Yini i-Gadoxetate: Ukusetshenziswa, Umthamo, Imiphumela Eceleni nokuningi

I-Gadoxetate iyisithako esikhethekile esisetshenziswa ngesikhathi sokuskena kwe-MRI ukusiza odokotela ukuthi babone isibindi sakho nemisele yenyongo ngokusobala. Cabanga ngayo njengethuluzi lokugqamisa elenza izingxenye ezithile zomzimba wakho zivele kangcono ezithombeni zezokwelapha, njengoba umaka egqamisa umbhalo ephepheni.

Lo muthi ungoweqembu elibizwa ngokuthi ama-ejenti okuqhathanisa asekelwe ku-gadolinium. Unikezwa ngomugqa we-IV ngesikhathi sokuqokwa kwakho kwe-MRI futhi usebenza ngokushintsha okwesikhashana ukuthi izicubu zesibindi sakho zivela kanjani ezithombeni zokuskena.

Yini i-Gadoxetate Esetshenziselwa Yona?

I-Gadoxetate isetshenziswa ikakhulukazi ukusiza odokotela ukuthi bathole futhi bahlole izinkinga zesibindi ngesikhathi sokuskena kwe-MRI. Udokotela wakho angase ancome le ejenti yokuqhathanisa lapho bedinga isithombe esicacile sokuthi kwenzekani esibindini sakho.

Lo muthi usiza ukuhlonza izimo ezihlukahlukene zesibindi okuhlanganisa izimila, ama-cyst, nezinye izinto ezingavamile ezingase zingabonakali kahle ku-MRI evamile. Ilusizo ikakhulukazi ekutholeni izilonda ezincane zesibindi ezingase ziphuthelwe ngaphandle kokuthuthukiswa kokuqhathanisa.

Odokotela futhi basebenzisa i-gadoxetate ukuhlola ukuthi isibindi sakho sisebenza kahle kangakanani nokuhlola imisele yakho yenyongo ukuze kutholakale ukuvinjelwa noma ezinye izinkinga. Lokhu kucabanga okuningiliziwe kusiza ithimba lakho lokunakekelwa kwezempilo ukuthi lenze ukuxilongwa okunembile nezinhlelo zokwelapha.

Isebenza Kanjani i-Gadoxetate?

I-Gadoxetate isebenza ngokumuncwa ngokuqondile ngamaseli esibindi anempilo, okwenza avele ekhanya ezithombeni ze-MRI. Lokhu kuthathwa okukhethiwe kudala umehluko ocacile phakathi kwezicubu zesibindi ezivamile nezindawo ezingase zibe nezinkinga.

Lapho ifakwe emgudwini wakho wegazi, lo muthi uhamba emzimbeni wakho wonke kodwa ugxilwe esibindini sakho ngemizuzu. Amaseli esibindi anempilo athatha i-ejenti yokuqhathanisa, kuyilapho izindawo ezilimele noma ezingavamile zingayimunci kahle, okudala umehluko ocacile ekuskeneni.

Umzimba wakho ngokwemvelo ukhipha i-gadoxetate ngazo zombili izinso zakho nesibindi sakho. Cishe ingxenye ikhishwa ngomchamo wakho, kanti enye ingxenye idlula emanzini akho e-bile bese iphuma ngohlelo lwakho lokugaya ukudla.

Kufanele Ngiyithathe Kanjani I-Gadoxetate?

Awuyithathi ngempela i-gadoxetate ngokwakho - inikezwa uchwepheshe wezempilo ngomugqa we-IV ngesikhathi sokuqokwa kwakho kwe-MRI. Umuthi ufakwa ngqo emthanjeni engalweni yakho, ngokuvamile ngemizuzwana embalwa.

Ngaphambi kokuqokwa kwakho, ungaqhubeka udla futhi uphuze ngokujwayelekile ngaphandle uma udokotela wakho ekunikeza imiyalelo ethile ngenye indlela. Abantu abaningi abadingi ukwenza izinguquko ezikhethekile ekudleni ngaphambi kokuthola i-gadoxetate.

