Yini i-Lapatinib: Ukusetshenziswa, Umthamo, Imiphumela Eceleni nokuningi

I-Lapatinib iyimithi yomdlavuza eqondiwe esiza ukunciphisa ukukhula kwezinhlobo ezithile zamaseli omdlavuza wamabele. Ingowomndeni wemithi ebizwa ngokuthi ama-tyrosine kinase inhibitors, asebenza ngokuvimba amaprotheni athile asiza amaseli omdlavuza ukuthi akhule futhi asakazeke emzimbeni wakho wonke.

Le mithi isetshenziswa ikakhulukazi ngokuhlanganyela nezinye izindlela zokwelapha umdlavuza ukusiza iziguli ezinomdlavuza wamabele oqhubukayo noma ometastatic. Ukuqonda ukuthi i-lapatinib isebenza kanjani nokuthi yini ongayilindela kungakusiza ukuthi uzizwe ulungiswe kangcono futhi uqiniseke ngohambo lwakho lokwelashwa.

Yini i-Lapatinib?

I-Lapatinib iyimithi yomdlavuza yomlomo eqondise ngqo amaseli omdlavuza anama-receptor amaprotheni athile. Isebenza ngokuvimba amaprotheni amabili abalulekile abizwa ngokuthi i-HER2 ne-EGFR asiza amaseli omdlavuza ukuthi akhule futhi aphindaphindeke.

Le ndlela eqondiwe isho ukuthi i-lapatinib igxila ekumeni amaseli omdlavuza ngenkathi ngokuvamile ibangela ukulimala okuncane kumaseli anempilo uma kuqhathaniswa ne-chemotherapy yendabuko. Imithi iza ngesimo samaphilisi, okwenza kube lula ukuyithatha ekhaya njengengxenye yomsebenzi wakho wansuku zonke.

Udokotela wakho uzonquma ukuthi i-lapatinib ilungele yini wena ngokusekelwe ezintweni ezithile zamaseli akho omdlavuza. Le ndlela yomuntu ngamunye isiza ukuqinisekisa ukuthi uthola ukwelashwa okuphumelela kakhulu esimweni sakho esithile.

Isetshenziselwani i-Lapatinib?

I-Lapatinib isetshenziswa ikakhulukazi ukwelapha umdlavuza wamabele oqhubukayo noma ometastatic onama-marker amaprotheni athile abizwa ngokuthi i-HER2-positive. Ngokuvamile kubhalwa lapho umdlavuza usakazekela ezinye izingxenye zomzimba wakho noma lapho ezinye izindlela zokwelapha zingasebenzi.

Imithi ivame ukuhlanganiswa neminye imithi yomdlavuza efana ne-capecitabine noma i-letrozole ukuze kwakhiwe indlela yokwelapha ebanzi kakhulu. Le ndlela yokwelapha ehlanganisiwe ingasiza ukunciphisa ukuqhubeka komdlavuza futhi ingasiza ukunciphisa izimila kwezinye iziguli.

Udaktela wakho we-oncologist angase ancome i-lapatinib uma ngabe uke wathola ukwelashwa nge-trastuzumab (Herceptin) kanye ne-anthracycline-based chemotherapy. Lokhu kwenza i-lapatinib ibe yindlela ebalulekile ezigulini ezidinga ezinye izindlela zokwelashwa.

Isebenza Kanjani I-Lapatinib?

I-Lapatinib isebenza ngokuvimba amaprotheni amabili athile kumaseli omdlavuza abizwa ngokuthi ama-HER2 kanye nama-EGFR receptors. Lawa maprotheni ngokuvamile athumela amasignali atshela amaseli omdlavuza ukuthi akhule futhi ahlukaniswe ngokushesha.

Ngokuvimba lawa masignali, i-lapatinib empeleni ibeka amabhuleki ekukhuleni kwamaseli omdlavuza. Cabanga ngayo njengokunqamula imigqa yokuxhumana amaseli omdlavuza ayisebenzisela ukuxhumanisa ukukhula kwawo nokusabalala emzimbeni wakho wonke.

