Yini i-Everolimus: Ukusetshenziswa, Umthamo, Imiphumela Eceleni nokuningi

I-Everolimus iyimithi kadokotela esiza ukunciphisa ukukhula kwezinhlobo ezithile zamaseli omdlavuza futhi ivimbele ukwenqatshwa kwezitho ngemva kokufakelwa. Lo muthi onamandla wokucindezela amasosha omzimba usebenza ngokuvimba amaprotheni athile emzimbeni wakho alawula ukuhlukaniswa kwamaseli nokuphendula kwamasosha omzimba.

Ungase unikezwe i-everolimus uma unomdlavuza wezinso, umdlavuza wamabele, izimila ezithile zobuchopho, noma uma uthole ukufakelwa izinso. Udokotela wakho uzokugada ngokucophelela ngenkathi uthatha lo muthi ukuze aqinisekise ukuthi usebenza ngempumelelo nangokuphepha esimweni sakho esithile.

Yini i-Everolimus?

I-Everolimus ingeyeqembu lemithi ebizwa ngokuthi ama-mTOR inhibitors. Kuyindlela yokwelapha eqondiwe ephazamisa indlela yamaprotheni ebizwa ngokuthi i-mTOR, elawula indlela amaseli akhula ngayo, azale ngayo, futhi asinde ngayo.

Lo muthi uza ngesimo samaphilisi futhi uthathwa ngomlomo nsuku zonke. Umuthi waqala ukuthuthukiswa ukuze uvimbele ukwenqatshwa kwezitho ezigulini ezifakelwe izitho, kodwa abacwaningi bathola ukuthi futhi unempahla enamandla yokulwa nomdlavuza. Namuhla, odokotela basebenzisa i-everolimus ukwelapha izimo eziningana ezihlukene lapho ukulawula ukukhula kwamaseli kubalulekile.

Cabanga nge-everolimus njengomlawuli wethrafikhi wamaselula. Inciphisa amasignali atshela amaseli ukuthi akhule futhi ahlukanise ngokushesha, okungasiza ukumisa amaseli omdlavuza ukuthi angasakazi noma kuvimbele amasosha akho omzimba ukuthi angahlaseli isitho esifakelwe.

Isetshenziselwani i-Everolimus?

I-Everolimus iphatha izimo eziningana ezingathi sína zezokwelapha ngokulawula indlela amaseli akho akhula ngayo nokuthi amasosha akho omzimba asabela kanjani. Udokotela wakho uyayibhala lapho udinga ukunciphisa izinqubo ezithile zamaselula emzimbeni wakho.

Nawa amakhambi amakhulu i-everolimus esiza ukuwapheka, ngalinye lidinga ukugadwa kwezokwelapha ngokucophelela:

• Umhlaza wamaphaphu othuthukile (i-renal cell carcinoma) - uma umdlavuza usabalale noma ubuyile ngemva kweminye imithi
• Umhlaza wamabele omuhle ngama-hormone receptor - ikakhulukazi uma isetshenziswa ne-exemestane kubantu besifazane abase ngemva kokuya esikhathini
• Ukuvimbela ukwenqatshwa kokufakelwa izinso - kusiza umzimba wakho ukwamukela ilungu elisha
• Ukuvimbela ukwenqatshwa kokufakelwa kwesibindi - kusebenza kanye neminye imithi ecindezela amasosha omzimba
• I-Subependymal giant cell astrocytoma (SEGA) - uhlobo lomdlavuza wobuchopho oluhambisana ne-tuberous sclerosis complex
• Amathumba e-pancreatic neuroendocrine - uma kungenakwenzeka ukuwasusa ngokuhlinzwa
• I-Tuberous sclerosis complex (TSC) - isiza ukuphatha izinkinga zezinso ezibizwa ngokuthi i-angiomyolipomas

Ngamunye walezi zimo udinga izindlela ezahlukene zokulinganisa nokugada. Ithimba lakho lokunakekelwa kwezempilo lizokwenza uhlelo lwakho lokwelashwa ngokusekelwe ekuxilongweni kwakho okuthile kanye nesimo sempilo yakho esiphelele.

Isebenza Kanjani I-Everolimus?

I-Everolimus isebenza ngokuvimba indlela yamaprotheni ebizwa ngokuthi i-mTOR, okusho ukuthi "i-mechanistic target of rapamycin." Le ndlela ilawula ukuthi amaseli akhula kanjani, ahlukanise, futhi asebenzise amandla emzimbeni wakho wonke.

