Yini i-Istradefylline: Ukusetshenziswa, Umthamo, Imiphumela Eceleni nokuningi

I-Istradefylline iyimithi esiza ukuphatha iziqephu ze- "off" esifo sikaParkinson lapho ukwelashwa kwakho okuvamile kungasebenzi kahle njengoba kufanele. Uma wena noma othile omkhathalelayo ebhekene nesifo sikaParkinson, kungenzeka ukuthi uqaphele ukuthi ngezinye izikhathi imithi eyinhloko ibonakala iphela ngaphambi kokuthi umthamo olandelayo ufike, ikushiye uzizwa uqina noma unzima ukuhamba kahle.

Le mithi isebenza njengokwelashwa okwengeziwe kanye nemithi yakho yamanje ye-Parkinson. Yenzelwe ukusiza ukunciphisa lezo zikhathi ezikhungayo lapho izimpawu zakho zibuyela phakathi kwemithamo, ikunikeza ukukhululeka okuqhubekayo usuku lonke.

Yini i-Istradefylline?

I-Istradefylline uhlobo lomuthi obizwa ngokuthi i-adenosine A2A receptor antagonist. Ngamazwi alula, isebenza ngokuvimba izimpawu ezithile ebuchosheni bakho ezingaphazamisa ukunyakaza okubushelelezi nokuxhumana.

Yicabange njengomuthi osizayo osebenza kanye nokwelashwa kwakho okuyinhloko kwe-Parkinson. Ngenkathi umuthi wakho oyinhloko (ngokuvamile i-levodopa/carbidopa) unikeza izinzuzo eziyinhloko, i-istradefylline ingena ukusiza ukugcina lezo zinzuzo ngokuqhubekayo usuku lonke.

Umuthi uza ngesimo samaphilisi futhi uthathwa ngomlomo. Ivunyelwe ngokuqondile kubantu abadala abanesifo sikaParkinson abahlangabezana nokuguquguquka kwemoto, okuyizikhathi lapho izimpawu zakho zibonakala ziza futhi zihambe ngendlela engalindelekile.

Isetshenziselwani i-Istradefylline?

I-Istradefylline isetshenziswa ikakhulukazi ukwelapha iziqephu ze- "off" kubantu abanesifo sikaParkinson. Lezi ziqephu ze-off yizikhathi lapho umuthi wakho ovamile we-Parkinson ubonakala uyeka ukusebenza ngempumelelo, futhi izimpawu zakho ezifana nokuthuthumela, ukuqina, nokunyakaza okuhamba kancane kubuya.

Abantu abaningi abanesifo sikaParkinson ekugcineni bahlangabezana nokuguquguquka njengoba isimo sabo siqhubeka. Ungase uqaphele ukuthi imithi yakho isebenza kahle amahora ambalwa ngemva kokuyithatha, kodwa-ke uqala ukuzwa uqina noma ukuthuthumela futhi ngaphambi komthamo wakho olandelayo ohleliwe.

Lo muthi uhlala usetshenziswa kanye ne-levodopa/carbidopa, ungalokothi uwedwa. Yenzelwe ukusiza ukwelula izikhathi lapho uzizwa ungcono kakhulu futhi unciphise isikhathi osichitha kulezo zimo ezingakhululekile.

Isebenza Kanjani I-Istradefylline?

I-Istradefylline isebenza ngokuvimba ama-adenosine A2A receptors ebuchosheni bakho. Lawa ma-receptor ngokuvamile anciphisa umsebenzi we-dopamine, ikhemikhali yobuchopho esiza ukulawula ukunyakaza futhi eshoda esifweni sikaParkinson.

Ngokuvimba la ma-receptor, i-istradefylline ivumela i-dopamine ukuthi isebenze ngempumelelo. Lokhu kusho ukuthi imithi yakho ekhona ye-Parkinson inganikeza izinzuzo eziqhubekayo usuku lonke, inciphise lezo zikhathi eziphazamisayo.

Ithathwa njengomuthi onamandla aphakathi nendawo onikeza ukusekelwa okuqinile kunokushintsha okukhulu. Abantu abaningi baqaphela ukuthuthuka kancane kancane ngesikhathi sabo sokuphumula emasontweni amaningana okwelashwa, kunokuba nemiphumela esheshayo emangalisayo.

Kufanele Ngiyithathe Kanjani I-Istradefylline?