Lo muthi ubhekwa njengokwelashwa komdlavuza okuqinile okulinganiselwe okuvame ukuba mnene kune-chemotherapy yendabuko. Ngenkathi isebenza ekuhloseni amaseli omdlavuza, ngokuvamile ibangela imiphumela emibi embalwa kuneminye imithi yomdlavuza.

Kufanele Ngiyithathe Kanjani I-Lapatinib?

Thatha i-lapatinib ngendlela udokotela wakho ayichazayo, ngokuvamile kanye ngosuku ngesikhathi esifanayo nsuku zonke. Umthamo ojwayelekile ngamaphilisi amahlanu (1,250 mg isiyonke) athathwa ndawonye, ​​noma kunjalo udokotela wakho angase alungise lokhu ngokuya ngezidingo zakho ezithile.

Kufanele uthathe i-lapatinib esiswini esingenalutho, okungenani ihora elilodwa ngaphambi kokudla noma okungenani ihora elilodwa ngemuva kokudla. Lokhu kusiza umzimba wakho ukuthi umunce umuthi ngendlela efanele futhi kuqinisekisa ukuthi usebenza ngempumelelo ngangokunokwenzeka.

Gwinya amaphilisi wonke ngenkomishi yamanzi egcwele. Ungawachobozi, uwahlafune, noma uwaphule amaphilisi, ngoba lokhu kungathinta indlela umzimba wakho oqhubula ngayo umuthi. Uma unenkinga yokugwinya amaphilisi, khuluma nethimba lakho lezempilo ngamasu angase asize.

Zama ukuthatha umuthi wakho ngesikhathi esifanayo nsuku zonke ukuze usize ukugcina amazinga aqhubekayo egazini lakho. Iziguli eziningi zikuthola kuwusizo ukusetha isikhumbuzi sansuku zonke noma ukusihlanganisa nomkhuba wazo wasekuseni noma kusihlwa.

Kufanele Ngiyithathe Isikhathi Esingakanani I-Lapatinib?

Ubude bokwelashwa nge-lapatinib buhlukahluka kakhulu kumuntu nomuntu, kuye ngokuthi umdlavuza wakho usabela kahle kangakanani nokuthi ukumelana kahle kangakanani nomuthi. Ezinye iziguli zingawuthatha izinyanga eziningana, kanti ezinye zingaqhubeka unyaka noma ngaphezulu.

Udokotela wakho we-oncologist uzoqapha inqubekela phambili yakho ngokuhlolwa njalo, ukuhlolwa kwegazi, kanye nokuskena ngemifanekiso. Lokhu kuhlolwa kusiza ukunquma ukuthi umuthi usebenza ngempumelelo yini nokuthi ngabe uhlangabezana nemiphumela emibi ekhathazayo.

Ungayeki ukuthatha i-lapatinib ngokuzumayo ngaphandle kokuxoxa ngayo nodokotela wakho kuqala. Noma ngabe uzizwa kahle, ukuyeka kungazelelwe kungavumela amaseli omdlavuza ukuthi aqale ukukhula futhi. Ithimba lakho lezempilo lizokuqondisa kunoma yiziphi izinguquko ohlelweni lwakho lokwelashwa.

Yini Imiphumela Emibi ye-Lapatinib?

Njengayo yonke imithi yomdlavuza, i-lapatinib ingabangela imiphumela emibi, yize kungewona wonke umuntu oyitholayo. Imiphumela eminingi emibi ilawuleka ngokunakekelwa okufanele nokuxhumana nethimba lakho lezempilo.

Nansi imiphumela emibi evame kakhulu ongase uyithole ngenkathi uthatha i-lapatinib:

• Ukuqunjelwa (kuthinta iziguli eziningi kepha ngokuvamile kulawuleka)
• Ukuqubuka kwesikhumba noma isikhumba esomile ezandleni nasemilenzeni
• Ukukhathala noma ukuzizwa ukhathele kunokujwayelekile
• Ukucasuka kwesisu noma isisu esicasukile
• Ukulahlekelwa isifiso sokudla
• Izilonda zomlomo noma izinguquko ekunambithekeni

Le miphumela emibi ejwayelekile ivame ukuthuthuka njengoba umzimba wakho ujwayela umuthi. Ithimba lakho lezempilo lingahlinzeka ngamasu athile okusiza ukuphatha ngempumelelo ngasinye salezi zimpawu.

