Yini i-Idelalisib: Ukusetshenziswa, Umthamo, Imiphumela Eceleni nokuningi

I-Idelalisib ngumuthi womdlavuza oqondiswe ngqo osiza ukulwa nezinhlobo ezithile zomdlavuza wegazi ngokuvala amaprotheni athile amaseli omdlavuza awadingayo ukuze asinde futhi akhule. Lo muthi othathwa ngomlomo usebenza njengokwelashwa okunembile, okusho ukuthi wenzelwe ukuhlasela amaseli omdlavuza ngenkathi ezama ukonga amaseli anempilo ekulimaleni.

Uma wena noma othile omkhathalelayo enikwe i-idelalisib, cishe unemibuzo eminingi mayelana nokuthi isebenza kanjani nokuthi yini ongayilindela. Lo muthi umelele intuthuko ebalulekile ekwelashweni komdlavuza, unikeza ithemba kubantu abanezinhlobo ezithile ze-lymphomas kanye ne-leukemia ezingase zingasabeli kahle ekhemotherapy yendabuko.

Yini i-Idelalisib?

I-Idelalisib wuhlobo lomuthi womdlavuza obizwa ngokuthi i-kinase inhibitor owuthatha ngomlomo njengamaphilisi. Isebenza ngokuvimba iprotheni ethile ebizwa nge-PI3K delta, esetshenziswa amaseli omdlavuza ukuze aziphindaphinde futhi asakazeke emzimbeni wakho wonke.

Lo muthi ungowesigaba esisha sokwelashwa komdlavuza esibizwa ngokuthi ukwelashwa okuqondiwe. Ngokungafani ne-chemotherapy yendabuko ethinta amaseli amaningi ahlukene emzimbeni wakho, i-idelalisib yenzelwe ukugxila ngqo ezindleleni ezisetshenziswa amaseli omdlavuza wegazi ukuze asinde. Cabanga ngayo njengethuluzi elinembile elihlose ukuphazamisa ukukhula komdlavuza ngenkathi kungenzeka kubangele imiphumela emincane eceleni kunezelashwa ezibanzi.

Lo muthi wathuthukiswa ngeminyaka yocwaningo lokuthi imidlavuza ethile yegazi iziphatha kanjani ezingeni le-molecular. Ososayensi bathola ukuthi eminingi yale midlavuza incike kakhulu endleleni ye-PI3K delta protein, okuyenza ibe yindawo ekahle yokwelashwa.

Isetshenziselwani i-Idelalisib?

I-Idelalisib ivunyelwe ngokuqondile ukwelapha izinhlobo ezithile zomdlavuza wegazi, ikakhulukazi i-chronic lymphocytic leukemia (CLL) kanye nezinhlobo ezithile ze-non-Hodgkin's lymphoma. Udokotela wakho ngokuvamile uzonquma lo muthi lapho ezinye izindlela zokwelapha zingasebenzi kahle noma lapho umdlavuza wakho ubuyele ngemva kokwelashwa kwangaphambilini.

Izimo ezivame kakhulu eziphathwa nge-idelalisib zihlanganisa i-chronic lymphocytic leukemia ngokuhlanganyela ne-rituximab, i-follicular B-cell non-Hodgkin's lymphoma, kanye ne-small lymphocytic lymphoma. Lezi zonke ziyizifo ezingumdlavuza ezithinta amaseli akho amhlophe egazi, okuyingxenye yamasosha akho omzimba.

Udokotela wakho we-oncologist angase futhi acabangele i-idelalisib ye-relapsed noma i-refractory lymphoma, okusho ukuthi umdlavuza wakho ubuyele ngemva kokwelashwa noma awuzange uphendule eminye imithi. Lo muthi unikeza inketho lapho izindlela zokwelapha ngamakhemikhali zendabuko zingase zingafaneleki noma zingasebenzi kahle esimweni sakho esithile.

Isebenza Kanjani I-Idelalisib?

I-Idelalisib isebenza ngokuvimba i-enzyme ethile ebizwa nge-PI3K delta edingwa amaseli omdlavuza ukuze asinde, akhule, futhi azale. Leli phrotheni lisebenza njengokushintsha okutshela amaseli omdlavuza ukuthi aqhubeke ehlukana futhi asakazeke emzimbeni wakho wonke.