Lapho i-everolimus ivimba i-mTOR, empeleni ibeka amabhuleki ekukhuleni kwamaseli okusheshayo. Ekwelashweni komdlavuza, lokhu kusho ukuthi amaseli omdlavuza awakwazi ukuzala ngokushesha noma ukusabalala kalula. Kubantu abafakelwe izitho, kusho ukuthi amasosha akho omzimba mancane amathuba okuthi ahlasele futhi enqabe ilungu elisha.

Lo muthi ubhekwa njengokwelashwa okuqondiswe ngamandla kunomuthi ojwayelekile we-chemotherapy. Iqondisa ngqo indlela ye-mTOR ngaphandle kokuthinta ezinye izinhlelo eziningi zomzimba. Kodwa-ke, ngoba icindezela amasosha akho omzimba, uzodinga ukuqapha njalo ukuvimbela izifo nezinye izinkinga.

Kuthatha isikhathi esingakanani ukuthi umuthi usebenze?

Umuthi ngokuvamile uthatha amasonto amaningana ukuze ufinyelele ekusebenzeni kwawo okuphelele emzimbeni wakho. Udokotela wakho cishe uzohlola amazinga egazi lakho njalo ezinyangeni ezimbalwa zokuqala ukuze aqinisekise ukuthi uthola inani elifanele.

Kufanele ngiyithathe kanjani i-Everolimus?

Thatha i-everolimus njengoba nje udokotela wakho ekuyala ngayo, ngokuvamile kanye ngosuku ngesikhathi esifanayo nsuku zonke. Ukuqina ngesikhathi kusiza ukugcina amazinga aqhubekayo omuthi egazini lakho.

Kufanele uthathe i-everolimus esiswini esingenalutho, kungaba ihora elilodwa ngaphambi kokudla noma amahora amabili ngemuva kokudla. Lokhu kusiza umzimba wakho ukuthi umunce umuthi kahle. Gwinya amaphilisi wonke ngengilazi yamanzi egcwele - ungawachobozi, uwahlafune, noma uwaphule.

Uma uthatha amaphilisi okumiswa (asetshenziselwa izimo ezithile), landela imiyalelo kamakhemisi wakho ngokucophelela ekuxubeni. Ukumiswa kufanele kulungiswe ngaso sonke isikhathi futhi kusetshenziswe ngokushesha ngemuva kokuxuba.

Nawa amakhodi abalulekile okufanele uwalandele ngenkathi uthatha i-everolimus:

• Yithathe ngesikhathi esifanayo nsuku zonke ukuze ugcine amazinga egazi aqhubekayo
• Ungadli ama-grapefruit noma uphuze ijusi le-grapefruit, ngoba lokhu kungandisa imiphumela emibi
• Gwema imithi yokugomela esaphila ngenkathi uthatha lo muthi
• Gcina amaphilisi ekamelweni lokushisa kude nomswakama nokushisa
• Gcina amaphilisi esitsheni sawo sokuqala kuze kube yilapho usukulungele ukuwathatha
• Ungabelani ngemithi yakho nabanye

Uma unenkinga yokugwinya amaphilisi, khuluma nodokotela wakho mayelana nokwakheka okuhlukile. Ungalokothi ushintshe indlela othatha ngayo i-everolimus ngaphandle kwesiqondiso sezokwelapha, ngoba lokhu kungathinta ukuthi isebenza kahle kangakanani.

Kufanele ngiyithathe isikhathi esingakanani i-Everolimus?

Ubude bokwelashwa nge-everolimus buqondile ngokuya ngesimo sakho esithile nokuthi usabela kahle kangakanani emuthini. Abanye abantu bayayithatha izinyanga, kanti abanye bangayidinga iminyaka noma isikhathi eside.

Ukwelashwa komdlavuza, ngokuvamile uzoqhubeka nokuthatha i-everolimus uma nje isiza ukulawula isifo sakho futhi ungaqali ukuzwa imiphumela emibi kakhulu. Udokotela wakho uzoqapha inqubekela phambili yakho ngokuskena njalo nokuhlolwa kwegazi ukuze anqume ukuthi imithi isasebenza yini.