Ezinye iziguli zingahlangabezana nemiphumela emibi engathi sína edinga ukunakekelwa kwezempilo ngokushesha:

• Ukuqunjelwa okukhulu okungathuthuki ngemithi
• Izimpawu zezinkinga zesibindi (ukuphuzi kwesikhumba noma amehlo, umchamo omnyama)
• Izinkinga zenhliziyo (ukuphefumula okungavamile, ubuhlungu besifuba)
• Ukuphendula okukhulu kwesikhumba noma ukuqubuka okukhulu
• Izinkinga zamaphaphu (ukukhwehlela okuqhubekayo, ubunzima bokuphefumula)

Xhumana nethimba lakho lezempilo ngokushesha uma uhlangabezana nanoma yiziphi zalezi zimpawu ezingathi sína. Ukuxhumana okusheshayo kusiza ekuqinisekiseni ukuthi noma yiziphi izinkinga zixazululwa ngokushesha nangokuphepha.

Imiphumela emibi engavamile kodwa engathi sína

Ngenkathi kungavamile, ezinye iziguli zingase zibe nemiphumela emibi engavamile kodwa engase ibe yingozi edinga ukuqashwa ngokucophelela:

• Izinkinga zenhliziyo ezinzima ezihlanganisa ukwehla komsebenzi wenhliziyo
• Umonakalo omkhulu wesibindi ongase ube yingozi ekuphileni
• Ukuvuvukala okukhulu kwamaphaphu (i-pneumonitis)
• Ukuphendula okukhulu kwesikhumba okungaholela ekulalisweni esibhedlela
• Ukungalingani okukhulu kwama-electrolyte okuvela ekuqunjelweni isikhathi eside

Udokotela wakho uzokuqapha eduze ukuze abone lezi zinkinga ezingavamile ngokuhlolwa kwegazi okujwayelekile nokuhlolwa komsebenzi wenhliziyo. Ukutholwa kwasekuqaleni nokwelashwa kwalezi zinkinga kungazivimbela ukuthi zingabi zimbi kakhulu.

Ubani Ongafanele Athole I-Lapatinib?

I-Lapatinib ayifanele wonke umuntu, futhi udokotela wakho uzohlola ngokucophelela ukuthi iphephile yini kuwe. Izimo ezithile zezempilo noma izimo zingenza le mithi ibe yingozi kakhulu ukuyisebenzisa.

Akufanele uthathe i-lapatinib uma wazi ukuthi unokungezwani komzimba nemithi noma yiziphi izithako zayo. Ngaphezu kwalokho, uma unesifo sesibindi esibi noma izinkinga ezinkulu zenhliziyo, udokotela wakho angase ancome ezinye izindlela zokwelapha.

Abesifazane abakhulelwe noma abancelisa ngamabele akufanele bathathe i-lapatinib, njengoba ingalimaza izingane ezisakhula. Uma uneminyaka yokuzala, uzodinga ukusebenzisa izindlela zokuvimbela inzalo eziphumelelayo ngesikhathi sokwelashwa kanye nesikhathi esithile ngemva kokuyeka imithi.

Udktela wakho uzophinda aqaphele mayelana nokunika i-lapatinib uma unomlando wesifo senhliziyo, izinkinga zesibindi, noma isifo samaphaphu. Lezi zimo zidinga ukuqashwa ngokucophelela futhi zingathinta uhlelo lwakho lokwelashwa.

Amagama Omkhiqizo we-Lapatinib

Igama lomkhiqizo le-lapatinib lithi Tykerb e-United States nakwamanye amazwe amaningi. Ezinye izifunda zingalazi ngegama lomkhiqizo elithi Tyverb, nakuba zombili ziqukethe isithako esifanayo esisebenzayo.

