Yini i-Faricimab: Ukusetshenziswa, Umthamo, Imiphumela Eceleni Nokunye

I-Faricimab iyikhambi elisha elenzelwe ukwelapha izimo zamehlo ezingathi sína ezingasongela umbono wakho. Kuyindlela yokwelapha ejovwayo udokotela wakho wamehlo ayinika ngqo esweni lakho ukusiza ukugcina futhi ngezinye izikhathi ukuthuthukisa umbono wakho uma unezifo ezithile ze-retinal.

Le mithi isebenza ngendlela ehlukile kunokwelashwa okudala ngoba iqondise izindlela ezimbili ezithile ezibangela izinkinga zombono. Cabanga ngayo njengendlela ebanzi yokuvikela umbono wakho uma ubhekene nezimo ezinjengokuguga okuhlobene ne-macular degeneration noma isifo samehlo esinesifo sikashukela.

Yini i-Faricimab?

I-Faricimab iyisidakamizwa esenziwe elabhorethri esivimba amaprotheni amabili ayingozi esweni lakho. Lawa maprotheni, abizwa ngokuthi i-VEGF-A ne-angiopoietin-2, asebenza ndawonye ukulimaza imithambo yegazi ethambile ku-retina yakho, okuyizicubu ezizwa ukukhanya ngemuva kweso lakho.

Ngokuvala womabili lawa maprotheni ngasikhathi sinye, i-faricimab isiza ukuvimbela ukukhula kwemithambo yegazi okungajwayelekile futhi inciphise ukuvuvukala ku-macula yakho. I-macula yingxenye emaphakathi ye-retina yakho enomthwalo wemfanelo wokubona okucacile, okuningiliziwe okusebenzisayo ekufundeni, ekushayeleni, nasekuhlonipheni ubuso.

Le mithi ingeyeqembu lemithi ebizwa ngokuthi ama-antibody a-bispecific, okusho ukuthi ingaqondisa izindlela ezimbili ezihlukene zesifo ngasikhathi sinye. Le ndlela emibili ingase inikeze imiphumela engcono kunezindlela zokwelapha ezivimba indlela eyodwa kuphela.

Isetshenziselwani i-Faricimab?

I-Faricimab iphatha izimo ezimbili eziyinhloko zamehlo ezingabangela ukulahlekelwa umbono okukhulu uma zingelashwa. Udokotela wakho angase ancome lokhu kwelashwa uma une-wet age-related macular degeneration noma i-diabetic macular edema.

Ukuguga okuhlobene ne-macular degeneration kwenzeka lapho imithambo yegazi engavamile ikhula ngaphansi kwe-retina yakho futhi ivuze uketshezi noma igazi. Lesi simo ngokuvamile sithinta abantu abangaphezu kweminyaka engama-50 futhi singabangela ukulahlekelwa umbono okusheshayo, okwenza imigqa eqondile ibonakale inamaza noma idale amabala amnyama embonweni wakho ophakathi nendawo.

I-Diabetic macular edema yenzeka lapho isifo sikashukela silimaza imithambo yegazi emincane ku-retina yakho, okubangela ukuthi ivuze uketshezi ku-macula. Lokhu kuvuvukala kungenza umbono wakho ube mnyama noma ugwegwe, futhi kungenye yezimbangela eziphambili zokulahlekelwa umbono kubantu abanesifo sikashukela.

Zombili lezi zimo zihlanganyela izinkinga ezifanayo ezingaphansi ngomonakalo wemithambo yegazi nokuvuvukala. I-Faricimab ibhekana nalezi zimbangela eziyisisekelo kunokumane iphathe izimpawu.

Isebenza Kanjani I-Faricimab?

I-Faricimab ithathwa njengomuthi oqinile nothuthukisiwe osebenza ngokuvimba amaprotheni amabili abalulekile abangela umonakalo wamehlo. Ngokungafani nokwelashwa okudala okuqondise indlela eyodwa kuphela, lo muthi uthatha indlela ebanzi yokuvikela umbono wakho.

