Yini i-Isosorbide Dinitrate kanye ne-Hydralazine: Ukusetshenziswa, Umthamo, Imiphumela Eceleni nokuningi

I-Isosorbide dinitrate kanye ne-hydralazine kuyinhlanganisela yemithi esiza inhliziyo yakho ukuba ipompe igazi ngempumelelo. Le mithi esebenza kabili isebenza ngokukhulula imithambo yegazi nokunciphisa umsebenzi wenhliziyo yakho, okwenza kube lula ngenhliziyo yakho ukwenza umsebenzi wayo. Yenzelwe ngqo abantu abanenhliziyo ehlulekayo abadinga ukusekelwa okwengeziwe ukuze bagcine ukugeleza kwegazi okunempilo emzimbeni wabo wonke.

Yini i-Isosorbide Dinitrate kanye ne-Hydralazine?

Le mithi ihlanganisa imithi emibili yenhliziyo ibe yiphilisi elilodwa ukuze kube lula nemiphumela engcono. I-Isosorbide dinitrate ivula imithambo yakho yegazi, kuyilapho i-hydralazine ikhulula izindonga zemithambo yakho nemithambo. Ngokuhlanganyela, bakha iqembu elinamandla elisiza ukunciphisa ukucindezeleka emisipheni yenhliziyo yakho.

Le nhlanganisela yakhiwe ngqo ngemuva kokuthi ucwaningo lwabonisa ukuthi iziguli zase-Afrika-American ezinokuhluleka kwenhliziyo zithole kahle kakhulu kulokhu kubhanwa. Kodwa-ke, odokotela manje bayayibhala iziguli zazo zonke izizinda lapho eminye imithi yenhliziyo ingazange inikeze ukukhululeka okwanele.

Isetshenziselwani i-Isosorbide Dinitrate kanye ne-Hydralazine?

Le mithi iphatha ukuhluleka kwenhliziyo, isimo lapho inhliziyo yakho ilwela ukumpompa igazi ngempumelelo emzimbeni wakho wonke. Uma inhliziyo yakho ingakwazi ukumpompa kahle, ungase uzizwe ukhathele, uphefumula kanzima, noma uqaphele ukuvuvukala emilenzeni yakho nasezinyaweni zakho.

Odokotela bavame ukubhala le nhlanganisela lapho imithi ejwayelekile yokuhluleka kwenhliziyo efana ne-ACE inhibitors noma i-ARBs inganele yodwa. Ingasetshenziswa futhi kanye neminye imithi yenhliziyo ukuhlinzeka ngosekelo olwengeziwe ohlelweni lwakho lwe-cardiovascular.

Abanye odokotela bangase bayibhale ngenxa yegazi eliphezulu elingaphendulanga kahle kwezinye izindlela zokwelapha, nakuba lokhu kungavamile kunokusetshenziswa kwayo ekuhlulekeni kwenhliziyo.

Isebenza kanjani i-Isosorbide Dinitrate kanye ne-Hydralazine?

Lo muthi usebenza ngezindlela ezimbili ezihlukene kodwa ezigcwalisanayo ukusiza inhliziyo yakho. Ingxenye ye-isosorbide dinitrate iphumuza imithambo ebuyisa igazi enhliziyweni yakho, inciphisa inani legazi inhliziyo yakho okudingeka ukuba ilipompe ngokuqina ngakunye.

Ngesikhathi esifanayo, i-hydralazine iphumuza imithambo yegazi ethwala igazi lisuka enhliziyweni yakho, okwenza kube lula ukuthi inhliziyo yakho iphushe igazi emzimbeni wakho. Cabanga ngakho njengokunciphisa kokubili ukucindezela okungenayo nokuphumayo epompini yamanzi.

Lokhu kuthathwa njengomuthi wenhliziyo olungile oluqinile onikeza ukusekelwa okukhulu kwenhliziyo nemithambo yegazi. Umphumela wokuhlanganisa uvame ukuba namandla kakhulu kunanoma yimuphi umuthi ngaphandle kwalowo, yingakho udokotela wakho ekhethe leli qembu eliqondile lesimo sakho.

Kufanele Ngiyithathe Kanjani I-Isosorbide Dinitrate ne-Hydralazine?

Thatha lo muthi njengoba nje udokotela wakho ekuyala, ngokuvamile kathathu kuya kane ngosuku ngesikhathi sokudla. Ukuwuthatha nokudla kusiza ukunciphisa isisu esibuhlungu futhi kuthuthukisa ukuthi umzimba wakho umunca kahle kangakanani umuthi.

