Yini i-Fedratinib: Ukusetshenziswa, Umthamo, Imiphumela Eceleni nokuningi

I-Fedratinib iyimithi yomdlavuza eqondiwe esiza ukwelapha iminyango ethile yomdlavuza wegazi ngokuvimba amaprotheni athile aqhuba ukukhula kwesifo. Le mithi yomlomo ingeyohlobo olubizwa ngokuthi ama-JAK2 inhibitors, asebenza ngokuphazamisa amasignali atshela amaseli omdlavuza ukuthi aphindaphindeke futhi abangele izimpawu ezinjengesibindi esikhulu nokukhathala okukhulu.

Udokotela wakho angase akubhalele i-fedratinib uma une-myelofibrosis, umdlavuza wegazi ongavamile othinta ikhono lomnkantsha wakho wamathambo lokukhiqiza amaseli egazi anempilo. Ngenkathi lokhu kuxilongwa kungase kuzizwe kukhulu, i-fedratinib inikeza ithemba ngokuqondisa imbangela eyisisekelo yezimpawu zakho nokusiza ukubuyisela izinga lempilo yakho.

Yini i-Fedratinib Esetshenziselwa Yona?

I-Fedratinib iphatha i-myelofibrosis, uhlobo lomdlavuza wegazi lapho umnkantsha wakho wamathambo uba nezibazi futhi ungakwazi ukukhiqiza amaseli egazi ngendlela evamile. Lesi simo sibangela ukuthi isibindi sakho sikhule njengoba sizama ukukhokhela ngokwenza amaseli egazi, okuholela ezimpawini ezingakhululeki ezithinta impilo yakho yansuku zonke.

Udokotela wakho ngokukhethekile ubhala i-fedratinib ye-intermediate-2 noma i-high-risk primary myelofibrosis, noma i-secondary myelofibrosis eyakhula kwezinye izimo zegazi. Umuthi usiza ukunciphisa isibindi sakho esikhulisiwe futhi unciphise izimpawu ezibuthakathaka njengokukhathala okukhulu, ukujuluka ebusuku, nokuzizwa ugcwele ngemva kokudla amanani amancane.

Kwezinye izimo, i-fedratinib ingase incomwe uma uzamile ezinye izithiyo ze-JAK njenge-ruxolitinib kodwa waba nemiphumela emibi noma ukwelashwa kwayeka ukusebenza ngempumelelo. Lokhu kukunikeza enye inketho yokwelapha lapho ubhekene nalesi simo esiyinselele.

Isebenza Kanjani i-Fedratinib?

I-Fedratinib isebenza ngokuvimba amaprotheni e-JAK2, asebenza ngokweqile ku-myelofibrosis futhi athumele amasignali aqhubekayo ukuze umzimba wakho ukhiqize amaseli egazi angavamile. Cabanga nge-JAK2 njengokushintsha okunamathiselwe endaweni ethi "kuvuliwe", okubangela ukuthi umnkantsha wakho wamathambo usebenze ngokungafanele futhi isibindi sakho sikhule.

Lo muthi ubhekwa njengokwelashwa okuqinile, okuhloswe ngqo okubhekisa ekuguqulweni kwezakhi zofuzo okuqhubela phambili i-myelofibrosis yakho. Ngokuvala lezi zimpawu, i-fedratinib isiza ukunciphisa usayizi we-spleen, ukunciphisa umthwalo wezimpawu, futhi kungase kwehlise ukuqhubeka kwesifo.

Umuthi ungena egazini lakho ngemva kokuthi uwuthatha ngomlomo futhi uhamba emzimbeni wakho wonke ukuze ufinyelele amaseli athintekile. Iningi leziguli liqaphela ukuthuthuka kwezimpawu ezinyangeni ezimbalwa zokuqala zokwelashwa, nakuba izimpendulo zomuntu ngamunye zingahluka.

Kufanele Ngiyithathe Kanjani I-Fedratinib?