Umuthi ngokukhethekile uvimba i-VEGF-A, ebangela ukukhula kwemithambo yegazi engavamile nokuvuza. Ngesikhathi esifanayo, ivimba i-angiopoietin-2, eyenza imithambo yegazi ingazinzi futhi ithambekele ekuvuzeni. Uma zombili izindlela zivinjwe ndawonye, ​​iso lakho linethuba elingcono lokuphola nokugcina imithambo yegazi enempilo.

Uma isifakwe esweni lakho, i-faricimab iqala ukusebenza ngokushesha ku-gel ye-vitreous egcwalisa iso lakho. Umuthi usakazeka kancane kancane kuyo yonke indwangu ye-retinal, lapho ungafinyelela ngempumelelo ezindaweni ezilimele futhi unikeze ukuvikelwa izinyanga eziningana.

Le ndlela yokuvimba kabili ingakusiza ukuthi ugcine umbono ongcono isikhathi eside phakathi kokwelashwa uma kuqhathaniswa nemithi emidala. Iziguli eziningi zithola ukuthi zingahamba isikhathi eside phakathi kwemijovo ngenkathi zisaqhubeka nokuvikela umbono wazo.

Kufanele Ngiyithathe Kanjani I-Faricimab?

I-Faricimab inikezwa njengomjovo ngqo esweni lakho ngudokotela wakho wamehlo ehhovisi lakhe noma emtholampilo. Awukwazi ukuthatha lo muthi ekhaya, futhi kufanele ngaso sonke isikhathi unikezwe uchwepheshe wezempilo oqeqeshiwe esebenzisa izindlela eziqeqeshiwe.

Ngaphambi komjovo wakho, udokotela wakho uzonambisa iso lakho ngamaconsi akhethekile ukunciphisa ukungakhululeki. Bazophinda bahlanze indawo ezungeze iso lakho ngokucophelela ukuvimbela ukutheleleka. Umjovo wangempela uthatha imizuzwana embalwa kuphela, nakuba lonke i-aphoyintimenti lingathatha imizuzu engama-30 kuya ehora elilodwa.

Akudingeki ukuthi ugweme ukudla noma ukuphuza ngaphambi kwe-aphoyintimenti yakho, futhi akukho imikhawulo ethile yokudla. Kodwa-ke, kufanele uhlele ukuthi othile akuqhubele ekhaya ngemuva komjovo, njengoba umbono wakho ungase ube mnyama okwesikhashana noma iso lakho lingase lizizwe lingakhululekile.

Ngemuva komjovo, udokotela wakho uzokuqapha kafushane ukuze aqiniseke ukuthi ukhululekile futhi awunayo imiphumela esheshayo. Bazokunikeza imiyalelo ethile mayelana nokunakekelwa kwamehlo nokuthi yini okufanele uyibheke ezinsukwini ezilandelayo.

Kufanele Ngithathe Isikhathi Esingakanani I-Faricimab?

Abantu abaningi badinga imijovo ye-faricimab ngokuqhubekayo ukuze bagcine ukuthuthukiswa kwabo kombono. Lokhu akuyona ikhambi lesimo sakho samehlo, kodwa kunalokho ukwelashwa kwesikhathi eside okusiza ukuphatha isifo nokuvimbela ukulahlekelwa kombono okwengeziwe.

Ekuqaleni, ngokuvamile uzothola imijovo masonto onke ama-4 ezinyangeni ezimbalwa zokuqala. Udokotela wakho uzoqapha eduze ukuthi usabela kahle kangakanani ekwelashweni ngalesi sikhathi. Uma amehlo akho esabela kahle, ungase ukwazi ukwelula isikhathi phakathi kwemijovo kuya ku-8, 12, noma ngisho namasonto angu-16.

Umgomo uwukuthola igebe elide kakhulu phakathi kwemijovo elisaqhubeka nokugcina umbono wakho uzinzile futhi unempilo. Abanye abantu bangagcina imiphumela emihle ngemijovo njalo emavikini ama-4, kanti abanye bangase bayidinge kaningi. Impendulo yakho ngamunye izonquma uhlelo lwakho lokwelashwa.