Gwinya amaphilisi wonke ngengilazi yamanzi egcwele. Ungawachobozi, uwahlafune, noma uwaphule amaphilisi, ngoba lokhu kungathinta indlela umuthi okhishwa ngayo emzimbeni wakho. Uma unenkinga yokugwinya amaphilisi, khuluma nodokotela wakho mayelana nezinye izindlela.

Zama ukuthatha imithamo yakho ngesikhathi esifanayo nsuku zonke ukuze ugcine amazinga aqhubekayo egazini lakho. Abantu abaningi bakuthola kuwusizo ukusetha izikhumbuzi zocingo noma ukusebenzisa umhleli wamaphilisi ukuze bahlale emgqeni neshejuli yabo yokulinganisa.

Ungayeki ukuthatha lo muthi ngokuzumayo, ngisho noma uzizwa ungcono. Inhliziyo yakho iye yazijwayeza ukusekelwa, futhi ukuyeka kungazelelwe kungabangela ukuthi izimpawu zakho zibuye noma zibe zimbi.

Kufanele Ngiyithathe Isikhathi Esingakanani I-Isosorbide Dinitrate ne-Hydralazine?

Abantu abaningi abanenhliziyo ehlulekayo badinga ukuthatha lo muthi isikhathi eside ukuze bagcine umsebenzi wenhliziyo yabo kanye nekhwalithi yempilo yabo. Ukuhluleka kwenhliziyo ngokuvamile kuyisimo esingamahlala-khona esidinga ukuphathwa okuqhubekayo kunokulungiswa kwesikhashana.

Udokotela wakho uzoqapha intuthuko yakho njalo ngezikhathi zokuhlolwa, ukuhlolwa kwegazi, kanye nokuhlolwa komsebenzi wenhliziyo. Ngokuya ngokuthi usabela kanjani kahle kanye nanoma yimaphi imiphumela emibi oyitholayo, bangase balungise umthamo wakho noma bashintshele kweminye imithi ngokuhamba kwesikhathi.

Abanye abantu bangase bagcine bedlulela kweminye imithi yenhliziyo njengoba imithi emisha itholakala noma njengoba isimo sabo sishintsha. Kodwa-ke, iziguli eziningi ziqhubeka nale nhlanganisela iminyaka ngoba iphatha ngempumelelo izimpawu zazo futhi ithuthukisa ukusebenza kwazo kwansuku zonke.

Yini Imiphumela Eceleni ye-Isosorbide Dinitrate kanye ne-Hydralazine?

Njengayo yonke imithi, le nhlanganisela ingabangela imiphumela emibi, nakuba kungewona wonke umuntu oyitholayo. Ukuqonda okungase kwenzeke kungakusiza ukuthi uzizwe ulungiselelwe kakhulu futhi wazi ukuthi ungaxhumana nini nodokotela wakho.

Imiphumela emibi evame kakhulu ongase uyibone ihlanganisa ikhanda elibuhlungu, isiyezi, nokuzizwa unomuzwa wokukhanya lapho usukuma ngokushesha. Le miphumela ivame ukuthuthuka njengoba umzimba wakho ujwayela umuthi emasontweni ambalwa okuqala okwelashwa.

Nansi imiphumela emibi ongase uyithole:

• Ikhanda elibuhlungu elingase lizizwe libuhlungu noma lishaya
• Isiyezi noma ukukhanya ekhanda, ikakhulukazi lapho umile
• Isicanucanu noma isisu esibuhlungu
• Ukukhathala noma ukuzizwa ukhathele kunokujwayelekile
• Ukubomvu noma ukuzizwa ufudumele ebusweni nasifubeni sakho
• Ukushaya kwenhliziyo okusheshayo noma okungajwayelekile

Le miphumela emibi ejwayelekile ivame ukuba mnene futhi ithambekele ekunciphiseni njengoba umzimba wakho ujwayela umuthi. Uma ziqhubeka noma ziba yinkinga, udokotela wakho angasiza ngokulungisa umthamo wakho noma isikhathi.

Abanye abantu bangase babe nemiphumela engavamile kodwa ekhathazayo edinga ukunakekelwa kwezokwelapha. Nakuba lokhu kungavamile, kubalulekile ukukwazi ukuze ukwazi ukufuna usizo uma kudingeka.