Izinhlobo ze-lapatinib ezi-generic ziya zitholakala emazweni athile, okungase kunikeze ukonga izindleko ngenkathi kunikezwa izinzuzo ezifanayo zokwelapha. Ikhemisi lakho noma ithimba lokunakekelwa kwezempilo lingakusiza ukuthi uqonde ukuthi iyiphi inguqulo etholakalayo endaweni yakho.

Noma ngabe igama lomkhiqizo lithini, zonke izinhlobo ze-lapatinib ziqukethe umuthi ofanayo osebenzayo futhi zisebenza ngendlela efanayo. Udokotela wakho uzoqoka inguqulo efanele kakhulu futhi etholakalayo esimweni sakho.

Ezinye izindlela ze-Lapatinib

Imithi eminingi ehlukile iyatholakala yokwelapha umdlavuza webele we-HER2-positive, kuye ngesimo sakho esithile nomlando wokwelashwa. Lezi ezinye izindlela zisebenza ngezindlela ezihlukene kodwa zihlose ukufeza imigomo efanayo.

I-Trastuzumab (Herceptin) ivame ukusetshenziswa njengokwelashwa kokuqala komdlavuza webele we-HER2-positive. Ezinye izinketho zihlanganisa i-pertuzumab (Perjeta), i-T-DM1 (Kadcyla), nemithi emisha efana ne-tucatinib (Tukysa) noma i-neratinib (Nerlynx).

Udokotela wakho we-oncologist uzocabangela izinto ezinjengokwelashwa kwakho kwangaphambilini, isimo sakho samanje sempilo, nezici ezithile zomdlavuza lapho encoma ezinye izindlela. Umuthi ngamunye unezinzuzo zawo kanye nemiphumela engemihle engadingeka ukuthi ihlolwe ngokucophelela.

Ukukhethwa kokwelashwa kuhlukaniswa kakhulu, futhi okusebenzela umuntu oyedwa kungase kungabi yindlela ekahle komunye. Thembela eqenjini lakho lokunakekelwa kwezempilo ukuthi likuqondise ekukhetheni okufanele kakhulu esimweni sakho esiyingqayizivele.

Ingabe i-Lapatinib Ingcono Kune-Trastuzumab?

I-Lapatinib ne-trastuzumab zisebenza ngendlela ehlukile futhi zivame ukusetshenziswa ezigabeni ezihlukene zokwelashwa, okwenza ukuqhathanisa okuqondile kube yinselelo. Zombili ziyimithi esebenzayo yomdlavuza webele we-HER2-positive, kodwa ngalinye linobuhle obuyingqayizivele.

I-Trastuzumab ngokuvamile isetshenziswa njengokwelashwa komugqa wokuqala futhi inganikezwa nge-intravenously, kuyilapho i-lapatinib ivame ukugcinelwa ukwelashwa komugqa wokugcina futhi iza njengomuthi omlomo. I-Lapatinib ingase ibe usizo ikakhulu ezigulini ezinomdlavuza osabalale ebuchosheni, njengoba ingawela umgoqo wegazi-ubuchopho ngempumelelo.

Ezinye iziguli zingazuza ekutholeni yomibili imithi ngokulandelana noma ngokuhlanganiswa. Udokotela wakho we-oncologist uzoqoka indlela engcono kakhulu ngokusekelwe ezimweni zomdlavuza wakho, umlando wakho wokwelashwa, kanye nesimo sakho sempilo esiphelele.

Esikhundleni sokucabanga ngomunye njengoba

Uma ngabe uthathe i-lapatinib eningi ngengozi kunaleyo ebekwe ngudokotela, xhumana nomhlinzeki wakho wezempilo noma isikhungo sokulawula ubuthi ngokushesha. Ukuthatha okuningi kungakhuphula ingozi yakho yemiphumela emibi, ikakhulu izinkinga zenhliziyo nohudo olukhulu.

Ungalindi ukubona ukuthi uzizwa yini izimpawu ngaphambi kokufuna usizo. Noma ngabe uzizwa kahle ekuqaleni, ukweqisa umthamo kungabangela imiphumela elibazisekile edinga ukunakekelwa kwezempilo. Gcina ibhodlela lemithi nawe uma ushayela ucingo ukuze uthole usizo.

