Liyini i-Fecal Microbiota Live-jslm (Indlela ye-Rectal): Ukusetshenziswa, Umthamo, Imiphumela Eceleni nokuningi

I-Fecal microbiota live-jslm ngumuthi kadokotela oqukethe amagciwane anempilo avela endleni yokuhlolwa ngokucophelela yomnikeli. Lokhu kwelapha kusiza ukubuyisela ibhalansi yemvelo yamagciwane amahle emathunjini akho lapho amagciwane ayingozi esethathe, ikakhulukazi ngemuva kokutheleleka okukhulu njenge-C. difficile.

Kucabange njengendlela yokuthi "usethe kabusha" umphakathi wamagciwane amathumbu akho ubuyele esimweni esinempilo. Umuthi unikezwa ngendlela ye-rectum njenge-enema, okuvumela amagciwane anenzuzo ukuthi afinyelele ngqo e-colon yakho lapho engazimisela khona futhi axoshe amagciwane ayingozi abangela ukugula kwakho.

Isetshenziselwani i-Fecal Microbiota Live-jslm?

Lo muthi wenzelwe ngqo ukuvimbela ukutheleleka kwe-C. difficile okuphindaphindayo kubantu abadala. I-C. difficile yibhaktheriya eyingozi engabangela isifo sohudo esibi, i-colitis, nezinkinga ezisongela impilo lapho ikhula ngokweqile emathunjini akho.

Ukwelashwa kuba okudingekayo lapho ama-antibiotics ajwayelekile engakwazanga ukuvimbela i-C. diff ukuthi ibuye ngokuphindaphindiwe. Udokotela wakho ngokuvamile uzocabangela le nketho uma uke waba neziqephu eziningi zokutheleleka kwe-C. difficile ngaphandle kokuqeda ukwelashwa ngama-antibiotics.

Umuthi usebenza ngokwethula izigidi zamagciwane anempilo aqhudelana ne-C. difficile ngendawo kanye nezakhamzimba emathunjini akho. Lokhu empeleni kusiza imvelo yakho yamathumbu ukuthi ibuyele esimweni sayo semvelo, esivikelayo.

Isebenza kanjani i-Fecal Microbiota Live-jslm?

Lo muthi usebenza ngokubuyisela i-microbiome yakho yamathumbu, okuyindawo eyinkimbinkimbi yamagciwane ahlala emathunjini akho. Lapho ukutheleleka kwe-C. difficile kwenzeka, kuvame ukususa amaningi amagciwane akho okuvikela, okushiya indawo yamagciwane ayingozi ukuthi achume.

Amagciwane anempilo kulokhu kwelapha asebenza njengempi evikelayo emathunjini akho. Akhiqiza izinto ezenza kube nzima ukuthi i-C. difficile iphile futhi yande, kuyilapho futhi isiza amasosha akho omzimba ukuthi asebenze ngempumelelo.

Lokhu kuthathwa njengendlela yokwelapha eqondiwe kodwa enamandla. Nakuba kungewona umuthi “oqinile” ngomqondo wendabuko, usebenza kahle kakhulu ngoba ubhekana nembangela eyinhloko yokutheleleka okuphindaphindayo kunokumane ucindezele izimpawu okwesikhashana.

Ngingawuthatha Kanjani I-Fecal Microbiota Live-jslm?

Lo muthi unikezwa njenge-enema eyodwa ye-rectal, ngokuvamile enikezwa ngumhlinzeki wezempilo endaweni yezokwelapha. Ukwelashwa kuhilela ukufaka umuthi oluwuketshezi emathunjini akho usebenzisa ipayipi elikhethekile, elifana nendlela okunikezwa ngayo ezinye izinto ze-enema.

Ngaphambi kokwelashwa kwakho, udokotela wakho cishe uzokucela ukuthi uqedele inkambo yama-antibiotics ukunciphisa amagciwane e-C. difficile ohlelweni lwakho. Kuzodingeka uyeke ukuthatha ama-antibiotics okungenani amahora angu-24 kuya kwangu-48 ngaphambi kokuthola ukwelashwa kwe-fecal microbiota.

