Yini i-Fidaxomicin: Ukusetshenziswa, Umthamo, Imiphumela Eceleni nokuningi

I-Fidaxomicin iyisibulala-magciwane esikhethekile esiqondise ngqo esinye isifo esibucayi emathunjini esibizwa ngokuthi i-C. difficile colitis. Lo muthi usebenza ngendlela ehlukile kunezinye izibulala-magciwane ngoba uhlala ikakhulukazi emathunjini akho, ulwa namagciwane ayingozi lapho inkinga yenzeka khona ngaphandle kokuthinta kakhulu amagciwane awusizo emzimbeni wakho wonke.

Yini i-Fidaxomicin?

I-Fidaxomicin iyisibulala-magciwane esinikezwa ngudokotela esenzelwe ngqo ukwelapha izifo ze-Clostridioides difficile (C. diff) emathunjini akho amakhulu. Ngokungafani nezibulala-magciwane ezisebenza emzimbeni wakho wonke, i-fidaxomicin yilokho odokotela abakubiza ngokuthi isibulala-magciwane esithi "narrow-spectrum" esigxila ekusebenzeni kwaso ikakhulukazi emathunjini akho.

Le ndlela eqondiswe ngqo yenza i-fidaxomicin isebenze ngempumelelo ngoba izifo ze-C. diff zenzeka lapho amagciwane ayingozi ekhula ngokweqile emathunjini akho, ngokuvamile ngemuva kokuthi ezinye izibulala-magciwane ziphazamise ibhalansi yakho yemvelo yamagciwane amathunjini. Cabanga nge-fidaxomicin njengethuluzi eliqondile kunokuba yisando uma kuziwa ekulweni nale nkinga ethile.

Lo muthi ungowesigaba sezibulala-magciwane esibizwa ngokuthi ama-macrocyclics, anesakhiwo esiyingqayizivele esifana nendandatho esiwusizo ekubopheni nasekuyekiseni amagciwane e-C. diff ukuthi azande. Le ndlela ekhethekile yenza i-fidaxomicin isebenze ngempumelelo ngenkathi ithambile emagciwaneni akho awusizo amathunjini.

Yini i-Fidaxomicin Esetshenziselwa Yona?

I-Fidaxomicin iphatha isifo sohudo esihambisana ne-Clostridioides difficile (CDAD) kubantu abadala kanye nezingane ezineminyaka engu-6 ubudala nangaphezulu. Lesi sifo sibangela isifo sohudo esibi nokuvuvukala emathunjini okungasuka ekungakhululeki kuya ekuphatheni impilo uma singelashwa.

Ungase udinge i-fidaxomicin uma uthola i-C. diff colitis ngemva kokuthatha amanye ama-antibiotics ngenxa yokutheleleka okuhlukile. Lokhu kwenzeka ngoba ama-antibiotics ngezinye izikhathi angabulala amagciwane akho amathumbu okuvikela, okudala indawo lapho i-C. diff ingachuma khona futhi ikhiqize ubuthi obulimaza umugqa wakho we-colon.

Udkt wakho ngokuvamile uzonikeza i-fidaxomicin uma uqinisekisile ukutheleleka kwe-C. diff ngokuhlolwa kwesitulo, ikakhulukazi uma uke waba nokutheleleka okuphindaphindayo noma ungazange uphendule kahle kwezinye izindlela zokwelapha. Umuthi ubaluleke kakhulu ekuvikeleni ukuthi ukutheleleka kungabuyi, okuyinselele ejwayelekile nge-C. diff.

Kwezinye izimo, odokotela bangase bakhethe i-fidaxomicin njengendlela yokuqala yokwelapha ukutheleleka okukhulu kwe-C. diff noma ezigulini ezisengozini enkulu yokuphindeka. Lokhu kuhlanganisa abadala, abantu abanezinhlelo zokuzivikela ezikhubazekile, noma labo abake baba neziqephu eziningi ezedlule.

Isebenza Kanjani I-Fidaxomicin?

I-Fidaxomicin isebenza ngokuvimba inqubo ebalulekile edingwa amagciwane e-C. diff ukuze akwazi ukuzala futhi asinde. Iqondise ngqo i-enzyme ebizwa nge-RNA polymerase esetshenziswa amagciwane ukwenza amaprotheni abalulekile ekukhuleni kwawo nasekuzaleni.