Ukuhlolwa kwamehlo njalo nokuhlolwa kombono kusiza udokotela wakho ukuthi anqume ukuthi udinga nini umjovo wakho olandelayo. Ungalokothi uyeke ukwelashwa ngaphandle kokuxoxa ngakho nodokotela wakho wamehlo, njengoba umbono wakho ungawohloka ngokushesha ngaphandle kokuvikelwa okuqhubekayo.

Yiziphi Imiphumela Eceleni ye-Faricimab?

Njengayo yonke imithi, i-faricimab ingabangela imiphumela emibi, nakuba abantu abaningi beyibekezelela kahle. Imiphumela eminingi emibi imnene futhi yesikhashana, ithinta iso elilashwayo kuphela kunokuthi ithinte wonke umzimba wakho.

Imiphumela emibi evame kakhulu ongase uyithole ihlanganisa ukungakhululeki kwesikhashana noma ukucasuka esweni lakho ngemva komjovo. Nansi imiphumela emibi ebizwa njalo iziguli:

• Ubuhlungu obuncane esweni noma ukungakhululeki usuku olulodwa noma ezimbili
• Umbono ongaboni kahle wesikhashana noma ukubona ama-floaters
• Ukuzwa sengathi kukhona okuthile esweni lakho
• Ukubomvu okuncane noma ukuvuvukala endaweni yomjovo
• Ukuzwela okukhulu ekukhanyeni
• Amehlo anamanzi noma omile

Le miphumela emibi evamile ngokuvamile iyaphela ezinsukwini ezimbalwa futhi ngokuvamile ayidingi ukwelashwa. Nokho, kufanele uxhumane nodokotela wakho uma ziqhubeka noma ziba zimbi.

Imiphumela emibi engathi sína ayivamile kodwa idinga ukunakekelwa kwezempilo ngokushesha. Lokhu kuhlanganisa izimpawu zokutheleleka, ubuhlungu obukhulu, izinguquko zombono ezingazelelwe, noma ukubona izibani ezikhanyayo. Nansi imikhondo yokuxwayisa esho ukuthi kufanele ushayele udokotela wakho ngokushesha:

• Ubuhlungu obukhulu esweni obungathuthuki ngamaphilisi obuhlungu angathengwa ngaphandle kwemvume kadokotela
• Ukwehla okungazelelwe kombono noma amabala amasha angaboni kahle
• Ukubona izibani ezikhanyayo noma isithunzi esinjengokwekhethini embonweni wakho
• Ukuphuma okukhulu noma i-pus esweni lakho
• Umkhuhlane kanye nezimpawu zamehlo
• Ikhanda elibuhlungu elinamandla nobuhlungu esweni

Ngezinye izikhathi ezingavamile, ezinye iziguli zingase zibe nokuhlukana kwe-retinal, lapho i-retina idonswa ngemuva kweso, noma i-endophthalmitis, isifo esibucayi samehlo. Lezi zinkinga zenzeka ngaphansi kwesiguli esingu-1 kwabangu-1,000 kodwa zidinga ukwelashwa okuphuthumayo ukuvimbela ukulahlekelwa umbono unomphela.

Ubani Ongafanele Athathe i-Faricimab?

I-Faricimab ayifanele wonke umuntu, futhi udokotela wakho uzohlola ngokucophelela ukuthi ngabe ukwelashwa okulungile yini lesi simo sakho esithile. Ezinye izimo zezokwelapha noma izimo zingenza lo muthi ungafaneleki noma ube yingozi.

Akufanele uthole i-faricimab uma unesifo esisebenzayo esweni lakho noma ngaphandle kwalo. Noma yiluphi uhlobo lokutheleleka kwamehlo kufanele lwelashwe ngokuphelele futhi luxazululwe ngaphambi kokuthi ukwazi ukuthola umjovo ngokuphepha. Lokhu kufaka phakathi izimo ezinjengokuthi i-conjunctivitis, ama-styes, noma izifo ezingathi sína.