Lapho i-idelalisib ivimba lokhu kushintsha, empeleni inquma izimpawu ezibalulekile zokusinda ezincike kumaseli omdlavuza. Ngaphandle kwalezi zimpawu, amaseli omdlavuza aqala ukufa ngokwemvelo ngenqubo ebizwa ngokuthi i-apoptosis. Le ndlela eqondiwe isho ukuthi umuthi ungasebenza kahle ezinhlotsheni ezithile zomdlavuza wegazi ngenkathi kungenzeka ukuthi udala imiphumela emibi embalwa kunezindlela zokwelapha ezithinta wonke amaseli ahlukana ngokushesha.

Njengomuthi olinganiselwe oqinile womdlavuza, i-idelalisib ingaveza imiphumela ebalulekile ekulweni umdlavuza wegazi, kodwa idinga ukuqashwa ngokucophelela yithimba lakho lezempilo. Umuthi ngokuvamile uqala ukusebenza kungakapheli amasonto ambalwa, nakuba kungase kuthathe izinyanga eziningana ukubona izinzuzo ezigcwele mayelana nokunciphisa ukubalwa kwamaseli omdlavuza nokuthuthukisa izimpawu.

Kufanele Ngiyithathe Kanjani I-Idelalisib?

Kufanele uthathe i-idelalisib ngendlela eqondile udokotela wakho ayala ngayo, ngokuvamile kabili ngosuku ngaphandle kokudla. Amaphilisi kufanele agwinywe wonke ngenkomishi yamanzi, futhi akufanele uwachoboze, uwaphule, noma uwahlafune ngoba lokhu kungathinta indlela umuthi omuncwa ngayo.

Ukuthatha i-idelalisib nokudla ngezinye izikhathi kungasiza ukunciphisa ukuqunjelwa kwesisu, nakuba kungadingeki ukuthi umuthi usebenze kahle. Ungayithatha ngesnakhi esilula noma ukudla uma ukuthola kulula esiswini sakho. Zama ukuthatha imithamo yakho cishe ngezikhathi ezifanayo nsuku zonke ukuze ugcine amazinga aqhubekayo omuthi ohlelweni lwakho.

Uma uthatha eminye imithi, xoxa ngesikhathi nomhlinzeki wakho wezempilo ngoba eminye imithi ingasebenzisana ne-idelalisib. Udokotela wakho angase ancome ukuthatha imithi ethile ngezikhathi ezihlukene zosuku ukuze ugweme ukusebenzisana okungathinta ukuthi umuthi ngamunye usebenza kahle kangakanani.

Kufanele Ngiyithathe Isikhathi Esingakanani I-Idelalisib?

Ngokuvamile uzoqhubeka nokuthatha i-idelalisib uma nje isiza ukulawula umdlavuza wakho futhi uyayibekezelela kahle. Ngokungafani neminye imithi oyithatha isikhathi esithile, ukwelashwa komdlavuza njenge-idelalisib kuvame ukuqhubeka isikhathi eside njengokwelashwa kokulungisa.

Udokotela wakho uzoqapha ukusabela kwakho emuthini ngokuhlolwa kwegazi njalo kanye nezifundo zokuthwebula izithombe. Uma umdlavuza wakho uphendula kahle futhi awutholi imiphumela emibi engathi sína, ungaqhubeka nokuthatha i-idelalisib izinyanga noma iminyaka. Umgomo uwukugcina umdlavuza wakho ulawulwa ngenkathi ugcina izinga lempilo yakho.

Nokho, uma uthola imiphumela emibi engathi sína noma uma umdlavuza wakho uyeka ukuphendula emuthini, udokotela wakho angase ancome ukuyeka i-idelalisib futhi ashintshele endleleni yokwelapha ehlukile. Lezi zinqumo zenziwa ngaso sonke isikhathi ngokucophelela, kulinganiswa izinzuzo zokuqhubeka nokwelashwa ngokumelene nanoma yiziphi izingozi noma imiphumela emibi ongase uyithole.

Yini Imiphumela Emibi Ye-Idelalisib?

Njengazo zonke izidakamizwa zomdlavuza, i-idelalisib ingabangela imiphumela emibi, nakuba kungewona wonke umuntu oyitholayo. Imiphumela emibi evame kakhulu ngokuvamile iyalawuleka ngokugadwa okufanele nokunakekelwa okusekelayo okuvela eqenjini lakho labanakekeli bezempilo.

