Yini i-Edoxaban: Ukusetshenziswa, Umthamo, Imiphumela Eceleni nokuningi

I-Edoxaban iyisidakamizwa esibhalwe ngudokotela esinciphisa igazi esisiza ukuvimbela ukwakheka kwamahlule egazi ayingozi emzimbeni wakho. Ingaphansi kwesigaba esisha sama-anticoagulants abizwa ngokuthi ama-anticoagulants aqondile omlomo (ama-DOAC) asebenza ngokuvimba iphrotheni ethile yokujiya egazini lakho. Lo muthi uvame ukunqunyelwa abantu abane-atrial fibrillation noma labo abake baba namahlule egazi emilenzeni yabo noma emaphashini.

Yini i-Edoxaban?

I-Edoxaban ngumuthi omlomo we-anticoagulant ovimbela igazi lakho ukuthi lingajiyi kalula. Cabanga ngayo njengomqaphi ogcina igazi lakho ligeleza kahle ngemithambo yakho ngaphandle kokwakha amahlule ayingozi. Ngokungafani nama-blood thinners amadala afana ne-warfarin, i-edoxaban isebenza ngendlela engcono futhi ayidingi ukuhlolwa kwegazi njalo ukuqapha imiphumela yayo.

Lo muthi uqondise ngqo i-Factor Xa, iphrotheni ebalulekile enqubweni yokujiya yomzimba wakho. Ngokuvimba le phrotheni, i-edoxaban isiza ukugcina ibhalansi efanele phakathi kokuvimbela amahlule ayingozi nokuvumela ukujiya okuvamile uma ulimala.

Isetshenziselwani i-Edoxaban?

I-Edoxaban iphatha futhi ivimbele izimo eziningana ezinzima zamahlule egazi. Udokotela wakho angase akubhalele uma une-atrial fibrillation, isifo senhliziyo esinyusa ingozi yakho yokushaywa unhlangothi. Iphinde isetshenziselwe ukwelapha i-deep vein thrombosis (amahlule egazi emithanjeni yomlenze) kanye ne-pulmonary embolism (amahlule emithanjeni yamaphaphu).

Abantu abane-atrial fibrillation babhekene nethuba eliphezulu lokushaywa unhlangothi ngoba ukushaya kwenhliziyo kwabo okungajwayelekile kungabangela ukuthi igazi liqoqane futhi lakhe amahlule. I-Edoxaban isiza ukunciphisa le ngozi yokushaywa unhlangothi ngokugcina igazi ligeleza kahle. Kulabo asebevele benamahlule egazi, lo muthi uvimbela ukwakheka kwamasha ngenkathi usiza umzimba wakho ukuthi uncibilikise ngokwemvelo amahlule akhona.

Ngokuvamile, odokotela bangase babhale i-edoxaban kwezinye izifo zokujiya kwegazi noma njengesinyathelo sokuvimbela ngaphambi kokuhlinzwa okuthile. Umhlinzeki wakho wokunakekelwa kwezempilo uzoqaphela ukuthi i-edoxaban ilungile yini esimweni sakho esithile esuselwe emlandweni wakho wezokwelapha kanye nezici eziyingozi.

Isebenza Kanjani I-Edoxaban?

I-Edoxaban isebenza ngokuvimba i-Factor Xa, i-enzyme ebalulekile ekujiyeni kwegazi lakho. Le enzyme isebenza njengomdlali obalulekile ochungechungeni oluholela ekwakhekeni kwegazi. Ngokuvimbela i-Factor Xa, i-edoxaban iphazamisa le nqubo ngaphambi kokuthi amahlule akwazi ukuthuthuka ngokugcwele.

Lo muthi ubhekwa njengonamandla ngokulinganisela phakathi kwabanciphisi begazi. Inamandla kune-aspirin kodwa ngokuvamile ibangela ingozi encane yokuphuma kwegazi kunezinye izinto ezilwa nokujiya kwegazi. Imiphumela ye-edoxaban iyabikezeleka futhi iyafana, okusho ukuthi udokotela wakho angabhala umthamo ojwayelekile ngaphandle kokudinga ukuwulungisa ngokusekelwe ekuhlolweni kwegazi okuningi.

