Yini i-Hydralazine kanye ne-Hydrochlorothiazide: Ukusetshenziswa, Umthamo, Imiphumela Eceleni nokuningi

I-Hydralazine kanye ne-hydrochlorothiazide iyinhlanganisela yemithi esiza ukulawula umfutho wegazi ophezulu ngokusebenza ohlelweni lwakho lwe-cardiovascular ngezindlela ezimbili ezihlukene. Lo muthi oqokiwe uhlanganisa umthambisi wemithambo yegazi (i-hydralazine) ne-water pill (i-hydrochlorothiazide) ukuhlinzeka ngokuphathwa komfutho wegazi okusebenzayo kakhulu kunanoma yimuphi umuthi ngamunye. Udokotela wakho angase aqoke le nhlanganisela uma imithi eyodwa inganele ukugcina umfutho wakho wegazi ebangeni elinempilo.

Yini i-Hydralazine kanye ne-Hydrochlorothiazide?

Lo muthi uhlanganisa imithi emibili eqinisekisiwe yomfutho wegazi ibe iphilisi elilodwa elilula. I-Hydralazine ingeyeqembu elibizwa ngokuthi ama-vasodilators, okusho ukuthi isiza imithambo yakho yegazi ukuba iphumule futhi yande. I-Hydrochlorothiazide yilokho odokotela abakubiza ngokuthi i-thiazide diuretic, eyaziwa kakhulu njenge-water pill ngoba isiza izinso zakho ukususa usawoti namanzi engeziwe emzimbeni wakho.

Uma le mithi emibili isebenza ndawonye, idala iqembu elinamandla ngokumelene nomfutho wegazi ophezulu. I-hydralazine ngokuqondile ithambisa izindonga zemithambo yakho yegazi, kuyilapho i-hydrochlorothiazide inciphisa inani lamanzi emithanjeni yakho yegazi. Lesi senzo esiphindwe kabili sisiza ukwehlisa umfutho wakho wegazi ufinyelele emazingeni aphephile futhi siwugcine lapho usuku lonke.

Isetshenziselwani i-Hydralazine kanye ne-Hydrochlorothiazide?

Udokotela wakho uqoka le nhlanganisela yemithi ikakhulukazi ukwelapha umfutho wegazi ophezulu, obizwa nangokuthi i-hypertension. Umfutho wegazi ophezulu uvame ukubizwa ngokuthi “umbulali othule” ngoba ngokuvamile awunazo izimpawu kodwa ungaholela ezinkingeni ezinkulu zempilo ngokuhamba kwesikhathi.

Lo muthi ulusizo ikakhulukazi uma udinga imithi yomfutho wegazi engaphezu kweyodwa ukuze ufinyelele izinombolo zakho ozihlosile. Abantu abaningi abanomfutho wegazi ophezulu bayazuza ekwelashweni okuhlanganisiwe ngoba kuhlasela inkinga ngamakhona amaningi. Udokotela wakho angase akhethe le nhlanganisela uma uzamile eminye imithi yomfutho wegazi engasebenzi kahle yodwa.

Kwezinye izimo, odokotela bangase futhi banikeze lo muthi wokuhluleka kwenhliziyo, lapho inhliziyo yakho idinga ukwesekwa okwengeziwe ukuze ipompe igazi ngempumelelo. Le nhlanganisela ingasiza ekunciphiseni umsebenzi wenhliziyo yakho ngokwenza kube lula ukuthi igazi ligeleze ohlelweni lwakho.

Isebenza Kanjani i-Hydralazine ne-Hydrochlorothiazide?

Lo muthi ohlanganisiwe usebenza ngezindlela ezimbili ezihlukene kodwa ezigcwalisanayo zokwehlisa umfutho wegazi lakho. Cabanga ngakho njengomzamo ohlanganisiwe lapho umuthi ngamunye ubhekana nengxenye ehlukile yomsebenzi.

I-Hydralazine isebenza ngokuqondile emangqamuzaneni emisipha ebushelelezi ezindongeni zemithambo yakho yegazi, okubangela ukuthi aphumule futhi ande. Uma imithambo yakho yegazi ivulekile, igazi lakho lingageleza kalula, okunciphisa umfutho odongeni lwemithambo yakho. Le nqubo ngokuvamile iqala kungakapheli amahora ambalwa ngemva kokuthatha umuthi.