Abantu abanezifo ezithile zokungezwani komzimba nabo bangase badinge ukugwema lo muthi. Uma uke waba nokusabela okukhulu ku-faricimab esikhathini esidlule noma une-allergy kunoma iyiphi yezingxenye zayo, udokotela wakho uzoncoma ezinye izindlela zokwelapha.

Udokotela wakho uzocabangela nalezi zinto lapho enquma ukuthi i-faricimab ikufanele yini:

• Ukuhlinzwa kwamehlo noma ukulimala kwamuva
• Ukuvuvukala okukhulu ngaphakathi kweso lakho
• Umfutho wegazi ophezulu ongagadiwe
• Ukushaywa unhlangothi noma ukuhlaselwa yinhliziyo kwamuva
• Ukukhulelwa noma izinhlelo zokukhulelwa
• Ukuncelisa ibele

Ukucatshangelwa okukhethekile kuyadingeka uma unomlando wama-clot egazi, ukushaywa unhlangothi, noma izinkinga zenhliziyo, njengoba imithi evimbela i-VEGF ingase ikhulise kancane ingozi yalezi zinkinga. Udokotela wakho uzohlola izinzuzo ngokumelene nezingozi zesimo sakho ngasinye.

Amagama Omkhiqizo we-Faricimab

I-Faricimab ithengiswa ngaphansi kwegama lomkhiqizo elithi Vabysmo e-United States nakwamanye amazwe amaningi. Leli yigama lomkhiqizo elilodwa elitholakalayo njengamanje kulo muthi, njengoba lisavikelwe ngamalungelo obunikazi.

Uma uthola umjovo wakho, ibhodlela noma ukupakishwa kuzokhombisa ngokucacile ukuthi "Vabysmo" kanye negama elivamile elithi "faricimab-svoa." Ingxenye ethi "svoa" iyisijobelelo esisiza ukuhlukanisa le nguqulo ethile yomuthi kwezinye izinhlobo ezingase zibe khona.

Umshwalense wakho kanye nemibhalo yakho yokwelashwa ngokuvamile izobhekisela kokubili egameni lomkhiqizo elithi Vabysmo kanye negama elivamile elithi faricimab. Lokhu kusiza ekuqinisekiseni ukuxhumana okucacile phakathi kwabahlinzeki bakho bezempilo abahlukahlukene kanye nenkampani yakho yomshwalense.

Ezinye Izindlela Zokwelapha i-Faricimab

Eminye imithi eminingi ingelapha izimo zamehlo ezifanayo ne-faricimab, nakuba isebenza ngendlela ehlukile kancane. Udokotela wakho angase acabangele lezi ezinye izindlela uma i-faricimab ingakulungele noma uma ungasabeli kahle ekwelashweni.

Ezinye izindlela ezisetshenziswa kakhulu zihlanganisa i-ranibizumab (Lucentis), i-aflibercept (Eylea), kanye ne-bevacizumab (Avastin). Le mithi itholakale isikhathi eside futhi inemininingwane ebanzi yokuphepha, nakuba ngokuvamile ivimba kuphela indlela ye-VEGF kunokuba ivimbe kokubili i-VEGF ne-angiopoietin-2.

Nazi izindlela zokwelapha eziyinhloko okungenzeka ukuthi udokotela wakho uzoxoxa ngazo:

• Ranibizumab (Lucentis) - Ngokuvamile inikezwa njalo ngenyanga noma njalo ngemva kwenyanga
• Aflibercept (Eylea) - Ngokuvamile inikezwa njalo ngemva kwamasonto angu-6-8 ngemva kwemithamo yokuqala
• Bevacizumab (Avastin) - Inikezwa njalo ngenyanga, ngokuvamile inketho engabizi kakhulu
• Brolucizumab (Beovu) - Enye inketho entsha enezikhathi zokulinganisa ezinde

Ukukhetha phakathi kwale mithi kuncike ezintweni ezifana nesimo samehlo akho esithile, ukuthi usabela kahle kangakanani ekwelashweni, umshwalense wakho, kanye nekhono lakho lokuya ekuqokweni njalo. Abanye abantu bangase badinge ukuzama imithi ehlukene ukuze bathole okusebenza kangcono esimweni sabo.