Akukho imikhawulo ethile yokudla ngaphambi kokwelashwa, kodwa ukuhlala unamanzi njalo kuyasiza. Umhlinzeki wakho wezempilo uzokunikeza imiyalelo enemininingwane mayelana nokuthi yini ongayilindela nokuthi uzilungiselela kanjani.

Ngemva kokuthola i-enema, uzocelwa ukuba ulale ngohlangothi lwakho bese uzama ukugcina umuthi isikhathi eside ngangokunokwenzeka, okungcono okungenani imizuzu engu-15. Lokhu kunika amagciwane anenzuzo isikhathi sokuzimisa emathunjini akho.

Kufanele Ngiyithathe Isikhathi Esingakanani I-Fecal Microbiota Live-jslm?

Lokhu ngokuvamile ukwelashwa kwesikhathi esisodwa, hhayi into oyithatha ngokuphindaphindiwe njengemithi yendabuko. Abantu abaningi badinga umthamo owodwa kuphela ukuze bavimbele ngempumelelo ukutheleleka kwe-C. difficile esikhathini esizayo.

Amagciwane alusizo avela emuthini asebenza ukusungula ikoloni elihlala njalo, elinempilo emathunjini akho. Uma sesunguliwe, lawa magciwane aqhubeka nokusebenza ukukuvikela ezifweni zesikhathi esizayo ngaphandle kokudinga imithamo eyengeziwe.

Udokotela wakho uzoqapha inqubekela phambili yakho ngokuqokwa okulandelayo ukuqinisekisa ukuthi umuthi usebenza ngempumelelo. Uma izimpawu ze-C. difficile zibuyela, umhlinzeki wakho wezempilo angase acabangele ezinye izindlela zokwelapha, nakuba lokhu kungavamile.

Yiziphi Imiphumela Eceleni Ye-Fecal Microbiota Live-jslm?

Abantu abaningi bayawuthola kahle lo muthi, nemiphumela emibi ngokuvamile iba mncane futhi yesikhashana. Ukusabela okuvame kakhulu kwenzeka ngemva nje kokuthola i-enema futhi ngokuvamile kulungiswa ngosuku olulodwa noma ezimbili.

Nansi imiphumela emibi ongase uyithole, iqala ngaleyo evame kakhulu:

• Ukugcwala kwesisu noma ukungakhululeki ngesikhathi noma ngemva kwenqubo
• Ukuqunjelwa noma igesi njengoba uhlelo lwakho lokugaya ukudla luzivumela
• Isicanucanu esincane, esivame ukudlula ngokushesha
• Ushintsho lwesikhashana ekuhambeni kwamathumbu noma ukungaguquguquki kwendle
• Ukukhathala ngosuku lokwelashwa

Lezi zindlela zokuphendula ngokuvamile ziyindlela yomzimba wakho yokuzivumelanisa nemvelo entsha yamagciwane. Abantu abaningi bathola ukuthi noma yikuphi ukungakhululeki kuncane kakhulu kunalokho ababezizwa ngaso ngezifo zabo ze-C. difficile.

Imiphumela emibi engavamile kodwa engathi sína ingenzeka ngezikhathi ezithile, nakuba ingavamile ngalo muthi:

• Ubuhlungu obukhulu besisu obungathuthuki
• Umkhuhlane ophezulu noma izimpawu zokutheleleka
• Ukuphalaza okuqhubekayo
• Ukuphendula komzimba ngaphandle, nakuba lokhu kungavamile kakhulu

Uma uhlangabezana nanoma yiziphi izimpawu ezinzima noma ezikhathazayo, xhumana nomhlinzeki wakho wezempilo ngokushesha. Bangasiza ukunquma ukuthi lokho okuhlangenwe nakho kuvamile yini noma kudinga ukunakekelwa kwezokwelapha.

Ubani Ongafanele Athole I-Fecal Microbiota Live-jslm?

Le nyango alifanele wonke umuntu, ikakhulukazi labo abanezinhlelo zokuzivikela ezithintekile noma izimo ezithile zezokwelapha. Udokotela wakho uzoqapha ngokucophelela ukuthi lo muthi uphephile yini esimweni sakho esithile.

