Yini i-Lanadelumab: Ukusetshenziswa, Umthamo, Imiphumela Eceleni Nokunye

I-Lanadelumab iyimithi kadokotela eyenzelwe ngqo ukuvimbela ukuhlaselwa kwe-hereditary angioedema (HAE), isimo esingavamile sezakhi zofuzo esibangela ukuvuvukala okungazelelwe ezingxenyeni ezihlukahlukene zomzimba wakho. Le mithi ejovwayo isebenza ngokuvimba iphrotheni ebizwa ngokuthi i-kallikrein, ebangela izigameko zokuvuvukala ezingaba buhlungu futhi eziyingozi.

Uma wena noma othile omthandayo etholiwe ukuthi une-HAE, cishe uzizwa ukhungathekile ngenkinga yokuphatha lesi simo. Izindaba ezinhle ukuthi i-lanadelumab imelela ukuqonda okukhulu ekwelashweni kwe-HAE, inikeza abantu abaningi ithuba lokuphila ngokuhlaselwa okuncane nokuthula okukhulu kwengqondo.

Yini i-Lanadelumab?

I-Lanadelumab iyimithi ye-monoclonal antibody eyisigaba semithi ebizwa ngokuthi ama-kallikrein inhibitors. Cabanga ngayo njengokwelashwa okuhloswe ngakho okusebenza njengomqaphi wokuphepha okhethekile emzimbeni wakho, obheka ngqo futhi uvimbele iphrotheni ebangela ukuhlaselwa kwe-HAE.

Le mithi iza njengoketshezi olucacile olujova ngaphansi kwesikhumba sakho (subcutaneously) usebenzisa i-syringe egcwaliswe ngaphambilini. Lo muthi waziwa nangegama lomkhiqizo i-Takhzyro, futhi ukhiqizwa kusetshenziswa i-biotechnology ethuthukisiwe ukudala ukwelashwa okucacile kwe-HAE.

Okuhlukanisa i-lanadelumab ukunemba kwayo. Esikhundleni sokucindezela ngokuphana amasosha akho omzimba njengeminye imithi, iqondisa kuphela indlela ethile ebangela ukuhlaselwa kwe-HAE, ishiya okunye ukusebenza kwamasosha akho omzimba kungashintshiwe.

Isetshenziselwani i-Lanadelumab?

I-Lanadelumab i-FDA-igunyazwe ngokuqondile ukuvimbela ukuhlaselwa kwe-hereditary angioedema kubantu abadala nasebancane abaneminyaka engu-12 nangaphezulu. I-HAE yisimo sezakhi zofuzo lapho umzimba wakho ungayilawuli kahle iphrotheni ebizwa ngokuthi i-C1 esterase inhibitor, okuholela ezigamekweni zokuvuvukala okukhulu.

Ngesikhathi sokuhlasela kwe-HAE, ungase uzwe ukuvuvukala okungazelelwe ebusweni bakho, ezindebeni, olwimini, emqaleni, ezandleni, ezinyaweni, noma ezingxenyeni zakho zangasese. Lezi zigameko zingaba ezingaqagelwayo futhi zihluke ngokuqina. Okunye ukuhlasela kungase kubangele ukungakhululeki okuncane, kanti okunye kungaba yingozi ekuphileni uma kuhilela umoya wakho.

Umuthi wenzelwe ukuvimbela isikhathi eside, hhayi ukwelapha ukuhlasela okwenzeka kakade. Uma uhlaselwa yi-HAE olukhulu, uzodinga imithi ehlukene ephuthumayo esebenza ngokushesha ukumisa ukuvuvukala.

Udokotela wakho angase ancome i-lanadelumab uma uhlaselwa njalo yi-HAE ethinta kakhulu izinga lempilo yakho, umsebenzi, noma imisebenzi yansuku zonke. Umgomo ukunciphisa kokubili imvamisa nokuqina kwalezi zigameko.

Isebenza Kanjani I-Lanadelumab?

I-Lanadelumab isebenza ngokuvimba i-plasma kallikrein, iphrotheni edlala indima ebalulekile ochungechungeni lwezenzakalo eziholela ekuhlaselweni kwe-HAE. Lapho le phrotheni isebenza, iqala ukukhiqizwa kwe-bradykinin, into ebangela ukuthi imithambo yegazi ibe yizimbotshana futhi iholele ekuvuvukeni okuyisici se-HAE.