Ingabe i-Faricimab Ingcono Kune-Aflibercept?

I-Faricimab kanye ne-aflibercept (Eylea) yizo zombili izindlela zokwelapha ezisebenzayo, kodwa zisebenza ngezindlela ezehlukene. I-Faricimab ivimba izindlela ezimbili kuyilapho i-aflibercept ngokuyinhloko ivimba eyodwa, okungenzeka ukuthi kunikeza i-faricimab ezinye izinzuzo ezimweni ezithile.

Ucwaningo lwezempilo luphakamisa ukuthi i-faricimab ingavumela izikhawu ezinde phakathi kwemijovo kubantu abaningi. Ngenkathi i-aflibercept ngokuvamile idinga imijovo njalo ngemva kwamasonto angu-6-8, abanye abantu bangakwazi ukwelula ukwelashwa kwe-faricimab kuze kube ngamasonto angu-12-16 ngenkathi begcina izinga elifanayo lokuvikelwa kombono.

Imiphumela yombono phakathi kwale mithi emibili ibonakala ifana kakhulu ezigulini eziningi. Zombili zingakwazi ukuzinzisa umbono ngempumelelo futhi zinciphise uketshezi ku-macula. Inzuzo enkulu ye-faricimab kungaba lula kwemijovo embalwa kwabanye abantu.

Kodwa-ke, i-aflibercept isitholakala isikhathi eside futhi inemininingwane ebanzi yokuphepha yesikhathi eside. Abanye odokotela neziguli bakhetha umlando oqoshiwe we-aflibercept, ikakhulukazi kubantu asebevele benza kahle kulolu hlobo lokwelashwa.

Udokotela wakho uzokusiza ukuthi unqume ukuthi yimuphi umuthi ongcono esimweni sakho esithile ngokusekelwe esimweni samehlo akho, umlando wokwelashwa, kanye nezintandokazi zomuntu siqu mayelana nemvamisa yomjovo.

Imibuzo Evame Ukubuzwa Mayelana ne-Faricimab

Ingabe i-Faricimab iphephile kubantu abanesifo sikashukela?

Yebo, i-faricimab ngokuvamile iphephile kubantu abanesifo sikashukela futhi empeleni ivunyelwe ngokukhethekile ukwelapha i-diabetic macular edema. Kodwa-ke, udokotela wakho uzofuna ukuqinisekisa ukuthi isifo sakho sikashukela silawulwa kahle ngaphambi kokuqala ukwelashwa.

Ukuba nesifo sikashukela akukuvimbeli ukuthi uthole i-faricimab, kodwa kusho ukuthi udokotela wakho uzokuqapha eduze. Ushukela wegazi ongagadiwe ungenza isimo samehlo akho sibe sibi futhi ungase uthinte ukuthi umuthi usebenza kahle kangakanani.

Udktela wakho angase asebenzisane nethimba lakho lokunakekelwa kwesifo sikashukela ukuze alawule kahle ushukela wakho wegazi kanye nokwelashwa kwamehlo akho. Le ndlela ehlanganisiwe ivame ukunikeza imiphumela emihle kakhulu yokuvikela umbono wakho isikhathi eside.

Kufanele ngenzeni uma ngiphuthelwa ngengozi umthamo we-Faricimab?

Uma uphuthelwa umjovo we-faricimab ohleliwe, xhumana nehhovisi likadokotela wakho wamehlo ngokushesha ngangokunokwenzeka ukuze uhlele kabusha. Ungalindi kuze kube yilapho uqokwe khona ngokujwayelekile, njengoba ukubambezeleka ekwelashweni kungavumela isimo samehlo akho ukuthi sibe sibi kakhulu.