Xhumana nodokotela wakho uma uhlangabezana nanoma yimiphi yale miphumela emibi kakhulu:

• Ikhanda elibuhlungu eliqinile noma eliqhubekayo elingathuthuki ngokuhamba kwesikhathi
• Ubuhlungu besifuba noma ukucindezela
• Ukuphefumula kanzima noma ukuphelelwa umoya
• Ukuvuvukala ezandleni zakho, ezinyaweni, noma emilenzeni
• Ukukhuluphala ngokushesha ngenxa yokugcinwa kwamanzi
• Ukuquleka noma isiyezi esikhulu
• Ukuba ndikindiki noma ukuluma ezandleni zakho noma ezinyaweni

Ngokungavamile kakhulu, abanye abantu bangase bathuthukise isimo esibizwa ngokuthi i-drug-induced lupus, engabangela ubuhlungu bamalunga, ukuqubuka kwesikhumba, nezimpawu ezinjenge-flu. Nakuba kungavamile, lokhu ngokuvamile kuyaxazululwa lapho umuthi uyekiswa ngaphansi kokuqondisa kwezokwelapha.

Ubani Ongafanele Athathwe I-Isosorbide Dinitrate kanye ne-Hydralazine?

Lo muthi awuphephile kuwo wonke umuntu, futhi izimo ezithile zezempilo noma izimo zenza kungafaneleki noma kuyingozi ukuwusebenzisa. Udokotela wakho uzobukeza ngokucophelela umlando wakho wezokwelapha ngaphambi kokubhala le nhlanganisela.

Akufanele uthathe lo muthi uma unokungezwani komzimba ne-isosorbide dinitrate noma i-hydralazine, noma uma uke waba nokusabela okukhulu emithini efanayo esikhathini esidlule. Hlala utshela udokotela wakho nganoma yikuphi ukungezwani komzimba nemithi oye wahlangabezana nakho.

Abantu abanezimo ezithile zenhliziyo kufanele bagweme lo muthi ngoba ungenza isimo sabo sibe sibi kakhulu. Uma unezinkinga ezinkulu ze-aortic noma ze-mitral valve, le nhlanganisela ingase ingafaneleki ohlotsheni lwakho oluthile lwesifo senhliziyo.

Nawa amakhondishini amakhulu enza lo muthi ungafaneleki:

• Isifo esibi sezinso noma ukwehluleka kwezinso
• Isifo esibi sesibindi noma ukwehluleka kwesibindi
• Umfutho wegazi ophansi kakhulu (hypotension)
• Izinhlobo ezithile zesifo se-valve yenhliziyo
• Ukuquleka kwenhliziyo kwamuva ezinsukwini ezimbalwa ezedlule
• Isifo semithambo yenhliziyo ene-angina engazinzile

Ngaphezu kwalokho, lo muthi udinga ukuqapha okukhethekile uma ukhulelwe noma uncelisa, njengoba ungangena enganeni yakho futhi ungase ulimaze. Udokotela wakho uzoqaphela izinzuzo uma ziqhathaniswa nezingozi zesimo sakho esithile.

Uma unesifo sikashukela, izinkinga zezinso, noma izimo ze-autoimmune, uzodinga ukuqapha okuseduze ngenkathi uthatha lo muthi, nakuba kungenzeka ukuthi usafaneleka ngokuphathwa ngokucophelela.

Amagama e-Brand e-Isosorbide Dinitrate kanye ne-Hydralazine

Igama elivamile le-brand lale nhlanganisela yi-BiDil, okuyiyona muthi yokuqala evunywe ngokuqondile ukwehluleka kwenhliziyo ezigulini zase-African American. I-BiDil iqukethe yomibili imithi kuthebhulethi eyodwa elula.

Ungase futhi uthole imithi emibili njengemiyalelo ehlukene, lapho uzothatha khona i-isosorbide dinitrate (etholakala njenge-Isordil noma i-Dilatrate-SR) kanye ne-hydralazine (etholakala njenge-Apresoline). Odokotela abathile bakhetha le ndlela ukuze benze ngendlela oyifisayo umthamo ngamunye ngamunye.

Izinhlobo ze-generic zazo zombili izidakamizwa zitholakala kabanzi futhi zisebenza ngempumelelo njengezinhlobo ze-brand. Umshwalense wakho ungase ukhethe izinketho ze-generic, futhi ngokuvamile zishibhile kakhulu ngenkathi zinikeza izinzuzo ezifanayo zokwelapha.