Ngokuvimbela i-kallikrein, i-lanadelumab empeleni imisa lokhu kusabela ngaphambi kokuthi kubangele izimpawu. Umuthi ubopha ku-kallikrein futhi uyivimbela ekwenzeni umsebenzi wayo, okunciphisa kakhulu amathuba okuthi ukuhlasela kwenzeke.

Lokhu kuthathwa njengomuthi onamandla futhi oqondiswe kakhulu. Ngokungafani nokunye ukwelashwa okuthinta kabanzi amasosha akho omzimba, i-lanadelumab yenzelwe ukuthi ibe ngqo kakhulu esenzweni sayo, okusho ukuthi imiphumela emincane engemihle nokuxhumana nezinye izinhlelo zomzimba.

Imiphumela ye-lanadelumab yakheka ngokuhamba kwesikhathi, yingakho kubalulekile ukuyithatha njalo njengoba kunqunyiwe. Abantu abaningi baqala ukuqaphela ukwehla kwemvamisa yokuhlasela ezinyangeni ezimbalwa zokuqala zokwelashwa.

Kufanele Ngiyithathe Kanjani I-Lanadelumab?

I-Lanadelumab inikezwa njengomjovo ongaphansi kwesikhumba, okusho ukuthi uyikhipha esicutshini esinamanzi ngaphansi kwesikhumba sakho. Umthamo ojwayelekile ungama-300 mg njalo emavikini amabili, nakuba udokotela wakho angase alungise lokhu ngokuya ngokuthi usabela kahle kangakanani ekwelashweni.

Ungakwazi ukujova i-lanadelumab ethangeni lakho, engalweni engenhla, noma esiswini. Kubalulekile ukushintshanisa izindawo zokujova ukuvimbela ukucasuka kwesikhumba noma ukuthuthukiswa kwamaqhubu aqinile ngaphansi kwesikhumba. Umhlinzeki wakho wezempilo uzokufundisa wena noma ilungu lomndeni ukuthi ungalinikeza kanjani le mithi ngokuphepha ekhaya.

Ngaphambi kokujova, khipha imithi esiqandisini bese uyiyeka ifinyelele izinga lokushisa legumbi imizuzu engaba ngu-15-20. Imithi ebandayo ingase ingakhululeki kakhulu ukuyijova. Njalo hlola ukuthi uketshezi lucacile futhi alinawo umbala ngaphambi kokulusebenzisa.

Ungathatha i-lanadelumab ngaphandle kokudla noma ngaphandle kokudla, njengoba ijovwa kunokuba ithathwe ngomlomo. Nokho, kuyasiza ukusungula isimiso, njengokuyijova ngezinsuku ezifanayo zeviki, ukukusiza ukuthi ukhumbule imithamo yakho.

Kufanele Ngiyithathe Isikhathi Esingakanani I-Lanadelumab?

I-Lanadelumab ngokuvamile ihloselwe ukusetshenziswa isikhathi eside, njengoba i-HAE iyisimo esingamahlalakhona esidinga ukuphathwa okuqhubekayo. Abantu abaningi baqhubeka nokuthatha le mithi unomphela ukuze bagcine ukuvikeleka ekuhlaselweni.

Udokotela wakho uzoqapha ukusabela kwakho ekwelashweni ezinyangeni ezimbalwa zokuqala futhi angase alungise isimiso sokulinganisa ngokusekelwe ekutheni wenza kahle kangakanani. Abanye abantu abalawula kahle kakhulu izimpawu zabo bangase bakwazi ekugcineni ukuhlukanisa imijovo yabo kube njalo emavikini amane esikhundleni samaviki amabili.

Kubalulekile ukuthi ungayeki ukuthatha i-lanadelumab ngokuzumayo ngaphandle kokukhuluma nodokotela wakho kuqala. Njengoba imithi isebenza ngokugcina amazinga aqinile ohlelweni lwakho, ukuyeka kungazelelwe kungaholela ekubuyeni kokuhlaselwa kwe-HAE.

Umhlinzeki wakho wokunakekelwa kwezempilo uzobuyekeza njalo uhlelo lwakho lokwelashwa futhi ahlolisise ukuthi i-lanadelumab iyaqhubeka yini iyindlela engcono kakhulu kuwe. Bazocabangela izinto ezinjengobuningi bokuhlaselwa, imiphumela emibi, kanye nekhwalithi yakho yempilo iyonke.