Thatha i-fedratinib ngendlela udokotela wakho ayala ngayo, ngokuvamile kanye ngosuku ngesikhathi esifanayo nsuku zonke. Ungayithatha ngaphandle noma ngaphandle kokudla, kodwa ukuyithatha nokudla kungasiza ukunciphisa isisu uma uhlangabezana nesicanucanu.

Gwinya amaphilisi wonke ngenkomishi yamanzi egcwele - ungawachobozi, uwahlafune, noma uwaqhumise ngoba lokhu kungathinta ukuthi umuthi usebenza kanjani. Uma unenkinga yokugwinya amaphilisi, khuluma nodokotela wakho mayelana nezinketho ezingezinye esikhundleni sokuzama ukuguqula amaphilisi ngokwakho.

Ngaphambi kokuqala i-fedratinib, udokotela wakho uzohlola amazinga akho e-thiamine (ivithamini B1) futhi angase ancome izithasiselo. Lokhu kubalulekile ngoba i-fedratinib ingathinta i-thiamine emzimbeni wakho, futhi ukugcina amazinga afanele kusiza ukuvimbela imiphumela emibi engathí sina.

Gcina umuthi wakho ekamelweni lokushisa kude nomswakama nokushisa. Gcina esitsheni sawo sokuqala futhi kude nezingane nezilwane ezifuywayo ukuze kuphephe.

Kufanele Ngiyithathe Isikhathi Esingakanani I-Fedratinib?

Ngokuvamile uzothatha i-fedratinib uma nje iqhubeka nokusiza ukulawula izimpawu zakho ze-myelofibrosis futhi umzimba wakho uyayibekezelela kahle. Iningi leziguli lithatha lo muthi izinyanga kuya eminyakeni, njengoba i-myelofibrosis iyisimo esingapheli esidinga ukwelashwa okuqhubekayo.

Udktela wakho uzoqapha impendulo yakho ngokusebenzisa izivivinyo zegazi ezivamile kanye nokuhlolwa komzimba ukuze ahlulele ukuthi imithi isebenza kahle kangakanani. Bazokala usayizi we-spleen yakho futhi bahlole izimpawu zakho ukuze banqume ukuthi i-fedratinib iyaqhubeka yini ukukuzuzisa.

Uma uhlangabezana nemiphumela emibi ebalulekile noma imithi iyeka ukulawula izimpawu zakho ngempumelelo, udokotela wakho angase alungise umthamo wakho noma acabange ngezindlela zokwelapha ezingezinye. Ungayeki ukuthatha i-fedratinib ngokuzumayo ngaphandle kokuxoxa ngayo neqembu lakho lezempilo kuqala.

Yini Imiphumela Eceleni Ye-Fedratinib?

Njengayo yonke imithi, i-fedratinib ingabangela imiphumela emibi, nakuba kungewona wonke umuntu oyitholayo. Imiphumela eminingi eceleni ilawuleka ngokuqapha okufanele nokunakekelwa okusekelayo okuvela eqenjini lakho lezempilo.

Nansi imiphumela emibi evame kakhulu ongase uyithole ngenkathi uthatha i-fedratinib:

• Ukuqunjelwa, okungahluka kusuka kokulula kuya kokukhulu
• Ukucanuzela kwenhliziyo nokuhlanza
• I-Anemia (ukwehla kwamaseli egazi abomvu)
• Ukwehla kwenani lama-platelet, okungandisa ingozi yokopha
• Ukukhathala nobuthakathaka
• Izifo zomgudu womchamo
• Ama-muscle spasms
• Isiyezi

Le miphumela emibi ivame ukuthuthuka njengoba umzimba wakho ujwayela imithi, futhi udokotela wakho angahlinzeka ngemithi yokusiza ukuyilawula ngempumelelo.

Eminye imiphumela emibi engavamile kodwa ebucayi idinga ukunakekelwa kwezempilo ngokushesha. Xhumana nodokotela wakho ngokushesha uma uhlangabezana nokudideka, izinkinga zenkumbulo, ubunzima bokugxila, noma yiziphi izimpawu zokutheleleka njengomkhuhlane noma ukukhwehlela okuqhubekayo.