Ezinye izindlela ze-Isosorbide Dinitrate kanye ne-Hydralazine

Eminye imithi eminingi yokwehluleka kwenhliziyo inganikeza izinzuzo ezifanayo, nakuba udokotela wakho ekhethe le nhlanganisela ngezizathu ezithile ezihlobene nesimo sakho. Ezinye izindlela ezivamile zihlanganisa ama-ACE inhibitors afana ne-lisinopril noma i-enalapril, nawo asiza ukuphumuza imithambo yegazi futhi anciphise ukucindezeleka kwenhliziyo.

Ama-ARBs (ama-angiotensin receptor blockers) afana ne-losartan noma i-valsartan asebenza ngendlela efana nama-ACE inhibitors kodwa angase abangele imiphumela emincane efana nokukhwehlela. Le mithi ivame ukuzanywa kuqala ngaphambi kokucabangela inhlanganisela ye-isosorbide dinitrate kanye ne-hydralazine.

Imithi emisha yokuhluleka kwenhliziyo efana ne-sacubitril/valsartan (Entresto) ihlanganisa i-ARB nemithi esiza umzimba wakho ukuthi usebenze kahle ama-hormone avikela inhliziyo. Le nketho ingase icatshangelwe uma ungasabeli kahle enhlanganiseleni yamanje.

Ama-beta-blockers afana ne-metoprolol noma i-carvedilol anciphisa izinga lokushaya kwenhliziyo yakho futhi anciphise umsebenzi emisipha yenhliziyo yakho. Lawa avame ukusetshenziswa kanye nemithi yakho yamanje kunokuthi kube yizithuthi.

Ingabe i-Isosorbide Dinitrate ne-Hydralazine Ingcono Kune-Enalapril?

Zombili le mithi iyasebenza ekuhlulekeni kwenhliziyo, kodwa zisebenza ngezindlela ezihlukene futhi zingase zifaneleke kangcono kubantu abahlukene. Ucwaningo lukhombisile ukuthi inhlanganisela ye-isosorbide dinitrate kanye ne-hydralazine ingasebenza ikakhulukazi ezigulini zase-Afrika-American ezinokuhluleka kwenhliziyo.

I-Enalapril (i-ACE inhibitor) ivame ukuzanywa kuqala ngoba ineminyaka eminingi yocwaningo olusekela ukusetshenziswa kwayo ekuhlulekeni kwenhliziyo futhi ngokuvamile ibangela imiphumela emincane. Kodwa-ke, abanye abantu abakwazi ukubekezelela ama-ACE inhibitors ngenxa yokukhwehlela okomile okuqhubekayo noma eminye imiphumela.

Izifundo zikhombisile ukuthi lapho ama-ACE inhibitors afana ne-enalapril enganele wona, ukwengeza inhlanganisela ye-isosorbide dinitrate kanye ne-hydralazine kungahlinzeka ngezinzuzo ezengeziwe. Kwezinye izimo, le nhlanganisela ikhombiswe ukunciphisa ukulaliswa esibhedlela futhi ithuthukise izinga lempilo ngaphezu kwama-ACE inhibitors kuphela.

Udokotela wakho wakhetha imithi yakho yamanje ngokusekelwe ohlotsheni lwakho oluthile lokuhluleka kwenhliziyo, ukusabela kwakho ekwelashweni kwangaphambilini, kanye nezici zakho eziyingozi. Ukukhetha

Imibuzo Evame Ukubuzwa Mayelana ne-Isosorbide Dinitrate kanye ne-Hydralazine

Ingabe i-Isosorbide Dinitrate kanye ne-Hydralazine iphephile ku-Diabetes?

Yebo, lo muthi ngokuvamile uphephe kubantu abanesifo sikashukela, nakuba uzodinga ukuqapha okuseduze kwamazinga akho kashukela egazini. Le nhlanganisela ayithinti ngokuqondile ushukela wegazi, kodwa abanye abantu baqaphela izinguquko ekulawuleni kwabo isifo sikashukela lapho beqala imithi emisha yenhliziyo.

Udokotela wakho uzofuna ukuhlola ukusebenza kwezinso zakho kaningi ngoba isifo sikashukela singathinta izinso zakho, futhi lo muthi ucubungulwa ngezinso zakho. Qiniseka ukuthi uhambisana nokuqokwa kwakho okuvamile kokunakekelwa kwesifo sikashukela kanye nokuhlolwa kwegazi.