Yini Imiphumela Eceleni Ye-Lanadelumab?

Njengayo yonke imithi, i-lanadelumab ingabangela imiphumela emibi, nakuba abantu abaningi beyibekezelela kahle. Imiphumela emibi evame kakhulu ivame ukuba milde futhi yenzeka endaweni yokujova.

Nawa amanye emiphumela emibi ebikwa kaningi ongase uyithole:

• Ukuphendula endaweni yokujova okuhlanganisa ububomvu, ukuvuvukala, ukulimala, noma ubuhlungu
• Izifo eziphezulu zokuphefumula njengomkhuhlane
• Ukucabanga
• Isiyezi
• Ukuqubuka noma ukucasuka kwesikhumba

Le miphumela emibi evamile ivame ukuthuthuka yodwa futhi ayidingi ukuyeka umuthi. Indlela efanele yokujova nokujikeleza kwendawo kungasiza ekunciphiseni ukusabela endaweni yokujova.

Kukhona neminye imiphumela emibi engavamile kodwa ebucayi edinga ukunakekelwa kwezempilo ngokushesha. Nakuba lokhu kungavamile, kubalulekile ukukwazi:

• Ukuphendula okukhulu komzimba okuhlanganisa ubunzima bokuphefumula, ukuvuvukala kobuso noma umphimbo, noma ukuqubuka okusabalale kakhulu
• Izimpawu zokutheleleka okukhulu njengomkhuhlane, amaqhwa, noma izimpawu eziqhubekayo ezinjengomkhuhlane
• Ukuphuma kwegazi okungavamile noma ukulimala
• Ukucabanga okukhulu noma okuqhubekayo

Abantu abaningi bathola ukuthi noma yimiphi imiphumela emibi abayitholayo iyalawuleka futhi ayiphazamisi kangako kunokuhlaselwa kwe-HAE ababenakho ngaphambi kokwelashwa.

Ubani Ongafanele Athatha I-Lanadelumab?

I-Lanadelumab ayifanele wonke umuntu, futhi zikhona izimo ezithile lapho udokotela wakho angase ancome indlela yokwelashwa ehlukile. Ukuphikisana okubaluleke kakhulu ukuthi uma uke waba nokusabela okukhulu komzimba ku-lanadelumab noma yiziphi izithako zayo esikhathini esidlule.

Udktora wakho uzohlola ngokucophelela ukuthi i-lanadelumab ikufanele yini uma unesinye salezi zimo:

• Izifo eziqhubekayo ezingathi sína
• Isifo sesibindi noma sezinso esibi kakhulu
• Umlando wokungezwani komzimba okukhulu kweminye imithi ye-monoclonal antibody
• Ukukhulelwa noma izinhlelo zokukhulelwa
• Ukuncelisa

Ukucatshangelwa okukhethekile kuyadingeka futhi kubantu abanezimo ze-autoimmune, njengoba i-lanadelumab ithinta ukusebenza komzimba wokuzivikela. Udktora wakho uzoqaphela izinzuzo ezingaba khona ezingozini ezikhona kulezi zimo.

Ubudala obunye futhi yisici esibalulekile. I-Lanadelumab ivunyelwe kuphela kubantu abaneminyaka engu-12 nangaphezulu, njengoba kungekho mininingwane eyanele yokuphepha nokusebenza kwabantwana abancane.

Igama Lomkhiqizo we-Lanadelumab

I-Lanadelumab ithengiswa ngaphansi kwegama lomkhiqizo elithi Takhzyro. Leli igama ozolibona kulebula kadokotela kanye nokupakishwa uma uthatha imithi yakho ekhemisi.

I-Takhzyro yenziwa yi-Takeda Pharmaceuticals futhi yaqala ukugunyazwa yi-FDA ngonyaka ka-2018. Umuthi uza ngamasirinji agcwaliswe ngaphambilini aqukethe i-150 mg ye-lanadelumab ku-1 mL yesixazululo.

Njengamanje, azikho izinhlobo ezivamile ze-lanadelumab ezitholakalayo, njengoba umuthi usavikelwe ngamalungelo obunikazi. Lokhu kusho ukuthi i-Takhzyro yiyona kuphela inguqulo yegama lomkhiqizo ongayithola.

