Yini i-Guanidine: Ukusetshenziswa, Umthamo, Imiphumela Eceleni nokuningi

I-Guanidine iyimithi kadokotela esetshenziselwa ikakhulukazi ukwelapha isimo esingavamile sokubuthaka kwemisipha esibizwa nge-Lambert-Eaton myasthenic syndrome (LEMS). Lesi simo sithinta ukuxhumana phakathi kwemizwa yakho nemisipha, okwenza imisebenzi yansuku zonke efana nokuhamba, ukukhuphuka izitebhisi, noma ngisho nokubamba izinto kuzizwe kunzima ngokungalindelekile.

Ngenkathi i-guanidine ingelona igama elivamile njengeminye imithi eminingi, isebenza njengenketho ebalulekile yokwelapha abantu abaphila nezimo ezithile ze-neuromuscular. Cabanga ngayo njengethuluzi elikhethekile elisiza ukubuyisela ukuxhumana okuthile phakathi kohlelo lwakho lwezinzwa nemisipha lapho lokho kuxhumana kungasebenzi kahle.

Yini i-Guanidine?

I-Guanidine iyimithi esebenza ngokuqondile ezimpawini zikagesi phakathi kwemizwa yakho nemisipha. Ingesigaba semithi esiza ukuthuthukisa ukuxhumana kwemizwa-misipha, ikakhulukazi lapho izimo ezithile ze-autoimmune ziphazamisa le nqubo.

Le mithi isetshenziswe emkhakheni wezokwelapha amashumi eminyaka, nakuba ithathwa njengokwelashwa okukhethekile kunokwelashwa kokuqala. Udokotela wakho ngokuvamile uzocabangela i-guanidine lapho ezinye izindlela zokwelapha zinganikezanga ukukhululeka okwanele noma lapho isimo sakho esithile sikwenza kube ukukhetha okufanele.

Isetshenziselwani i-Guanidine?

I-Guanidine ikakhulukazi inikezwa i-Lambert-Eaton myasthenic syndrome (LEMS), isimo esingavamile se-autoimmune esithinta cishe umuntu oyedwa kwabangu-100,000. Ku-LEMS, amasosha akho omzimba ngokungafanele ahlasela iziteshi ze-calcium eziphethweni zakho zemizwa, ephazamisa izimpawu ezitshela imisipha yakho ukuthi iqine.

Ngezinye izikhathi odokotela bangase bacabangele i-guanidine kwezinye izimo ezibandakanya ubuthakathaka bemisipha, nakuba lokhu kungavamile. Lokhu kungabandakanya izinhlobo ezithile zokuphazamiseka kwemisipha lapho ukuxhumana kwemizwa-emisipha kulimalile, kodwa ukusetshenziswa okunjalo kuvame ukugcinelwa izimo ezithile lapho ezinye izindlela zokwelapha zingasebenzi.

Umuthi usebenza kahle kubantu abanobuthakathaka bemisipha obuthuthuka kancane ngokusebenzisa imisipha ethintekile ngokuphindaphindiwe. Uma uqaphela ukuthi amandla akho athuthuka kancane njengoba uqhubeka nokunyakaza usuku lonke, i-guanidine ingase ibe usizo olukhulu esimweni sakho.

Isebenza Kanjani I-Guanidine?

I-Guanidine isebenza ngokwandisa ukukhululwa kwesithunywa samakhemikhali esibizwa nge-acetylcholine ekuhlanganyeleni phakathi kwemizwa yakho nemisipha. Cabanga nge-acetylcholine njengokhiye ovula ukuncipha kwemisipha - uma ungenayo ngokwanele, imisipha yakho ayikwazi ukusabela kahle ezimpawini zemizwa.

Lo muthi empeleni usiza iziphetho zemizwa yakho ukuthi zikhiphe i-acetylcholine eyengeziwe, eqinisa isignali efinyelela imisipha yakho. Kufana nokukhulisa ivolumu kusignali yomsakazo ebuthakathaka ukuze ukwazi ukuzwa umculo ngokucacile.

I-Guanidine ithathwa njengomuthi onamandla ngokulinganisela mayelana nemiphumela yawo. Ayinamandla njengeminye imithi yokwelapha ubuthakathaka bemisipha, kodwa inganikeza ukuthuthuka okukhulu kubantu abaningi abane-LEMS, ikakhulukazi uma ihlanganiswe nezinye izindlela zokwelapha.