Lapho i-fidaxomicin ingena ohlelweni lwakho lokugaya ukudla, ihlala igxilile emathunjini akho kunokuba ingene egazini lakho. Lokhu kusho ukuthi inganikeza ukugxila okuphezulu komuthi ngqo lapho amagciwane e-C. diff abangela izinkinga khona, kuyilapho inciphisa imiphumela emagciwaneni akwezinye izingxenye zomzimba wakho.

Umuthi ubhekwa njengonamandla ngokulinganisela futhi usebenza kahle kakhulu ngokumelene ne-C. diff ngokuqondile. Okwenza ibaluleke kakhulu ukukhetha kwayo - iqondise amagciwane e-C. diff ngendlela enobudlova obukhulu kunokuthi ithinte amagciwane akho amathumbu anenzuzo, okusiza ukugcina ibhalansi yakho yemvelo yokugaya ukudla.

Lesi senzo esiqondiswe ngqo sisho nokuthi i-fidaxomicin inethuba eliphansi lokudala ukumelana nama-antibiotic uma iqhathaniswa nama-antibiotic abanzi. Umuthi uyaqhubeka nokusebenza ngisho nangemva kokuqeda ukwelashwa kwakho, njengoba ungahlala usebenza emathunjini akho amakhulu izinsuku eziningana.

Kufanele Ngiyithathe Kanjani I-Fidaxomicin?

Thatha i-fidaxomicin ngendlela eqondile udokotela wakho ayalela ngayo, ngokuvamile ama-200 mg kabili ngosuku izinsuku eziyi-10. Ungayithatha nokudla noma ngaphandle kokudla, kodwa ukuyithatha nokudla okulula kungasiza ukunciphisa noma yikuphi ukuphatheka kwesisu ongase ukuzwe.

Gwinya amaphilisi wonke ngamanzi agcwele - ungaqobi, uhlafune, noma uwaphule njengoba lokhu kungathinta indlela umuthi osebenza ngayo. Zama ukuthatha imithamo yakho ngesikhathi esifanayo nsuku zonke, uqhelelane ngamahora angaba ngu-12 ukuze ugcine amazinga aqhubekayo ohlelweni lwakho.

Akudingeki ukuthi ugweme noma yikuphi ukudla okuthile ngenkathi uthatha i-fidaxomicin, kodwa ukudla ukudla okungenambitheki kungasiza uhlelo lwakho lokugaya ukudla ukuthi lululame ekuthelelekeni kwe-C. diff. Ukudla okufana nobhanana, ilayisi, i-applesauce, kanye nesinkwa esosiwe kuvame ukuba lula ukukubekezelela ngesikhathi sokwelashwa.

Uma uthatha eminye imithi, yihlukanise okungenani ngamahora ama-2 ukusuka ku-fidaxomicin uma kungenzeka. Lokhu kusiza ukuvimbela noma yikuphi ukusebenzisana okungenzeka futhi kuqinisekisa ukuthi umuthi ngamunye ungasebenza ngempumelelo.

Kufanele Ngiyithathe Isikhathi Esingakanani I-Fidaxomicin?

Abantu abaningi bathatha i-fidaxomicin izinsuku eziyi-10 ngqo, okuyisikhathi esijwayelekile esifundweni somtholampilo esiye sabonisa ukuthi sisebenza kahle kakhulu. Kubalulekile ukuqeda inkambo yonke ngisho noma uqala ukuzwa ngcono ngemva kwezinsuku ezimbalwa.

Ungase uqaphele ukuthuthuka kwezimpawu zakho phakathi kwezinsuku ezi-2-3 zokuqala ukwelashwa, kodwa amagciwane angase abe khona futhi abe yingozi uma uyeka umuthi ngaphambi kwesikhathi. Ukuyeka ngokushesha kakhulu kwandisa ingozi yakho yokuthi ukutheleleka kubuye, okungase kube nzima ukukwelapha.

Ezimweni ezingavamile, udokotela wakho angase alungise ubude bokwelashwa ngokuya ngesimo sakho esithile, njengobunzima bokutheleleka kwakho noma isimo sakho sempilo esiphelele. Kodwa-ke, iziguli eziningi zizonamathela ohlelweni olujwayelekile lwezinsuku eziyi-10 ukuze zithole imiphumela emihle.