Thatha i-istradefylline ngendlela eqondile udokotela wakho ayiyalela ngayo, ngokuvamile kanye ngosuku. Ungayithatha ngaphandle noma ngaphandle kokudla, noma yikuphi okuzizwa kukhululekile kuwe.

Kungcono ukuthatha umthamo wakho ngesikhathi esifanayo nsuku zonke ukusiza ukugcina amazinga aqinile ohlelweni lwakho. Abantu abaningi bakuthola kuwusizo ukuyithatha nemithi yabo yasekuseni njengengxenye yomsebenzi wabo wansuku zonke.

Uma unenkinga yokugwinya amaphilisi, ungachoboza amaphilisi e-istradefylline bese uwaxuba ne-applesauce noma i-pudding. Kodwa-ke, ungalumi noma uqhekeze amaphilisi ngaphandle uma udokotela wakho ekutshela ngokuqondile ukuthi kulungile ukwenza kanjalo.

Qhubeka nokuthatha yonke eminye imithi yakho ye-Parkinson njengoba kunqunyiwe. I-Istradefylline yenzelwe ukusebenza kanye nokwelashwa kwakho kwamanje, hhayi ukukufaka esikhundleni.

Kufanele Ngiyithathe Isikhathi Esingakanani I-Istradefylline?

I-Istradefylline ngokuvamile iyindlela yokwelapha yesikhathi eside ozoqhubeka uyithatha uma nje isiza ukuphatha izimpawu zakho ze-Parkinson. Abantu abaningi abazuza kulo muthi badinga ukuwuthatha unomphela ukuze bagcine ngcono.

Ungase uqale ukuqaphela ezinye izinzuzo emasontweni ambalwa okuqala, kodwa kungathatha kufika kumaviki angu-12 ukuzwa imiphumela ephelele. Lokhu kuthuthuka kancane kancane kuvamile futhi akusho ukuthi umuthi awusebenzi.

Udokotela wakho uzohlola njalo ukuthi umuthi usebenza kahle kangakanani kuwe futhi angase alungise uhlelo lwakho lokwelapha ngokuhamba kwesikhathi. Ungayeki ukuthatha i-istradefylline ngokuzumayo ngaphandle kokuxoxa ngayo nomhlinzeki wakho wezempilo kuqala, ngoba lokhu kungabangela ukuthi iziqephu zakho zibuye noma zibe zimbi.

Yiziphi Imiphumela Eceleni ye-Istradefylline?

Njengayo yonke imithi, i-istradefylline ingabangela imiphumela emibi, nakuba kungewona wonke umuntu oyitholayo. Ukuqonda okukulindele kungakusiza ukuthi uzizwe ulungiseleleke kakhulu futhi wazi ukuthi ungaxhumana nini nodokotela wakho.

Imiphumela emibi evame kakhulu ivamise ukuba mnene futhi ivame ukuthuthuka njengoba umzimba wakho ujwayela umuthi:

• Isicanucanu noma isisu esibuhlungu
• Isiyezi noma ukukhathala
• Ubunzima bokulala noma izinguquko emaphethini okulala
• Ukuqunjelwa
• Ukucabanga (ukubona noma ukuzwa izinto ezingekho)

Le miphumela emibi ivamise ukungabonakali ngemva kwamasonto ambalwa okwelashwa. Ukuthatha umuthi nokudla kungasiza ukunciphisa isicanucanu, futhi ukuhlala unamanzi kungasiza ngokuqunjelwa.

Abanye abantu bangase babe nemiphumela emibi kakhulu edinga ukunakekelwa kwezempilo. Nakuba lokhu kungavamile, kubalulekile ukwazi ukuthi yini okufanele uyibheke:

• Ukufisa okungavamile noma ukuziphatha (njengokugembula ngokweqile, ukuthenga, noma ukudla)
• Ushintsho olukhulu lwemizwa noma ukucindezeleka
• Ukwanda okukhulu kokunyakaza okungazithandeli
• Ubuhlungu besifuba noma ukushaya kwenhliziyo okungajwayelekile
• Isiyezi esikhulu noma ukuquleka

Uma uhlangabezana nanoma yimaphi alawa maphuzu abucayi, xhumana nodokotela wakho ngokushesha. Bangakwazi ukusiza ekutholeni ukuthi ngabe umuthi udinga ukulungiswa noma ngabe udinga ukusekelwa okwengeziwe.