Iziguli ezinamalunga zivame ukuthatha i-everolimus impilo yazo yonke ukuvimbela ukwenqatshwa kwamalunga. Ithimba lakho lezempilo lizolungisa umthamo wakho ngokuhamba kwesikhathi ngokusekelwe emazingeni egazi lakho kanye nempilo yakho yonke, kodwa ukuyeka imithi kungabeka ilunga lakho elishintshiwe engozini.

Udokotela wakho uzohlola njalo ukuthi kufanele uqhubeke yini nokwelashwa ngokucabangela izinto ezinjengokuthi imithi isebenza kahle kangakanani, yimiphi imiphumela emibi oyizwayo, kanye nekhwalithi yakho yempilo yonke. Ungalokothi uyeke ukuthatha i-everolimus ngokuzumayo ngaphandle kokuqondiswa ngudokotela, ngoba lokhu kungaba yingozi kuye ngesimo sakho.

Yiziphi Imiphumela Eceleni ye-Everolimus?

Njengayo yonke imithi enamandla, i-everolimus ingabangela imiphumela emibi evela kokuncane kuya kokukhulu. Abantu abaningi bazwa eminye imiphumela emibi, kodwa eminingi iyaphathwa ngokunakekelwa okufanele nokuqapha.

Ukuqonda okulindelekile kungakusiza ukuthi ubone lapho kufanele uxhumane nethimba lakho lezempilo nokuthi yiziphi izimpawu eziyingxenye yenqubo yokulungisa ejwayelekile:

Imiphumela Eceleni Ejwayelekile

Le miphumela emibi yenzeka kubantu abaningi abathatha i-everolimus futhi ngokuvamile iyaphathwa:

• Izilonda zomlomo noma izilonda - ngokuvamile umphumela okhathaza kakhulu
• Ukukhathala nobuthakathaka - kungase kuthuthuke njengoba umzimba wakho uzivumelanisa
• Ukuqunjelwa - ngokuvamile kulula kuya ngokuphakathi
• Ukucasuka nokuncipha kwesifiso sokudla - ukudla ukudla okuncane, okuvame kakhulu kungasiza
• Ukuqubuka kwesikhumba noma ukuvela okufana nezinduna - ngokuvamile ebusweni nasengxenyeni engenhla yomzimba
• Ukukhwehlela - ngokuvamile komile futhi okuqhubekayo
• Ukuvuvukala ezandleni, ezinyaweni, noma emilenzeni - ngenxa yokugcinwa kwamanzi
• Ikhanda - ngokuvamile lilula futhi lilawuleka

Imiphumela emibi engathi sína

Le miphumela emibi idinga ukunakekelwa kwezokwelapha ngokushesha futhi ingase idinge ukulungiswa kokwelashwa:

• Izinkinga ezinzima zamaphaphu - okuhlanganisa umshini wokuphefumula noma ukuvuvukala kwezicubu zamaphaphu
• Izifo ezinzima - amasosha akho omzimba acindezelwe, okukwenza ube sengozini enkulu
• Izinkinga zezinso - kubaluleke kakhulu ezigulini ezinamalungu omzimba
• Izilonda zomlomo ezinzima - eziphazamisa ukudla noma ukuphuza
• Ushukela ophezulu wegazi noma isifo sikashukela - idinga ukuqapha kanye nezinguquko ezingaba khona zemithi
• Amazinga aphezulu e-cholesterol - angase adinge izinguquko zokudla noma imithi eyengeziwe
• Ukuphendula kwesikhumba okunzima - okuhlanganisa ukuqubuka okubanzi noma ukuqhekeka

Imiphumela emibi engavamile kodwa engathi sína

Lezi zinkinga azivamile kodwa zidinga ukunakekelwa kwezokwelapha eziphuthumayo:

• Ukuphendula okukhulu komzimba emithini - ukuba nzima ukuphefumula, ukuvuvukala kobuso noma umphimbo
• Izinkinga zenhliziyo - ukushaya kwenhliziyo okungajwayelekile noma ubuhlungu besifuba
• Umonakalo omkhulu wesibindi - ukuphuzi kwesikhumba noma amehlo, umchamo omnyama
• Amaqhubu egazi - ubuhlungu bomlenze obuzumayo, ubuhlungu besifuba, noma ukuphefumula okuncane
• Ukuphuma kwegazi okukhulu - ukulimala okungajwayelekile noma ukuphuma kwegazi okungami
• Ukuvuvukala kobuchopho - ikhanda elibuhlungu kakhulu, ukudideka, noma izinguquko embonweni

Iqembu lakho lezempilo lizokugada ngokucophelela ukuze libone le miphumela emibi ngokusebenzisa ukuhlolwa kwegazi njalo nokuhlolwa. Imiphumela eminingi emibi ingavinjelwa noma incishiswe ngokuthatha izinyathelo zokuphepha ezifanele nokungenelela ngokushesha.