Ngokungafani nokunye ukwelashwa kwe-C. diff, i-fidaxomicin ngokuvamile ayidingi izifundo ezinwetshiwe noma amashejuli okunciphisa. Izakhiwo ezihlukile zomuthi zimvumela ukuthi aqhubeke nokusebenza izinsuku eziningana ngemuva kokuthatha umthamo wakho wokugcina, enikeza ukuqhubeka nokuvikela ekuphindweni.

Yiziphi Imiphumela Eceleni ye-Fidaxomicin?

I-Fidaxomicin ivame ukubekezelelwa kahle, iningi labantu libhekana nemiphumela emincane noma engekho eceleni. Imiphumela ejwayelekile kakhulu eceleni imnene futhi ivame ukuhlobana nohlelo lwakho lokugaya njengoba kululama ekuthelelekeni kwe-C. diff.

Nansi imiphumela eceleni ongase uyithole, ukhumbula ukuthi abantu abaningi bathatha i-fidaxomicin ngaphandle kwezinkinga nhlobo:

• Ukucasuka noma ukungakhululeki kwesisu okuncane
• Ubuhlungu besisu noma ukucindezela
• Ukuphalaza (akuvamile)
• Ikhanda
• Isiyezi
• Ukuqunjelwa njengoba ukuhamba kwamathumbu akho kujwayeleka

Le miphumela emnene ivame ukuthuthuka njengoba umzimba wakho uzivumela emuthini futhi nokutheleleka kwakho kuqeda. Abantu abaningi bathola ukuthi noma yikuphi ukungakhululeki kulawuleka kakhulu kunezimpawu zokuqala ze-C. diff.

Imiphumela emibi kakhulu ayivamile kodwa ingenzeka. Xhumana nodokotela wakho ngokushesha uma uhlangabezana nokusabela okukhulu komzimba okufana nobunzima bokuphefumula, ukuvuvukala kobuso bakho noma umphimbo, noma ukusabela okukhulu kwesikhumba. Futhi funa ukwelashwa uma uthola ubuhlungu obukhulu besisu, igazi esitulweni sakho, noma izimpawu zokutheleleka okusha.

Abanye abantu bakhathazeka ngokuthuthukisa isifo sohudo esihlobene ne-antibiotic esivela ku-fidaxomicin, kodwa lokhu empeleni kungenzeka kancane uma kuqhathaniswa namanye ama-antibiotics ngenxa yesenzo sawo esiqondiwe. Kodwa-ke, uma uthola isifo sohudo esisha noma esiba sibi ngesikhathi sokwelashwa, yazisa umhlinzeki wakho wokunakekelwa kwezempilo.

Ubani Ongafanele Athole i-Fidaxomicin?

I-Fidaxomicin ayifanele wonke umuntu, nakuba uhlu lwabantu abangayitholi lufushane. Okukhathaza kakhulu ukuthi ngabe uke waba nokusabela okukhulu komzimba ku-fidaxomicin noma yiziphi izithako zayo esikhathini esidlule.

Udokotela wakho uzodinga ukucabangela ngokucophelela i-fidaxomicin uma unezifo ezinzima zezinso noma zesibindi, njengoba lezi zimo zingathinta indlela umzimba wakho oqhubula ngayo imithi. Nakuba i-fidaxomicin ingagxili kakhulu emsingeni wakho wegazi, udokotela wakho angase afune ukukuqapha eduze.

Abantu abanezimo ezithile ezingavamile zofuzo ezithinta ikhono labo lokucubungula ushukela othile kufanele baxoxe ngalokhu nodokotela wabo, njengoba amaphilisi e-fidaxomicin equkethe amanani amancane e-lactose. Nokho, inani livame ukuba lincane kakhulu ukuthi lingabangela izinkinga kubantu abaningi abangakwazi ukubekezelela i-lactose.

Uma ukhulelwe noma uncelisa, udokotela wakho uzokala izinzuzo ngokumelene nezingozi ezingaba khona. Nakuba izifundo zingazange zikhombise ukukhathazeka okukhulu, izifo ze-C. diff zingaba zimbi ngesikhathi sokukhulelwa, ngakho ukwelashwa kuvame ukudingeka. Umhlinzeki wakho wokunakekelwa kwezempilo uzokusiza ukuthi wenze isinqumo esingcono kakhulu sesimo sakho esithile.