Ubani Ongafanele Athathe Istradefylline?

Istradefylline ayifanele wonke umuntu, futhi izimo ezithile zempilo noma imithi kungayenza ingaphephile. Udokotela wakho uzobukeza ngokucophelela umlando wakho wezokwelapha ngaphambi kokukuyalela lo muthi.

Akufanele uthathe i-istradefylline uma unokungezwani nayo noma nganoma yiziphi izithako zayo. Xhumana nodokotela wakho mayelana nanoma yiziphi izimo zokungezwani komzimba ngaphambilini emithini, noma ngabe zibonakala zingahlobene.

Abantu abanezimo ezithile zempilo bangase badinge ukuqashwa okukhethekile noma bangase bangakwazi ukuthatha lo muthi ngokuphepha:

• Isifo esibi sezinso
• Isifo esibi sesibindi
• Umlando wezinkinga zokushaya kwenhliziyo
• I-psychosis esebenzayo noma izimo ezinzima zempilo yengqondo
• Ukukhulelwa noma ukuncelisa

Eminye imithi ingase ihlangane ne-istradefylline, okungenzeka ukuthi iyenze ingasebenzi kahle noma yandise imiphumela emibi. Qiniseka ukuthi utshela udokotela wakho ngayo yonke imithi oyithathayo, okuhlanganisa nemithi etholakala ngaphandle kwe-oda kanye nezithasiselo.

Igama Lomkhiqizo we-Istradefylline

I-Istradefylline ithengiswa ngaphansi kwegama lomkhiqizo elithi Nourianz e-United States. Le yindlela ejwayelekile ozoyibona ngayo iyalelwe futhi ihanjiswa emakhemisi.

Uma ukhuluma nodokotela wakho noma usokhemisi, ungasebenzisa igama elivamile (istradefylline) noma igama lomkhiqizo (Nourianz). Bazoqonda kahle ukuthi yimuphi umuthi okhuluma ngawo.

Njengamanje, i-Nourianz iyona kuphela inguqulo yomkhiqizo etholakala e-U.S., nakuba izinguqulo ezivamile zingase zitholakale esikhathini esizayo njengoba amalungelo obunikazi ephelelwa yisikhathi.

Ezinye Izindlela Zokwelapha Nge-Istradefylline

Uma i-istradefylline ingakulungele, kukhona eminye imithi engasiza ekuphatheni izigameko zokungasebenzi kahle ezigulini ze-Parkinson. Udokotela wakho angaxoxa ngalezi zinketho ngokusekelwe esimweni sakho esithile.

Eminye imithi esebenza ngendlela efanayo ukunciphisa isikhathi sokungasebenzi kahle ihlanganisa:

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• Safinamide (Xadago) - omunye umuthi owengeziwe
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• Rasagiline (Azilect) - i-MAO-B inhibitor
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• Selegiline (Eldepryl) - enye i-MAO-B inhibitor
\n
• Entacapone (Comtan) - i-COMT inhibitor
\n

Udokotela wakho angase futhi acabangele ukulungisa isimiso sakho samanje sokulinganisa i-levodopa/carbidopa noma ashintshele kwenye ifomula ngaphambi kokwengeza umuthi omusha. Ukukhetha okungcono kuncike ezimpawini zakho ezithile, ezinye izimo zempilo, nokuthi usabele kanjani ekwelashweni kwangaphambilini.

Ingabe i-Istradefylline Ingcono Kune-Rasagiline?

Kokubili i-istradefylline ne-rasagiline kungasiza ekunciphiseni izigameko zokungasebenzi kahle ezigulini ze-Parkinson, kodwa zisebenza ngezindlela ezihlukene ebuchosheni bakho. Akukho impendulo elula mayelana nokuthi iyiphi

Abantu abanezifo zenhliziyo bangavame ukuthatha i-istradefylline ngokuphepha, kodwa bangase badinge ukuqashwa eduze. Umuthi ungase ngezinye izikhathi uthinte ukushaya kwenhliziyo, ngakho udokotela wakho uzofuna ukubuyekeza impilo yenhliziyo yakho ngokucophelela ngaphambi kokuqala ukwelashwa.

Uma unomlando wezinkinga zenhliziyo, udokotela wakho angase ayale i-EKG (ukuhlolwa kokushaya kwenhliziyo) ngaphambi kokuthi uqale ukuthatha i-istradefylline futhi mhlawumbe ngesikhathi sokwelashwa. Lokhu kusiza ukuqinisekisa ukuthi umuthi awuthinti ukushaya kwenhliziyo yakho.