Udktela wakho cishe uzofuna ukukubona kungakapheli isonto elilodwa noma amabili kusukela ekuqokweni kwakho okungaphuthelwanga ukuze ahlolisise amehlo akho futhi anqume ukuthi ngabe zikhona yini izinguquko ezenzekile. Bangase futhi bafune ukulungisa isimiso sakho sokwelashwa esizayo ukuze ubuyele emkhondweni.

Ukuphuthelwa umjovo owodwa ngokuvamile akubangeli monakalo unomphela, kodwa kubalulekile ukungavumeli isikhathi esiningi sidlule phakathi kokwelashwa. Umbono wakho ungalimala uma uhamba isikhathi eside ngaphandle kwemiphumela evikelayo yomuthi.

Ngingayeka nini ukuthatha i-Faricimab?

Akufanele neze uyeke ukwelashwa nge-faricimab ngaphandle kokuxoxa ngakho ngokucophelela nodokotela wakho wamehlo. Lo muthi ulawula isimo samehlo akho kunokuba uselaphe, ngakho ukuyeka ukwelashwa kuvame ukuvumela isifo ukuthi sibuye futhi siqhubeke.

Udktela wakho angase acabangele ukunciphisa imvamisa yomjovo uma amehlo akho ehlala ezinzile isikhathi eside, kodwa ukuyeka ngokuphelele akuvamile ukuthi kunconywe. Noma ngabe umbono wakho uzizwa ulungile, inqubo yesifo esiyisisekelo ingase isebenze.

Abanye abantu bangase bakwazi ukuphumula ekwelashweni ezimweni ezithile kakhulu, kodwa lesi sinqumo sidinga ukuqapha ngokucophelela futhi kufanele senziwe ngesiqondiso sikadokotela wakho kuphela. Ingozi yokulahlekelwa umbono ngokuvamile idlula izinzuzo zokuyeka ukwelashwa.

Ngingashayela ngemuva kokuthola umjovo we-Faricimab?

Akufanele ushayele ngokushesha ngemva kokuthola umjovo we-faricimab. Umbono wakho ungase ube mnyama okwesikhashana, futhi iso lakho lingase lizizwe lingakhululekile noma lizwela ekukhanyeni amahora amaningi ngemva kwenqubo.

Hlela ukuthi othile akuqhubele futhi akuqede ekuqokweni kwakho, noma lungiselela ezinye izindlela zokuthutha njenge-taxi noma isevisi yokugibela. Abantu abaningi bazizwa bekhululekile ukushayela futhi kungakapheli amahora angama-24, kodwa lokhu kungahluka kumuntu nomuntu.

Uma usenazo izinguquko ezinkulu embonweni noma ukungakhululeki ngosuku olulandelayo umjovo wakho, gwema ukushayela kuze kube yilapho lezi zimpawu zinyamalala. Ukuphepha kwakho nokuphepha kwabanye emgwaqweni kufanele kube yinto eza kuqala ngaso sonke isikhathi.

Ingabe Umshwalense Wami Uzokhokhela Ukwelashwa Nge-Faricimab?

Izinhlelo eziningi zomshwalense, okuhlanganisa i-Medicare, zikhokhela i-faricimab uma kudingeka ngokwezokwelapha ukwelapha izimo zamehlo ezigunyaziwe. Kodwa-ke, imininingwane yokukhokhelwa ingahluka kakhulu phakathi kwabahlinzeki bomshwalense abahlukene nezinhlelo.

Ihhovisi likadokotela wakho lingasiza ekutholeni ukuthi ukukhokhelwa kwakho kunjani futhi lisebenze nenkampani yakho yomshwalense ukuze lithole noma yiziphi izimvume ezidingekayo zangaphambili. Le nqubo ngezinye izikhathi ithatha izinsuku ezimbalwa noma amasonto, ngakho kufanelekile ukuqala kusenesikhathi.

Uma unezinkathazo mayelana nezindleko noma ukukhokhelwa, xoxa ngalokhu nehhovisi likadokotela wakho ngaphambi komjovo wakho wokuqala. Bangase bakwazi ukusikisela izinhlelo zokusiza iziguli noma ezinye izindlela zokwelapha ezihambisana kangcono nesimo sakho somshwalense.