Yini i-Guanabenz: Ukusetshenziswa, Umthamo, Imiphumela Eceleni nokuningi

I-Guanabenz iyimithi kadokotela esetshenziselwa ikakhulukazi ukwelapha umfutho wegazi ophezulu (i-hypertension). Le mithi edliwayo yomlomo ingeyeqembu lemithi ebizwa ngokuthi ama-central alpha-2 agonists, asebenza ngokukhulula imithambo yegazi futhi anciphise umsebenzi wenhliziyo. Nakuba ngokuvamile kungewona umuthi okhethwa kuqala wokwelapha umfutho wegazi ophezulu namuhla, i-guanabenz ingaba yindlela ephumelelayo yabanye iziguli lapho eminye imithi ingasebenzi kahle noma ingafaneleki.

Yini i-Guanabenz?

I-Guanabenz yimithi yomfutho wegazi esebenza ngqo ohlelweni lwakho lwezinzwa oluphakathi ukuze wehlise umfutho wegazi. Yathuthukiswa ngeminyaka yawo-1980 futhi isisize abantu ukuthi balawule i-hypertension amashumi eminyaka. Lo muthi uza njengamaphilisi omlomo owathatha ngomlomo, ngokuvamile kabili ngosuku.

Lo muthi uthathwa njengokwelashwa kwesibili komfutho wegazi ophezulu. Lokhu kusho ukuthi odokotela bavame ukuzama eminye imithi yomfutho wegazi kuqala, njengama-ACE inhibitors noma ama-diuretics, ngaphambi kokucabangela i-guanabenz. Kodwa-ke, kungasiza ikakhulukazi abantu abangazange basabele kahle kwezinye izindlela zokwelapha noma labo abanezimo ezithile zezokwelapha ezenza eminye imithi ingafaneleki.

Isetshenziselwani i-Guanabenz?

I-Guanabenz ikakhulukazi inikezwa ukwelapha umfutho wegazi ophezulu kubantu abadala. Umfutho wegazi ophezulu wenzeka lapho amandla egazi odongeni lwemithambo yakho ephakeme njalo, okungase kuqede amandla enhliziyo yakho futhi kulimaze imithambo yakho yegazi ngokuhamba kwesikhathi.

Udokotela wakho angase akunikeze i-guanabenz uma unomfutho wegazi ophezulu obalulekile, okungumfutho wegazi ophezulu ongenayo imbangela ebonakalayo. Lolu hlobo luthatha cishe u-90% wazo zonke izimo zomfutho wegazi ophezulu. Lo muthi usiza ukwehlisa umfutho wakho wegazi ufinyelele emazingeni aphephile, okunganciphisa ingozi yakho yokuhlaselwa yinhliziyo, unhlangothi, nezinye izinkinga zenhliziyo nemithambo yegazi.

Kwezinye izimo, odokotela bangase banikeze i-guanabenz kanye neminye imithi yokwehlisa umfutho wegazi ukuze bathole ukulawula okungcono. Le ndlela yokuhlanganisa ivamile uma umuthi owodwa unganele ukuletha umfutho wegazi emazingeni aqondiwe.

Isebenza Kanjani I-Guanabenz?

I-Guanabenz isebenza ngokuvuselela izamukeli ezikhethekile ebuchosheni bakho ezibizwa ngokuthi ama-alpha-2 adrenergic receptors. Uma lezi zamukeli zivuliwe, zithumela amasignali anciphisa umsebenzi wesimiso sakho sezinzwa esinobungane, esibhekele impendulo yomzimba wakho ethi "ukulwa noma ukubaleka".

Lokhu kuncipha komsebenzi wesimiso sezinzwa esinobungane kuholela emiphumeleni eminingi enenzuzo. Isilinganiso senhliziyo yakho sinciphisa kancane, imithambo yakho yegazi iyakhululeka futhi yanda, futhi inhliziyo yakho akudingeki isebenze kanzima ukuze ipompe igazi. Cabanga ngakho njengokwehlisa ivolumu ohlelweni lomzimba wakho lokuphendula ukucindezeleka.