Umuthi uqala ukusebenza kungakapheli amahora ngemva kokuwuthatha, futhi imiphumela yawo ihlala cishe amahora angama-24. Lolu hlu lwesikhathi olubikezelwayo lwenza kube lula ukuphatha uma kuqhathaniswa nabanciphisi begazi abadala ababenemiphumela ehlukahlukene.

Kufanele Ngiyithathe Kanjani I-Edoxaban?

Thatha i-edoxaban ngendlela udokotela wakho ayala ngayo, ngokuvamile kanye ngosuku ngaphandle kokudla noma ngaphandle kokudla. Ungayithatha ngamanzi, ubisi, noma ijusi - ukudla akuthinti ngendlela ebalulekile ukuthi umzimba wakho umunca kanjani umuthi. Abantu abaningi bakuthola kuwusizo ukuthatha i-edoxaban ngesikhathi esifanayo nsuku zonke ukuze bagcine amazinga aqhubekayo egazini labo.

Awudingi ukulandela imikhawulo ekhethekile yokudla ngenkathi uthatha i-edoxaban, ngokungafani ne-warfarin. Kodwa-ke, kungcono ukugwema ukusetshenziswa ngokweqile kotshwala njengoba kungakhuphula ingozi yakho yokuphuma kwegazi. Uma unenkinga yokugwinya amaphilisi, ungaqoba amaphilisi e-edoxaban bese uwaxuba namanzi noma i-applesauce, kodwa qala uhlole nomuthi wakho.

Zama ukusungula isimiso mayelana nokuthatha imithi yakho. Abantu abaningi bayithatha ngesidlo sasekuseni noma sakusihlwa ukusiza ukukhumbula umthamo wabo wansuku zonke. Ukusetha isikhumbuzi sefoni nakho kungasiza ekuqinisekiseni ukuthi awuphuthelwa imithamo.

Kufanele Ngiyithathe Isikhathi Esingakanani I-Edoxaban?

Ubude bokwelashwa nge-edoxaban buxhomeke esimweni sakho esithile kanye nezici eziyingozi. Ngokushaya kwenhliziyo okungajwayelekile, cishe uzodinga ukwelashwa kwesikhathi eside ukuze uqhubeke nokuvikela engozini yokushaywa unhlangothi. Ngamagazi ahlanganayo emilenzeni yakho noma emaphashini, ukwelashwa kuvame ukuthatha izinyanga ezintathu kuya kweziyisithu, nakuba abanye abantu bengase badinge ukwelashwa isikhathi eside.

Udokotela wakho uzohlola njalo ukuthi usayidinga yini i-edoxaban ngokusekelwe esimweni sakho, ingozi yokopha, kanye nempilo yakho yonke. Abanye abantu abanezici eziqhubekayo eziyingozi bangase badinge ukwelashwa impilo yabo yonke, kanti abanye bangayeka ngemva kokuba ingozi yabo yamahlule incipha. Ungayeki ukuthatha i-edoxaban ngokuzumayo ngaphandle kokubonisana nodokotela wakho, ngoba lokhu kungakhuphula ingozi yakho yamahlule ayingozi.

Uma uke waba namahlule amaningi egazi noma unezimo ezithile zofuzo, udokotela wakho angase ancome ukwelashwa okwandisiwe ngaphandle kwesikhathi esivamile. Bazohlola izinzuzo zokuvimbela amahlule ngokumelene nezingozi ezingaba khona zokulwa negazi isikhathi eside.

Yiziphi Imiphumela Eceleni Ye-Edoxaban?

Njengazo zonke izinciphisi zegazi, umphumela oyinhloko we-edoxaban ukwanda kwengozi yokopha. Abantu abaningi bayayibekezelela kahle le mithi, kodwa kubalulekile ukwazi ukuthi yini okufanele uyibheke. Imiphumela ejwayelekile eceleni ngokuvamile imnene futhi ingalawuleka ngokuqapha okufanele.

