Yini i-Efbemalenograstim-alfa-vuxw: Ukusetshenziswa, Umthamo, Imiphumela Eceleni Nokunye

I-Efbemalenograstim-alfa-vuxw iyimithi esiza umzimba wakho ukuthi ukhiqize amaseli amaningi amhlophe egazi lapho ukwelashwa komdlavuza kuye kwenza buthaka amasosha akho omzimba. Le mithi kadokotela ingeyeqembu elibizwa ngokuthi ama-colony-stimulating factors, asebenza njengezimpawu zemvelo emzimbeni wakho ukuze akhulise amaseli alwa nezifo. Ungase uyazi kangcono ngegama layo lomkhiqizo elithi Rolvedon, futhi yenzelwe ngqo ukusiza ekuvikeleni izifo ezingathi sína ngesikhathi se-chemotherapy.

Yini i-Efbemalenograstim-alfa-vuxw?

I-Efbemalenograstim-alfa-vuxw iyiphrotheni eyenziwe ngumuntu elingisa into yemvelo umzimba wakho oyikhiqizayo ukuze udale amaseli amhlophe egazi. Cabanga ngayo njengomsizi otshela umnkantsha wakho ukuthi usebenze kanzima ekwenzeni amaseli alwa nezifo. Le mithi yilokho odokotela abakubiza ngokuthi i-biosimilar, okusho ukuthi isebenza ngendlela efana kakhulu neminye imithi esungulwe kahle emndenini ofanayo.

Igama elide lingase lizwakale lisabisa, kodwa limane nje liyindlela eqondile yokukhomba le nguqulo ethile yomuthi. Ingxenye ethi "vuxw" ekugcineni injengento ehlukile esiza ukuyihlukanisa neminye imithi efanayo. Ithimba lakho lezempilo ngokuvamile lizobhekisela kuyo ngegama layo lomkhiqizo ukuze kwenze izinto zibe lula.

Isetshenziselwani i-Efbemalenograstim-alfa-vuxw?

Le mithi isetshenziswa ikakhulukazi ukuvimbela ukwehla okuyingozi kwamaseli amhlophe egazi okubizwa ngokuthi i-neutropenia, okuvame ukwenzeka ngesikhathi sokwelashwa komdlavuza. Uma uthola i-chemotherapy, le mithi enamandla ayigcini nje ngokugxila kumaseli omdlavuza - ingase futhi yehlise okwesikhashana ikhono lomzimba wakho lokwenza amaseli amhlophe egazi anempilo. Lokhu kukushiya ubuthakathaka ezifweni ezingase zibe zimbi noma zibeke nokuphila engozini.

Udktora wakho angase akunike lo muthi uma wamukela i-chemotherapy eyaziwa ngokwehlisa kakhulu inani lamaseli amhlophe egazi. Lusizo ikakhulukazi kubantu abathola ukwelashwa ngezinhlobo ezahlukene zomdlavuza, okuhlanganisa umdlavuza webele, umdlavuza wamaphaphu, nomdlavuza wegazi. Umgomo uwukugcina amaseli akho alwa nezifo emazingeni aphephile ukuze uqhubeke nokwelashwa komdlavuza wakho njengoba kuhleliwe.

Ngezinye izikhathi odokotela basebenzisa lo muthi kwezinye izimo ezithinta ukukhiqizwa kwamaseli amhlophe egazi, nakuba ukusekela ukwelashwa komdlavuza kuhlala kuyinto esetshenziswa kakhulu. Umhlinzeki wakho wezempilo uzoqaphela ukuthi lo muthi ulungile yini esimweni sakho esithile ngokusekelwe ohlelweni lwakho lokwelapha nezidingo zakho zempilo.

Isebenza Kanjani I-Efbemalenograstim-alfa-vuxw?

Lo muthi usebenza ngokubopha kuma-receptors athile emnkantshubomvu wakho, okuyilapho umzimba wakho wenza khona amaseli egazi. Uma isinamathela kula ma-receptors, ithumela amasignali akhuthaza ukukhiqizwa nokukhululwa kwama-neutrophils, amaseli akho amhlophe egazi abaluleke kakhulu alwa nezifo. Kufana nokunika umnkantshubomvu wakho ukukhuthaza okumnene kodwa okuphumelelayo ukuthi usebenze kanzima ekwenzeni la maseli okuvikela.