Ukuqonda okulindelekile kungakusiza ukuthi uzizwe ulungiseleleke kakhulu futhi wazi ukuthi ungathintana nini ukuze uthole usizo. Nansi imiphumela emibi ongase uyithole, ihlelwe kusukela kokuvamile kakhulu kuya kokungavamile:

Imiphumela emibi ejwayelekile abantu abaningi abayitholayo ihlanganisa:

• Ukuqunjelwa, okungase ngezinye izikhathi kube kubi futhi kungase kudingeke imithi yokulawula
• Ukucanuzela kwenhliziyo nokuncipha kwesifiso sokudla, okuvame ukulawuleka ngemithi elwa nokucanuzela kwenhliziyo
• Ukukhathala nobuthakathaka, okungase kuthuthuke njengoba umzimba wakho ujwayela ukwelashwa
• Ukuqubuka kwesikhumba noma ukuluma, okuvame ukuba mnene futhi kulashwa ngemithi yendawo
• Ukukhwehlela noma ukuphefumula kanzima, okufanele kubikwe kudokotela wakho
• Umkhuhlane noma amaqhwa, okungase kubonise ukuthi amasosha akho omzimba ayathinteka

Le miphumela emibi ejwayelekile ivame ukuthuthuka ngokuhamba kwesikhathi nokunakekelwa okusekelayo. Ithimba lakho labanakekeli bezempilo linganikeza imithi namasu okusiza ukulawula lezi zimpawu futhi likugcine ukhululekile ngesikhathi sokwelashwa.

Imiphumela emibi engathi sína kodwa engavamile edinga ukunakekelwa kwezempilo ngokushesha ihlanganisa:

• Ukuvuvukala kwamaphaphu okukhulu (i-pneumonitis) okubangela ubunzima bokuphefumula noma ukukhwehlela okuqhubekayo
• Izinkinga zesibindi ezingathi sína, okuthi udokotela wakho azigade ngezivivinyo zegazi ezivamile
• Ukuqunjelwa okukhulu okuholela ekuphelelwe amanzi emzimbeni noma ukungalingani kwama-electrolyte
• Izifo ezingathi sína ngenxa yamasosha omzimba abuthakathaka
• Ukuphendula kwesikhumba okungathi sína ngamabhamuza noma ukuxebuka

Nakuba le miphumela emibi engathi sína ingavamile, idinga ukunakekelwa kwezempilo ngokushesha. Ithimba lakho labanakekeli bezempilo lizokugada ngokucophelela ngezikhathi ezivamile zokuhlolwa kanye nezivivinyo zegazi ukuze libambe noma yiziphi izinkinga zisasekuqaleni.

Imiphumela emibi engavamile kodwa engase ibe yingozi empilweni ihlanganisa:

• Ukwehluleka kwesibindi okukhulu okudinga ukulaliswa esibhedlela
• Ukuvuvukala kwamaphaphu okusongela impilo okungaphenduli emithini
• Ukuvuvukala kwamathumbu okukhulu (i-colitis) okungase kudingeke ukuhlinzwa
• Izifo ezigqithisayo ezingabulala ezigulini ezinomzimba obuthakathaka
• I-Tumor lysis syndrome, lapho amaseli omdlavuza efa ngokushesha kangangokuthi ahlula izinso

Lezi zinkinga ezingavamile zigcizelela ukuthi kungani ukuqapha njalo kubaluleke kangaka ngesikhathi sokwelashwa nge-idelalisib. Ithimba lakho le-oncology liqeqeshwe ukubona izimpawu zokuqala zokuxwayisa futhi lithathe isinyathelo ngokushesha uma kudingeka.

Ubani Ongafanele Athathe I-Idelalisib?

I-Idelalisib ayifanele wonke umuntu, futhi udokotela wakho uzobuyekeza ngokucophelela umlando wakho wezokwelapha ngaphambi kokukuyalela lo muthi. Ezinye izimo zempilo noma izimo zingenza i-idelalisib ingaphephile noma ingasebenzi kahle kuwe.

Udokotela wakho uzodinga ukwazi ngazo zonke izimo zakho zempilo nemithi ukuze anqume ukuthi i-idelalisib ikufanele yini. Nazi izizathu eziyinhloko zokuthi kungani lo muthi kungenzeka unganconywa:

Izimo zezokwelapha ezingase zikuvimbele ukuthatha i-idelalisib zihlanganisa:

• Izifo ezinzima ezisebenzayo ukuthi amasosha akho omzimba asevele elwa nazo
• Isifo sesibindi esinzima noma ukwehluleka kwesibindi okungavimbela ukucutshungulwa komuthi okufanele
• Isifo samaphaphu esinzima noma umlando wokuqubuka kwamaphaphu okukhulu
• Isifo sezinso esinzima esithinta indlela umzimba wakho oqeda ngayo umuthi
• Umlando wokungezwani komzimba okukhulu ne-idelalisib noma imithi efanayo

Uma unezinye zalezi zimo, udokotela wakho kungase kudingeke azelaphe kuqala noma akhethe ukwelashwa komdlavuza okuhlukile okuphephe kakhulu esimweni sakho esithile.