Ezinye izindlela ze-Lanadelumab

Ngenkathi i-lanadelumab isebenza kahle kakhulu kubantu abaningi abane-HAE, akuyona yona kuphela inketho yokwelashwa etholakalayo. Udktora wakho angase acabangele ezinye izindlela uma i-lanadelumab ingasebenzi kahle kuwe noma uma uhlangabezana nemiphumela engemihle engabekezeleleki.

Eminye imithi yokuvimbela i-HAE ihlanganisa:

• I-Berotralstat (Orladeyo) - umuthi omlomo othathwa nsuku zonke
• I-C1 esterase inhibitor concentrates enikezwa nge-IV infusion
• I-Danazol - umuthi omlomo osetshenziswe amashumi eminyaka
• I-Tranexamic acid - umuthi omlomo ongasiza abanye abantu

Ngamunye walokhu okuhlukile unenzuzo kanye nokubi okuhlukene. Ngokwesibonelo, i-berotralstat inikeza lula lokuthatha umuthi ngomlomo nsuku zonke, kanti ama-C1 esterase inhibitor concentrates athatha indawo yeprotheni engashodi ku-HAE.

Udokotela wakho uzokusiza ukuthi uhlole izinto ezifana nokusebenza kahle, imiphumela emibi, ukulula, kanye nezindleko lapho ekhetha ukwelashwa okungcono kakhulu esimweni sakho esithile.

Ingabe i-Lanadelumab Ingcono Kune-Berotralstat?

Kokubili i-lanadelumab kanye ne-berotralstat kuyindlela yokwelapha yesimanje esebenzayo yokuvimbela i-HAE, kodwa zisebenza ngezindlela ezihlukene futhi zinezinto ezihlukene eziwusizo. Ukukhetha okungcono kuncike ezidingweni zakho, okuthandayo, kanye nesimo sezokwelapha.

I-Lanadelumab inikezwa njengomjovo njalo emavikini amabili, kanti i-berotralstat ithathwa njenge-capsule yomlomo yansuku zonke. Abanye abantu bakhetha ukulula kokungadingeki ukukhumbula imithi yansuku zonke, kanti abanye bakhetha ukugwema imijovo.

Ngokuqondene nokusebenza kahle, yomibili imithi inciphisa kakhulu amazinga okuhlaselwa yi-HAE kubantu abaningi. Izifundo zomtholampilo zibonisa ukuthi i-lanadelumab inciphisa amazinga okuhlaselwa ngamaphesenti angama-87% ngokwesilinganiso, kanti i-berotralstat iyawanciphisa ngamaphesenti angama-44%. Kodwa-ke, izimpendulo zomuntu ngamunye zingahluka kakhulu.

Amaphrofayili emiphumela emibi nawo ahlukile phakathi kwemithi emibili. Imiphumela emibi eyinhloko ye-Lanadelumab yizindawo zokujova, kanti i-berotralstat ingabangela izimpawu zamathumbu njengokucasuka kwesisu nobuhlungu besisu kwabanye abantu.

Udokotela wakho uzocabangela imvamisa yakho yokuhlaselwa, indlela yokuphila, eminye imithi oyithathayo, kanye nezintandokazi zakho lapho ekusiza ukuthi ukhethe phakathi kwalezi zinketho.

Imibuzo Evame Ukubuzwa Mayelana ne-Lanadelumab

Q1. Ingabe i-Lanadelumab Iphephile Kubantu Abanezifo Zenhliziyo?

I-Lanadelumab ngokuvamile ithathwa njengephephile kubantu abanezifo zenhliziyo, njengoba ingayithinti ngokuqondile ukusebenza kwenhliziyo nemithambo yegazi. Kodwa-ke, udokotela wakho uzofuna ukukuqapha ngokucophelela uma unezinkinga ezinkulu zenhliziyo.

Umuthi ngokuvamile awubangeli izinguquko emfutheni wegazi noma esigqi senhliziyo. Njengoba ujovwa ngaphansi kwesikhumba kunokuba uthathwe ngomlomo, awusebenzisani nemithi eminingi yenhliziyo ngendlela imithi yomlomo engase yenze ngayo.

Uma unesifo senhliziyo, qiniseka ukuthi utshela udokotela wakho ngayo yonke imithi yakho yenhliziyo ngaphambi kokuqala i-lanadelumab. Bangase bafune ukwenza ezinye izivivinyo zokuqala futhi bakuqaphele eduze ekuqaleni.