Abantu okufanele bagweme le nyango bahlanganisa nalabo abane:

• Izifo ezinzima zokuntuleka kokuzivikela noma izimo ezenza buthaka uhlelo lokuzivikela
• Ukuphuma kwegazi okusebenzayo emathunjini noma isifo samathumbu esivuvukalayo esinzima
• Ukungezwani okwaziwayo kunoma yiziphi izithako zomuthi
• Izinhlobo ezithile zomdlavuza ezithinta uhlelo lokugaya ukudla
• Ukukhulelwa noma ukuncelisa (ukuphepha akukamiswanga)

Ngaphezu kwalokho, abantu abathatha imithi ethile ecindezela uhlelo lokuzivikela kungenzeka badinge ukucatshangelwa okukhethekile noma ezinye izindlela zokwelapha.

Umhlinzeki wakho wezempilo uzobuyekeza umlando wakho wezokwelapha ophelele kanye nemithi yamanje ukuze anqume ukuthi le nyango ilungele yini wena. Bazophinda bacabangele izici ezinjengobudala bakho, impilo yonke, kanye nobukhulu bezifo zakho ze-C. difficile.

Igama Lomkhiqizo we-Fecal Microbiota Live-jslm

Lo muthi uyatholakala ngaphansi kwegama lomkhiqizo elithi Rebyota, okuyinto eyayiyinto yokuqala ye-FDA evunyelwe umkhiqizo we-fecal microbiota wokuvimbela izifo ze-C. difficile eziphindaphindayo. I-Rebyota imelela intuthuko enkulu ekwelapheni lesi simo esiyinselele.

Umuthi ukhiqizwa ngaphansi kwezindinganiso eziqinile zokuphepha nekhwalithi, ngokuhlola okubanzi kwezinto ezinikelwe ukuqinisekisa ukuphepha nokusebenza kahle. Le nqubo eqinile isiza ekuqinisekiseni ukuthi iziguli zithola ukwelashwa okuqhubekayo, okusezingeni eliphezulu.

Ezinye izindlela ze-Fecal Microbiota Live-jslm

Ezinye izinketho zokwelapha ziyatholakala zokuvimbela izifo ze-C. difficile eziphindaphindayo, yize zisebenza ngezindlela ezahlukene. Udokotela wakho angase acabangele lezi zindlela ezinye ngokuya ngezimo zakho ezithile kanye nomlando wezokwelapha.

Izindlela zendabuko zama-antibiotic zihlanganisa:

• Izifundo ezinwetshiwe ze-vancomycin ezinokuncipha kancane kancane
• I-Fidaxomicin, engase ibe mnene emathunjini akho ajwayelekile amagciwane
• Ukwelashwa ngemithi elwa namagciwane ehlanganisiwe

Ezinye izindlela zokwelapha ezisekelwe ku-microbiome nazo ziya zitholakala, okuhlanganisa amafomula e-capsule yomlomo yamagciwane anenzuzo. Lezi zinketho ezintsha zingase zibe lula ukuziphatha kune-rectal enemas.

Ezimweni ezinzima, ezinye iziguli zingase zizuze ekufakweni kwe-fecal microbiota (FMT) okwenziwa nge-colonoscopy noma ezinye izinqubo. Udokotela wakho we-gastroenterologist angasiza ekunqumeni ukuthi iyiphi indlela engasebenza kahle esimweni sakho.

Ingabe i-Fecal Microbiota Live-jslm ingcono kune-Vancomycin?

Lezi zindlela zokwelapha ezimbili zisebenza ngezindlela ezingafani ngokuyisisekelo, okwenza ukuqhathanisa okuqondile kube nzima. I-Vancomycin iyisibulala-magciwane esibulala amagciwane e-C. difficile, kuyilapho i-fecal microbiota live-jslm ibuyisela amagciwane okuvikela ukuvimbela izifo zesikhathi esizayo.

I-Vancomycin ivame ukusetshenziselwa ukwelapha izifo ze-C. difficile ezisebenzayo futhi ingasebenza kahle kakhulu ekumeni izimpawu zamanje. Kodwa-ke, ayibhekiseli enkingeni eyisisekelo yamagciwane amathumbu aphazamisekile avumela ukuthi i-C. difficile ibuye.