I-Hydrochlorothiazide isebenza ezinso zakho ukusiza ukususa i-sodium namanzi amaningi emzimbeni wakho ngokwanda kokuchama. Njengoba umzimba wakho uqeda lokhu ketshezi olwengeziwe, kuncane ivolumu yegazi okufanele inhliziyo yakho ipompe, okunciphisa ngokwemvelo umfutho emithanjeni yakho yegazi. Lo mphumela uvame ukubonakala ezinsukwini zokuqala zokwelashwa.

Ngokuhlangene, le mithi idala umphumela ophakathi nendawo kuya oqinile wokwehlisa umfutho wegazi. Le nhlanganisela ithathwa njengephumelela kakhulu kubantu abaningi, nakuba kungase kuthathe amasonto ambalwa ukubona izinzuzo eziphelele njengoba umzimba wakho ujwayela umuthi.

Kufanele Ngiyithathe Kanjani i-Hydralazine ne-Hydrochlorothiazide?

Thatha lo muthi ngendlela udokotela wakho akuyala ngayo, ngokuvamile kanye noma kabili ngosuku ngaphandle kokudla noma ngakho. Abantu abaningi bakuthola kuwusizo ukuphuza umuthi ngesikhathi esifanayo nsuku zonke ukuze kugcinwe amazinga egazi aqhubekayo omuthi.

Ungawuthatha lo muthi ngemva kokudla uma ukhathaza isisu sakho, nakuba ukudla kungadingeki ukuze umuthi usebenze kahle. Abantu abaningi bakhetha ukuwuthatha ekuseni noma emini kunokuba kusihlwa ukuze bagweme ukuya endlini yangasese ebusuku, njengoba ingxenye ye-hydrochlorothiazide yandisa ukuchama.

Gwinya amaphilisi wonke ngengilazi yamanzi egcwele. Ungawachobozi, uwaphule, noma uwahlafune amaphilisi ngaphandle uma udokotela wakho ekutshela ngqo ukuthi wenze kanjalo. Uma unenkinga yokugwinya amaphilisi, khuluma nomuthi wakho mayelana nokuthi lo muthi uza ngamanye amafomu noma uma zikhona izindlela ezingasiza.

Hlala unamanzi amaningi ngenkathi uthatha lo muthi, kodwa ungadluli ngamanzi. I-hydrochlorothiazide izokwenza ukuthi uchame kaningi, ikakhulukazi emasontweni ambalwa okuqala okwelashwa. Lokhu kuvamile futhi ngokuvamile kuba ngaphansi kokuqashelwa njengoba umzimba wakho uzivumela.

Kufanele Ngithathe Isikhathi Esingakanani I-Hydralazine kanye ne-Hydrochlorothiazide?

Umfutho wegazi ophezulu ngokuvamile uyisimo sempilo yonke, okusho ukuthi cishe uzodinga ukuthatha lo muthi iminyaka noma ngisho unomphela. Abantu abaningi baqhubeka nokuthatha imithi yomfutho wegazi isikhathi eside ukuze bagcine izinombolo zabo zisesimweni esinempilo futhi bavikele izinhliziyo zabo nemithambo yegazi.

Udokotela wakho uzoqapha impendulo yakho emuthini ngokuhlolwa okuvamile nokufundwa komfutho wegazi. Ngesikhathi salezi zivakashi, bangase balungise umthamo wakho noma bakushintshele kweminye imithi ngokusekelwe ekutheni uphendula kahle kangakanani nanoma yimaphi imiphumela emibi oyitholayo.

Ungayeki ukuthatha lo muthi kungazelelwe ngaphandle kokukhuluma nodokotela wakho kuqala. Ukuyeka kungazelelwe kungabangela ukuthi umfutho wegazi lakho unyuke ngendlela eyingozi, okungaholela ezinkingeni ezinzima njengesifo senhliziyo noma unhlangothi. Uma udinga ukuyeka umuthi, udokotela wakho uzokwenza uhlelo oluphephile lokunciphisa umthamo wakho kancane kancane.

