukulungisa isimiso sakho sokwelashwa noma uthathe ikhefu elihleliwe ku-edaravone. Udokotela wakho angakusiza ukuthi unqume indlela engcono kakhulu ngokusekelwe ezinhlelweni zakho zokuhamba kanye nesimo sakho samanje sempilo.