Isimo esingavamile kodwa esibucayi esibizwa ngokuthi i-Wernicke encephalopathy singenzeka uma amazinga akho e-thiamine eba phansi kakhulu. Yingakho udokotela wakho eqapha amazinga akho e-thiamine futhi angase anikeze izithasiselo - kuyisinyathelo sokuphepha esibalulekile esisiza ukuvimbela lokhu kunzima.

Ubani Ongafanele Athathwe I-Fedratinib?

I-Fedratinib ayifanele wonke umuntu, futhi udokotela wakho uzohlola ngokucophelela ukuthi iphephile yini kuwe ngokusekelwe emlandweni wakho wezokwelapha kanye nesimo sakho sempilo yamanje. Ezinye izimo noma izimo zenza lo muthi ube yingozi.

Akufanele uthathe i-fedratinib uma unezifo ezinzima zezinso, njengoba umzimba wakho ungase ungakwazi ukucubungula umuthi ngendlela efanele. Udokotela wakho uzohlola ukusebenza kwezinso zakho ngaphambi kokukuyala lo muthi.

Abantu abanezifo eziqhubekayo, ezingathi sína akufanele baqale i-fedratinib ngoba ingacindezela amasosha akho omzimba futhi yenze izifo zibe zimbi kakhulu. Udokotela wakho uzokwelapha noma yiziphi izifo kuqala ngaphambi kokucabangela lo muthi.

Uma ukhulelwe noma uncelisa, i-fedratinib ingalimaza ingane yakho futhi ayinconywa. Abesifazane abaneminyaka yokuzala kufanele basebenzise izindlela zokuvimbela inzalo ezisebenzayo ngenkathi bethatha lo muthi kanye okungenani inyanga eyodwa ngemva kokuyeka ukuwuthatha.

Udokotela wakho uzophinda aqaphele mayelana nokuyala i-fedratinib uma unomlando wezinkinga ezinkulu zesibindi, izimo ezithile zenhliziyo, noma uke waba nokusabela okungalungile kuma-inhibitors e-JAK.

Amagama Omkhiqizo we-Fedratinib

I-Fedratinib ithengiswa ngaphansi kwegama lomkhiqizo elithi Inrebic e-United States nakwamanye amazwe. Leli yigama eliyinhloko lomkhiqizo ozolibona ebhodleleni lakho lemithi kanye nokupakishwa kwemithi.

Njengamanje, i-Inrebic iwumkhiqizo oyinhloko otholakalayo, nakuba izinguqulo ezivamile zingase zitholakale esikhathini esizayo njengoba amalungelo obunikazi ephelelwa yisikhathi. Njalo sebenzisa umkhiqizo othile noma inguqulo ejwayelekile edokotela wakho ayiyalayo, njengoba amafomula ahlukene angase abe nemiphumela ehlukile.

Uma uhamba noma uthola imiyalelo egcwaliswe emakhemisi ahlukene, qiniseka ukuthi usho kokubili igama elivamile (fedratinib) negama lomkhiqizo (Inrebic) ukuze ugweme ukudideka.

Ezinye izindlela ze-Fedratinib

Imithi eminingi ehlukile ingelapha i-myelofibrosis uma i-fedratinib ingakulungele noma iyeka ukusebenza ngempumelelo. Udokotela wakho uzocabangela isimo sakho esithile, ukwelashwa kwangaphambilini, kanye nempilo yonke lapho encoma ezinye izindlela.

I-Ruxolitinib (Jakafi) ivame ukuba yindlela yokwelapha yokuqala ye-myelofibrosis futhi isebenza ngendlela efana ne-fedratinib ngokuvimba amaprotheni e-JAK. Iziguli eziningi zizama i-ruxolitinib kuqala ngaphambi kokucabangela i-fedratinib, ikakhulukazi uma zingakaze zithole ukwelashwa kwe-JAK inhibitor.