Izimo ezikhethekile ezidinga ukuqapha okwengeziwe zihlanganisa:

• Ukukhulelwa noma izinhlelo zokukhulelwa, njengoba i-idelalisib ingalimaza umntwana ongakazalwa
• Ukuncelisa, njengoba umuthi ungangena obisini
• Ukuphuza imithi ethile exhumana ngendlela eyingozi ne-idelalisib
• Ukwamukela imithi yokugoma esanda kutholwa, njengoba amasosha akho omzimba engase abe buthakathaka
• Ukuhlela ukuhlinzwa, njengoba umuthi ungathinta ukuphola kanye nengozi yokutheleleka

Iqembu lakho lezempilo lizosebenza nawe ukubhekana nalezi zinkinga futhi linqume indlela yokwelapha ephephe kakhulu esimweni sakho.

Igama Lomkhiqizo le-Idelalisib

I-Idelalisib ithengiswa ngaphansi kwegama lomkhiqizo elithi Zydelig, elenziwa yi-Gilead Sciences. Lolu okwamanje yilona kuphela uhlobo lomkhiqizo olutholakalayo, njengoba umuthi usavikelwe ngamalungelo obunikazi.

Lapho uthatha umuthi wakho, uzobona elithi "Zydelig" ebhodleleni kanye negama elivamile elithi "idelalisib." Womabili la magama abhekisela emuthini ofanayo, kodwa umshwalense wakho noma ikhemisi lingase lisebenzise noma yiliphi igama lapho kuxoxwa ngomuthi wakho.

Njengoba lo ngumuthi oqondene nomdlavuza, ngokuvamile utholakala kuphela ngamakhemisi akhethekile anolwazi lokuphatha imithi ye-oncology. Ithimba lakho lezempilo lizosiza ekuhleleni ukuthola umuthi wakho ugcwaliswe ngekhemisi efanele.

Ezinye izindlela ze-Idelalisib

Kukhona ezinye izinketho zokwelapha eziqondiwe zokwelapha imidlavuza yegazi efana nalezo eziphathwa nge-idelalisib. Udokotela wakho angase acabangele lezi zindlela uma i-idelalisib ingakulungele noma uma umdlavuza wakho ungasabeli kahle ekwelashweni.

Imithi ehlukile isebenza ngezindlela ezihlukene kodwa ihlose ukufeza imiphumela efanayo ekulawuleni imidlavuza yegazi. Nazi ezinye izinketho i-oncologist yakho engase ixoxe ngazo:

Ezinye izinketho zokwelapha eziqondiwe zihlanganisa:

• Ibrutinib (Imbruvica), evimba iphrotheni ehlukile ebizwa nge-BTK
• Acalabrutinib (Calquence), enye i-BTK inhibitor enezinye izinto ezingase zibe zimbalwa
• Venetoclax (Venclexta), esebenza ngokuvimba amaphrotheni avimbela ukufa kweseli lomdlavuza
• Rituximab (Rituxan), ukwelashwa ngama-antibody okuvame ukusetshenziswa ngokuhlangana neminye imithi
• Duvelisib (Copiktra), enye i-PI3K inhibitor evimba izindlela eziningi

Udokotela wakho uzocabangela izinto ezifana nohlobo oluthile lomdlavuza wakho, ukwelashwa kwangaphambilini, impilo yonke, kanye nemiphumela engase ibe khona lapho encoma enye indlela engcono kakhulu yesimo sakho.

Izindlela zokwelapha zendabuko ezingase zicatshangelwe zihlanganisa:

• Ukuhlanganiswa kwemithi ye-chemotherapy efana ne-FCR noma i-BR
• Ukwelashwa ngama-antibody e-Monoclonal
• Ukufakelwa kwamaseli esiqu kubantu abasha, abanempilo enhle
• Izivivinyo zomtholampilo zokuhlola ukwelashwa okusha okusavela

Ukukhetha phakathi kwalezi ezinye izindlela kuncike ezintweni eziningi zomuntu ngamunye, futhi ithimba lakho le-oncology lizokusiza ukuthi uqonde izinzuzo kanye nobubi benketho ngayinye yesimo sakho esithile.