Umuthi uthathwa njengomaphakathi ngokuqina uma kuziwa ekusebenzeni kwawo. Abantu abaningi babona ukuthi inani labo lamaseli amhlophe egazi liqala ukuthuthuka ezinsukwini ezimbalwa ngemva kokuqala ukwelashwa. Imiphumela ivame ukuhlala izinsuku eziningana ngemva komthamo ngamunye, yingakho odokotela bevame ukuwunika ngokusho kweshejuli ethile ehambisana nokwelashwa kwakho kwe-chemotherapy.

Okuthatha lo muthi ukuthi usizo ikakhulukazi ukuthi usebenza ngokushesha. Inani lamaseli akho amhlophe egazi livame ukuqala ukukhuphuka phakathi kwezinsuku eziyi-1-2, futhi livame ukufinyelela emazingeni okuvikela ngaphakathi kwezinsuku eziyi-3-5. Lokhu kusabela okusheshayo kusiza ukuxazulula igebe lapho ukukhiqizwa kwamaseli akho emvelo kuhlehla okwesikhashana ngenxa yokwelashwa komdlavuza.

Kufanele Ngiyithathe Kanjani I-Efbemalenograstim-alfa-vuxw?

Lo muthi unikezwa ngomjovo ngaphansi kwesikhumba sakho, ngokuvamile engalweni yakho engenhla, ethangeni, noma esiswini. Ithimba lakho lokunakekelwa kwezempilo lizokukhombisa inqubo efanele yokujova uma uzoyizenzela ekhaya, noma lingayiphatha emtholampilo. Indawo yokujova kufanele ijikeleziswe njalo ukuvimbela ukucasuka noma ubuhlungu kunoma iyiphi indawo eyodwa.

Akudingeki ukuthi uthathe lo muthi nokudla noma ubisi ngoba ujovwa kunokuba ugwinywe. Kodwa-ke, kubalulekile ukugcina umuthi efrijini uze ukulungele ukuwusebenzisa. Wukhiphe cishe imizuzu engama-30 ngaphambi kwesikhathi sokujova ukuze uvumele ukuthi ufike ezingeni lokushisa legumbi, okwenza umjovo ukhululeke kakhulu.

Isikhathi semithamo yakho sizohlelwa ngokucophelela ngohlelo lwakho lwe-chemotherapy. Abantu abaningi bathola umthamo wabo wokuqala ngemuva kwamahora angama-24-72 ngemuva kwe-chemotherapy, bese beqhubeka nemijovo yansuku zonke izinsuku eziningana. Udokotela wakho uzokunikeza uhlelo oluqondile olwenzelwe uhlelo lwakho lokwelashwa nokuthi umzimba wakho usabela kanjani emuthini.

Kufanele Ngithathe Isikhathi Esingakanani I-Efbemalenograstim-alfa-vuxw?

Ubude bokwelashwa buyahluka ngokuya ngesimo sakho somuntu ngamunye nokuthi umzimba wakho usabela kanjani emuthini. Abantu abaningi bayithatha izinsuku eziyi-7-14 ngemuva komjikelezo ngamunye we-chemotherapy, kodwa abanye bangase bayidinge isikhathi esifushane noma eside. Udokotela wakho uzoqapha ukubalwa kwamaseli akho amhlophe egazi ngokuhlolwa kwegazi okuvamile ukuze anqume ubude obufanele bokwelashwa kwakho.

Ngokuvamile, uzoqhubeka nokuthatha lo muthi kuze kube yilapho ukubalwa kwamaseli akho amhlophe egazi kululama kuya emazingeni aphephile. Lokhu kuvame ukwenzeka phakathi kwamasonto ayi-1-2, kodwa umzimba womuntu ngamunye usabela ngendlela ehlukile. Abanye abantu babuyela ngokushesha, kanti abanye bangase badinge isikhathi esengeziwe nokusekelwa.

Uma uthola imijikelezo eminingi ye-chemotherapy, cishe uzodinga lo muthi ngemva komjikelezo ngamunye wokwelashwa. Ithimba lakho lezempilo lizobuyekeza izidingo zakho ngaphambi komjikelezo ngamunye futhi lilungise uhlelo lokwelashwa uma kunesidingo. Umgomo uhlale ukuhlinzeka ngosizo olwanele ukuze ukugcine uphephile ngaphandle kokweqisa.

Yiziphi Imiphumela Eceleni ye-Efbemalenograstim-alfa-vuxw?