Abanye abantu bangase bakwazi ukunciphisa umthamo wabo womuthi noma bashintshele kwenye indlela yokwelapha, ikakhulukazi uma benza izinguquko ezinkulu zokuphila njengokulahlekelwa isisindo, ukuzivocavoca njalo, noma ukulandela ukudla okunempilo enhliziyo. Kodwa-ke, lezi zinguquko kufanele zenziwe ngaphansi kokuqondisa kwezokwelapha.

Yiziphi Izimo Ezingezinhle Zokusebenzisa I-Hydralazine kanye ne-Hydrochlorothiazide?

Njengayo yonke imithi, le nhlanganisela ingabangela imiphumela emibi, nakuba abantu abaningi beyibekezelela kahle. Ukuqonda okulindelekile kungakusiza ukuthi uzizwe uqiniseka ngokuphathelene nokwelashwa kwakho futhi wazi ukuthi ungaxhumana nini nodokotela wakho.

Imiphumela emibi evame kakhulu ngokuvamile imnene futhi ivame ukuthuthuka njengoba umzimba wakho ujwayela umuthi emasontweni ambalwa okuqala okwelashwa:

• Ukucabuka kwekhanda, ikakhulukazi ezinsukwini ezimbalwa zokuqala
• Isiyezi noma ukuzwa ukukhathala, ikakhulukazi uma usukuma ngokushesha
• Ukunyuka kokuchama, ikakhulukazi okubonakalayo ngesonto lokuqala
• Ukukhathala noma ukuzizwa ukhathele
• Isicanucanu noma isisu esibuhlungu
• Ukuvuvukala noma ukuzwa ukushisa
• Ukushaya kwenhliziyo okusheshayo noma ukushaya kwenhliziyo okungajwayelekile

Le miphumela ejwayelekile ivame ukuba ngaphansi kokukhathaza njengoba umzimba wakho ujwayela umuthi. Uma ziqhubeka noma ziba nezinkinga, udokotela wakho uvame ukulungisa umthamo wakho noma isikhathi sokunciphisa ukungakhululeki.

Abanye abantu bahlangabezana nemiphumela emibi ebaluleke kakhulu edinga ukunakekelwa kwezokwelapha. Xhumana nodokotela wakho uma uqaphela noma yiziphi lezi zimpawu ezikhathazayo:

• Isiyezi esikhulu noma ukuquleka
• Ubuhlungu besifuba noma ukushaya kwenhliziyo okungajwayelekile
• Ubunzima bokuphefumula noma ukuphelelwa umoya
• Ikhanda elibuhlungu elingathuthuki
• Ubuthakathaka bemisipha noma ukuqaqamba
• Ukudideka noma izinguquko zemizwa
• Ukuphuma igazi okungajwayelekile noma ukulimala

Imiphumela emibi engavamile kodwa ebucayi ingenzeka, nakuba ithinta kuphela iphesenti elincane labantu abathatha lo muthi. Lokhu kufaka phakathi izimpawu ezinjenge-lupus (ubuhlungu bamalunga, ukuqubuka, umkhuhlane), ukusabela okukhulu komzimba, izinkinga zezinso, noma izifo zegazi. Nakuba lezi zinkinga zingavamile, kubalulekile ukuxhumana njalo nomhlinzeki wakho wezempilo ukuze uqashwe.

Ubani Ongafanele Athathe I-Hydralazine ne-Hydrochlorothiazide?

Lo muthi awuphephile kuwo wonke umuntu, futhi udokotela wakho uzobuyekeza ngokucophelela umlando wakho wezokwelapha ngaphambi kokuwunika. Izimo ezithile zezempilo nezimo zenza le nhlanganisela ingafaneleki noma ingaba yingozi.

Akufanele uthathe lo muthi uma wazi ukuthi unokungezwani komzimba ne-hydralazine, i-hydrochlorothiazide, noma imithi efanayo ebizwa ngokuthi ama-sulfonamides. Abantu abanezifo ezinzima zezinso noma labo abangakwazi ukuchama (anuria) kufanele futhi bagweme le nhlanganisela ngoba ingxenye ye-hydrochlorothiazide incike ekusebenzeni kwezinso ukuze isebenze kahle.

Izimo eziningi zenhliziyo zenza lo muthi ungafaneleki, okuhlanganisa izinhlobo ezithile zezinkinga zamavalvu enhliziyo, ikakhulukazi isifo se-mitral valve rheumatic. Uma unesifo semithambo yenhliziyo, udokotela wakho uzohlola izinzuzo nezingozi ngokucophelela, njengoba i-hydralazine ngezinye izikhathi ingakhuphula izinga lenhliziyo kanye nesidingo somoya-mpilo.