I-Fecal microbiota live-jslm yenzelwe ngokuqondile ukuvimbela izifo eziphindaphindayo ngokwakha kabusha izivikelo zakho zemvelo zamagciwane. Ucwaningo luphakamisa ukuthi lungasebenza ngempumelelo kunezifundo ezinde zama-antibiotic zokuvimbela iziqephu zesikhathi esizayo.

Iziguli eziningi empeleni zithola zombili izindlela zokwelapha ngokulandelana. Okokuqala, ama-antibiotics afana ne-vancomycin asusa ukutheleleka okusebenzayo, bese i-fecal microbiota live-jslm isiza ukuvimbela ukuphindeka ngokubuyisela amagciwane amathumbu anempilo.

Imibuzo Evame Ukubuzwa Mayelana ne-Fecal Microbiota Live-jslm

Umbuzo 1. Ingabe i-Fecal Microbiota Live-jslm iphephile kubantu abanesifo sikashukela?

Yebo, ukuba nesifo sikashukela ngokuvamile akukuvimbeli ukuthola lokhu kwelashwa. Kodwa-ke, udokotela wakho uzofuna ukuqinisekisa ukuthi amazinga kashukela egazini lakho alawulwa kahle ngaphambi nangemva kwenqubo, njengoba noma yikuphi ukwelashwa kungase kuthinte ukuphathwa kwesifo sikashukela.

Abantu abanesifo sikashukela abasengozini enkulu yemiphumela emibi evela ku-fecal microbiota live-jslm ngokukhethekile. Ithimba lakho lezempilo lizokuqapha ngokucophelela futhi lingase linikeze isiqondiso esengeziwe mayelana nokuphatha ushukela wakho wegazi ngesikhathi sokwelashwa.

Umbuzo 2. Kufanele ngenzeni uma ngithola i-Fecal Microbiota Live-jslm eningi ngengozi?

Lesi simo asivamile kakhulu njengoba umuthi unikezwa ochwepheshe bezempilo ezindaweni zokwelapha ezilawulwayo. Ukwelashwa kuza njengomthamo owodwa olinganiselwe ngaphambili, oqondiswe ngokucophelela ngoba uphephile futhi usebenza kahle.

Uma unokukhathazeka mayelana nokwelashwa kwakho noma uhlangabezana nezimpawu ezingalindelekile ngemva kokuthola umuthi, xhumana nomhlinzeki wakho wezempilo ngokushesha. Bangahlola isimo sakho futhi banikeze isiqondiso esifanele noma ukuqapha uma kudingeka.

Umbuzo 3. Kufanele ngenzeni uma ngiphuthelwa umthamo wami ohleliwe we-Fecal Microbiota Live-jslm?

Njengoba lokhu ngokuvamile kuyindlela yokwelashwa yesikhathi esisodwa enikezwa endaweni yezokwelapha,

Amagciwane alusizo aqhubeka nokusebenza ukuvikela kuwe ezifweni zesikhathi esizayo ze-C. difficile ngaphandle kokudinga imithamo eyengeziwe. Udokotela wakho uzoqapha inqubekela phambili yakho ngokuqokwa okulandelayo ukuqinisekisa ukuthi ukwelashwa kuqhubeka nokusebenza ngokuhamba kwesikhathi.

Q5. Ngingakwazi yini Ukuthatha Ama-Probiotics Ngenkathi Ngisebenzisa I-Fecal Microbiota Live-jslm?

Udokotela wakho ngokuvamile uzoncoma ukugwema ama-probiotics nezinye izithasiselo ezingase ziphazamise ukwelashwa isikhathi esithile ngaphambi nangemva kokuthola i-fecal microbiota live-jslm. Lokhu kusiza ukuqinisekisa ukuthi amagciwane alusizo avela ekwelashweni angazakhela kahle.

Ngemuva kokuthi ukwelashwa sekuthatha isikhathi sokusebenza, ngokuvamile amasonto ambalwa, umhlinzeki wakho wezempilo angakweluleka ngokuphephile mayelana nokwethula kabusha ama-probiotics noma ezinye izithasiselo uma kudingeka. Hlala uhlola nodokotela wakho ngaphambi kokuqala noma yiziphi izithasiselo ezintsha ngesikhathi sokwelashwa kwakho.