Ukujova kwenzeka ngenkathi ulele emshinini we-MRI, futhi cishe uzokuthola phakathi nendawo yokuskena kwakho. Ungase uzwe umuzwa opholile lapho umuthi ungena egazini lakho, kodwa lokhu kujwayelekile ngokuphelele.

Kufanele Ngiyithathe Isikhathi Esingakanani I-Gadoxetate?

I-Gadoxetate iyisijovo esisodwa esinikezwa kuphela ngesikhathi sokuskena kwakho kwe-MRI. Ngeke kudingeke ukuthi uthathe lo muthi ekhaya noma uqhubeke nawo ngemuva kokuqokwa kwakho kokuthwebula izithombe.

Imiphumela yomkhiqizo ohlukile ihlala isikhathi eside ngokwanele ukuze ukuskena kwakho kwe-MRI kuqedwe, ngokuvamile phakathi kwemizuzu engama-30 kuya kwengama-60. Umzimba wakho uqala ukukhipha umuthi ngokushesha ngemuva kokujova.

Iningi le-gadoxetate lizosuswa ohlelweni lwakho kungakapheli amahora angama-24 ngomsebenzi wakho ojwayelekile wezinso nesibindi. Akudingeki ukuthi wenze noma yini ekhethekile ukuze usize umzimba wakho ukuyikhipha.

Yiziphi Imiphumela Eceleni ye-Gadoxetate?

Abantu abaningi bayayibekezelela kahle i-gadoxetate, nemiphumela emibi ngokuvamile ibuthakathaka futhi yesikhashana. Ukusabela okuvame kakhulu kwenzeka ngesikhathi noma ngemuva nje kokujova futhi ngokuvamile kulungiswa ngokwako.

Nansi imiphumela emibi ongase uyithole, ukhumbula ukuthi abantu abaningi abanayo imiphumela emibi nakancane:

Imiphumela emibi ejwayelekile ihlanganisa:

• Ukuzwa ukushisa noma ukubomvu ngesikhathi sokujova
• Ukunambitheka kwensimbi emlonyeni wakho
• Isicanucanu esincane
• Ukuqaqamba kwekhanda
• Isiyezi
• Ukuphatheka kabi endaweni yokujova

Lezi zimo zivame ukuba mfushane futhi azidingi ukwelashwa. Ukuzwa ukushisa nokunambitheka kwensimbi kuvamile kakhulu futhi kuyizimpendulo ezijwayelekile ngokuphelele kumuthi ohlukile.

Imiphumela emibi engavamile kodwa ebucayi ihlanganisa:

• Ukungezwani komzimba okunezinduna noma ukuqubuka
• Ubunzima bokuphefumula
• Ukuvuvukala kobuso, izindebe, noma umphimbo
• Isicanucanu esibi noma ukuhlanza
• Ubuhlungu besifuba noma ukushaya kwenhliziyo okungajwayelekile
• Isiyezi esibi noma ukuquleka

Ngenkathi lezi zimo ezinzima zingavamile, zidinga ukunakekelwa kwezempilo ngokushesha. Ithimba lezempilo eliqapha ukuskena kwakho liqeqeshwe ukubona nokwelapha lezi zimo ngokushesha uma zenzeka.

Izinkinga ezingavamile kakhulu kodwa ezinzima zihlanganisa:

• I-Nephrogenic systemic fibrosis (kubantu abanezifo ezinzima zezinso)
• Ukungezwani komzimba okukhulu (i-anaphylaxis)
• Izinkinga zezinso kubantu abanezifo zezinso ezikhona

Lezi zinkinga ezinzima azivamile kakhulu, ikakhulukazi kubantu abanomsebenzi wezinso ojwayelekile. Udokotela wakho uzohlola impilo yakho yezinso ngaphambi kokuncoma i-gadoxetate ukunciphisa lezi zingozi.

Ubani Ongafanele Athole I-Gadoxetate?

I-Gadoxetate ayifanele wonke umuntu, futhi udokotela wakho uzobuyekeza ngokucophelela umlando wakho wezokwelapha ngaphambi kokuncoma lo muthi ohlukile. Abantu abanezimo ezithile zezempilo bangase badinge izindlela zokuthwebula ezingezinye.