Nawa amanye imiphumela ejwayelekile eceleni ongase uyithole:

• Ukulimala kalula noma ukulimala okuvelayo ngaphandle kwembangela ecacile
• Ukuphuma kwegazi okuncane okuvela ekuqhekekeni okuthatha isikhathi eside ukuyeka
• Ukuphuma kwegazi ngezinye izikhathi
• Izikhathi ezinzima kakhulu kwabesifazane
• Ukuphazamiseka kwesisu okuncane noma isicanucanu
• Isiyezi noma ukuzwa ukukhanya ekhanda

Lezi zinto ezivamile ngokuvamile ziyathuthuka njengoba umzimba wakho ujwayela imithi. Abantu abaningi baqhubeka nokwelashwa kwabo ngaphandle kwezinkinga ezinkulu.

Imiphumela emibi kakhulu ayivamile kodwa idinga ukunakekelwa kwezempilo ngokushesha. Lokhu kufaka phakathi izimpawu zokuphuma kwegazi okukhulu okungase kubeke impilo engozini:

• Ikhanda elibuhlungu eliqinile noma ukudideka (kungenzeka ukopha ebuchosheni)
• Ukuphalaza igazi noma into ebukeka njengomhlabathi wekhofi
• Izihlalo ezimnyama, ezinama-tarry noma igazi elibomvu ngokugqamile esitulweni
• Ubuthakathaka obungavamile noma ukuquleka
• Ubuhlungu obukhulu besisu
• Ukuphefumula kanzima noma ubuhlungu besifuba

Uma uhlangabezana nanoma yiziphi lezi zimpawu ezimbi, funa ukunakekelwa kwezempilo eziphuthumayo ngokushesha. Nakuba kungavamile, lezi zinkinga zidinga ukwelashwa ngokushesha ukuze kuvinjelwe imiphumela emibi.

Obani okungafanele basebenzise i-Edoxaban?

Abantu abathile akufanele basebenzise i-edoxaban ngenxa yengozi eyengeziwe yokuphuma kwegazi noma ezinye izimo zezokwelapha. Udokotela wakho uzobukeza ngokucophelela umlando wakho wezokwelapha ngaphambi kokukuyala le mithi. Abantu abanezinkinga zokuphuma kwegazi noma izigameko zokuphuma kwegazi ezinkulu muva nje ngokuvamile abakwazi ukusebenzisa i-edoxaban ngokuphepha.

Nazi izimo ezingase zikuvimbele ukuthi ungasebenzisi i-edoxaban:

• Ukuphuma kwegazi kwangaphakathi okusebenzayo noma ukuphuma kwegazi okukhulu kwamuva
• Isifo sezinso esibi noma ukuhluleka kwezinso
• Ama-valve enhliziyo emishini
• Ukukhulelwa noma ukuncelisa
• Isifo sesibindi esibi
• Ukungezwani okwaziwayo ne-edoxaban noma imithi efanayo

Udokotela wakho uzobheka nezici eziyingozi zokuphuma kwegazi ngaphambi kokukuyala i-edoxaban. Lokhu kungase kuhlanganise umlando wezilonda zesisu, ukuhlinzwa kwamuva, noma izimo ezenza ingozi yokuphuma kwegazi ikhule.

Abanye abantu badinga ukuqapha okukhethekile noma ukulungiswa komthamo esikhundleni sokugwema imithi ngokuphelele. Umhlinzeki wakho wezempilo uzonquma indlela ephephe kakhulu esekelwe esimweni sakho ngasinye nezidingo zezokwelapha.

Amagama e-Edoxaban Brand

I-Edoxaban iyatholakala ngaphansi kwegama lomkhiqizo elithi Savaysa e-United States. Kwamanye amazwe, ingathengiswa ngaphansi kwamanye amagama omkhiqizo afana ne-Lixiana. Isithako esisebenzayo sihlala singashintshi ngaphandle kwegama lomkhiqizo.

