Yini i-Hydralazine: Ukusetshenziswa, Umthamo, Imiphumela Eceleni nokuningi

I-Hydralazine iyimithi kadokotela esiza ukwehlisa umfutho wegazi ophezulu ngokukhulula imisipha ezindongeni zemithambo yakho yegazi. Lokhu kuvumela imithambo yakho ukuthi yande, okwenza kube lula ukuthi igazi ligeleze futhi kunciphisa umfutho ohlelweni lwakho lwe-cardiovascular. Isetshenziswe ngokuphepha amashumi eminyaka futhi iseyithuluzi elibalulekile ekuphatheni umfuthe wegazi ophezulu, ikakhulukazi ezimweni ezithile lapho eminye imithi yomfutho wegazi ingase ingafaneleki.

Yini i-Hydralazine?

I-Hydralazine ingeyodwa yohlobo lwemithi ebizwa ngokuthi ama-vasodilators, okusho ukuthi isebenza ngokwandisa imithambo yakho yegazi. Cabanga ngayo njengokusiza ukuvula izindlela zokugeleza kwegazi emzimbeni wakho wonke. Uma imithambo yakho yegazi ikhululeke futhi ivulekile, inhliziyo yakho akudingeki isebenze kanzima ukuze ipompe igazi, okwehlisa umfutho wakho wegazi ngokwemvelo.

Le mithi isikhona kusukela ngeminyaka yawo-1950 futhi ithathwa njengenketho yokwelapha esungulwe kahle. Ibaluleke kakhulu ngoba ingasetshenziswa ngokuphepha ezinye izinhlobo zabantu, okuhlanganisa abesifazane abakhulelwe abanomfutho wegazi ophezulu, lapho eminye imithi yomfutho wegazi inganconywa.

Isetshenziselwani i-Hydralazine?

I-Hydralazine ikakhulukazi inikezwa ukwelapha umfutho wegazi ophezulu, kodwa isetshenziswa ezimweni eziningana ezithile. Udokotela wakho angase ayincomise njengengxenye yohlelo lwakho lokuphatha umfutho wegazi, ikakhulukazi uma eminye imithi ingasebenzi kahle kuwe noma ingafaneleki esimweni sakho sempilo esithile.

Nawa amazwi amakhulu lapho i-hydralazine ibonakala ilusizo:

• Umfutho wegazi ophezulu ongazange uphendule kahle eminye imithi
• Ukuphathwa komfutho wegazi ngesikhathi sokukhulelwa lapho ezinye izidakamizwa zingaphephile
• Ukuhluleka kwenhliziyo, lapho kuvame ukuhlanganiswa nenye imithi ebizwa ngokuthi i-isosorbide dinitrate
• Izimo eziphuthumayo ze-Hypertensive ezilungiselelwe esibhedlela, ngokuvamile zinikezwa nge-IV

Ngokuvamile, odokotela banikeza i-hydralazine yokuhluleka kwenhliziyo ngoba ingasiza ekunciphiseni umsebenzi wenhliziyo yakho. Uma isetshenziselwa le njongo, ngokuvamile iyingxenye yokwelashwa okuhlanganisiwe kunokuba kube yindlela yokwelapha ezimele.

Isebenza Kanjani I-Hydralazine?

I-Hydralazine isebenza ngokukhulula ngokuqondile imisipha ebushelelezi ezungeze imithambo yakho kanye nama-arterioles (imithambo yegazi emincane). Lokhu kwehluke endleleni izidakamizwa eziningi zokucindezela igazi ezisebenza ngayo, okwenza kube yindlela yokwelapha enamandla aphakathi nendawo engaba usizo ikakhulukazi ezimweni ezithile.

Lapho le misipha ikhululeka, imithambo yakho yegazi iyanda, okunciphisa ukumelana inhliziyo yakho ebhekana nakho lapho ipompa igazi. Le nqubo, ebizwa ngokuthi i-vasodilation, ngokwemvelo yehlisa umfutho wegazi lakho. Umuthi ikakhulukazi uthinta imithambo kunemithambo, okusho ukuthi ilungele ikakhulukazi ukunciphisa umfutho inhliziyo yakho esebenza ngawo.