Njengemithi eminingi, i-efbemalenograstim-alfa-vuxw ingabangela imiphumela emibi, nakuba abantu abaningi beyibekezelela kahle. Umphumela ovamile eceleni ubuhlungu emathanjeni, obenzeka ngoba umuthi ugqugquzela umnkantsha wakho wamathambo ukuthi usebenze kanzima. Lolu buhlungu luvame ukuba buthuntu kuya phakathi nendawo futhi luvame ukuthuthuka njengoba umzimba wakho ujwayela ukwelashwa.

Nansi imiphumela emibi ejwayelekile ongase uyithole:

• Ubuhlungu emathanjeni noma ubuhlungu, ikakhulu emhlane wakho, ezingalweni, noma emilenzeni
• Ubuhlungu emisipheni noma ubuhlungu bomzimba obujwayelekile
• Ikhanda
• Ukukhathala noma ukuzizwa ukhathele kunokujwayelekile
• Isicanucanu noma isisu esincane
• Ukuphendula kwendawo yokujova njengobubomvu, ukuvuvukala, noma ukuzwela
• Umkhuhlane omncane

Iningi lale miphumela emibi iyaphathwa futhi ivame ukuthuthuka ngemva kwemithamo embalwa yokuqala. Udokotela wakho angase ancome izidambisi zobuhlungu ezingathengiswa ngaphandle kwemithi yobuhlungu emathanjeni nemisipheni, futhi ukusebenzisa iqhwa ezindaweni zokujova kungasiza ekuphenduleni kwendawo.

Imiphumela emibi engavamile kodwa ebucayi ingenzeka, nakuba ingavamile. Lokhu kungabandakanya ukusabela okukhulu komzimba, izinkinga zokuphefumula, noma ukuvuvukala okungavamile. Nakuba lezi zindlela ezimbi ezingathí sina zingenzeki kaningi, kubalulekile ukwazi ukuthi yini okufanele uyibheke ukuze ufune usizo ngokushesha uma kudingeka.

Abanye abantu bangase babe nesimo esibizwa ngokuthi i-tumor lysis syndrome uma benohlobo oluthile lomdlavuza wegazi, nakuba lokhu kungavamile. Ithimba lakho lezempilo lizokuqapha ngokucophelela, ikakhulukazi ngesikhathi sokwelashwa kwakho kokuqala, ukuze libambe noma yiziphi izinguquko ezikhathazayo ekuqaleni.

Obani okungafanele basebenzise i-Efbemalenograstim-alfa-vuxw?

Lo muthi awulungile kuwo wonke umuntu, futhi ziningi izimo lapho odokotela ngokuvamile begwema ukuwunikeza. Abantu abake baba nokusabela okukhulu komzimba emithini efanayo noma kunoma yiziphi izithako zalo muthi akufanele bawusebenzise. Udokotela wakho uzobukeza umlando wakho wokungezwani komzimba ngokucophelela ngaphambi kokuqala ukwelashwa.

Uma unezinhlobo ezithile zomdlavuza wegazi, ikakhulukazi ezinye izinhlobo ze-leukemia noma i-myelodysplastic syndrome, lo muthi kungenzeka awufanele. Lezi zimo ngezinye izikhathi zingaba zimbi kakhulu ngemithi ekhuthaza ukukhiqizwa kwamangqamuzana amhlophe egazi, ngakho-ke udokotela wakho we-oncologist uzodinga ukukala izinzuzo nezingozi ngokucophelela okukhulu.

Abantu abanezifo ezisebenzayo ngokuvamile akufanele baqale lo muthi kuze kube yilapho ukutheleleka sekulawulwa. Ngenkathi umuthi usiza ukuvimbela izifo ngokukhulisa amangqamuzana amhlophe egazi, ukuwuqala ngesikhathi sokutheleleka okusebenzayo kungase kube nzima ekwelashweni. Ithimba lakho lezempilo lizofuna ukubhekana nanoma yiziphi izifo ezikhona kuqala.

Abesifazane abakhulelwe noma abancelisa ngamabele kufanele baxoxe ngezingozi nezinzuzo nodokotela babo, njengoba kunolwazi olulinganiselwe mayelana nokuphepha ngesikhathi sokukhulelwa. Ngokufanayo, abantu abanezimo ezithile zenhliziyo noma umlando wezinkinga ezingathi sína zamaphaphu bangase badinge ukuqashwa okukhethekile noma ezinye izindlela zokwelapha.