I-Guanabenz ithathwa njengomuthi wokwehlisa umfutho wegazi olungakanani. Ayinamandla njengeminye imithi emisha, kodwa inganciphisa ngempumelelo umfutho wegazi ngo-10-15 mmHg systolic kanye no-5-10 mmHg diastolic ezigulini eziningi. Umphumela ogcwele wokwehlisa umfutho wegazi uvame ukuthuthuka ngaphezu kwamasonto angu-2-4 okusetshenziswa njalo.

Kufanele Ngiyithathe Kanjani I-Guanabenz?

Thatha i-guanabenz ngendlela enembile njengoba udokotela wakho ekunqumele ngayo, ngokuvamile kabili ngosuku ngaphandle noma ngaphandle kokudla. Abantu abaningi bakuthola kulula ukukhumbula uma bethathwa nokudla, kodwa ukudla akuthinti ngendlela enkulu ukuthi umuthi usebenza kanjani. Ungayithatha ngamanzi, ijusi, noma ubisi ngokokukhetha kwakho.

Umthamo ovamile wokuqala ngu-4 mg kabili ngosuku, okungenzeka ukuthi udokotela wakho awunyuse kancane kancane ngokusekelwe ekuphenduleni kwakho umfutho wegazi. Ungalokothi ushintshe umthamo wakho ngaphandle kokubonisana nomhlinzeki wakho wezempilo kuqala. Kubalulekile ukuthatha i-guanabenz cishe ngezikhathi ezifanayo nsuku zonke ukuze ugcine amazinga aqhubekayo emzimbeni wakho.

Uma unenkinga yokugwinya amaphilisi, ungaqhekeza amaphilisi aqoshiwe phakathi, kodwa ungaqobi noma uwahlafune. Ukuthatha imithi ngokuqhubekayo ngezikhathi ezifanayo kusiza umzimba wakho ukuthi ugcine ukulawulwa kwengcindezi yegazi ezinzile usuku lonke.

Kufanele Ngiyithathe Isikhathi Esingakanani I-Guanabenz?

I-Guanabenz ngokuvamile iyimithi yesikhathi eside yokulawula umfutho wegazi ophezulu. Abantu abaningi badinga ukuyithatha unomphela ngoba umfutho wegazi ophezulu ngokuvamile uyisimo esingapheli esinganyamalali sodwa. Udokotela wakho uzoqapha umfutho wakho wegazi njalo ukuze aqinisekise ukuthi imithi iyaqhubeka isebenza ngempumelelo.

Akufanele uyeke ukuthatha i-guanabenz ngokuzumayo ngaphandle kwesiqondiso sikadokotela wakho. Ukuyeka kungazelelwe kungabangela umfutho wakho wegazi ukuthi ukhuphuke ngendlela eyingozi, isimo esibizwa ngokuthi i-rebound hypertension. Uma udinga ukuyeka imithi, udokotela wakho uzokwehlisa kancane kancane umthamo wakho ezinsukwini ezimbalwa noma emasontweni.

Abanye abantu bangase bakwazi ukunciphisa umthamo wabo noma bashintshele kweminye imithi ngokuhamba kwesikhathi, ikakhulukazi uma benza izinguquko ezinkulu zokuphila njengokulahlekelwa isisindo, ukuzivocavoca njalo, noma ukunciphisa ukudla kwe-sodium. Kodwa-ke, noma yiziphi izinguquko ekuhlelweni kwemithi yakho kufanele zihlale zixoxwa nomhlinzeki wakho wezempilo kuqala.

Yiziphi Imiphumela Eceleni Ye-Guanabenz?

Njengayo yonke imithi, i-guanabenz ingabangela imiphumela emibi, nakuba kungewona wonke umuntu oyitholayo. Imiphumela emibi evame kakhulu ngokuvamile imnene futhi ivame ukuthuthuka njengoba umzimba wakho ujwayela imithi emasontweni ambalwa okuqala.