Into eyodwa okufanele uyiqonde ukuthi i-hydralazine ngezinye izikhathi ingabangela ukuthi izinga lokushaya kwenhliziyo yakho likhuphuke kancane njengoba umzimba wakho uzama ukugcina ukugeleza kwegazi okwanele. Lokhu kuyimpendulo ejwayelekile, kodwa yingakho odokotela bevame ukuyinikeza kanye neminye imithi engasiza ekulawuleni izinga lokushaya kwenhliziyo.

Kufanele Ngiyithathe Kanjani I-Hydralazine?

Ukwenza kahle i-hydralazine kubalulekile kokubili ukusebenza kahle nokuphepha. Udokotela wakho uzokunikeza imiyalelo ethile, kodwa ngokuvamile, uzoyithatha ngomlomo ngenkomishi yamanzi egcwele. Ukuyithatha nokudla kungasiza ekunciphiseni isisu esicasulayo, okuhlangenwe nakho ngabanye abantu lapho beqala umuthi.

Abantu abaningi bathatha i-hydralazine izikhathi ezimbili kuya kwezine ngosuku, kuye ngomthamo wabo obekiwe nokuthi umzimba wabo usabela kanjani. Kungcono ukuyithatha ngezikhathi ezifanayo nsuku zonke ukuze kugcinwe amazinga aqhubekayo ohlelweni lwakho. Uma uyithatha kabili ngosuku, zama ukuhlukanisa imithamo cishe ngamahora angu-12.

Nawa amanye amaqondiso abalulekile okufanele uwalandele:

• Yithatha ngokudla uma ikwenza uzizwe ungakhululekile esiswini sakho
• Ungazichobozi noma uhlafune amaphilisi akhishwa kancane uma unqunyelwe
• Zama ukuyithatha ngezikhathi ezifanayo nsuku zonke
• Ungayeki ukuyithatha kungazelelwe ngaphandle kokukhuluma nodokotela wakho
• Qhubeka nokuyithatha ngisho noma uzizwa ulungile, njengoba umfutho wegazi ophezulu ngokuvamile ungenazo izimpawu

Uma unzima ukukhumbula ukuthatha imithi yakho, cabangela ukusetha izikhumbuzi zocingo noma ukusebenzisa umhleli wamaphilisi. Ukuqina kubalulekile ekutholeni imiphumela emihle kakhulu evela ku-hydralazine.

Ngingayithatha isikhathi esingakanani i-Hydralazine?

Ubude besikhathi ozodinga ukuthatha ngaso i-hydralazine busekelwe esimweni sakho esithile nokuthi usabela kahle kangakanani ekwelashweni. Kubantu abaningi abanomfutho wegazi ophezulu, lo muthi ngokuvamile ukwelashwa kwesikhathi eside, okusho ukuthi ungase udinge ukuwuthatha izinyanga noma iminyaka.

Udokotela wakho uzoqapha umfutho wegazi lakho njalo futhi angase alungise umthamo wakho noma ubude bokwelashwa ngokusekelwe ekutheni usebenza kahle kangakanani. Abanye abantu bathola ukuthi umfutho wegazi labo uyathuthuka ngokwanele ngezinguquko zokuphila kangangokuthi bangagcina beciphisa imithi yabo, kodwa lokhu kufanele kwenziwe ngaphansi kokuqashwa kwezokwelapha.

Uma uthatha i-hydralazine ngenhliziyo ehlulekayo, ubude bokwelashwa buzoxhomeka empilweni yakho yonke yenhliziyo nokuthi usabela kanjani emuthini. Kwezinye izimo, iba yingxenye ehlala njalo yohlelo lwakho lokwelashwa, kanti kwezinye, ingase isetshenziswe isikhathi esifushane ngenkathi ezinye izindlela zokwelapha zisebenza.

Yiziphi Imiphumela Eceleni ye-Hydralazine?

Njengayo yonke imithi, i-hydralazine ingabangela imiphumela emibi, nakuba kungathi akubona bonke abantu abayitholayo. Imiphumela eminingi emibi imnene futhi ivame ukuthuthuka njengoba umzimba wakho ujwayela umuthi. Ukuqonda ukuthi yini ongayilindela kungakusiza ukuthi uzizwe uqiniseka kakhulu ngokwelashwa kwakho.