Amagama Omkhiqizo we-Fidaxomicin

I-Fidaxomicin itholakala kakhulu ngaphansi kwegama lomkhiqizo elithi Dificid e-United States. Leli igama lomkhiqizo langempela elizobonwa odokotela abaningi kanye nabokhemisi lapho bebhala noma benikeza umuthi.

Emazweni angaphandle, ungase uthole i-fidaxomicin ithengiswa ngaphansi kwamagama omkhiqizo ahlukene, njenge-Dificlir emakethe ethile yaseYurophu. Nokho, isithako esisebenzayo nokusebenza kahle kuhlala kufana kungakhathaliseki igama lomkhiqizo elisepakethe.

Izinhlobo ze-generic ze-fidaxomicin ziya ngokuya zitholakala emakethe ethile, okungasiza ukunciphisa izindleko zokwelashwa. Umkhemisi wakho angakutshela ukuthi ngabe inguqulo ye-generic iyatholakala endaweni yakho nokuthi ingabe ingafaneleka yini ekunikezeni kwakho.

Kungakhathaliseki ukuthi igama lomkhiqizo lithini, qiniseka ukuthi uthola i-fidaxomicin ngqo ukwelapha i-C. diff, njengoba ihluke kakhulu kwamanye ama-antibiotics futhi ayishintshani neminye imithi.

Ezinye Izindlela Zokwelapha i-Fidaxomicin

Amanye ama-antibiotics amaningana angelapha izifo ze-C. diff, nakuba i-fidaxomicin ivame ukuba nezinzuzo mayelana nokuvimbela ukuphindeka. I-Vancomycin iyona esetshenziswa kakhulu futhi ibilokhu iyindlela yokwelapha ejwayelekile iminyaka eminingi.

I-Metronidazole yayivame ukusetshenziswa njalo ezifweni ezilula ze-C. diff, kodwa imihlahlandlela yezokwelapha yamanje ngokuvamile incoma i-vancomycin noma i-fidaxomicin njengezinketho ezingcono zokuqala. Udokotela wakho angase asacabangela i-metronidazole ezimweni ezithile, ikakhulukazi uma izindleko ziyisithiyo esikhulu.

Ezimweni ezinzima noma eziyinkimbinkimbi, udokotela wakho angase ancome ukwelashwa okuhlanganisiwe noma ukwelashwa okusha njenge-bezlotoxumab, okuyindlela yokwelapha ngama-antibody esiza ukuvimbela ukuphindeka. Ezimweni ezinzima kakhulu, ukungenelela kokuhlinzwa kungase kudingeke, nakuba lokhu kungavamile.

Ukukhetha phakathi kwezinye izindlela kuncike ezintweni ezinjengobunzima besifo sakho, umlando wakho wezokwelapha, iziqephu ze-C. diff ezedlule, kanye nesimo sakho sempilo esiphelele. Udokotela wakho uzocabangela zonke lezi zinto lapho enquma indlela engcono kakhulu yokwelapha isimo sakho esithile.

Ingabe i-Fidaxomicin Ingcono Kune-Vancomycin?

I-Fidaxomicin ibonise ezinye izinzuzo ngaphezu kwe-vancomycin, ikakhulukazi ekuvikeleni izifo ze-C. diff ukuthi zingabuyi. Izifundo zomtholampilo zithole ukuthi abantu abaphathwa nge-fidaxomicin mancane amathuba okuba nezifo eziphindayo uma kuqhathaniswa nalabo abaphathwa nge-vancomycin.

Zombili lezi zindlela zokwelapha zisebenza kahle kakhulu ekusuleni isifo sokuqala se-C. diff, ngamazinga okuphumelela afana kakhulu. Kodwa-ke, ikhono le-fidaxomicin lokugcina amabhaktheriya akho amahle emathunjini ngenkathi ilwa ne-C. diff libonakala linikeza ukuvikelwa okungcono kwesikhathi eside.

Into okukhulu okucatshangelwayo kwiziguli eziningi yizindleko, njengoba i-fidaxomicin ivamise ukubiza kakhulu kune-vancomycin. Kodwa-ke, uma ufaka engozini encishisiwe yokuphindeka kanye nesidingo esingaba khona sokwelashwa okwengeziwe, i-fidaxomicin ingase ibe nenzuzo ngesikhathi eside.