Ngingayithatha Kanjani I-Guanidine?

Udokotela wakho uzoqala ngomthamo ophansi we-guanidine futhi awunyuse kancane kancane ngokuya ngendlela osabela ngayo. Abantu abaningi baqala ngo-10-15 mg ngekhilogramu ngayinye yesisindo somzimba nsuku zonke, ehlukaniswe ngemithamo eminingana emincane usuku lonke.

Ungayithatha i-guanidine ngaphandle noma ngaphandle kokudla, nakuba ukuyithatha nokudla kungasiza ukunciphisa isisu uma uhlangabezana nanoma yini. Kungcono ukuhlukanisa imithamo yakho ngokulinganayo usuku lonke ukuze ugcine amazinga aqhubekayo ohlelweni lwakho.

Noma kunjalo, ukuqina kubalulekile ngalo muthi. Zama ukuthatha imithamo yakho ngezikhathi ezifanayo nsuku zonke, futhi ungeqi imithamo ngisho noma uzizwa ungcono. Amandla emisipha yakho ancike ekugcineni amazinga afanele omuthi ohlelweni lwakho.

Kufanele Ngiyithathe Isikhathi Esingakanani I-Guanidine?

Ubude bokwelashwa nge-guanidine buhluka kakhulu kumuntu nomuntu futhi buxhomeke esimweni sakho esiyisisekelo. Nge-Lambert-Eaton myasthenic syndrome, abantu abaningi badinga ukuthatha i-guanidine isikhathi eside ukuze bagcine amandla emisipha yabo nokusebenza kwabo.

Udokotela wakho uzoqapha ukusabela kwakho emuthini emasontweni amaningana kuya ezinyangeni. Abanye abantu baqaphela ukuthuthuka ezinsukwini ezimbalwa, kanti abanye bangase badinge amasonto amaningana ukuze bathole izinzuzo eziphelele.

Ukuqokwa okulandelayo njalo kubalulekile ngoba udokotela wakho udinga ukuhlola kokubili ukusebenza kahle kokwelashwa futhi aqaphele noma yimaphi imiphumela engemihle engaba khona. Ungayeki ukuthatha i-guanidine ngokuzumayo ngaphandle kokuxoxa ngayo nomhlinzeki wakho wezempilo, ngoba lokhu kungaholela ekubuyeni kobuthakathaka bemisipha.

Yiziphi Imiphumela Emiqoka Ye-Guanidine?

Njengayo yonke imithi, i-guanidine ingabangela imiphumela emibi, nakuba kungewona wonke umuntu oyitholayo. Ukuqonda ukuthi yini ongayilindela kungakusiza ukuthi uzizwe ulungiseleleke kakhulu futhi wazi ukuthi ungaxhumana nini nodokotela wakho.

Imiphumela emibi evame kakhulu ivame ukuba mnene futhi ivame ukuthuthuka njengoba umzimba wakho ujwayela umuthi:

• Isicanucanu noma isisu esibuhlungu
• Ukuqunjelwa noma izitulo ezixekile
• Isiyezi noma ukukhathala
• Ukuqubuka kwesikhumba noma ukuluma
• Ikhanda
• Ukukhathala noma ukuzizwa ukhathele ngokungavamile

Le miphumela emibi ejwayelekile ivame ukuzinza phakathi nezinsuku ezimbalwa kuya emavikini njengoba umzimba wakho ujwayela umuthi. Uma ziqhubeka noma ziba yizithiyo, udokotela wakho uvame ukulungisa umthamo wakho noma isikhathi sokusiza ukuzinciphisa.

Imiphumela emibi engathi sína ayivamile kodwa idinga ukunakekelwa kwezokwelapha ngokushesha. Lokhu kufaka phakathi ukusabela okukhulu komzimba, izinguquko ezinkulu ekushayeni kwenhliziyo, noma izimpawu zezinkinga zezinso njengokushintsha kwamaphethini okuchama noma ukuvuvukala emilenzeni yakho nasezinyaweni.

Abanye abantu bangase futhi babe nemiphumela engavamile kodwa ekhathazayo njengokuthuthumela kwemisipha okukhulu, ukudideka, noma ubunzima bokuphefumula. Nakuba lokhu kungavamile, kubalulekile ukwazi ukuthi ukunakekelwa kwezokwelapha okusheshayo kungabhekana nalezi zinkinga ngempumelelo.