Imiphumela emibi evame kakhulu ongase uyibone ihlanganisa:

• Ukuba nobuhlungu bekhanda, ikakhulukazi uma uqala ukuyithatha
• Ukushaya kwenhliziyo okusheshayo noma okuqinile
• Isiyezi noma ukuzizwa unovalo, ikakhulukazi uma usukuma
• Ukucasuka kwesisu noma isicanucanu
• Ukubomvu noma ukuzizwa ufudumele
• Ukhuhlane
• Ukulahlekelwa isifiso sokudla

Le miphumela emibi ejwayelekile ivame ukuba ngaphansi kokuqashelwa ngemva kwezinsuku ezimbalwa noma amasonto njengoba umzimba wakho ujwayela umuthi. Uma ziqhubeka noma ziba yinkinga, unganqikazi ukukhuluma nodokotela wakho mayelana nokulungisa umthamo wakho noma isikhathi.

Kukhona neminye imiphumela emibi engathi sína edinga ukunakekelwa kwezokwelapha ngokushesha, nakuba ingavamile:

• Ubuhlungu besifuba noma ukushaya kwenhliziyo okungajwayelekile
• Isiyezi esibi noma ukuquleka
• Ukuvuvukala ezandleni zakho, ezinyaweni, noma emaqakaleni
• Ukuphefumula kanzima
• Ukuba ndikindiki noma ukuluma ezandleni zakho noma ezinyaweni
• Ubuhlungu bamalunga noma imisipha ebuhlungu engapheli

Ngokuvamile, ukusetshenziswa kwesikhathi eside kwe-hydralazine kungaholela esimweni esibizwa ngokuthi i-drug-induced lupus, ebangela ubuhlungu bamalunga, umkhuhlane, nezinye izimpawu. Lokhu kungenzeka kakhulu kubantu abathatha imithamo ephezulu isikhathi eside, kodwa kuyabuyiseka ngokuphelele uma umuthi uyekwa.

Ubani Ongafanele Athathwe I-Hydralazine?

Ngenkathi i-hydralazine ivikelekile ngokujwayelekile kubantu abaningi, kunezimo ezithile lapho kungenzeka ingabi yindlela engcono kakhulu. Udokotela wakho uzocabangela umlando wakho wezokwelapha ophelele ngaphambi kokuyinika, kodwa kubalulekile ukuqonda ukuthi lo muthi kungenzeka ungafaneleki nini.

Akufanele uthathe i-hydralazine uma une:

• Ukungezwani okwaziwayo ne-hydralazine noma imithi efanayo
• Isifo semithambo yenhliziyo noma umlando wokuhlaselwa yinhliziyo
• Izinkinga ze-mitral valve enhliziyweni yakho
• Isimo esingavamile esibizwa ngokuthi i-systemic lupus erythematosus

Ngaphezu kwalokho, kudingeka ukuqapha okwengeziwe uma unezimo ezithile zempilo. Udokotela wakho angase akwazi ukukwelapha nge-hydralazine kodwa uzokuqapha eduze uma unezinkinga zezinso, izinkinga zesibindi, noma umlando wokushaywa unhlangothi.

Uma usebenzisa eminye imithi, ikakhulukazi leyo yokwelapha izifo zenhliziyo noma umfutho wegazi, qiniseka ukuthi udokotela wakho uyazi ngayo yonke. Ezinye izinhlanganisela zemithi zingabangela ukuthi umfutho wegazi wakho wehle kakhulu noma zibangele ezinye izinkinga.

Amagama Omkhiqizo we-Hydralazine

I-Hydralazine itholakala ngaphansi kwamagama amaningi omkhiqizo, nakuba ivame ukunqunywa njengomuthi ojwayelekile. Igama lomkhiqizo elaziwa kakhulu yi-Apresoline, ebelitholakala iminyaka eminingi futhi empeleni ngumuthi ofanayo ne-hydralazine ejwayelekile.

Ungase futhi uhlangane ne-hydralazine njengengxenye yemithi ehlanganisiwe. Isibonelo, i-BiDil ihlanganisa i-hydralazine ne-isosorbide dinitrate futhi igunyazwe ngokuqondile ukwelapha ukuhluleka kwenhliziyo ezigulini ezithile. Umuthi wakho we-pharmacist angakusiza ukuthi uqonde ukuthi ngabe uthola inguqulo yegama lomkhiqizo noma ejwayelekile yomuthi.

I-hydralazine ejwayelekile isebenza kahle njengezinguqulo zegama lomkhiqizo futhi ivame ukushibhile. Isithako esisebenzayo kanye nokulinganisa kuyafana, ngakho-ke ungaqiniseka ngokusebenzisa noma iyiphi inguqulo udokotela wakho ayincomayo noma umshwalense wakho owukhokhelayo.