Ubani Ongafanele Athathe I-Everolimus?

I-Everolimus ayiphephile kuwo wonke umuntu, futhi izimo ezithile zezokwelapha noma izimo zikwenza kungafaneleki noma kube yingozi. Udokotela wakho uzobukeza ngokucophelela umlando wakho wezokwelapha ngaphambi kokukuyala lo muthi.

Akufanele uthathe i-everolimus uma wazi ukuthi unokungezwani komzimba nomuthi noma izithako zawo. Izimpawu zokungezwani komzimba zihlanganisa imihuzuko, ukuba nzima ukuphefumula, noma ukuvuvukala kobuso bakho, izindebe, ulimi, noma umphimbo.

Izimo eziningana zezempilo zidinga ukuqapha okukhethekile noma zingakuvimbela ukuthi ungathathi i-everolimus ngokuphepha:

• Izifo ezisebenzayo - amasosha akho omzimba adinga ukuqina ngokwanele ukulwa nezifo zamanje
• Isifo sesibindi esibi - isibindi sakho sicubungula lo muthi, ngakho ukungasebenzi kahle kuyingozi
• Isifo sezinso esibi - singase siqhubekisele phambili ukusebenza kwezinso
• Ukuhlinzwa kwamuva - i-everolimus ingaphazamisa ukuphola kwamanxeba
• Isifo samaphaphu - okuhlanganisa isifuba somoya noma isifo samaphaphu esingamahlalakhona
• Ukukhulelwa noma ukuncelisa - kungalimaza izingane ezisakhula
• Imithi yokugomela esanda kutholwa - amasosha akho omzimba acindezelwe awakwazi ukubhekana nemithi yokugomela ngendlela ephephile

Imithi ethile ingase isebenzisane ngendlela eyingozi ne-everolimus, ikakhulukazi imithi elwa nesikhunta, ama-antibiotics, kanye neminye imithi ecindezela amasosha omzimba. Hlala utshela udokotela wakho ngayo yonke imithi, izithasiselo, kanye nemikhiqizo yemithi yezitshalo oyithathayo.

Udokotela wakho uzobuye acabangele iminyaka yakho, isimo sempilo yakho esiphelele, kanye nekhono lakho lokulandela izidingo zokuqapha ngaphambi kokunquma i-everolimus.

Amagama e-Brand e-Everolimus

I-Everolimus itholakala ngaphansi kwamagama amaningi e-brand, ngalinye lenzelwe izimo ezithile zezokwelapha. Amagama e-brand ajwayelekile afaka i-Afinitor, i-Afinitor Disperz, kanye ne-Zortress.

I-Afinitor iyibrendi enqunywe kakhulu, etholakala ngamaphilisi avamile okwelapha umdlavuza kanye nezimo ezithile zofuzo. I-Afinitor Disperz iza ngamaphilisi ancibilika emanzini, okwenza kube lula kubantu abanobunzima bokugwinya amaphilisi noma abadinga amashubhu okuphakela.

I-Zortress yenziwe ngokuqondile iziguli ezinamathambo futhi iza ngamandla ahlukene kunama-version okwelapha umdlavuza. Izidingo zokulinganisa nokuqapha zingase zihluke phakathi kwama-brand, ngakho kubalulekile ukunamathela kubrendi ethile udokotela wakho ayinqumayo.

Izinhlobo ezivamile ze-everolimus nazo ziyatholakala futhi ziqukethe isithako esifanayo esisebenzayo. Kodwa-ke, udokotela wakho angase akhethe ukuthi uhlale nohlobo oluthile ukuze aqinisekise amazinga egazi aqhubekayo nokusebenza kahle.

Ezinye Izindlela Zokwelapha Nge-Everolimus

Imithi eminingi ehlukile iyatholakala uma i-everolimus ingafaneleki esimweni sakho noma uma uhlangabezana nemiphumela emibi ebalulekile. Enye indlela engcono kakhulu incike esimweni sakho esithile sezokwelapha.