Obani okungafanele basebenzise i-Guanidine?

Abantu abathile kufanele bagweme i-guanidine noma bayisebenzise ngokuqapha okwengeziwe. Udokotela wakho uzobuyekeza ngokucophelela umlando wakho wezokwelapha ngaphambi kokukuyalela lo muthi ukuze aqinisekise ukuthi uphephile kuwe.

Abantu abanezinkinga ezinkulu zezinso ngokuvamile kufanele bagweme i-guanidine, njengoba umuthi ucubungulwa ngezinso. Uma unesifo sezinso, udokotela wakho uzodinga ukukugada eduze kakhulu noma acabangele ezinye izindlela zokwelapha.

Ngaphezu kwalokho, i-guanidine ingase ingafaneleki uma unezimo ezithile zenhliziyo, ikakhulukazi lezo ezihilela ukushaya kwenhliziyo okungajwayelekile. Umuthi ngezinye izikhathi ungase uthinte ukusebenza kwenhliziyo, ngakho-ke udokotela wakho uzohlola impilo yakho yenhliziyo ngaphambi kokuqala ukwelashwa.

Abesifazane abakhulelwe nabancelisayo kufanele baxoxe ngezinhlekelele nezinzuzo ngokucophelela nomhlinzeki wabo wezempilo, njengoba kunolwazi olulinganiselwe mayelana nokuphepha kwe-guanidine ngesikhathi sokukhulelwa nokuncelisa.

Amagama e-Guanidine Brand

I-Guanidine iyatholakala ngaphansi kwamagama amaningi ebhrendi, nakuba ukutholakala kuhluka ngokuya ngezwe. Kwezinye izifunda, ungase ukubone kuthengiswa njenge-Guanidine HCl noma ngaphansi kwamagama athile ebhrendi yezemithi.

Usokhemisi wakho angakusiza ukuthi ukhombe uhlobo oluthile noma inguqulo ejwayelekile etholakalayo endaweni yakho. Isithako esisebenzayo sihlala sifana kungakhathaliseki ukuthi umenzi, nakuba abanye abantu bengase bathole ukuthi basabela kancane ezingxenyeni ezihlukene.

Ezinye izindlela ze-Guanidine

Uma i-guanidine ingakulungele noma ingakuniki ukukhululeka okwanele, kukhona ezinye izindlela zokwelapha i-Lambert-Eaton myasthenic syndrome kanye nezimo ezifanayo.

I-3,4-diaminopyridine (3,4-DAP) ivame ukubhekwa njengokwelashwa kokuqala kwe-LEMS futhi ingasebenza kangcono kune-guanidine kubantu abaningi. Lo muthi usebenza ngendlela efanayo kodwa uvame ukuba nemiphumela emincane futhi ukwazi ukubekezeleleka kangcono.

Ukwelashwa okucindezela amasosha omzimba njenge-prednisone, i-azathioprine, noma i-mycophenolate kungase futhi kube ezinye izinketho, ikakhulukazi uma isimo sakho sinengxenye enkulu ye-autoimmune. Le mithi isebenza ngokunciphisa ukuhlasela kwamasosha omzimba ekuxhumaneni kwakho kwemizwa-emisipha.

Kwezinye izimo, ukushintshaniswa kwe-plasma noma ukwelashwa nge-intravenous immunoglobulin (IVIG) kungase kunconywe, ikakhulukazi ngezikhathi lapho izimpawu ziba zimbi kakhulu.

Ingabe i-Guanidine Ingcono Kune-3,4-Diaminopyridine?

I-3,4-diaminopyridine (3,4-DAP) ngokuvamile ibhekwa njengephumelela kakhulu kune-guanidine ekwelapheni i-Lambert-Eaton myasthenic syndrome. Imikhombandlela eminingi yezokwelapha incoma i-3,4-DAP njengokwelashwa kokuqala ngoba ngokuvamile inikeza ukuthuthuka okungcono kwezimpawu ezinemiphumela emincane.