Akufanele uthole i-gadoxetate uma unezifo ezinzima zezinso noma ukwehluleka kwezinso. Abantu abanomsebenzi wezinso oncishiswe kakhulu (isilinganiso sokuhlunga se-glomerular esingaphansi kuka-30) babhekana nezingozi eziphakeme zezinkinga ezinzima.

Labo abaziwa ukuthi banomzimba ongavamile emithini eqinisa ukubonakala esekelwe ku-gadolinium kufanele bakugweme ukusebenzisa i-gadoxetate. Uma wake waba nokusabela okukhulu kunoma yiluphi uhlobo lwemithi eqinisa ukubonakala esikhathini esidlule, qiniseka ukuthi utshela ithimba lakho lezempilo ngaphambi kokuba uqokwe.

Abesifazane abakhulelwe ngokuvamile bayakugwema ukusebenzisa i-gadoxetate ngaphandle uma izinzuzo ezingaba khona ziqeda izingozi. Ngenkathi kungekho bufakazi bokulimala ezinganeni ezisakhula, odokotela bakhetha ukusebenzisa ezinye izindlela zokuthwebula izithombe uma kungenzeka ngesikhathi sokukhulelwa.

Abantu abanezimo ezithile zesibindi, ikakhulukazi ukwehluleka kwesibindi okukhulu, kungenzeka bangabi ngabantu abafanelekayo ukusebenzisa i-gadoxetate ngoba imithi incike ekusebenzeni kwesibindi ukuze iqedwe.

Amagama Omkhiqizo we-Gadoxetate

I-Gadoxetate itholakala ngaphansi kwegama lomkhiqizo elithi Eovist e-United States naseCanada. E-Europe nakwezinye izingxenye zomhlaba, ithengiswa njenge-Primovist.

Womabili amagama omkhiqizo abhekisela emuthini ofanayo - i-gadoxetate disodium - futhi asebenza ngokufanayo ekuthwebuleni izithombe zesibindi nge-MRI. Ukukhetha phakathi kwemikhiqizo kuvame ukuncika kulokho okutholakala ohlelweni lwakho lwezempilo.

Ezinye izindlela ze-Gadoxetate

Ezinye izinhlobo zemithi eqinisa ukubonakala zingasetshenziselwa ukuthwebula izithombe zesibindi nge-MRI, yize ngayinye inezakhiwo ezihlukene nokusetshenziswa. Udokotela wakho uzokhetha inketho engcono kakhulu ngokususelwe esimweni sakho esithile nokuthi yiluphi ulwazi abaludingayo kuskena sakho.

Ezinye izinhlobo zemithi eqinisa ukubonakala esekelwe ku-gadolinium njenge-gadopentetate (Magnevist) noma i-gadobenate (MultiHance) zingahlinzeka ngokuthwebula izithombe zesibindi, kodwa azinazo izakhiwo ezifanayo zokuthathwa ezithile zesibindi njenge-gadoxetate.

Ezimweni ezithile zesibindi, udokotela wakho angase ancome i-MRI ejwayelekile ngaphandle kokusetshenziswa kwemithi eqinisa ukubonakala, i-ultrasound, noma iskena se-CT esikhundleni salokho. Ukukhetha kuncike kulokho udokotela wakho akufunayo nezimo zakho zezokwelapha.

Ingabe i-Gadoxetate Ingcono Kunezinye Izinhlobo Zemithi Eqinisa Ukubonakala Yesibindi?

I-Gadoxetate inikeza izinzuzo eziyingqayizivele zokuthwebula isithombe sesibindi okwenza kube usizo ikakhulukazi ezimweni ezithile. Ikhono layo lokuthathwa ngokuqondile ngamaseli esibindi linikeza ulwazi olungalingani nezinye izinto eziphikisanayo.

Uma kuqhathaniswa nezinto eziphikisanayo zendabuko, i-gadoxetate inikeza odokotela izinhlobo ezimbili zolwazi: indlela igazi eligijima ngayo esibindini sakho nokuthi amaseli esibindi sakho asebenza kahle kangakanani. Leli khono eliphindwe kabili lenza libaluleke kakhulu ekutholeni izimila ezincane zesibindi.