Ukukhulelwa kudinga ukucatshangelwa okukhethekile ngalo muthi. Ngenkathi i-hydralazine ngezinye izikhathi isetshenziswa ngesikhathi sokukhulelwa ngenxa yomfutho wegazi ophezulu kakhulu, ingxenye ye-hydrochlorothiazide ingawela i-placenta futhi ingase ithinte ingane yakho. Uma ukhulelwe, uhlela ukukhulelwa, noma uncelisa, xoxa ngezindlela eziphephile nodokotela wakho.

Abantu abanezimo ezithile ze-metabolic badinga ukuqashwa ngokucophelela noma bangase badinge ukugwema lo muthi ngokuphelele. Lokhu kufaka phakathi labo abanesifo sikashukela, i-gout, i-lupus, noma isifo sesibindi esibi. Udokotela wakho uzoqonda ukuthi izinzuzo zidlula izingozi yini kulezi zimo.

Amagama Omkhiqizo we-Hydralazine ne-Hydrochlorothiazide

Lo muthi ohlanganisiwe utholakala ngaphansi kwamagama amaningi omkhiqizo, okujwayelekile kakhulu yi-Apresazide. Amanye amagama omkhiqizo angase afake phakathi izinhlobo ezihlukahlukene ze-generic eziqukethe izithako ezifanayo ezisebenzayo ngemithamo elinganayo.

Izinhlobo ze-Generic zale nhlanganisela zitholakala kabanzi futhi ziqukethe izithako ezifanayo ezisebenzayo njengezinhlobo zomkhiqizo. Umuthi wakho womuthi angakusiza ukuthi uqonde ukuthi iyiphi inguqulo oyitholayo futhi uqinisekise ukuthi uthola ifomula efanayo njalo uma ugcwalisa kabusha umuthi wakho.

Njalo hlola nomuthi wakho womuthi uma amaphilisi akho ebukeka ehlukile ekugcwalisweni kwakho kwangaphambilini. Ngenkathi imithi ye-generic ilingana ekusebenzeni, ingase ibe nemibala ehlukene, ukuma, noma izimpawu ngokuya ngomkhiqizi.

Ezinye izindlela ze-Hydralazine ne-Hydrochlorothiazide

Uma le nhlanganisela ingasebenzi kahle kuwe noma ibangela imiphumela emibi, udokotela wakho unezinye izinketho eziningi ezisebenzayo zokwelapha umfutho wegazi ophezulu. Imithi yesimanje inikeza izindlela eziningi zokuphatha umfutho wegazi.

Ama-ACE inhibitors afana ne-lisinopril noma i-enalapril avame ukuba yizindlela zokwelapha zokuqala ezisebenza ngokuvimba amakhemikhali aqinisa imithambo yegazi. Le mithi ivame ukubekezelelwa kahle futhi kufakazelwe ukuthi ivikela inhliziyo nezinso ngokuhamba kwesikhathi.

Ama-ARBs (ama-angiotensin receptor blockers) afana ne-losartan noma i-valsartan asebenza ngendlela efana nama-ACE inhibitors kodwa angase abangele imiphumela emincane efana nokukhwehlela okomile. Ama-calcium channel blockers afana ne-amlodipine noma i-nifedipine enye inketho enhle esebenza ngokukhulula izindonga zemithambo yegazi.

Ama-Beta-blockers afana ne-metoprolol noma i-atenolol angaba usizo ikakhulu uma futhi unezinkinga zesigqi senhliziyo noma uke wahlaselwa yinhliziyo. Kubantu abadinga imiphumela ye-diuretic, amanye amaphilisi amanzi afana ne-chlorthalidone noma i-indapamide angase abekezelelwe kangcono kune-hydrochlorothiazide.

Udokotela wakho angase futhi acabangele imithi emisha ehlanganisiwe ehlanganisa amakilasi ahlukene emithi yegazi, okungenzeka ukuthi inikeze ukubekezelelana okungcono noma amashejuli okulinganisa alula.

Ingabe i-Hydralazine ne-Hydrochlorothiazide Zingcono Kune-Lisinopril?