Uma uthatha imithi yesifo sikashukela, qaphela izimpawu zikashukela ophansi, ikakhulukazi uma uqala lo muthi wenhliziyo. Le nhlanganisela ngezinye izikhathi inganciphisa umfutho wegazi ngokwanele ukwenza izimpawu ze-hypoglycemia zizwakale zicacile.

Ngingenzani Uma Ngiphuzile i-Isosorbide Dinitrate kanye ne-Hydralazine eningi ngengozi?

Uma ngengozi uphuza okungaphezu komthamo wakho obekiwe, xhumana nodokotela wakho noma ukulawulwa kwemithi enobuthi ngokushesha ukuze uthole isiqondiso. Ukuphuza okuningi kungabangela umfutho wegazi ophansi ngokuyingozi, ikhanda elibuhlungu elibukhali, noma izinkinga zesigqi senhliziyo.

Qaphela izimpawu zokweqisa, ezihlanganisa isiyezi esikhulu, ukuquleka, ukushaya kwenhliziyo okusheshayo, noma ubuthakathaka obukhulu. Uma uhlangabezana nanoma yiziphi zalezi zimpawu, funa ukunakekelwa kwezempilo eziphuthumayo ngokushesha kunokulinda ukubona ukuthi ziyathuthuka yini.

Ungazami ukuthi "ukwenza" umthamo owengeziwe ngokuqaqa umthamo wakho olandelayo ohleliwe. Kunalokho, landela isiqondiso esivela kumhlinzeki wakho wokunakekelwa kwezempilo noma ukulawulwa kwemithi enobuthi mayelana nokuthi ungaluqala nini kabusha uhlelo lwakho lokulinganisa olujwayelekile.

Ngingenzani Uma Ngiphuthelwe Umthamo we-Isosorbide Dinitrate kanye ne-Hydralazine?

Uma uphuthelwa umthamo, wuthatha ngokushesha lapho ukhumbula, ngaphandle kwalapho sekuseduze isikhathi somthamo wakho olandelayo ohleliwe. Kulokho, weqa umthamo ophuthelwe futhi uqhubeke nohlelo lwakho olujwayelekile kunokuthi uphinde.

Ungathathi imithamo emibili ngesikhathi esisodwa ukuze ulungise umthamo owuphuthelwe, ngoba lokhu kungabangela ukuthi umfutho wegazi lakho wehle kakhulu futhi kukwenze uzizwe unesiyezi noma uzoquleka. Kungcono ukugcina isimiso sakho esivamile ukuqhubeka.

Uma uvame ukukhohlwa imithamo, cabangela ukusetha ama-alamu ocingweni noma ukusebenzisa umhleli wamaphilisi wamasonto onke ukukusiza ukuthi uhlale emgqeni. Ukuthatha imithi ngokuqhubekayo kubalulekile ekugcineni ukusekelwa kwenhliziyo okuqhubekayo usuku ngalunye.

Ngingayeka nini ukuthatha i-Isosorbide Dinitrate ne-Hydralazine?

Ungalokothi uyeke ukuthatha lo muthi kungazelelwe ngaphandle kokukhuluma nodokotela wakho kuqala. Inhliziyo yakho iye yazijwayeza ukusekelwa okunikezwa yilo muthi, futhi ukuyeka kungazelelwe kungabangela ukuthi izimpawu zakho zokuhluleka kwenhliziyo zibuye noma zibe zimbi kakhulu.

Udokotela wakho uzokuqondisa kunoma yiziphi izinguquko zemithi ngokusekelwe ekutheni inhliziyo yakho isebenza kahle kangakanani nokuthi ngabe uhlangabezana nemiphumela emibi. Uma udinga ukuyeka, ngokuvamile bazokwehlisa umthamo wakho kancane kancane ngokuhamba kwesikhathi.

Noma ngabe uzizwa ungcono kakhulu, lokhu ngokuvamile kusho ukuthi umuthi usebenza kahle kunokuthi awusadingi. Ukuhluleka kwenhliziyo ngokuvamile kuyisimo sesikhathi eside esidinga ukuphathwa okuqhubekayo ukuze kugcinwe izinga lempilo yakho elithuthukisiwe.

Abanye abantu bangase bagcine bedlulela kweminye imithi yenhliziyo njengoba imithi emisha itholakala, kodwa lesi sinqumo kufanele senziwe ngaso sonke isikhathi ngokubambisana nethimba lakho lezempilo ngokusekelwe entuthukweni yakho nezidingo zakho.