I-Pacritinib (Vonjo) enye i-JAK inhibitor engase ilungele uma unamazinga aphansi kakhulu e-platelet, njengoba yakhelwe ngqo iziguli ezingakwazi ukuthatha ezinye izithiyo ze-JAK ngenxa ye-thrombocytopenia enkulu.

Kwezinye iziguli, izinyathelo zokunakekelwa ezisekelayo njengokumpontshwa kwegazi, imithi yokulawula izimpawu, noma ngisho nokufakelwa komnkantsha wamathambo kungase kucatshangelwe kuye ngeminyaka, impilo yonke, nobukhulu besifo.

Ingabe i-Fedratinib Ingcono Kune-Ruxolitinib?

Kokubili i-fedratinib ne-ruxolitinib ziyizithiyo ze-JAK ezisebenzayo zokwelapha i-myelofibrosis, kodwa ngasinye sinobuhle obuyingqayizivele ngokuya ngesimo sakho esithile. Akukho noyedwa “ongcono” ngokujwayelekile - ukukhetha kuncike ezimweni zakho ngazinye kanye nomlando wokwelashwa.

I-Ruxolitinib ngokuvamile iyalelwa kuqala ngoba isitholakala isikhathi eside futhi inokuhlangenwe nakho okuningi komtholampilo. Kodwa-ke, i-fedratinib ingase ithandwe uma usuvele uzamile i-ruxolitinib futhi waba nemiphumela emibi noma uma umuthi uyeka ukusebenza ngempumelelo kuwe.

I-Fedratinib ingase inikeze izinzuzo ezimweni ezithile, njengokuthi uma udinga iphrofayili ehlukile yemiphumela emibi noma uma isifo sakho sinezici ezithile ezenza i-fedratinib ilungele kakhulu. Ezinye iziguli ziphendula kangcono kumshini othile wokusebenza we-fedratinib.

Udaktela wakho uzocabangela izinto ezinjengokubalwa kwegazi lakho, ukwelashwa kwangaphambilini, ukusebenza kwezinso, nempilo yonke lapho enquma phakathi kwale mithi. Ukukhetha "okungcono kakhulu" yilokho okulawula ngempumelelo izimpawu zakho ngenkathi kubangela imiphumela emibi embalwa kuwe uqobo.

Imibuzo Evame Ukubuzwa Mayelana ne-Fedratinib

Ingabe i-Fedratinib iphephile ezigulini ezinokugula kwezinso?

I-Fedratinib idinga ukucatshangelwa ngokucophelela uma unezinkinga zezinso, njengoba izinso zakho zisiza ukucubungula nokukhipha lo muthi emzimbeni wakho. Udokotela wakho uzohlola ukusebenza kwezinso zakho ngokusebenzisa ukuhlolwa kwegazi ngaphambi kokukuyalela i-fedratinib.

Uma unezinkinga zezinso eziphakathi nendawo, udokotela wakho angase akuyalele i-fedratinib kodwa uzokugada eduze futhi mhlawumbe alungise umthamo wakho. Kodwa-ke, uma unezinkinga zezinso ezinzima, i-fedratinib ingase ingakuphephile njengoba ingase iqoqane emazingeni ayingozi emzimbeni wakho.

Njalo yazisa udokotela wakho nganoma yiziphi izinkinga zezinso, futhi bazonquma indlela ephephe kakhulu yesimo sakho esithile. Ukuqapha njalo kusiza ukuqinisekisa ukuthi umuthi uhlala uphephile futhi usebenza kahle kuwe.

Ngingenzani uma ngiphuzile i-Fedratinib eningi ngengozi?

Uma ngengozi uthatha i-fedratinib eningi kunaleyo oyiyalelwe, xhumana nodokotela wakho noma isikhungo sokulawula ubuthi ngokushesha, ngisho noma uzizwa ulungile. Ukuthatha okuningi kungakhuphula ingozi yakho yemiphumela emibi engathi sína.