Izinhlobo ze-generic ze-edoxaban ziya ngokuya zitholakala kwezinye izifunda, ezingase zinikeze ukonga izindleko. Kodwa-ke, njalo xhumana nodokotela wakho noma usokhemisi ngaphambi kokushintsha phakathi kwezinhlobo zomkhiqizo ne-generic ukuze uqinisekise ukwelashwa okuqhubekayo.

Ezinye izindlela ze-Edoxaban

Ezinye izinciphisi zegazi ezingasebenza njengezinye izindlela ze-edoxaban uma ingakulungele. Ezinye izinciphisi zegazi eziqondile zomlomo (DOACs) zihlanganisa i-rivaroxaban (Xarelto), i-apixaban (Eliquis), kanye ne-dabigatran (Pradaxa). Ngamunye unezici ezihlukile kanye nezinhlelo zokulinganisa.

I-Warfarin isahlala iyindlela, ikakhulukazi kubantu abanezivalve zenhliziyo ezingokomshini noma isifo sezinso esibi. Ngenkathi i-warfarin idinga ukuqapha igazi njalo, isetshenziswe ngokuphepha amashumi eminyaka futhi inezidakamizwa ezitholakalayo uma kwenzeka izimo eziphuthumayo zokopha.

Kwabanye abantu, imithi elwa namaphlatelethi afana ne-aspirin noma i-clopidogrel ingase ibe ezinye izindlela ezifanele, nakuba ngokuvamile zingasebenzi kahle ekuvikeleni amahlule ku-atrial fibrillation. Udokotela wakho uzosiza ukukhetha inketho engcono kakhulu ngokusekelwe esimweni sakho esithile sezokwelapha kanye nezici eziyingozi.

Ingabe i-Edoxaban ingcono kune-Warfarin?

I-Edoxaban inikeza izinzuzo eziningi ngaphezu kwe-warfarin, nakuba yomibili imithi ivimbela ngempumelelo amahlule egazi. I-Edoxaban ayidingi ukuhlolwa kwegazi njalo ukuqapha imiphumela yayo, okwenza kube lula kubantu abaningi. Futhi inokuxhumana okuncane nokudla neminye imithi uma kuqhathaniswa ne-warfarin.

Ucwaningo lubonisa ukuthi i-edoxaban okungenani isebenza kahle njenge-warfarin ekuvikeleni ukushaywa unhlangothi kubantu abanokuthuthumela kwe-atrial. Kungase kubangele ukuphuma kwegazi okuncane ebuchosheni, okuyinkimbinkimbi enkulu kakhulu yezinciphisi zegazi. Kodwa-ke, i-edoxaban njengamanje ayinayo i-antidote ethile, kuyilapho i-warfarin ingahle ihlehle ngamavithamini K noma eminye imithi.

Ukukhetha phakathi kwe-edoxaban ne-warfarin kuncike ezimweni zakho. Abantu abahamba njalo, abanemisebenzi eminingi, noma abahlushwa yimikhawulo yokudla ye-warfarin bavame ukukhetha i-edoxaban. Kodwa-ke, i-warfarin ingase ibe ngcono kulabo abanezimo ezithile zamavalvu enhliziyo noma isifo esibi sezinso.

Imibuzo Evame Ukubuzwa Mayelana ne-Edoxaban

Ingabe i-Edoxaban iphephile kubantu abanesifo sezinso?

I-Edoxaban ingasetshenziswa kubantu abanesifo sezinso esingesibi kakhulu, kodwa ukulungiswa komthamo kuvame ukudingeka. Udokotela wakho uzohlola ukusebenza kwezinso zakho ngaphambi kokuqala ukwelashwa futhi akubheke njalo. Abantu abanesifo sezinso esibi noma ukwehluleka kwezinso ngokuvamile abakwazi ukusebenzisa i-edoxaban ngokuphepha.