Ukwelashwa komdlavuza, ezinye izindlela zingabandakanya ezinye izindlela zokwelapha ezihloswe ngqo njenge-sunitinib (Sutent), pazopanib (Votrient), noma i-axitinib (Inlyta) yomdlavuza wezinso. Abagulayo abanomdlavuza wamabele bangase bacabange ezinye izinhlanganisela zokwelapha ngamaphilisi noma izithiyo ze-CDK4/6.

Iziguli ezinokufakelwa kwezitho zinomuthi ohlukahlukene wokucindezela amasosha omzimba, okuhlanganisa i-tacrolimus (Prograf), i-mycophenolate (CellCept), noma i-sirolimus (Rapamune). Ngamunye unamaphrofayili ahlukene emiphumela emibi kanye nezidingo zokuqapha.

Ukukhethwa kwenye indlela kuncike ezintweni ezinjengomlando wakho wokwelashwa wangaphambilini, isimo sakho samanje sempilo, eminye imithi oyithathayo, nezintandokazi zomuntu siqu mayelana nemiphumela emibi kanye nezimiso zokuqapha.

Ingabe i-Everolimus Ingcono Kune-Sirolimus?

I-Everolimus ne-sirolimus ziyimithi ehlobene eduze esebenza ngezindlela ezifanayo, kodwa zomehluko obalulekile owenza enye ifaneleke kakhulu kunenye ezimweni ezithile.

I-Everolimus intsha futhi ifundwe kabanzi ekwelashweni komdlavuza. Ivame ukukhethwa ezigulini ezinomdlavuza ngoba inezinkomba ezengeziwe zomdlavuza ezivunyelwe yi-FDA kanye namazinga egazi aqagulekayo.

I-Sirolimus isetshenziswe isikhathi eside emithini yokufakelwa kwezitho futhi ingase ikhethwe ezigulini ezithile zokufakelwa kwezitho ngenxa yomlando wayo omude kanye nephrofayili ehlukile yemiphumela emibi. Abanye abantu bayayibekezelela kangcono enye kunenye.

Ukukhetha phakathi kwale mithi kuncike esimweni sakho esiqondile, ukwelashwa kwangaphambilini, ezinye izinkinga zempilo, kanye namaphethini okusabela komuntu ngamunye. Udokotela wakho uzocabangela zonke lezi zinto lapho enquma ukuthi imuphi umuthi onikeza ibhalansi engcono kakhulu yokusebenza kahle nemiphumela emibi elawulekayo yesimo sakho.

Imibuzo Evame Ukubuzwa Mayelana ne-Everolimus

Umbuzo 1. Ingabe i-Everolimus iphephile kubantu abanesifo sikashukela?

I-Everolimus ingathinta amazinga kashukela egazini futhi ingase yenze isifo sikashukela sibe sibi kakhulu noma iqale isifo sikashukela kubantu abangenawo kakade. Noma kunjalo, abantu abaningi abanesifo sikashukela bangayithatha ngokuphepha i-everolimus ngokugadwa ngokucophelela.

Udokotela wakho uzohlola amazinga kashukela egazini lakho njalo ngenkathi uthatha i-everolimus. Ungase udinge ukulungisa imithi yakho yesifo sikashukela noma uqaphele ushukela wakho wegazi kaningi. Abanye abantu bathuthukisa ushukela wegazi ophezulu okokuqala ngqa ngenkathi bethatha i-everolimus, kodwa lokhu kuvamile ukulawuleka ngezinguquko zokudla noma imithi.

Uma unesifo sikashukela, qiniseka ukuthi utshela ithimba lakho lezempilo nganoma yiziphi izinguquko kumaphethini akho kashukela wegazi, ukoma okwandayo, noma ukuchama njalo ngenkathi uthatha i-everolimus.

Umbuzo 2. Kufanele ngenzeni uma ngithatha i-Everolimus eningi ngengozi?

Uma ngengozi uthatha i-everolimus eningi kunaleyo ebekiwe, xhumana nodokotela wakho noma isikhungo sokulawula ubuthi ngokushesha, ngisho noma uzizwa kahle. Ukuthatha okuningi kungakhuphula ingozi yakho yemiphumela emibi engathi sína.

Ungazami ukwenza ngaphezu kwe-overdose ngokweqa umthamo wakho olandelayo. Esikhundleni salokho, funa iseluleko sezokwelapha mayelana nendlela yokuqhubeka ngokuphepha. Udokotela wakho angase afune ukukuqapha eduze noma alungise isimiso sakho sokulinganisa.

