Yini i-Fludrocortisone: Ukusetshenziswa, Umthamo, Imiphumela Eceleni nokuningi

I-Fludrocortisone iyimithi eyenziwe ngamakhemikhali e-corticosteroid esiza umzimba wakho ukuthi ugcine ibhalansi efanele kasawoti namanzi. Yimithi kadokotela esebenza ngendlela efana ne-aldosterone, i-hormone ekhiqizwa ngokwemvelo ngamadlala akho e-adrenal alawula indlela izinso zakho eziphatha ngayo i-sodium ne-potassium.

Le mithi idlala indima ebalulekile ekwelapheni izimo lapho umzimba wakho ungenakho ukulawula ibhalansi yamanzi kahle ngokwawo. Cabanga ngayo njengokunika umzimba wakho amathuluzi owadingayo ukuze ugcine umfutho wegazi ophilile futhi uvimbele ukushoda kwamanzi ezingeni lamaselula.

Isetshenziselwani i-Fludrocortisone?

I-Fludrocortisone ngokuyinhloko iphatha isifo sika-Addison, isimo lapho amadlala akho e-adrenal engakhiqizi ama-hormone anele. Iphinde inikezwe ngoba i-congenital adrenal hyperplasia, isimo sezakhi zofuzo esithinta ukukhiqizwa kwama-hormone kusukela ekuzalweni.

Udkt wakho angase futhi anikeze le mithi ngoba i-orthostatic hypotension, isimo lapho umfutho wegazi lakho wehla kakhulu uma usukuma. Lokhu kwenzeka ngoba umzimba wakho uzabalaza ukugcina ivolumu yegazi efanele nokulawulwa komfutho wegazi.

Kwezinye izimo, abahlinzeki bezempilo basebenzisa i-fludrocortisone ngaphandle kwelebula ngoba i-postural orthostatic tachycardia syndrome (POTS) noma i-chronic fatigue syndrome lapho izinkinga zokugcinwa kwamanzi zikhona. Lokhu kusetshenziswa kusiza iziguli ezinemizimba yazo enzima ukugcina umfutho wegazi ozinzile nokujikeleza.

Isebenza Kanjani i-Fludrocortisone?

I-Fludrocortisone isebenza ngokulingisa i-aldosterone, i-hormone etshela izinso zakho ukuthi zibambe i-sodium futhi zidedele i-potassium. Le nqubo isiza umzimba wakho ukuthi ugcine amanzi alungile futhi ugcine umfutho wegazi ophilile.

Uma uthatha lo muthi, ubopha kuma-receptors athile ezinso zakho nakwezinye izicubu. Lesi senzo sokubopha sibonisa umzimba wakho ukuthi ukhuphule ukumuncwa kwe-sodium, okudonsa ngokwemvelo amanzi amaningi emithanjeni yakho yegazi futhi kusiza ukugcina ivolumu yegazi efanele.

Umuthi uthathwa njengomuthi olukhuni ngokulinganisela emiphumeleni yawo ekulinganiseni amaminerali, kodwa uthambile kakhulu kunezinye izinhlobo ze-corticosteroids uma kuziwa ezenzweni ezilwa nokuvuvukala. Lokhu kwenza ukuthi kufaneleke ikakhulukazi ukusetshenziswa isikhathi eside ekwelashweni kokushintshwa kwamahomoni.

Kufanele Ngiyithathe Kanjani I-Fludrocortisone?

Thatha i-fludrocortisone ngendlela eqondile udokotela wakho ayiyalayo, ngokuvamile kanye ngosuku ekuseni. Ungayithatha ngaphandle noma ngaphandle kokudla, kodwa ukuyithatha nokudla kungasiza ukunciphisa noma yikuphi ukuphazamiseka kwesisu.

Kungcono ukuthatha lo muthi ngesikhathi esifanayo nsuku zonke ukuze kugcinwe amazinga aqhubekayo emzimbeni wakho. Ukulinganisa ekuseni kuvame ukunconywa ngoba kulingisa amaphethini akho emvelo amahomoni futhi kungasiza ekuvikeleni ukuphazamiseka kokulala.

Uma udinga ukuyithatha nokudla, khetha okuthile okulula njengosinkwa noma ama-crackers. Gwema ukuyithatha nejusi le-grapefruit, ngoba lokhu kungathinta indlela umzimba wakho oqhubula ngayo umuthi. Ngaso sonke isikhathi gwinya ithebhulethi yonke nengilazi yamanzi egcwele.

Kufanele Ngiyithathe Isikhathi Eside Kangakanani I-Fludrocortisone?

