Fam-trastuzumab deruxtecan-nxki (indlela ye-intravenous)
Imikhiqizo etholakalayo
Enhertu
Mayelana naleli khambi
Ishaja ye-Fam-trastuzumab deruxtecan-nxki isetyenziselwa ukwelapha umdlavuza webele onama-HER2 aphezulu (IHC 3+ noma ISH positive) osakazekile (umdlavuza osakazeke ezingxenyeni ezinye zomzimba) noma ongenakususwa (umdlavuza ongenakususwa ngokuthi) kubantu abake bamukela ukwelashwa komdlavuza webele we-anti-HER2 ngesifo esisakazekile noma abane-kansa yebhubesi ebuyile phakathi noma ngaphakathi kwezinyanga eziyi-6 zokuphela kokwelashwa kwesigaba sokuqala somdlavuza webele. Ukudubula kwe-Fam-trastuzumab deruxtecan-nxki futhi kusetshenziswa ukwelapha umdlavuza webele onama-HER2 aphansi osakazekile (umdlavuza osakazeke ezingxenyeni ezinye zomzimba) noma ongenakususwa (umdlavuza ongenakususwa ngokuthi) kubantu abake bamukela ukwelashwa ngesifo esisakazekile noma abane-kansa yebhubesi ebuyile phakathi noma ngaphakathi kwezinyanga eziyi-6 zokuphela kokwelashwa (emva kokuthi). Ukudubula kwe-Fam-trastuzumab deruxtecan-nxki futhi kusetshenziswa ukwelapha umdlavuza we-lung ongahlukile we-non-small cell (NSCLC) osakazekile (umdlavuza osakazeke ezingxenyeni ezinye zomzimba) noma ongenakususwa (umdlavuza ongenakususwa ngokuthi) kubantu abane-gene ye-HER2 engavamile futhi abake bamukela ukwelashwa. Ukudubula kwe-Fam-trastuzumab deruxtecan-nxki futhi kusetshenziswa ukwelapha umdlavuza wesisu onama-HER2 aphezulu (IHC 3+ noma IHC 2+/ ISH positive) osakazekile (umdlavuza osakazeke ezingxenyeni ezinye zomzimba) noma osakazekile endaweni (umdlavuza osakazeke ezindaweni eziseduze nesisu) okuthiwa yi-gastric noma i-gastroesophageal junction (GEJ) adenocarcinoma kubantu abake bamukela ukwelashwa okuqondene ne-trastuzumab. Ukudubula kwe-Fam-trastuzumab deruxtecan-nxki futhi kusetshenziswa ukwelapha iziphuzo eziqinile ezinomdlavuza we-HER2 aphezulu (IHC 3+) osakazekile (umdlavuza osakazeke ezingxenyeni ezinye zomzimba) noma ongenakususwa (umdlavuza ongenakususwa ngokuthi) kubantu abake bamukela ukwelashwa okungazange kusebenze kahle. Udokotela wakho uzohlola ukuba khona kwe-gene ye-HER2. I-protein ye-HER2 ikhiqizwa ezinye izicubu. I-Fam-trastuzumab deruxtecan-nxki iphazamisa ukukhula kwale protein okuvimba nokukhula kwezicubu. Izicubu zomdlavuza zizobhujiswa umzimba. Lolukhuni kufanele luphiwe kuphela yi-noma ngaphansi kokunakekelwa okuqondile kudokotela wakho. Lo mkhiqizo uyatholakala ngezindlela zokulinganisa ezilandelayo:
Ngaphambi kokusebenzisa leli khambi
Ekucatshangeni kokusebenzisa imithi, izingozi zokuthatha imithi kumele zilinganiswe nezinzuzo ezizoletha. Lo ngumqulu ozothatha wena nodokotela wakho. Kule mithi, okulandelayo kufanele kucabangelwe: Tshela udokotela wakho uma uke waba nanoma yiluphi uhlobo oluhlukile noma ukusabela okungokwe-alergi kule mithi noma kunoma iyiphi enye imithi. Tshela futhi ochwepheshe bakho bezempilo uma unezinye izinhlobo zokungezwani, njengokudla, izidakamizwa, izigcini, noma izilwane. Ngomkhiqizo ongenayo iresiphi, funda ilebula noma izithako zephakheji ngokucophelela. Izifundo ezifanele azikwenziwe ebuhlotsheni bobudala nemiphumela ye-Enhertu® kubantu abancane. Ukuphepha nokuphumelela akukaqiniswa. Izifundo ezifanele ezenziwe kuze kube manje azibonisi izinkinga ezikhethekile zabantu abadala ezingalinda ukusetshenziswa kwe-Enhertu® kubantu abadala. Noma kunjalo, abantu abadala banesikhathi esiningi sokuthola imiphumela emibi engadingeka ukuqapha kubantu abamukela le mithi. Ayikho izifundo ezifanele kubesifazane zokunquma ingozi yengane uma usebenzisa le mithi ngesikhathi sokuncelisa. Linganisa izinzuzo ezingaba khona nezingozi ezingaba khona ngaphambi kokuthatha le mithi ngesikhathi sokuncelisa. Nakuba ezinye izidakamizwa kufanele zingasetshenziswa ndawonye, kwezinye izimo imithi emibili ehlukene ingasetshenziswa ndawonye ngisho noma kungenzeka ukuhlangana. Kulezi zimo, udokotela wakho angase afune ukushintsha umthamo, noma ezinye izinyathelo zokuphepha zingadingeka. Tshela ochwepheshe bakho bezempilo uma uthatha noma iyiphi enye imithi yokuqaphela noma engaphezu kokuthengiswa (over-the-counter [OTC]). Ezinye izidakamizwa akufanele zisetshenziswe ngesikhathi sokudla noma ngesikhathi sokudla izinhlobo ezithile zokudla njengoba kungenzeka ukuhlangana. Ukusebenzisa utshwala noma utshako nezinye izidakamizwa kungabangela ukuhlangana. Xoxa nochwepheshe bakho bezempilo ngokusetshenziswa kwemithi yakho ngokudla, utshwala, noma utshako. Ukuba khona kwezinye izinkinga zezokwelapha kungathinta ukusetshenziswa kwale mithi. Qiniseka ukuthi utshela udokotela wakho uma unezinye izinkinga zezokwelapha, ikakhulukazi:
Indlela yokusebenzisa leli khambi
Imithi esetshenziswa ekwelapheni umdlavuza inamandla kakhulu futhi ingaba nemiphumela eminingi emibi. Ngaphambi kokuthola le mithi, qiniseka ukuthi uyayiqonda yonke imingcipheko nezinzuzo. Kubalulekile ukuthi usebenzisane eduze nodokotela wakho phakathi nokuphathwa kwakho. Udokotela noma omunye ochwepheshe bezempilo oqeqeshwe uzohlinzeka ngale mithi esikhungweni sezokwelapha. Inikezwa nge-IV catheter ebekwe kwenye yezinsimbi zakho. Imithi kufanele inikezwe kancane, ngakho i-IV izohlala ibekwe okungenani imizuzu engama-30 kuya kwengu-90. Ukugonywa kuvame ukwenziwa kanye njalo ngemva kwamasonto amathathu. Ungase futhi uthole eminye imithi ezosiza ukuvimbela isicanucanu nokugabha.
Umshwana wokuzihlangula: I-August iyinkundla yolwazi lwezempilo futhi izimpendulo zayo azihlanganisi iseluleko sezokwelapha. Njalo thintana nochwepheshe bezokwelapha onelayisensi eduze nawe ngaphambi kokwenza noma yiluphi ushintsho.