Nokho, i-guanidine isengaba yigugu kubantu abangayiphenduli kahle i-3,4-DAP noma abangakwazi ukubekezelela imiphumela yayo emibi. Abanye abantu bangase baphendule kangcono ku-guanidine, yingakho ukuba nezinketho eziningi zokwelapha kubaluleke kangako.

Udokotela wakho uzocabangela izimpawu zakho ezithile, umlando wezokwelapha, nokuphendula ekwelashweni okuhlukile lapho enquma phakathi kwale mithi. Ngezinye izikhathi, ukuhlanganisa zombili izindlela zokwelapha ngemithamo ephansi kungasebenza kangcono kunokusebenzisa eyodwa kuphela.

Imibuzo Evame Ukubuzwa Mayelana ne-Guanidine

Ingabe i-Guanidine Iphephile Kubantu Abanesifo Sikashukela?

I-Guanidine ingasetshenziswa kubantu abanesifo sikashukela, kodwa idinga ukuqapha ngokucophelela. Umuthi ungase uthinte amazinga kashukela egazini kwabanye abantu, nakuba lokhu kungavamile.

Udktela wakho uzofuna ukuqapha ushukela wakho wegazi eduze lapho uqala i-guanidine, ikakhulukazi uma unesifo sikashukela. Qiniseka ukuthi utshela umhlinzeki wakho wezempilo nganoma yiziphi izinguquko kumaphethini akho kashukela wegazi noma imithi yesifo sikashukela.

Kufanele ngenzeni uma ngithatha i-Guanidine eningi ngengozi?

Uma ngengozi uthatha i-guanidine eningi kunaleyo ebekiwe, xhumana nodokotela wakho noma isikhungo sokulawula ubuthi ngokushesha. Ukuthatha okuningi kungabangela imiphumela emibi ehlanganisa isicanucanu esibi, ukuhlanza, ukuthuthumela kwemisipha, noma izinkinga zesigqi senhliziyo.

Ungazami ukuzenza uhlanze ngaphandle uma uqondiswe ngqo uchwepheshe wezempilo. Gcina ibhodlela lemithi nawe lapho ufuna usizo lwezokwelapha ukuze abahlinzeki bezempilo bazi kahle ukuthi uthathe ini nokuthi ungakanani.

Kufanele ngenzeni uma ngiphuthelwa umthamo we-Guanidine?

Uma uphuthelwa umthamo we-guanidine, yithathe ngokushesha lapho ukhumbula, ngaphandle uma sekuyisikhathi somthamo wakho olandelayo obekiwe. Kulokho, weqa umthamo ophuthelwe bese uqhubeka neshejuli yakho ejwayelekile.

Ungalokothi uthathe umthamo ophindwe kabili ukuze ulungise lowo ophuthelwe, ngoba lokhu kungakhuphula ingozi yakho yemiphumela emibi. Uma uvame ukukhohlwa imithamo, cabangela ukusetha izikhumbuzi zocingo noma usebenzise umhleli wamaphilisi ukukusiza ukuthi uhlale emgwaqeni.

Ngingayeka nini ukuthatha i-Guanidine?

Kufanele uyeke kuphela ukuthatha i-guanidine ngaphansi kokuqondisa kukadokotela wakho. Kubantu abaningi abanesifo se-Lambert-Eaton myasthenic syndrome, ukuyeka imithi kuzobangela ubuthakathaka bemisipha ukuthi bubuye.

Udktela wakho angase asikisele ukunciphisa kancane kancane umthamo wakho kunokuyeka kungazelelwe. Le ndlela isiza ukunciphisa ubungozi bezimpawu zokuhoxisa futhi ikuvumela ukuthi uqaphe ukuthi umzimba wakho usabela kanjani emithamini ephansi.

Ngingashayela ngesikhathi ngithatha i-Guanidine?

I-Guanidine ingabangela isiyezi noma ukukhathala kwabanye abantu, okungase kuthinte ikhono lakho lokushayela ngokuphepha. Lapho uqala ukuthatha imithi, kuhle ukugwema ukushayela uze wazi ukuthi ikuthinta kanjani.

Uma usethathe umthamo ozinzile isikhashana futhi ungazange ube nesiyezi noma eminye imiphumela engathandeki, abantu abaningi bangashayela ngokujwayelekile. Kodwa-ke, hlala usebenzisa ukwahlulela kwakho futhi ungashayeli uma uzizwa ungaphilile noma ukhathele ngokungavamile.