Igama Lomkhiqizo le-Efbemalenograstim-alfa-vuxw

Igama lomkhiqizo le-efbemalenograstim-alfa-vuxw yi-Rolvedon. Leli gama kulula kakhulu ukulikhumbula nokuphimisela kunegama elide elivamile, yingakho abahlinzeki bezempilo abaningi kanye namakhemisi bezobhekisela kulo njenge-Rolvedon engxoxweni nakumaphilisi.

I-Rolvedon ikhiqizwa yi-Spectrum Pharmaceuticals futhi yavunywa yi-FDA njengomuthi we-biosimilar. Lokhu kusho ukuthi isebenza ngendlela efana kakhulu neminye imithi esunguliwe esigabeni esifanayo, kodwa ingase itholakale ngezindleko ezehlukile noma ngezinketho ezihlukene zomshwalense.

Uma uthatha umuthi wakho noma uxoxa ngemithi yakho nethimba lakho lezempilo, ungalithuki uma beshintsha phakathi kokusebenzisa igama elithi "Rolvedon" negama elide elivamile - bakhuluma ngomuthi ofanayo. Okubalulekile ukuthi uthola umuthi ofanele izidingo zakho ezithile.

Ezinye izindlela zokwelapha i-Efbemalenograstim-alfa-vuxw

Eminye imithi eminingi isebenza ngendlela efana ne-efbemalenograstim-alfa-vuxw, futhi udokotela wakho angase acabangele lezi ezinye izindlela ngokusekelwe esimweni sakho esithile, ukukhava komshwalense, noma ukuthi uzithola kanjani ezinye izinketho. Ezinye izindlela ezisetshenziswa kakhulu zihlanganisa i-filgrastim (Neupogen), i-pegfilgrastim (Neulasta), nezinye izinhlobo ze-biosimilar zale mithi.

I-Filgrastim ivame ukunikezwa nsuku zonke izinsuku eziningana ngemva kwe-chemotherapy, efana ne-efbemalenograstim-alfa-vuxw. Ngakolunye uhlangothi, i-Pegfilgrastim, iyinhlobo esebenza isikhathi eside evame ukunikezwa njengomjovo owodwa ngemva komjikelezo ngamunye we-chemotherapy. Zombili lezi zindlela zingasebenza, futhi ukukhetha kuvame ukuncika ekuthandeni kwakho, indlela yokuphila, neshejuli yokwelashwa.

Abanye abantu bakhetha ukulula komjovo owodwa, kanti abanye bathanda ukulawula okwengeziwe ukwelashwa kwabo ngemithamo yansuku zonke. Ithimba lakho lezempilo lizokusiza ukuthi uqonde izinzuzo nobubi benketho ngayinye. Bazocabangela izinto ezinjengokuthi umzimba wakho usabela kanjani ekwelashweni, ukukhava kwakho komshwalense, nokuthi yini evumelana kangcono nohlelo lwakho lokunakekelwa komdlavuza.

Izindaba ezinhle ukuthi uma omunye umuthi ungasebenzi kahle kuwe noma ubangela imiphumela emibi, ngokuvamile zikhona ezinye izinketho zokuzama. Udokotela wakho angakushintshela komunye umuthi uma kudingeka, futhi abantu abaningi bathola ukuthi izinguquko ezincane ekwelashweni zingenza umehluko omkhulu endleleni abazizwa ngayo.

Ingabe i-Efbemalenograstim-alfa-vuxw ingcono kune-Filgrastim?

Kokubili i-efbemalenograstim-alfa-vuxw kanye ne-filgrastim kuyasebenza ekuvikeleni ukwehla okuyingozi kwamaseli amhlophe egazi ngesikhathi se-chemotherapy. Zisebenza ngezindlela ezifanayo kakhulu futhi zinezilinganiso zempumelelo eziqhathanisekayo ezifundweni zomtholampilo. Ukukhetha phakathi kwazo kuvame ukwehla ezintweni ezingokoqobo kunokuthi enye ibe

Yebo, i-efbemalenograstim-alfa-vuxw ngokuvamile iphephile kubantu abanesifo sikashukela, kodwa uzodinga ukuqashwa eduze ngesikhathi sokwelashwa. Umuthi awuthinti ngokuqondile amazinga kashukela egazini, kodwa ukucindezeleka kokwelashwa komdlavuza nemiphumela emibi ethile efana nezinguquko esifisweni sokudla kungathinta ukuphathwa kwesifo sakho sikashukela. Ithimba lakho lezempilo lizofuna ukugcina iso eliseduze emazingeni akho kashukela egazini futhi lingase lilungise imithi yakho yesifo sikashukela uma kudingeka.