Nansi imiphumela emibi ebikwa kaningi ethinta abantu abaningi lapho beqala i-guanabenz:

• Ukozela noma ukukhathala, ikakhulukazi emasontweni ambalwa okuqala
• Isiyezi lapho usukuma ngokushesha
• Umlomo owomile
• Ikhanda
• Ubuthakathaka noma ukuzizwa ukhathele
• Isicanucanu noma isisu esibuhlungu

Lezi zimo ezivamile ezibangelwa imithi ngokuvamile ziba ngaphansi kokukhathaza njengoba umzimba wakho ujwayela imithi. Ukuphuza amanzi amaningi kungasiza ngomlomo owomile, futhi ukuvuka kancane ekuhlaliseni noma ekulaleni kunganciphisa isiyezi.

Imiphumela engavamile kodwa ebucayi edinga ukunakekelwa kwezempilo ngokushesha. Ngenkathi lokhu kwenzeka ngamaphesenti amancane abantu, kubalulekile ukuyazi:

• Isiyezi esikhulu noma ukuquleka
• Ukushaya kwenhliziyo okungajwayelekile noma ubuhlungu besifuba
• Ubunzima bokuphefumula
• Ushintsho olukhulu lwemizwa noma ukucindezeleka
• Ukuvuvukala ezandleni zakho, ezinyaweni, noma emaqakaleni
• Ubuhlungu obukhulu besisu

Uma uhlangabezana nanoma yiziphi zale miphumela emibi, xhumana nodokotela wakho ngokushesha noma funa ukunakekelwa kwezimo eziphuthumayo. Abantu abaningi bayayibekezelela i-guanabenz kahle, kodwa umhlinzeki wakho wezempilo udinga ukwazi nganoma yiziphi izimpawu ezikhathazayo.

Ubani Ongafanele Athatha I-Guanabenz?

I-Guanabenz ayifanele wonke umuntu, futhi izimo ezithile zezokwelapha noma izimo zenza kungaphephile ukuyisebenzisa. Udokotela wakho uzobuyekeza ngokucophelela umlando wakho wezokwelapha ngaphambi kokukuyalela le mithi.

Akufanele uthathe i-guanabenz uma unesifo senhliziyo esibi, ikakhulukazi izinhlobo ezithile zezinkinga zokushaya kwenhliziyo noma ukuhluleka kwenhliziyo. Imithi ingathinta izinga lokushaya kwenhliziyo yakho nomfutho wegazi ngezindlela ezingase zibe yingozi kubantu abanezimo ezinjalo.

Abantu abanezifo zesibindi ezinzima kufanele bagweme i-guanabenz ngoba isibindi sicubungula le mithi. Uma isibindi sakho singasebenzi kahle, imithi ingakwazi ukwakheka emazingeni ayingozi emzimbeni wakho. Ngokufanayo, labo abanezifo ezinzima zezinso bangase badinge ukulungiswa komthamo noma ukwelashwa okuhlukile.

Abesifazane abakhulelwe akufanele basebenzise i-guanabenz ngaphandle uma izinzuzo zicacile ukuthi zidlula izingozi. Umuthi ungaweqa i-placenta futhi ungase uthinte ingane esakhula. Uma uhlela ukukhulelwa noma uthola ukuthi ukhulelwe ngenkathi usebenzisa i-guanabenz, xoxa ngalokhu nodokotela wakho ngokushesha.

Omama abancelisa ngamabele kufanele futhi baqaphele, njengoba i-guanabenz ingadlulela obisini lwebele. Udokotela wakho angakusiza ukuthi ulinganise izinzuzo nezingozi noma asikisele ezinye izindlela zokwelapha eziphephe kakhulu ngesikhathi sokuncelisa.

Amagama e-Brand e-Guanabenz

I-Guanabenz itholakala ngaphansi kwegama lomkhiqizo elithi Wytensin kwamanye amazwe, nakuba lo mkhiqizo kungenzeka ungatholakali kabanzi kuzo zonke izimakethe. Umuthi uvame kakhulu ukunqunywa futhi unikezwe njenge-generic guanabenz acetate, esebenza kahle njengenguqulo yegama lomkhiqizo.