Ingabe i-Idelalisib ingcono kune-Ibrutinib?

Kokubili i-idelalisib ne-ibrutinib ziyindlela yokwelapha eqondiwe esebenzayo yomdlavuza wegazi, kodwa zisebenza ngezindlela ezihlukene futhi zingase zifaneleke kangcono ezigulini ezihlukene. Akukho imithi enye engcono kunenye - ukukhetha kuncike ohlotsheni lomdlavuza wakho, isimo sempilo, kanye nomlando wokwelashwa.

I-Ibrutinib (Imbruvica) ivimba iphrotheni ebizwa nge-BTK, kuyilapho i-idelalisib ivimba i-PI3K delta. Zombili lezi zindlela zingase zisebenze, kodwa zingase zisebenze kangcono ezinhlotsheni ezihlukene zomdlavuza wegazi noma ezimweni ezihlukene zomtholampilo. Udokotela wakho we-oncologist uzocabangela icala lakho ngalinye lapho encoma ukuthi iyiphi imithi engase isebenze kahle.

Ngokuqondene nemiphumela emibi, womabili amakhambi angabangela ukusabela okukhulu, kodwa imiphumela emibi ethile iyahluka. I-Ibrutinib kungenzeka kakhulu ukuthi ibangele izinkinga zesigqi senhliziyo nezinkinga zokuphuma kwegazi, kuyilapho i-idelalisib ivame kakhulu ukubangela isifo sohudo esibi nezinkinga zesibindi. Udokotela wakho uzocabangela izici eziyingozi zakho zale miphumela emibi ehlukene lapho enza izincomo zokwelashwa.

Izifundo zomtholampilo zikhombise ukuthi womabili amakhambi angasebenza ekwelapheni umdlavuza wegazi ophindelelayo noma oqinile. Kodwa-ke, ezinye iziguli zingase zisabele kangcono emuthini owodwa kunomunye, futhi ezinye zingase zikwazi ukubekezelela umuthi owodwa kangcono kunomunye ngokusekelwe kuphrofayela yazo yezempilo.

Imibuzo Evame Ukubuzwa Mayelana ne-Idelalisib

Ingabe i-Idelalisib iphephile kubantu abanezifo zesibindi?

I-Idelalisib idinga ukucatshangelwa ngokucophelela uma unezinkinga zesibindi ezikhona, njengoba umuthi ungathinta ukusebenza kwesibindi futhi ucutshungulwa esibindini. Udokotela wakho uzodinga ukuhlola impilo yesibindi sakho ngaphambi kokuqala ukwelashwa futhi aqaphe eduze ngesikhathi sokwelashwa.

Uma unezinkinga zesibindi ezincane, udokotela wakho angase akwazi ukukuyalela i-idelalisib kodwa cishe uzoncoma ukuqapha kaningi futhi mhlawumbe umthamo ophansi. Kodwa-ke, uma unesifo sesibindi esibi noma ukwehluleka kwesibindi, i-idelalisib kungenzeka ingakuphephile, futhi udokotela wakho cishe uzoncoma ezinye izindlela zokwelashwa.

Ukuhlolwa kwegazi okuvamile ukuhlola ukusebenza kwesibindi kuyingxenye ejwayelekile yokwelashwa kwe-idelalisib kuzo zonke iziguli, kungakhathaliseki ukuthi zinezinkinga zesibindi ezikhona ngaphambili. Lokhu kuqapha kusiza ukubamba noma yimiphi imiphumela emibi ehlobene nesibindi kusenesikhathi ukuze inganakekelwa ngokushesha.

Kufanele ngenzeni uma ngiphuthelwa ngithatha i-Idelalisib eningi kakhulu?

Uma ngabe uthatha i-idelalisib eningi kunaleyo oyinikiwe, xhumana nodokotela wakho noma isikhungo sokulawula ubuthi ngokushesha, ngisho noma ungezwa ugula ngokushesha. Ukuthatha umuthi omningi kakhulu kungakhuphula ingozi yakho yemiphumela emibi, ikakhulukazi izinkinga zesibindi nohudo olukhulu.