Ungazami "ukulungisa" ukweqisa ngokweqa imithamo yesikhathi esizayo - lokhu kungaba yingozi futhi kuthinte ukusebenza kokwelashwa kwakho. Esikhundleni salokho, landela isiqondiso sikadokotela wakho sokuthi ungaqhubeka kanjani ngeshejuli yakho yokwelashwa ngokuphepha.

Izimpawu zokuthatha i-fedratinib eningi zingabandakanya isicanucanu esibi, ukuhlanza, isifo sohudo, noma ukukhathala okungavamile. Funani ukunakekelwa kwezokwelapha ngokushesha uma uhlangabezana nanoma yiziphi izimpawu ezikhathazayo ngemuva kokuthatha umuthi owengeziwe.

Ngingenzani uma ngiphuthelwa umthamo we-Fedratinib?

Uma uphuthelwa umthamo we-fedratinib, yithathe ngokushesha nje lapho ukhumbula, ngaphandle uma sekuseduze isikhathi somthamo wakho olandelayo ohleliwe. Kuleso simo, weqa umthamo ophuthelwe bese uqhubeka neshejuli yakho ejwayelekile.

Ungalokothi uthathe imithamo emibili ngesikhathi esisodwa ukuze ulungise umthamo ophuthelwe, ngoba lokhu kungakhuphula ingozi yakho yemiphumela emibi. Ukuthatha imithamo emibili kungaba yingozi futhi kungase kubangele izinkinga ezinzima.

Uma uvame ukukhohlwa imithamo, cabangela ukusetha izikhumbuzi zocingo noma usebenzise umhleli wamaphilisi ukukusiza ukuthi uhlale emgqeni. Ukuthatha imithamo yansuku zonke okuqhubekayo kubalulekile ekugcineni ukusebenza kahle komuthi ekulawuleni i-myelofibrosis yakho.

Ngingayeka nini Ukuthatha i-Fedratinib?

Kufanele uyeke kuphela ukuthatha i-fedratinib ngaphansi kwesiqondiso sikadokotela wakho, ngoba ukuyeka kungazelelwe kungavumela izimpawu zakho ze-myelofibrosis ukuthi zibuye noma zibe zimbi. Udokotela wakho uzohlola njalo ukuthi umuthi uyaqhubeka yini ukukuzuzisa.

Udokotela wakho angase ancome ukuyeka i-fedratinib uma uhlangabezana nemiphumela emibi engalawuleki, uma umuthi uyeka ukulawula izimpawu zakho ngempumelelo, noma uma impilo yakho yonke ishintsha kakhulu.

Ngaphambi kokuyeka, udokotela wakho uzoxoxa ngezinketho zokwelapha ezingezinye ukuze aqinisekise ukuthi uyaqhubeka nokuthola ukunakekelwa okufanele kwe-myelofibrosis yakho. Bangase futhi banciphise kancane umthamo wakho kunokuyeka kungazelelwe ukuze banciphise noma yiziphi izinkinga ezingaba khona.

Ngingayithatha i-Fedratinib Neminye Imithi?

I-Fedratinib ingasebenzisana neminye imithi, ngakho-ke kubalulekile ukutshela udokotela wakho ngayo yonke imithi kadokotela, imithi etholakala ngaphandle kwe-oda, kanye nezithasiselo ozithathayo. Ezinye izinhlanganisela zingakhuphula imiphumela emibi noma zinciphise ukusebenza kahle.

Imithi ethile ethinta ikhono lesibindi sakho lokucubungula izidakamizwa ingase idinge ukulungiswa komthamo noma ukwelashwa okuhlukile. Udokotela wakho uzobuyekeza yonke imithi yakho ukuze aqinisekise izinhlanganisela eziphephile.

Njalo xhumana nodokotela wakho noma usokhemisi ngaphambi kokuqala imithi emisha, okuhlanganisa izithasiselo zemithi yezitshalo noma amavithamini, ngenkathi usebenzisa i-fedratinib. Lesi sinyathelo esilula sisiza ekuvimbeleni ukuxhumana okungase kube yingozi kwemithi futhi siqinisekisa ukuthi ukwelashwa kwakho kuhlala kuphephile futhi kusebenza kahle.