Nokho, “ngcono” kuncike kulokho okudingwa udokotela wakho ukuthi akubone. Ezimweni ezithile zesibindi, izinto eziphikisanayo zendabuko zisebenza kahle ngokuphelele futhi zingase zifaneleke kakhulu. Ithimba lakho lezempilo lizokhetha into ephikisayo ephendula kangcono imibuzo yakho ethile yezokwelapha.

Imibuzo Evame Ukubuzwa Mayelana ne-Gadoxetate

Q1. Ingabe i-gadoxetate iphephile kubantu abanesifo sikashukela?

Yebo, i-gadoxetate ngokuvamile iphephile kubantu abanesifo sikashukela, uma nje umsebenzi wezinso zabo ujwayelekile. Isifo sikashukela ngokwaso asikuvimbeli ukuthi uthole le nto ephikisayo.

Nokho, uma unesifo sezinso esihlobene nesifo sikashukela, udokotela wakho uzodinga ukuhlola ukusebenza kwezinso zakho ngaphambi kokugunyaza i-gadoxetate. Abantu abane-diabetic nephropathy bangase badinge izindlela zokuthwebula ezinye izithombe ukuze bagweme izinkinga ezingaba khona.

Q2. Kufanele ngenzeni uma ngithola i-gadoxetate eningi ngengozi?

Ukweqisa kwe-Gadoxetate akunakwenzeka kakhulu njengoba kunikezwa ochwepheshe bezempilo abaqeqeshiwe ezindaweni zezokwelapha ezilawulwayo. Ukulinganisa kubalwa ngokucophelela ngokusekelwe esisindweni somzimba wakho futhi kulawulwa nge-IV injection.

Uma ukhathazekile ngobuningi obutholile, khuluma nethimba lakho lezempilo ngokushesha. Bangakwazi ukukuqapha nganoma yiziphi izimpawu ezingavamile futhi banikeze ukunakekelwa okufanele uma kudingeka.

Q3. Kufanele ngenzeni uma ngiphuthelwa ukuqokwa kwami ​​kwe-gadoxetate injection?

Njengoba i-gadoxetate inikezwa kuphela ngesikhathi sokuqokwa kwe-MRI okuhleliwe, ukweqa ukuqokwa kwakho kusho ukuhlela kabusha ukuskena kwakho konke. Xhumana nomhlinzeki wakho wezempilo noma isikhungo sokuthwebula izithombe ngokushesha ngangokunokwenzeka ukuze uhlele kabusha.

Ungakhathazeki ngokweqa umuthi uqobo - akukho imiphumela yokuhoxisa noma izinkinga zokungatholi i-gadoxetate. Okukhathaza kakhulu ukuthola izithombe zakho zezokwelapha ezidingekayo eziqediwe ngesikhathi esifanele.

Q4. Ngingaqala nini kabusha imisebenzi ejwayelekile ngemva kokuthola i-gadoxetate?

Ngokuvamile ungaqala kabusha yonke imisebenzi ejwayelekile ngokushesha ngemva kokuskena kwakho kwe-MRI nge-gadoxetate. Abantu abaningi bazizwa bephile ngokuphelele futhi bangazishayela imoto ekhaya, basebenze, futhi bahlanganyele emisebenzini ejwayelekile.

Uma uzwa isiyezi noma uzizwa ungaphilile ngemva komjovo, linda kuze kube yilapho lezi zimpawu zixazululwa ngaphambi kokushayela noma ukusebenzisa imishini. Le miphumela ivame ukuba mfushane futhi ibe mnene.

Q5. Ngingamuncisa ngemva kokuthola i-gadoxetate?

Imihlahlandlela yezokwelapha yamanje iphakamisa ukuthi ukuncelisa kungaqhubeka ngokujwayelekile ngemva kokuthola i-gadoxetate. Amanani amancane kuphela omuthi adlulela obisini lwebele, futhi awamuncwa kahle yizingane ngohlelo lokugaya ukudla.

Uma ukhathazekile, ungaqeda futhi ulahle ubisi lwebele amahora angu-24 ngemva kokuskena kwakho, nakuba leli qophelo lingadingeki ngokwezokwelapha. Xoxa ngesimo sakho esithile nodokotela wakho uma unemibuzo mayelana nokuncelisa ngemva kwe-gadoxetate.