Ezinye izindlela ze-Hydralazine

Uma i-hydralazine ingasebenzi kahle kuwe noma ibangela imiphumela emibi, kunezindlela eziningana zemithi ezingase zicatshangelwe udokotela wakho. Ukukhetha kuncike esimweni sakho esithile sempilo, eminye imithi oyithathayo, nokuthi umzimba wakho usabela kanjani ekwelashweni okuhlukene.

Ezinye izindlela ezivamile zokuphatha umfutho wegazi zihlanganisa:

• Ama-ACE inhibitors afana ne-lisinopril noma i-enalapril
• Ama-ARB (angiotensin receptor blockers) afana ne-losartan noma i-valsartan
• Ama-calcium channel blockers afana ne-amlodipine noma i-nifedipine
• Ama-beta-blockers afana ne-metoprolol noma i-atenolol
• Ama-diuretics afana ne-hydrochlorothiazide noma i-furosemide

Ngenhliziyo ebuthaka, ezinye izindlela zingabandakanya inhlanganisela ehlukene yama-ACE inhibitors, ama-beta-blockers, noma imithi emisha efana ne-sacubitril/valsartan. Udokotela wakho uzosebenza nawe ukuthola enye indlela engcono kakhulu esekelwe ezidingweni zakho kanye nokuthi uyithatha kahle kangakanani imithi ehlukene.

Ngezinye izikhathi, ukushintshela kwenye indlela akukhona ngemithi engasebenzi, kodwa kumayelana nokuthola okuthile okuhambisana kangcono nendlela yakho yokuphila noma okunamiphumela emincane engakukhathazi.

Ingabe i-Hydralazine ingcono kune-Lisinopril?

Ukuqhathanisa i-hydralazine ne-lisinopril akulula ngoba zisebenza ngezindlela ezihlukene futhi zivame ukusetshenziswa ezimweni ezihlukene. Zombili ziyimithi esebenzayo yokwehlisa umfutho wegazi, kodwa ngamunye unamandla awo kanye nezimo ezinhle zokusetshenziswa.

I-Lisinopril, i-ACE inhibitor, ivame ukubhekwa njengokwelashwa kokuqala komfutho wegazi ophezulu ngoba inezinzuzo ezengeziwe ngaphandle kokwehlisa umfutho wegazi. Ingasiza ukuvikela izinso zakho nenhliziyo, futhi ivame ukubekezelelwa kahle ngabantu abaningi. I-Lisinopril nayo ivame ukuba nemiphumela emincane abantu abayibonayo nsuku zonke.

I-Hydralazine, ngakolunye uhlangothi, ingase ibe ngcono ezimweni ezithile. Ibaluleke kakhulu ngesikhathi sokukhulelwa lapho imithi eminingi yokwehlisa umfutho wegazi ingaphephile ukuyisebenzisa. Ingasiza futhi kubantu abangazange basabele kahle emithini ethile noma labo abanezinhlobo ezithile zokuhluleka kwenhliziyo.

Ukukhetha "okungcono" ngempela kuncike kumlando wakho wezempilo, ezinye izimo ongase ube nazo, nokuthi umzimba wakho usabela kanjani emuthini ngamunye. Udokotela wakho uzocabangela zonke lezi zinto lapho enquma ukuthi yimuphi umuthi ofaneleka kakhulu kuwe.

Imibuzo Evame Ukubuzwa Mayelana ne-Hydralazine

Ingabe i-Hydralazine iphephile ezigulini ezinokugula kwezinso?

I-Hydralazine ingasetshenziswa kubantu abanezifo zezinso, kodwa idinga ukuqapha ngokucophelela. Njengoba izinso zakho zisiza ukucubungula nokukhipha umuthi emzimbeni wakho, ukusebenza kwezinso okuncishisiwe kungasho ukuthi udinga umthamo ophansi noma ukuthatha umuthi kaningi.

Izindaba ezinhle ukuthi i-hydralazine ngokuvamile ayikwenzi kubi ukusebenza kwezinso ngendlela abanye abanye imithi yokwehlisa umfutho wegazi abangase bayenze ngayo. Eqinisweni, ngokwehlisa umfutho wegazi lakho, empeleni kungasiza ukuvikela izinso zakho ekulimaleni okuqhubekayo ngokuhamba kwesikhathi. Udokotela wakho cishe uzohlola ukusebenza kwezinso zakho njalo ngenkathi uthatha i-hydralazine ukuze aqinisekise ukuthi isebenza ngokuphepha kuwe.