Udokotela wakho uzocabangela izici zakho eziyingozi zokuphindeka, ubukhulu bokutheleleka kwakho, kanye nempilo yakho yonke lapho ekhetha phakathi kwalezi zinketho. Zombili ziyimithi emihle kakhulu, futhi ukukhetha okungcono kuncike ezimweni zakho ezithile kunokuba enye ibe ngcono ngendlela yonke.

Imibuzo Evame Ukubuzwa Mayelana ne-Fidaxomicin

Ingabe i-Fidaxomicin iphephile kubantu abanesifo sikashukela?

Yebo, i-fidaxomicin ngokuvamile iphephile kubantu abanesifo sikashukela. Umuthi awuthinti ngokuphawulekayo amazinga kashukela egazini ngoba uhlala ikakhulukazi emathunjini akho kunokuba umuncwe egazini lakho.

Kodwa-ke, ukutheleleka kwe-C. diff kwesinye isikhathi kungathinta ukudla kwakho namaphethini okudla, okungase kuthinte ukulawulwa kukashukela wakho. Qapha amazinga akho e-glucose yegazi njengenjwayelo futhi uthinte umhlinzeki wakho wezempilo uma ubona izinguquko ezingavamile ngesikhathi sokwelashwa.

Ngingenzani uma ngiphuzile i-Fidaxomicin eningi ngengozi?

Uma ngengozi uphuza umthamo owengeziwe we-fidaxomicin, ungangeni ekuqeqeshweni. Ngenxa yokuthi umuthi awumuncwa ngokuphawulekayo egazini lakho, izimpawu zokweqisa umthamo akunakwenzeka ukuthi zibe zimbi.

Xhumana nodokotela wakho noma usokhemisi ukuze uthole isiqondiso, ikakhulukazi uma uphuze okuningi kakhulu kunokuba kunqunywe. Bangakuncoma ukuthi ngabe udinga ukunakekelwa kwezokwelapha nokuthi ungayilungisa kanjani isimiso sakho sokulinganisa ngokuqhubekayo.

Ngingenzani uma ngiphuthelwa umthamo we-Fidaxomicin?

Uma uphuthelwa umthamo, wuthatha ngokushesha lapho ukhumbula, ngaphandle kokuthi sekuseduze isikhathi somthamo wakho olandelayo ohleliwe. Kulokho, weqa umthamo ophuthelwe futhi uqhubeke nesimiso sakho esijwayelekile - ungaqedi imithamo emibili.

Zama ukugcina isikhathi esingamahora angu-12 phakathi kwemithamo uma kungenzeka. Uma uvame ukukhohlwa imithamo, cabangela ukusetha izikhumbuzi zocingo noma usebenzise umhleli wamaphilisi ukukusiza ukuthi uhlale emgqeni wokwelashwa kwakho.

Ngingayeka nini ukuthatha i-Fidaxomicin?

Yeka kuphela ukuthatha i-fidaxomicin uma usuqedele inkambo ephelele yezinsuku eziyi-10 ebekwe ngudokotela wakho, ngisho noma uzizwa ungcono ngokuphelele. Ukuyeka ngaphambi kwesikhathi kwandisa kakhulu ingozi yokuthi ukutheleleka kubuye.

Uma uhlangabezana nemiphumela emibi kakhulu noma ukusabela komzimba, xhumana nodokotela wakho ngokushesha ukuze uthole isiqondiso. Bangase badinge ukulungisa ukwelashwa kwakho, kodwa ungayeki imithi ngokwakho ngaphandle kokuqondiswa kwezokwelapha.

Ngingawathatha ama-Probiotics ne-Fidaxomicin?

Odokotela abaningi batusa ukulinda kuze kube ngemva kokuqeda inkambo yakho ye-fidaxomicin ngaphambi kokuqala ama-probiotics. Lokhu kuvumela i-antibiotic ukuthi isebenze ngempumelelo ngaphandle kokuphazanyiswa amagciwane angeziwe, ngisho nalawa alusizo.

Ngemva kokuqeda i-fidaxomicin, ama-probiotics angase asize ukubuyisela ibhalansi yamagciwane emathunjini akho, kodwa xoxa ngalokhu nomhlinzeki wakho wezempilo kuqala. Bangase bancomise isikhathi esifanele nezinhlobo zama-probiotics ngokusekelwe ezidingweni zakho zokululama.