Imithi ye-Generic iqukethe isithako esifanayo esisebenzayo futhi isebenza ngendlela efanayo njengemithi yegama lomkhiqizo. Ngokuvamile zibiza kancane futhi yizona ama-pharmacy amaningi azigcinayo. Noma ngabe uthola i-guanabenz yegama lomkhiqizo noma i-generic, uthola umuthi ofanayo onemiphumela efanayo.

I-pharmacy yakho ingase ithwale izinhlobo ezahlukene zabaqambi be-generic guanabenz. Ngenkathi zonke ziqukethe isithako esifanayo esisebenzayo, izithako ezingasebenzi (njengama-fillers kanye nemibala) zingahluka kancane phakathi kwabaqambi. Abantu abaningi abaqapheli noma yimuphi umehluko, kodwa uma unezinto ezithile ozwelayo noma ukungezwani komzimba, yazisa usokhemisi wakho.

Ezinye izindlela ze-Guanabenz

Eminye imithi eminingi ingelapha umfutho wegazi ophezulu uma i-guanabenz ingakulungele. Udokotela wakho uzocabangela isimo sakho esithile sezokwelapha, ezinye izimo zempilo, nokuthi uzithola kanjani kahle imithi ehlukene lapho ekhetha ezinye izindlela.

Izivimbeli ze-ACE ezifana ne-lisinopril noma i-enalapril zivame ukuba yizindlela zokwelapha zokuqala zengcindezi yegazi ephezulu. Le mithi isebenza ngokuvimba i-enzyme enciphisa imithambo yegazi, ibasiza ukuthi bahlale bekhululekile futhi bevulekile. Ngokuvamile bayabekezeleleka kahle futhi banezinzuzo eziqinisekisiwe zempilo yenhliziyo.

Izivimbeli zesiteshi se-calcium ezifana ne-amlodipine noma i-nifedipine zingenye inketho ethandwayo. Le mithi ivimbela i-calcium ukuthi ingangeni emangqamuzini emisipha yenhliziyo yakho nemithambo yegazi, ibasiza ukuthi bakhululeke. Zisebenza kahle ikakhulukazi kubantu abanezinhlobo ezithile zengcindezi yegazi ephezulu.

Ama-diuretics, avame ukubizwa ngokuthi

I-Guanabenz ingase ibangele ukuthula okuncane nokozela uma iqhathaniswa ne-clonidine, okuthile abantu bakuthola kulungele. Kodwa-ke, yomibili imithi ingabangela imiphumela efanayo engemihle efana nomlomo owomile, isiyezi, nokukhathala. Ukukhetha phakathi kwazo kuvame ukuncika ekutheni uyikwazi kangakanani ukubekezelela imithi ngayinye kanye nolwazi lukadokotela wakho ekuyincomeni.

Yomibili imithi idinga ukuqashwa ngokucophelela uma iqala noma iyekiswa, njengoba ukuyeka kungazelelwe kungabangela ukwanda okuyingozi komfutho wegazi. Udokotela wakho uzocabangela impilo yakho yonke, eminye imithi oyithathayo, nendlela yakho yokuphila lapho enquma ukuthi iyiphi imithi engasebenza kangcono kuwe.

Imibuzo Evame Ukubuzwa Mayelana ne-Guanabenz

Ingabe i-Guanabenz iphephile ku-Diabetes?

I-Guanabenz ngokuvamile iphephile kubantu abanesifo sikashukela, futhi ngokuvamile ayithinti amazinga kashukela egazini ngendlela ebalulekile. Ngokungafani neminye imithi yomfutho wegazi, i-guanabenz ayisifihli izimpawu zokuxwayisa zikashukela ophansi (i-hypoglycemia), okubalulekile kubantu abalawula isifo sikashukela.

Kodwa-ke, udokotela wakho uzokuqapha eduze uma unesifo sikashukela, ikakhulukazi uma uqala umuthi. Abanye abantu abanesifo sikashukela bangase babe nemiphumela ehlukile kancane emithini yomfutho wegazi, ngakho ukuhlolwa njalo kusiza ukuqinisekisa ukuthi kokubili umfutho wegazi lakho noshukela wegazi kuhlala kulawulwa kahle.