Ngingenzani uma ngiphuzile i-Hydralazine eningi ngengozi?

Uma ngengozi uthathe i-hydralazine eningi kunaleyo ebekiwe, ungangeni ekuvalelweni, kodwa thatha isinyathelo ngokushesha. Okukhathaza kakhulu nge-hydralazine eningi ukuthi umfutho wegazi lakho ungase wehle kakhulu, okungakwenza uzizwe unesiyezi, ukhathele, noma kukwenze uquleke.

Xhumana nodokotela wakho noma isikhungo sokulawula ubuthi ngokushesha uma uthathe okuningi kakhulu kunomthamo wakho obekiwe. Uma unesiyezi esikhulu, ubuhlungu besifuba, noma ubunzima bokuphefumula, funa usizo oluphuthumayo lwezokwelapha ngokushesha. Gcina ibhodlela lomuthi nawe ukuze ochwepheshe bezokwelapha bazi kahle ukuthi uthatheni ini nokuthi ungakanani.

Ngingenzani uma ngiphuthelwa umthamo we-Hydralazine?

Uma ukhohlwa umthamo we-hydralazine, yithathe ngokushesha nje lapho ukhumbula, ngaphandle uma sekuseduze isikhathi somthamo wakho olandelayo. Uma kunjalo, weqa umthamo owukhohlwe bese uqhubeka neshejuli yakho ejwayelekile. Ungaphindi imithamo emibili ukuze ulungise okukhohlwe, ngoba lokhu kungabangela ukuthi umfutho wakho wegazi wehle kakhulu.

Uma uvame ukukhohlwa imithamo, cabangela ukusetha izikhumbuzi ocingweni lwakho noma usebenzise umhleli wamaphilisi. Ukuthatha imithamo njalo kubalulekile ekulawuleni kahle umfutho wakho wegazi, ngakho-ke ukuthola uhlelo olusebenzelayo kuwe kungenza umehluko omkhulu empumelelweni yakho yokwelashwa.

Ngingayeka nini ukuthatha i-Hydralazine?

Ungayeki ukuthatha i-hydralazine ngokuzumayo ngaphandle kokukhuluma nodokotela wakho kuqala. Ukuyeka imithi yomfutho wegazi kungazelelwe kungabangela ukuthi umfutho wakho wegazi ukhuphuke, okungaba yingozi futhi kungaholela ezinkingeni ezinzima njengokuhlaselwa yinhliziyo noma unhlangothi.

Udokotela wakho angase anqume ukuyeka noma ukushintsha i-hydralazine yakho ngokusekelwe ekutheni umfutho wakho wegazi ulawulwa kahle kangakanani, ukuthi ngabe uhlangabezana nemiphumela emibi, noma uma isimo sakho sempilo yonke sishintsha. Uma sekuyisikhathi sokuyeka, ngokuvamile bazokwehlisa umthamo wakho kancane kancane ezinsukwini ezimbalwa noma emasontweni ukuze uvumele umzimba wakho ukuthi uzivumelanise ngokuphepha.

Ngingakwazi yini ukuphuza utshwala ngenkathi ngithatha i-Hydralazine?

Kungcono ukukhawulela ukusetshenziswa kotshwala ngenkathi uthatha i-hydralazine, njengoba utshwala bungathuthukisa imiphumela yokwehlisa umfutho wegazi yomuthi. Le nhlanganisela ingakwenza uzizwe unesiyezi noma unomuzwa wokukhanya kunokujwayelekile, futhi ikhuphula ingozi yakho yokuwa noma yokuphelelwa amandla.

Uma ukhetha ukuphuza utshwala, kwenze ngokulinganisela futhi unake indlela ozizwa ngayo. Qala kancane ukuze ubone ukuthi umzimba wakho usabela kanjani, futhi gwema ukuphuza utshwala uma usuvele unesiyezi noma eminye imiphumela emibi evela emuthini. Njalo xoxa ngokusebenzisa kwakho utshwala nodokotela wakho ukuze bakwazi ukukunikeza isiqondiso esiqondene nawe ngokusekelwe esimweni sakho sempilo.