Abantu abaningi abanesifo sika-Addison noma i-congenital adrenal hyperplasia badinga ukuthatha i-fludrocortisone impilo yabo yonke. Lezi zimo zidinga ukushintshwa kwamahomoni okuqhubekayo ngoba umzimba wakho awukwazi ukukhiqiza amanani afanele ngokwemvelo.

Kwezinye izimo ezinjenge-orthostatic hypotension, ubude besikhathi buxhomeke esimweni sakho sempilo esiyisisekelo. Abanye abantu bangase bayidinge okwesikhashana ngenkathi bekhuluma nezimbangela eziyisisekelo, kanti abanye badinga ukwelashwa isikhathi eside ukuze bagcine umfutho wegazi ozinzile.

Udktela wakho uzoqapha njalo impendulo yakho futhi angase alungise uhlelo lwakho lokwelapha ngokuhamba kwesikhathi. Ungayeki ukuthatha i-fludrocortisone ngokuzumayo, ngoba lokhu kungadala ukwehla okuyingozi komfutho wegazi kanye nokungalingani kwama-electrolyte okungase kube yingozi empilweni.

Yiziphi Izimo Ezingezinhle Ze-Fludrocortisone?

Imiphumela emibi evamile ye-fludrocortisone ngokuvamile iyalawuleka futhi ihlobene nemiphumela yayo ekulinganiseni uketshezi nosawoti. Umzimba wakho ungase udinge isikhathi sokujwayela umuthi, ngakho eminye imiphumela emibi yokuqala ivame ukuthuthuka ngokuqhubeka nokusebenzisa.

Nawa amanye amiphumela emibi ebikwa kaningi ongase uyithole:

• Ukugcinwa koketshezi okuholela ekuvuvukeni ezinyaweni zakho, emaqakaleni, noma ezandleni
• Umfutho wegazi owenyukile, ikakhulukazi uma uzwela usawoti
• Ukucindezeleka kwekhanda, ikakhulukazi emasontweni ambalwa okuqala okwelashwa
• Ubuthakathaka bemisipha noma ama-cramps njengoba amazinga akho e-electrolyte elungiswa
• Ukudla okwandisiwe nokuzuza isisindo esingaba khona
• Ushintsho lwemizwa njengokucasuka noma ukungazinzi

Le miphumela evamile ivame ukungabonakali njengoba umzimba wakho ujwayela umuthi. Udokotela wakho angakusiza ukuthi uyilawule ngokulungiswa kwemithamo noma ukuguqulwa kwendlela yokuphila.

Imiphumela emibi engavamile kodwa engathi sína idinga ukunakekelwa kwezempilo ngokushesha. Nakuba kungavamile, lezi zinkinga zingase zivele uma ukulinganisela kwama-electrolyte akho kuphazamiseka kakhulu noma uma uthola ukusabela komzimba okungalungile.

Xhumana nomhlinzeki wakho wezempilo ngokushesha uma uhlangabezana:

• Ukuvuvukala okukhulu okungathuthuki ngokuphakama
• Ubuhlungu besifuba noma ubunzima bokuphefumula
• Ukucindezeleka kwekhanda okukhulu nokushintsha kombono
• Izimpawu ze-potassium ephansi njengobuthakathaka bemisipha obukhulu noma ukushaya kwenhliziyo okungajwayelekile
• Izimpawu zokutheleleka njengomkhuhlane, njengoba umuthi ungase ucindezele umsebenzi womzimba wokuzivikela
• Ushintsho olukhulu lwemizwa noma ukucindezeleka

Izinkinga ezingavamile kodwa ezingathi sína zingabandakanya izinkinga zesigqi senhliziyo, umfutho wegazi ophezulu kakhulu, noma izimpawu zokuhlaselwa kwe-adrenal uma uyeka umuthi kungazelelwe. Lezi zimo zidinga ukunakekelwa kwezempilo okuphuthumayo.

Ubani Ongafanele Athathe I-Fludrocortisone?

I-Fludrocortisone ayifanele wonke umuntu, futhi izimo ezithile zezempilo ziyenza ibe yingozi. Udokotela wakho uzobukeza ngokucophelela umlando wakho wezokwelapha ngaphambi kokukuyalela lo muthi.

Akufanele uthathe i-fludrocortisone uma unezifo zefungal zesistimu, njengoba umuthi ungacindezela amasosha akho omzimba futhi uqhubekisele phambili lezi zifo. Abantu abaziwa ukuthi banezifo zokungezwani komzimba ne-fludrocortisone noma ama-corticosteroids afanayo kufanele futhi bagweme lo muthi.