Ukuqhathanisa le mithi akulula ngoba isebenza ngezindlela ezihlukene futhi isebenza ngezindima ezihlukene ekwelashweni kwegazi. Zombili ziyasebenza, kodwa ukukhetha okungcono kuncike ngokuphelele esimweni sakho sempilo kanye nokuphendula ekwelashweni.

I-Lisinopril, i-ACE inhibitor, ivame ukukhethwa njengokwelashwa komugqa wokuqala ngoba ngokuvamile ibekezeleleka kahle futhi inocwaningo oluningi olukhombisa ukuthi ivikela inhliziyo nezinso isikhathi eside. Ilungele ikakhulukazi abantu abanesifo sikashukela, ukuhluleka kwenhliziyo, noma isifo sezinso.

Inhlanganisela ye-hydralazine ne-hydrochlorothiazide ingase ibe ngcono kuwe uma ama-ACE inhibitors ebangela imiphumela emibi efana nokukhwehlela okomile okuqhubekayo, noma uma udinga inhlanganisela ethile yokuphumula kwemithambo yegazi nokuncishiswa koketshezi okunikezwa lezi zithako.

Udokotela wakho ucabangela izinto eziningi lapho ekhetha phakathi kwalezi zinketho, okuhlanganisa ezinye izimo zakho zempilo, imithi yamanje, ukusebenza kwezinso, nokuthi umzimba wakho uphendule kanjani ekwelashweni kwangaphambilini. Okusebenza kahle kumuntu oyedwa kungase kungabi kuhle komunye, yingakho ukunakekelwa kwezempilo okwenziwe ngendlela efanele kubaluleke kangako.

Imibuzo Evame Ukubuzwa Mayelana ne-Hydralazine kanye ne-Hydrochlorothiazide

Ingabe i-Hydralazine kanye ne-Hydrochlorothiazide iphephile ezigulini ezinokugula kwezinso?

Lo muthi udinga ukucatshangelwa ngokucophelela uma unezinkinga zezinso. Ngenkathi i-hydralazine ngokwayo ingazilimazi ngqo izinso, i-hydrochlorothiazide incike ekusebenzeni kahle kwezinso ukuze isebenze ngempumelelo futhi ngezinye izikhathi ingenza izinkinga zezinso zibe zimbi kubantu abanezinkinga zezinso eziqhubekayo.

Uma unezinkinga zezinso ezingatheni noma eziphakathi nendawo, udokotela wakho angase akubhalele lo muthi kodwa uzoqapha ukusebenza kwezinso zakho ngokucophelela ngokuhlolwa kwegazi okujwayelekile. Bangase balungise umthamo wakho noma bakhethe eminye imithi uma ukusebenza kwezinso zakho kwehla.

Abantu abanezinkinga zezinso ezinzima noma labo abenza i-dialysis ngokuvamile abakwazi ukuthatha i-hydrochlorothiazide ngoba izinso zabo azikwazi ukucubungula umuthi ngendlela efanele. Kulezi zimo, udokotela wakho uzoncoma eminye imithi yokwehlisa umfutho wegazi ephephe kakhulu ekusebenzeni kwezinso zakho.

Kufanele ngenzeni uma ngiphuzile i-Hydralazine kanye ne-Hydrochlorothiazide eningi ngengozi?

Uma ngengozi uphuze ngaphezu komthamo obekiwe, xhumana nodokotela wakho noma isikhungo sokulawula ubuthi ngokushesha, ngisho noma uzizwa kahle. Ukuphuza umuthi omningi kakhulu kungabangela ukwehla okuyingozi komfutho wegazi, ukushoda kwamanzi emzimbeni okukhulu, noma izinkinga zesigqi senhliziyo.

Izimpawu zokweqisa zingabandakanya isiyezi esikhulu, ukuquleka, ukushaya kwenhliziyo okusheshayo noma okungajwayelekile, ukuchama ngokweqile, noma ukudideka. Ungalindi ukubona ukuthi izimpawu ziyavela yini - ukuthola iseluleko sezokwelapha ngokushesha kuyindlela ephephe kakhulu ngaso sonke isikhathi.