Ukuvimbela ama-overdoses ngengozi, gcina imithi yakho esitsheni sayo sokuqala ngokulebula okucacile, setha izikhumbuzi zokuthi uthathe nini umthamo wakho wansuku zonke, futhi ungalokothi uphinde imithamo uma ungaqiniseki ukuthi uyithathile yini imithi yakho.

Umbuzo 3. Kufanele ngenzeni uma ngiphuthelwa umthamo we-Everolimus?

Uma uphuthelwa umthamo we-everolimus, yithathe ngokushesha lapho ukhumbula, kodwa kuphela uma sekudlule amahora angaphansi kwangu-6 kusukela ngesikhathi sakho esijwayelekile sokuthatha imithi. Uma sekudlule amahora angaphezu kwangu-6, weqa umthamo ophuthelwe bese uthatha umthamo wakho olandelayo ngesikhathi esijwayelekile.

Ungalokothi uthathe imithamo emibili ngesikhathi esisodwa ukuze ulungise umthamo ophuthelwe, ngoba lokhu kungandisa ingozi yakho yemiphumela emibi engathi sína. Kunalokho, qhubeka neshejuli yakho ejwayelekile yokuthatha imithi futhi wazise ithimba lakho lezempilo ngomthamo ophuthelwe ekuhlolweni kwakho okulandelayo.

Ukusetha ama-alamu ocingweni noma ukusebenzisa umhleli wamaphilisi kungakusiza ukuthi ukhumbule ukuthatha imithi yakho ngokuqhubekayo. Ukuthatha imithi ngokuqhubekayo kubalulekile ekugcineni amazinga aqhubekayo emithi emzimbeni wakho.

Q4. Ngingayeka nini Ukuthatha i-Everolimus?

Kufanele uyeke kuphela ukuthatha i-everolimus ngaphansi kokuqondiswa kwezokwelapha okuqondile. Isikhathi sincike esimweni sakho esithile, impendulo yokwelashwa, kanye nesimo sakho sempilo esiphelele.

Ukwelashwa komdlavuza, ngokuvamile uzoqhubeka nokuthatha i-everolimus uma nje isiza ukulawula isifo sakho futhi ukwazi ukumelana nemiphumela emibi kahle. Udokotela wakho uzosebenzisa izithombe kanye nokuhlolwa kwegazi ukuze aqaphe inqubekela phambili yakho futhi anqume ukuthi kungaba nini okufanelekile ukuyeka noma ukushintsha ukwelashwa.

Iziguli ezinamalunga zivame ukudinga ukuthatha i-everolimus isikhathi eside ukuze zivimbele ukwenqatshwa kwamalunga. Ukuyeka kungazelelwe kungabeka ilunga lakho elithuthukisiwe engozini enkulu. Noma yiziphi izinguquko ekwelashweni kwakho kokucindezela amasosha omzimba kumele kuhlelwe ngokucophelela futhi kuqashwe yithimba lakho lokuthuthukisa amalunga.

Q5. Ngingakhulelwa Ngesikhathi Ngithatha i-Everolimus?

I-Everolimus ingalimaza izingane ezisakhula, ngakho akufanele ukhulelwe ngenkathi uthatha lo muthi. Bobabili abesilisa nabesifazane badinga ukusebenzisa izindlela zokulawula inzalo ezisebenzayo ngesikhathi sokwelashwa kanye nesikhathi esithile ngemuva kokuyeka i-everolimus.

Abesifazane kufanele basebenzise izindlela zokuvimbela inzalo ezinokwethenjelwa ngesikhathi sokwelashwa kanye nangemva kwamasonto angu-8 ngemva komthamo wokugcina. Amadoda kufanele asebenzise izindlela zokuvimbela inzalo ezisebenzayo ngesikhathi sokwelashwa kanye nangemva kwamasonto angu-4 ngemva kokuyeka ukusebenzisa i-everolimus, njengoba umuthi ungathinta isidoda.

Uma uzama ukukhulelwa noma ucabanga ukuthi ungase ukhulelwe ngenkathi usebenzisa i-everolimus, xhumana nodokotela wakho ngokushesha. Bazodinga ukuxoxa ngezingozi nezinzuzo zokuqhubeka nokwelashwa futhi bakusize ukuthi wenze isinqumo esiphephe kakhulu kuwe nakumntwana wakho.