Uma ukusebenza kwezinso zakho kushintsha ngenkathi uthatha i-edoxaban, udokotela wakho kungadingeka alungise umthamo wakho noma akushintshele emuthini ohlukile. Ukuhlolwa kwegazi okuvamile kusiza ekuqinisekiseni ukuthi umuthi uhlala uphephile futhi usebenza kahle esimweni sakho.

Ngingenzani uma ngithatha i-Edoxaban eningi ngengozi?

Uma ngengozi uthatha i-edoxaban eyengeziwe, xhumana nodokotela wakho noma isikhungo sokulawula ubuthi ngokushesha. Ukuthatha okuningi kwandisa ingozi yakho yokuphuma kwegazi kakhulu. Ungazami ukukhokhela ngokweqa umthamo wakho olandelayo, ngoba lokhu kungandisa ingozi yakho yegazi.

Qaphela izimpawu zokuphuma kwegazi njengokulimala okungavamile, ukuphuma kwegazi emakhaleni, noma ukopha izinsini. Funani ukunakekelwa kwezempilo eziphuthumayo uma uhlangabezana nekhanda elibuhlungu elibuhlungu, ukuhlanza igazi, noma ezinye izimpawu zokuphuma kwegazi okukhulu. Gcina ibhodlela lomuthi unawe lapho ufuna usizo lwezempilo.

Ngingenzani uma ngiphuthelwa umthamo we-Edoxaban?

Uma uphuthelwa umthamo we-edoxaban, yithathe ngokushesha nje lapho ukhumbula ngalo lolo suku. Uma sekuyilanga elilandelayo, weqa umthamo ophuthelwe bese uthatha umthamo wakho ovamile ngesikhathi esijwayelekile. Ungalokothi uthathe imithamo emibili ngesikhathi esisodwa ukuze ulungise umthamo ophuthelwe.

Ukuphuthelwa imithamo ngezikhathi ezithile ngokuvamile ngeke kubangele izinkinga ngokushesha, kodwa zama ukugcina ukuthatha imithamo yansuku zonke ngendlela efanayo ukuze uthole ukuvikeleka okungcono kakhulu. Ukusetha izikhumbuzi zocingo noma ukusebenzisa umhleli wamaphilisi kungakusiza ukuthi ukhumbule imithi yakho.

Ngingayeka nini ukuthatha i-Edoxaban?

Ungalokothi uyeke ukuthatha i-edoxaban ngaphandle kokubonisana nodokotela wakho kuqala. Ukuyeka kungazelelwe kungakhuphula ingozi yakho yamaqhubu egazi ayingozi ezinsukwini ezimbalwa. Udokotela wakho uzonquma ukuthi kuphephile nini ukuyeka ngokusekelwe esimweni sakho kanye nezici eziyingozi zamaqhubu.

Kubantu abane-atrial fibrillation, ukuyeka i-edoxaban ngokuvamile akukhuthazwa ngaphandle uma izingozi zokuphuma kwegazi zidlula izinzuzo zokuvimbela isitroko. Labo abaphathwa ngamaqhubu egazi bangase bakwazi ukuyeka ngemva kokuqeda inkambo yabo ebekiwe, ngokuvamile izinyanga ezintathu kuya kweziyisithupha.

Ngingakwazi yini ukuphuza utshwala ngenkathi ngithatha i-Edoxaban?

Ungaphuza utshwala ngokulinganisela ngenkathi uthatha i-edoxaban, kodwa ukuphuza ngokweqile kwandisa ingozi yakho yokuphuma kwegazi. Khawulela utshwala ekungeni ngaphezu kwesisodwa ngosuku kwabesifazane kanye neziphuzo ezimbili ngosuku kwabesilisa. Ukuphuza ngokweqile noma ukusetshenziswa kotshwala okungapheli kungaba yingozi nganoma yisiphi isinciphisi segazi.

Uma unezinkathazo mayelana nokusetshenziswa kotshwala noma unomlando wezinkinga zotshwala, xoxa ngalokhu nodokotela wakho. Bangakusiza ukuthi uqonde indlela ephephe kakhulu ngenkathi uthatha i-edoxaban.