Uma uqondiswe ukuthi uye egumbini eliphuthumayo, letha ibhodlela lomuthi wakho nawe ukuze abahlinzeki bezempilo bazi kahle ukuthi yini oyithathile nokuthi nini. Bangabe sebekwazi ukuhlinzeka ngemithi efanele nokuqapha kuze kube yilapho umuthi ususuka ohlelweni lwakho.

Kufanele ngenzeni uma ngiphuthelwe umthamo we-Hydralazine kanye ne-Hydrochlorothiazide?

Uma uphuthelwa umthamo, wuthatha ngokushesha nje lapho ukhumbula, ngaphandle uma sekuseduze isikhathi somthamo wakho olandelayo ohleliwe. Esimeni esinjalo, weqa umthamo ophuthelwe bese uqhubeka nohlelo lwakho olujwayelekile lokuthatha imithi.

Ungalokothi uthathe imithamo emibili ngesikhathi esisodwa ukuze ulungise umthamo ophuthelwe, ngoba lokhu kungadala ukwehla okuyingozi kwengcindezi yegazi noma eminye imiphumela emibi engathi sína. Uma uvame ukukhohlwa imithamo, cabanga ngokumisa izikhumbuzi zocingo noma usebenzise umhleli wamaphilisi ukukusiza ukuthi uhlale emgwaqeni.

Ukuphuthelwa imithamo ngezikhathi ezithile ngeke kubangele ukulimala ngokushesha, kodwa ukuqina kubalulekile ekugcineni ukulawulwa kwengcindezi yegazi okuzinzile. Uma uphuthelwa imithamo kaningi, khuluma nodokotela wakho ngamasu okuthuthukisa ukunamathela emithini noma ukuthi ngabe uhlelo oluhlukile lokuthatha imithi lungasebenza kangcono yini kuwe.

Ngingayeka nini ukuthatha i-Hydralazine ne-Hydrochlorothiazide?

Akufanele uyeke ukuthatha lo muthi ngaphandle kokubonisana nodokotela wakho kuqala. Ingcindezi yegazi ephezulu ngokuvamile iyisimo esingamahlalakhona esidinga ukwelashwa okuqhubekayo ukuvimbela izinkinga ezingathi sína njengokuhlaselwa yinhliziyo, unhlangothi, noma ukulimala kwezinso.

Udokotela wakho angase acabange ukunciphisa umthamo wakho noma ashintshe imithi uma uhlangabezana nemiphumela emibi ebalulekile, uma ingcindezi yakho yegazi iba ngcono ngezinguquko zokuphila, noma uma isimo sakho sempilo yonke sishintsha. Kodwa-ke, lezi zinqumo kufanele zenziwe ngaphansi kokuqondiswa kwezokwelapha.

Uma ucabanga ukuyeka ngenxa yemiphumela emibi noma ukukhathazeka ngemithi, xoxa ngalezi zinkinga nomhlinzeki wakho wezempilo. Bavame ukukwazi ukulungisa uhlelo lwakho lokwelapha ukuze babhekane nezinkingo zakho ngenkathi besavikele impilo yakho yenhliziyo nemithambo yegazi.

Ngingakwazi yini ukuphuza utshwala ngenkathi ngithatha i-Hydralazine ne-Hydrochlorothiazide?

Utshwala bungathuthukisa imiphumela yokwehlisa ingcindezi yegazi yalo muthi, okungenzeka ukuthi kubangele ukwehla okuyingozi kwengcindezi yegazi, ikakhulukazi uma usukuma. Lokhu kungaholela ekuzizweni unesiyezi, ukuquleka, noma ukuwa okungaholela ekulimaleni okungathi sína.

Uma ukhetha ukuphuza utshwala, kwenze ngokulinganisela futhi uqaphele ukuthi umzimba wakho usabela kanjani. Qala ngamanani amancane futhi unake noma yikuphi ukugcwala kwekhanda noma ukukhathala okwandayo. Njalo sukuma kancane uma usuka ekuhlaliseni noma ekulaleni.

Kungcono ukuxoxa ngokusebenzisa kwakho utshwala nodokotela wakho, njengoba bengakunikeza iseluleko esiqondene nawe ngokusekelwe empilweni yakho yonke, eminye imithi oyithathayo, nokuthi umfutho wegazi lakho ulawulwa kahle kangakanani. Bangase batusa ukugwema utshwala ngokuphelele noma baphakamise izinyathelo ezithile zokuthatha uma uphuza.