Uma unesifo sikashukela, qiniseka ukuthi utshela udokotela wakho we-oncologist futhi uqhubeke nokusebenza nethimba lakho lokunakekelwa kwesifo sikashukela ngesikhathi sokwelashwa komdlavuza wakho. Bangakusiza ukuphatha zombili izimo ngempumelelo futhi baqaphele noma yikuphi ukusebenzisana phakathi kwemithi yakho yesifo sikashukela nokwelashwa komdlavuza.

Kufanele Ngenzeni Uma Ngisebenzisa Ngengozi I-Efbemalenograstim-alfa-vuxw Eningi Kakhulu?

Uma ngengozi uzijova ngaphezu komthamo wakho obekiwe, xhumana nomhlinzeki wakho wezempilo noma usokhemisi ngokushesha, ngisho noma uzizwa ulungile. Ngenkathi ukweqisa okukodwa kungenzeki ukuthi kubangele izinkinga ezinkulu, kubalulekile ukwazisa ithimba lakho lezokwelapha ukuze likuqaphe ngendlela efanele futhi lilungise uhlelo lwakho lokwelashwa uma kudingekile.

Ungazami ukweqa umthamo wakho olandelayo ukuze

Ukushoda komthamo akulungile ngoba kungakushiya nokuvikeleka okuncane ezifweni ngesikhathi esibucayi. Kodwa-ke, ungesabi - ithimba lakho lezempilo lingakusiza ukuthi ubuyele emkhondweni futhi lingase lifune ukuqapha ukubalwa kwegazi lakho ngokucophelela ukuqinisekisa ukuthi usavikelekile ngokwanele.

Ngingayeka nini ukuthatha i-Efbemalenograstim-alfa-vuxw?

Kufanele uyeke kuphela ukuthatha lo muthi lapho udokotela wakho ekutshela ukuthi kuphephile ukwenza kanjalo, ngokuvamile lapho ukubalwa kwamaseli akho amhlophe egazi sekubuyele emazingeni amukelekayo. Lokhu kuvame ukwenzeka phakathi kwamasonto angu-1-2 ngemuva kokuqala ukwelashwa, kodwa isikhathi esiqondile siyahluka kumuntu nomuntu. Ithimba lakho lezempilo lizogada ukubalwa kwegazi lakho njalo ukuze linqume isikhathi esifanele sokuyeka.

Ungayeki ukuthatha umuthi ngokwakho, ngisho noma uzizwa ungcono noma uhlangabezana nemiphumela emibi. Ukuyeka ngaphambi kwesikhathi kungakushiya ubhekene nezifo ezinzima lapho amasosha akho omzimba esalulama ekhemotherapy. Uma imiphumela emibi ikukhathaza, khuluma nomhlinzeki wakho wezempilo ngezindlela zokuphatha leyo miphumela kunokuyeka umuthi.

Ngingahamba yini ngenkathi ngithatha i-Efbemalenograstim-alfa-vuxw?

Ukuhamba kungenzeka ngenkathi uthatha lo muthi, kodwa kudinga ukuhlela ngokucophelela nokuxhumana nethimba lakho lezempilo. Umuthi udinga ukugcinwa efrijini, ngakho-ke uzodinga ukuhlela ukugcinwa okufanele ngesikhathi sohambo lwakho. Abantu abaningi basebenzisa izikhwama zemithi ezinomshini wokufaka umoya ngamaphakethe eqhwa ohambweni olufushane, kodwa uhambo olude lungadinga amalungiselelo akhethekile.

Okubaluleke nakakhulu, ukuhamba ngenkathi uthola ukwelashwa komdlavuza nokuthatha imithi esekela amasosha omzimba kudinga izinyathelo zokuphepha ezengeziwe. Ukubalwa kwamaseli akho amhlophe egazi kungase kusephansi kunokujwayelekile, okukwenza ube sengozini enkulu yokutheleleka. Izikhumulo zezindiza ezigcwele abantu, izindiza, kanye nezindawo ezingajwayelekile kungakhuphula izingozi zokutheleleka. Xoxa ngezinhlelo zakho zokuhamba nethimba lakho lezempilo kusenesikhathi ukuze bakusize uhambe ngokuphepha futhi ulungise isimiso sakho sokwelashwa uma kudingeka.