Ungazami ukulungisa umthamo owengeziwe ngokweqa umthamo wakho olandelayo ohleliwe, ngoba lokhu kungathinta ukuthi umuthi usebenza kahle kangakanani. Kunalokho, landela imiyalelo kadokotela wakho mayelana nendlela yokuqhubeka nohlelo lwakho olujwayelekile lokulinganisa.

Gcina umkhondo wokuthi uthatha nini umuthi wakho ukuze usize ukuvimbela ukweqisa ngengozi. Ukusebenzisa umhleli wamaphilisi noma ukusetha izikhumbuzi zocingo kungakusiza ukuthi ukhumbule ukuthi ngabe usuwuthathile yini umthamo wakho wosuku.

Kufanele Ngenzeni Uma Ngeqe Umthamo We-Idelalisib?

Uma weqa umthamo we-idelalisib, yithathe ngokushesha lapho ukhumbula, ngaphandle uma sekuyisikhathi somthamo wakho olandelayo ohleliwe. Kulokho, weqa umthamo oweqiwe bese uqhubeka nohlelo lwakho olujwayelekile - ungathathi imithamo emibili ngasikhathi sinye ukuze ulungise leyo eyeqiwe.

Uma ungaqiniseki ngesikhathi, xhumana nomhlinzeki wakho wezempilo noma usokhemisi ukuze uthole isiqondiso. Bangakusiza ukuthi unqume indlela engcono kakhulu ngokusekelwe ekutheni isikhathi esingakanani sesidlulile kusukela kumthamo wakho oweqiwe.

Ukuze usize ukukhumbula imithamo yakho, zama ukuthatha i-idelalisib ngezikhathi ezifanayo nsuku zonke futhi ucabangele ukusebenzisa izikhumbuzi ezinjengama-alamu ocingo noma abahleli bamaphilisi. Ukuqina ngesikhathi kusiza ukugcina amazinga aqinile omuthi ohlelweni lwakho.

Ngingayeka Nini Ukuthatha I-Idelalisib?

Akufanele uyeke ukuthatha i-idelalisib ngaphandle kokuxoxa ngayo kuqala nodokotela wakho we-oncologist, ngisho noma uzizwa ungcono noma unomuzwa wemiphumela emibi. Ukuyeka ukwelashwa komdlavuza kungavumela umdlavuza wakho ukuthi ukhule futhi usabalale futhi, okungenzeka ukuthi kwenze kube nzima ukuwulapha esikhathini esizayo.

Udkt wakho uzohlola njalo ukuthi imithi isebenza kahle kangakanani nokuthi uyayithola kahle yini. Bangase batusa ukuyeka i-idelalisib uma umdlavuza wakho uqhubeka ngaphandle kokwelashwa, uma uba nemiphumela emibi engalawuleki, noma uma kutholakala enye indlela yokwelapha engcono.

Uma ukhathazekile ngemiphumela emibi noma unemibuzo mayelana nohlelo lwakho lokwelashwa, xoxa ngalezi zinto obala nethimba lakho lezempilo. Bangase bakwazi ukulungisa umthamo wakho, bangeze imithi esekelayo, noma benze ezinye izinguquko ukukusiza ukuthi uqhubeke nokwelashwa ngokuphepha nangokunethezeka.

Ngingayithatha i-Idelalisib neminye imithi?

I-Idelalisib ingasebenzisana neminye imithi eminingi, ngakho-ke kubalulekile ukutshela udokotela wakho ngayo yonke imithi kadokotela, imithi etholakala ngaphandle kwe-oda, kanye nezithasiselo ozithathayo. Ezinye izindlela zokusebenzisana zingaba zimbi futhi zingase zidinge ukulungiswa komthamo noma eminye imithi.

Imithi ethile ingakhuphula amazinga e-idelalisib egazini lakho, okungenzeka kuholele emiphumeleni eminingi emibi, kanti eminye inganciphisa ukusebenza kwayo. Usokhemisi wakho nodokotela bazobuyekeza yonke imithi yakho ukuze bathole ukusebenzisana okungenzeka futhi benze izincomo ezifanele.

Njalo hlola nomhlinzeki wakho wezempilo ngaphambi kokuqala noma iyiphi imithi emisha, okuhlanganisa imithi etholakala ngaphandle kwe-oda kanye nezithasiselo zemithi, ngenkathi uthatha i-idelalisib. Ngisho nemikhiqizo ebonakala ingenangozi ngezinye izikhathi ingasebenzisana nemithi yomdlavuza ngezindlela ezingalindelekile.