Ukuvimbela ukweqisa umthamo ngengozi, sebenzisa umhleli wamaphilisi noma setha izikhumbuzi ocingweni lwakho. Ungalokothi uphinde umthamo uma weqa owodwa, ngoba lokhu kungaholela ekuthathweni kwemithi eningi ngasikhathi sinye.

Kufanele Ngenzeni Uma Ngeqe Umthamo We-Lapatinib?

Uma weqa umthamo we-lapatinib, yithathe ngokushesha lapho ukhumbula, kodwa kuphela uma sekudlule amahora angaphansi kwama-12 kusukela ngesikhathi sakho somthamo esihleliwe. Uma sekudlule amahora angaphezu kwama-12, weqa umthamo owuqeqile bese uthatha umthamo wakho olandelayo ngesikhathi esijwayelekile.

Ungalokothi uthathe imithamo emibili ngasikhathi sinye ukuze ulungise umthamo owuqeqile, ngoba lokhu kungakhuphula ingozi yakho yemiphumela emibi. Kunalokho, qhubeka neshejuli yakho ejwayelekile yokulinganisa futhi wazise ithimba lakho lezempilo nganoma yimiphi imithamo eqeqiwe.

Cabangela ukusetha izikhumbuzi zansuku zonke ocingweni lwakho noma usebenzise umhleli wamaphilisi ukukusiza ukhumbule imithi yakho. Ukuqina ekuthathweni kwe-lapatinib kusiza ukugcina amazinga aqhubekayo egazini lakho ukuze kusebenze kahle.

Ngingayeka Nini Ukuthatha I-Lapatinib?

Kufanele uyeke kuphela ukuthatha i-lapatinib ngaphansi kokuqondisa kwe-oncologist yakho, noma ngabe uzizwa kahle noma unomuzwa wemiphumela emibi. Ukuyeka ngaphambi kwesikhathi kungavumela amaseli omdlavuza ukuthi aqale ukukhula futhi.

Udokotela wakho uzoqaphela ukuthi kungcono nini ukuyeka ngokusekelwe ekutheni imithi isebenza kahle kangakanani, imiphumela emibi oyitholayo, kanye nesimo sakho sempilo esiphelele. Lesi sinqumo sihlanganisa ukucatshangelwa ngokucophelela kwezinto eziningi ezithile esimweni sakho.

Uma imiphumela emibi iba nzima ukuyilawula, khuluma neqembu lakho lezempilo mayelana nokulungiswa kwemithamo okungenzeka noma izinyathelo zokunakekela ezisekelayo ngaphambi kokucabangela ukuyeka umuthi. Imiphumela eminingi emibi ingalawulwa ngempumelelo ngokunakekelwa okufanele.

Ngingakwazi Ukuphuza Utywala Ngenkathi Ngithatha I-Lapatinib?

Ngenkathi kungekho ukuvinjelwa okuqondile kotshwala nge-lapatinib, kuvamile ukunconywa ukuthi unciphise noma ugweme utshwala ngesikhathi sokwelashwa komdlavuza. Utshwala bungase buqhubekisele phambili eminye imiphumela emibi futhi bungase buphazamise ikhono lomzimba wakho lokucubungula umuthi.

Njengoba i-lapatinib ingathinta ukusebenza kwesibindi, ukwengeza utshwala kungabeka ingcindezi eyengeziwe esibindini sakho. Uma ukhetha ukuphuza ngezikhathi ezithile, xoxa ngalokhu neqembu lakho lezempilo ukuze uqonde ukuthi yini engase iphephe esimweni sakho esithile.

Gxila ekuhlaliseni kahle ngamanzi nezinye iziphuzo ezinempilo ngesikhathi sokwelashwa. Umzimba wakho udinga ukudla okunomsoco nokuhambisana kahle ukuze usize ukulawula imiphumela emibi yokwelashwa futhi usekele impilo yakho yonke.