Izimo eziningana zezempilo zidinga ukuqapha okwengeziwe noma zingenza i-fludrocortisone ingakulungele:

• Ukwehluleka kwenhliziyo noma isifo senhliziyo esibi, njengoba ukugcinwa kwamanzi kungaqhubekisela phambili lezi zimo
• Umfutho wegazi ophezulu okunzima ukuwulawula
• Isifo sezinso, ngoba umuthi uthinta indlela izinso zakho eziphatha ngayo ama-electrolyte
• Isifo sesibindi, esingathinta indlela umzimba wakho oqhubula ngayo umuthi
• Isifo sikashukela, njengoba umuthi ungathinta amazinga kashukela egazini
• I-Osteoporosis, njengoba ukusetshenziswa kwesikhathi eside kungathinta ukuminyana kwamathambo

Udokotela wakho uzokala izinzuzo ngokumelene nezingozi ezingaba khona uma unezinye zalezi zimo. Ngezinye izikhathi umuthi usadingeka, kodwa uzodinga ukuqapha okuseduze futhi mhlawumbe ukwelashwa okwengeziwe ukuze ulawule imiphumela emibi.

Amagama Omkhiqizo we-Fludrocortisone

Igama elivamile lomkhiqizo we-fludrocortisone yi-Florinef Acetate, ekhiqizwa yizinkampani eziningana zemithi. Lo mkhiqizo ubelokhu utholakala amashumi eminyaka futhi waziwa kabanzi ngabahlinzeki bezempilo.

Ungase futhi uhlangane nezinhlobo ezivamile ezibizwa ngokuthi "i-fludrocortisone acetate" evela kubakhiqizi abahlukahlukene. Lezi zinhlobo ezivamile ziqukethe isithako esifanayo esisebenzayo futhi zisebenza ngempumelelo njengohlobo lwegama lomkhiqizo.

Njalo sebenzisa uhlobo olufanayo lomkhiqizo noma oluvamile ngokuqhubekayo uma kungenzeka, njengoba umehluko omncane ekukhiqizeni ngezinye izikhathi ungathinta indlela umzimba wakho osabela ngayo. Uma ikhemisi lakho lishintsha imikhiqizo, yazisa udokotela wakho ukuze bakwazi ukuqapha noma yiziphi izinguquko ezimpawini zakho.

Ezinye izindlela ze-Fludrocortisone

Ngesifo sika-Addison, azikho ezinye izindlela eziqondile ze-fludrocortisone ngoba ngokuqondile ithatha indawo ye-hormone ye-mineralocorticoid umzimba wakho ongayidingi. Kodwa-ke, udokotela wakho angase alungise umthamo wakho we-hydrocortisone noma ancome ukwanda kokudla usawoti njengezinyathelo zokusekela.

Nge-orthostatic hypotension, ziningi ezinye izindlela ezikhona ngokuya ngesimo sakho esithile. I-Midodrine iyindlela evamile esebenza ngokunciphisa imithambo yegazi ukuze kugcinwe umfutho wegazi uma usukuma.

Ezinye izinketho udokotela wakho angazicabangela zihlanganisa:

• Ukwanda kokudla usawoti noketshezi ngokushintsha kokudla
• Amasokisi okucindezela ukuthuthukisa ukujikeleza
• I-Droxidopa yezinhlobo ezithile ze-orthostatic hypotension
• Ukuguqulwa kwendlela yokuphila njengokushintsha kancane kancane kwesimo

Enye indlela engcono kakhulu incike esimweni sakho esiyisisekelo nokuthi ukubekezelela kahle kangakanani ukwelashwa okuhlukene. Udokotela wakho uzosebenza nawe ukuthola indlela esebenza kahle kakhulu ezidingweni zakho ezithile.

Ingabe i-Fludrocortisone ingcono kune-Hydrocortisone?

I-Fludrocortisone ne-hydrocortisone zisebenzela izinhloso ezihlukene, ngakho ukuqhathanisa ngokuqondile akulula. I-Fludrocortisone ngokuyinhloko ithinta ukulinganisela kwamaminerali nomfutho wegazi, kuyilapho i-hydrocortisone ngokuyinhloko inikeza imiphumela elwa nokuvuvukala nokufaka esikhundleni se-hormone yokucindezeleka.

Abantu abaningi abanesifo sika-Addison empeleni badinga imithi yomibili ngoba ithatha indawo yamahomoni ahlukene amanyikwe akho e-adrenal glands avamise ukuwakhiqiza. I-Hydrocortisone ithatha indawo ye-cortisol, kanti i-fludrocortisone ithatha indawo ye-aldosterone.