Ngingenzani uma ngiphuzile i-Guanabenz eningi ngengozi?

Uma ngengozi uthatha i-guanabenz eningi, xhumana nodokotela wakho noma isikhungo sokulawula ubuthi ngokushesha, ngisho noma uzizwa ulungile. Ukuthatha okuningi kungabangela ukuthi umfutho wegazi lakho wehle ngendlela eyingozi, okuholela esiyezini esibi, ukuquleka, noma ezinye izinkinga ezinzima.

Ungalindi ukuthi izimpawu zivele ngaphambi kokufuna usizo. Izimpawu zokweqisa zingabandakanya ukulala ngokweqile, izinga lokushaya kwenhliziyo elihamba kancane, ubunzima bokuphefumula, noma ukulahlekelwa ukwazi. Uma othile engazi noma enobunzima bokuphefumula, shayela izinsiza eziphuthumayo ngokushesha.

Kumele Ngenzeni Uma Ngiphuthelwa Umthamo We-Guanabenz?

Uma uphuthelwa umthamo we-guanabenz, yithathe ngokushesha nje lapho ukhumbula, ngaphandle uma sekuseduze isikhathi somthamo wakho olandelayo ohleliwe. Kulokho, weqa umthamo ophuthelwe bese uthatha umthamo wakho olandelayo ngesikhathi esijwayelekile. Ungalokothi uthathe imithamo emibili ngesikhathi esisodwa ukuze ulungise umthamo ophuthelwe.

Ukuphuthelwa imithamo ngezikhathi ezithile ngeke kubangele ukulimala ngokushesha, kodwa zama ukuthatha imithi ngokuqhubekayo ukuze uthole ukulawulwa okungcono kakhulu komfutho wegazi. Uma uvame ukukhohlwa imithamo, cabangela ukusetha izikhumbuzi zocingo noma ukusebenzisa umhleli wamaphilisi ukukusiza ukhumbule.

Ngingayeka Nini Ukuthatha I-Guanabenz?

Kufanele uyeke kuphela ukuthatha i-guanabenz ngaphansi kokuqondisa kukadokotela wakho. Umfutho wegazi ophezulu ngokuvamile uyisimo sempilo yonke, ngakho-ke abantu abaningi badinga ukuqhubeka nokuthatha imithi unomphela ukuze bagcine amazinga omfutho wegazi enempilo.

Uma wena nodokotela wakho ninquma ukuyeka i-guanabenz, kufanele kwenziwe kancane kancane ezinsukwini eziningana noma emasontweni ambalwa. Ukuyeka kungazelelwe kungabangela ukukhuphuka okuyingozi komfutho wegazi okubizwa ngokuthi i-rebound hypertension. Udokotela wakho uzokwenza uhlelo oluthile lokunciphisa kancane umthamo wakho ngenkathi eqapha umfutho wegazi lakho ngokucophelela.

Ngingakwazi Yini Ukuphuza Utshwala Ngenkathi Ngithatha I-Guanabenz?

Kungcono ukukhawulela ukusetshenziswa kotshwala ngenkathi uthatha i-guanabenz, njengoba utshwala bungakhuphula imiphumela yokwehlisa umfutho wegazi yomuthi. Le nhlanganisela ingabangela ukwehla ngokweqile komfutho wegazi, okuholela ekuzizweni unesiyezi, ukuquleka, noma ukuwa.

Uma ukhetha ukuphuza utshwala, kwenze ngokulinganisela futhi uqaphele ukuthi uzizwa kanjani. Qala kancane ukuze ubone ukuthi umzimba wakho usabela kanjani, futhi gwema ukuphuza utshwala lapho uqala ukuthatha i-guanabenz noma lapho umthamo wakho ukhuphukile. Njalo xoxa ngokusebenzisa kwakho utshwala nodokotela wakho ukuze bakwazi ukukunikeza isiqondiso esiqondene nawe esisekelwe esimweni sakho sempilo.