Ungavumeli izinkinga zenhliziyo zikuvimbele ukuthi uxoxe ngale ndlela yokwelapha nodokotela wakho. Abantu abaningi abanezimo zenhliziyo bathatha i-istradefylline ngempumelelo ngokuqashwa okufanele.

Q2. Kufanele Ngenzeni Uma Ngithatha I-Istradefylline Engaphezu Kwemithi Ngengozi?

Uma ngengozi uthatha i-istradefylline eningi kunaleyo ebekiwe, xhumana nodokotela wakho noma isikhungo sokulawula ubuthi ngokushesha. Ukuthatha okuningi kungakhuphula ingozi yakho yemiphumela emibi efana nesicanucanu, isiyezi, noma izinguquko ekushayeni kwenhliziyo.

Ungazami ukuthi "ulinganise" umthamo owengeziwe ngokuqaqa olandelayo. Kunalokho, landela isiqondiso esivela kumhlinzeki wakho wezempilo noma ukulawula ubuthi mayelana nokuthi yini okufanele uyenze ngokulandelayo.

Ukuvimbela ukweqisa ngengozi, cabanga ukusebenzisa umhleli wamaphilisi noma ukusetha izikhumbuzi zocingo ukukusiza ukuthi ulandelele ukuthi uthathe nini imithi yakho.

Q3. Kufanele Ngenzeni Uma Ngiphuthelwa Umthamo We-Istradefylline?

Uma uphuthelwa umthamo we-istradefylline, yithathe ngokushesha lapho ukhumbula, ngaphandle kokuthi sekuseduze isikhathi somthamo wakho olandelayo ohleliwe. Kulokho, weqa umthamo ophuthelwe futhi uqhubeke neshejuli yakho ejwayelekile.

Ungalokothi uthathe imithamo emibili ngesikhathi esisodwa ukuze ulungise umthamo ophuthelwe. Lokhu kungakhuphula ingozi yakho yemiphumela emibi ngaphandle kokuhlinzeka ngezinzuzo ezengeziwe.

Uma uvame ukukhohlwa imithamo, khuluma nodokotela wakho ngamasu okukusiza ukuthi ukhumbule, njengokuyithatha ngesikhathi esifanayo nomunye umuthi wansuku zonke noma ukusetha i-alamu yocingo.

Q4. Ngingayeka Nini Ukuthatha I-Istradefylline?

Kufanele uyeke kuphela ukuthatha i-istradefylline ngaphansi kokuqondisa kukadokotela wakho. Njengoba yenzelwe ukusiza ukuphatha izimpawu ze-Parkinson eziqhubekayo, ukuyeka cishe kuzobangela ukuthi iziqephu zakho zibuye.

Udokotela wakho angase ancome ukuyeka umuthi uma uhlangabezana nemiphumela emibi ebalulekile edlula izinzuzo, noma uma isifo sakho i-Parkinson siqhubeke safinyelela lapho ezinye izindlela zokwelapha zingaba zifaneleka kakhulu.

Uma wena nodokotela wakho ninquma ukuyeka i-istradefylline, ngokuvamile uzoyeka kancane kancane kunokuyeka kungazelelwe. Lokhu kusiza ukuvimbela noma yikuphi ukwanda okubuyayo kwezimpawu zakho.

Q5. Ngingakwazi yini ukuphuza utshwala ngenkathi ngithatha i-Istradefylline?

Ngokuvamile kungcono ukukhawulela utshwala ngenkathi uthatha i-istradefylline. Utshwala bungandisa ingozi yokugajwa futhi bungase luphazamise ukuthi umuthi usebenza kahle kangakanani.

Uma ukhetha ukuphuza ngezikhathi ezithile, kwenze ngokulinganisela futhi unake indlela ozizwa ngayo. Abanye abantu bathola ukuthi ngisho namanani amancane otshwala abenza bazizwe bengaqinile noma begajwa uma behlanganiswe nalo muthi.

Xoxa nodokotela wakho ngemikhuba yakho yokusebenzisa utshwala ukuze bakwazi ukukunikeza isiqondiso esiqondene nawe esisekelwe empilweni yakho yonke neminye imithi oyithathayo.