Ukuze kulawulwe umfutho wegazi nokulinganisela kwamanzi, i-fludrocortisone yenzelwe ngqo le njongo futhi ivamise ukusebenza kangcono kune-hydrocortisone. Kodwa-ke, i-hydrocortisone ingcono ekuphatheni ukuvuvukala nokuhlinzeka ngempendulo yokucindezeleka umzimba wakho oyidingayo ngesikhathi sokugula noma ukulimala.

Imibuzo Evame Ukubuzwa Mayelana ne-Fludrocortisone

Ingabe i-Fludrocortisone iphephile ezigulini zenhliziyo?

I-Fludrocortisone idinga ukucatshangelwa ngokucophelela uma unesifo senhliziyo, njengoba ingabangela ukugcinwa kwamanzi futhi ikhuphule umfutho wegazi. Udokotela wakho wenhliziyo nodokotela oqokayo kuzodingeka basebenzisane ukuze banqume ukuthi izinzuzo zidlula yini izingozi.

Uma udinga i-fludrocortisone ngesifo senhliziyo, cishe uzodinga ukuqapha umfutho wegazi lakho, isimo samanzi, nomsebenzi wenhliziyo kaningi. Udokotela wakho angase aqale ngomthamo ophansi futhi alungise kancane kancane ngenkathi ebheka izimpawu zokugcwala kwamanzi.

Ngingenzani uma ngiphuzile i-Fludrocortisone eningi ngengozi?

Uma uphuza i-fludrocortisone eningi ngengozi, xhumana nodokotela wakho noma isikhungo sokulawula ubuthi ngokushesha. Ukuphuza okuningi kungabangela ukwanda okuyingozi komfutho wegazi, ukugcinwa kwamanzi okukhulu, kanye nokungalingani kwama-electrolyte okungase kube yingozi empilweni.

Izimpawu zokweqisa zihlanganisa ikhanda elibuhlungu elibuhlungu, izinguquko zombono, ukuvuvukala okukhulu, ubuhlungu besifuba, noma ubunzima bokuphefumula. Ungalindi ukuthi izimpawu zibe zimbi kakhulu – funa ukunakekelwa kwezempilo okuphuthumayo uma uthathe okuningi kakhulu kunokunqunyiwe.

Ngingenzani uma ngiphuthelwa umthamo we-Fludrocortisone?

Uma uphuthelwa umthamo we-fludrocortisone, yithathe ngokushesha lapho ukhumbula, ngaphandle kokuthi sekuseduze isikhathi somthamo wakho olandelayo. Esimeni esinjalo, weqa umthamo ophuthelwe bese uqhubeka neshejuli yakho ejwayelekile.

Ungalokothi uthathe imithamo emibili ngesikhathi esisodwa ukuze ulungise umthamo ongekho, ngoba lokhu kungadala imiphumela emibi eyingozi. Uma uvame ukukhohlwa imithamo, cabangela ukusetha i-alamu yansuku zonke noma ukusebenzisa umhleli wamaphilisi ukukusiza ukuthi ukhumbule.

Ngingayeka nini ukuthatha i-Fludrocortisone?

Yeka kuphela ukuthatha i-fludrocortisone ngaphansi kokuqondisa okuqondile kukadokotela wakho. Uma unesifo sika-Addison noma i-congenital adrenal hyperplasia, cishe uzodinga lo muthi impilo yakho yonke, njengoba umzimba wakho ungenakukhiqiza amahomoni anele ngokwemvelo.

Kwezinye izimo, udokotela wakho uzoqoka ukuthi kuphephile nini ukuyeka ngokusekelwe empilweni yakho engaphansi kanye nokuthuthuka kwezimpawu. Ukuyeka kungazelelwe kungadala ukwehla okuyingozi komfutho wegazi kanye nokungalingani kwe-electrolyte, ngakho noma yikuphi ukuyeka kumele kube kancane kancane futhi kuqashwe ngokucophelela.

Ngingayithatha i-Fludrocortisone ngesikhathi sokukhulelwa?

I-Fludrocortisone ngokuvamile ithathwa njengephephile ngesikhathi sokukhulelwa uma kudingeka ngokwelashwa, ikakhulukazi kwabesifazane abanesifo sika-Addison. Izingozi zokunganele kwe-adrenal okungelashwanga ngokuvamile zidlula izingozi ezingaba khona zemithi.

Udokotela wakho uzoqapha ngokucophelela wena nomntwana wakho ngesikhathi sokukhulelwa, njengoba ukukhulelwa kungathinta izidingo zakho zemithi. Ungase udinge ukulungiswa komthamo, ikakhulukazi ngezikhathi zokucindezeleka njengomsebenzi wokubeletha.