Q2. Kufanele Ngenzeni Uma Ngiphuthelwa Ukusebenzisa I-Lanadelumab Eningi Kakhulu?

Uma ngengozi ujova i-lanadelumab eningi kunaleyo ebekiwe, ungangeni ekuqeqeshweni. Xhumana nodokotela wakho noma umhlinzeki wezempilo ngokushesha ukuze ubazise ngalokho okwenzekile futhi uthole isiqondiso esiqondile sesimo sakho.

Ezimweni eziningi, ukweqisa okukodwa kwe-lanadelumab akunakwenzeka ukuthi kubangele izinkinga ezinkulu ngokushesha, kodwa kufanele usafune usizo lwezokwelapha. Udokotela wakho angase afune ukukuqapha eduze noma alungise umthamo wakho olandelayo ohleliwe.

Gcina ukupakishwa komuthi nanoma yimaphi ama-syringe asele ukuze ukwazi ukutshela umhlinzeki wakho wezempilo ukuthi ungakanani umuthi owengeziwe owawuthatha. Lolu lwazi luzobasiza ukuthi bakunikeze iseluleko esingcono kakhulu.

Q3. Kufanele Ngenzeni Uma Ngiphuthelwa Umthamo We-Lanadelumab?

Uma uphuthelwa umthamo we-lanadelumab, yithathe ngokushesha lapho ukhumbula, bese uqhubeka nohlelo lwakho olujwayelekile lokulinganisa. Ungathathi umthamo ophindwe kabili ukuze ulungise lowo ophuthelwe.

Uma sekuseduze isikhathi somthamo wakho olandelayo ohleliwe, weqa umthamo ophuthelwe bese uqhubeka nohlelo lwakho olujwayelekile. Ukuthatha imithamo eseduze kakhulu kungakhuphula ingozi yakho yemiphumela engemihle ngaphandle kokuhlinzeka ngezinzuzo ezengeziwe.

Ukuphuthelwa umthamo owodwa ngezikhathi ezithile ngokuvamile ngeke kubangele izinkinga ngokushesha, kodwa zama ukugcina uhlelo lwakho olujwayelekile ngangokunokwenzeka ukuze uthole ukuvikelwa okungcono kakhulu ekuhlaselweni kwe-HAE.

Q4. Ngingayeka Nini Ukuthatha I-Lanadelumab?

Kufanele uyeke ukuthatha i-lanadelumab ngaphansi kokuqondisa kukadokotela wakho. Njengoba i-HAE iyisimo sezakhi zofuzo esihlala impilo yonke, abantu abaningi badinga ukuqhubeka nokwelashwa okuvikelayo unomphela ukuze baqhubeke nokuvikeleka ekuhlaselweni.

Udokotela wakho angase acabange ukuyeka noma ukuhlukanisa imithamo uma ubulawule kahle izimpawu zakho isikhathi eside. Kodwa-ke, lesi sinqumo kufanele sithathwe ngokucophelela ngokuqapha eduze.

Uma ufuna ukuyeka ukwelashwa nganoma yisiphi isizathu, xoxa ngalokhu nomhlinzeki wakho wezempilo kuqala. Bangakusiza ukuthi ulinganise izingozi nezinzuzo futhi mhlawumbe baphakamise ezinye izindlela zokwelapha uma kudingeka.

Q5. Ngingahamba ne-Lanadelumab?

Yebo, ungahamba ne-lanadelumab, kodwa kudinga ukuhlela okuthile ngoba umuthi udinga ukugcinwa efrijini. Hlala uphethe umuthi wakho emthwalweni wakho wokuqala uma undiza, ungalokothi uwufake emthwalweni ohloliwe.

Thola incwadi evela kudokotela wakho echaza ukuthi udinga ukuthwala umuthi ojovwayo ngenxa yesimo sezokwelapha. Lokhu kungasiza ngezokuphepha zesikhumulo sezindiza kanye namasiko uma uhamba phesheya.

Sebenzisa i-cooler encane enama-ice pack ukuze ugcine umuthi ezingeni lokushisa elifanele ngesikhathi sokuhamba. Umuthi ungaba ezingeni lokushisa legumbi isikhathi esifushane, kodwa akufanele uveze ukushisa okukhulu noma amazinga okushisa aqandayo.