Yini i-Lifitegrast: Ukusetshenziswa, Umthamo, Imiphumela Eceleni nokuningi

I-Lifitegrast iyisidakamizwa samehlo esinconywayo esisiza ukwelapha isifo samehlo esomile ngokunciphisa ukuvuvukala ebusweni bamehlo akho. Lesi sidakamizwa sisebenza ngendlela ehlukile emazinyweni okwenziwa ngokuthi siqondise enye yezimbangela eziyinhloko zamehlo omile kunokuthi nje sinikeze umswakama wesikhashana.

Uma ubhekene namehlo omile, acasukile angabonakali ukuthi angcono ngamaconsi angathengiswa ngaphandle kwemvume kadokotela, udokotela wakho wamehlo angase akuncomile i-lifitegrast njengenketho yokwelapha eqondiwe. Ake sihambe kukho konke okudingeka ukwazi ngalesi sidakamizwa ngamagama alula.

Yini i-Lifitegrast?

I-Lifitegrast iyisidakamizwa samehlo esilwa nokuvuvukala esingaphansi kwezigaba zemithi ebizwa ngokuthi i-lymphocyte function-associated antigen-1 (LFA-1) antagonists. Ngamagama alula, yisidakamizwa esikhethekile esivimba izimpawu ezithile zesimiso somzimba sokuzivikela ezifaka isandla ekuvuvukaleni kwamehlo nokoma.

Ngokungafani nezinyembezi ezingokoqobo ezingezi nje umswakama emehlweni akho, i-lifitegrast empeleni isebenza ukuthulisa inqubo yokuvuvukala ebangela izimpawu zakho zamehlo omile. Cabanga ngayo njengokwelapha inkinga eyisisekelo kunokumane imboze izimpawu.

Lesi sidakamizwa siza njengesixazululo esicacile, esingenazo izinto ezingcolile ozisebenzisa ngqo emehlweni akho usebenzisa amabhodlela okusetshenziswa kanye. Ibhodlela ngalinye liqukethe umthamo owodwa ngqo, okusiza ukuvimbela ukungcola futhi kuqinisekisa ukuthi uthola inani elifanele lomuthi.

Yini i-Lifitegrast Esetshenziselwa Yona?

I-Lifitegrast isetshenziswa ikakhulukazi ukwelapha isifo samehlo esomile, esaziwa nangokuthi i-keratoconjunctivitis sicca. Lesi simo senzeka lapho amehlo akho engakhiqizi izinyembezi ezinganele noma lapho izinyembezi zihwamuka ngokushesha kakhulu, zishiye amehlo akho ezizwa omile, enezinto eziqhumayo, futhi engakhululekile.

Udktela wakho angase akunikeze i-lifitegrast uma uhlangabezana nezimpawu eziqhubekayo ezingathuthukiswanga ngezinyembezi ezingokwenziwa noma ezinye izindlela zokwelapha eziyisisekelo. Lezi zimpawu zivame ukuhlanganisa umuzwa wokuba nesihlabathi emehlweni akho, ukusha noma ukuluma, ububomvu, futhi ngezinye izikhathi ngisho nokukhalisa ngokweqile njengoba amehlo akho ezama ukubuyisela ukoma.

Umuthi wenzelwe ngqo isifo samehlo esomile esiphakathi nendawo kuya kwesinzima lapho ukuvuvukala kudlala indima ebalulekile. Lusizo ikakhulukazi kubantu abamehlo abo omile abangelwa izimo ezinjenge-Sjögren's syndrome, ukungasebenzi kahle kwegland ye-meibomian, noma ezinye izimo ezivuvukalayo ezithinta ubuso bemehlo.

Isebenza Kanjani I-Lifitegrast?

I-Lifitegrast isebenza ngokuvimba izindlela ezithile zesimiso somzimba sokuzivikela ezifaka isandla ekuvuvukeni kwamehlo. Iqondise into ebizwa nge-LFA-1, okuyiphrotheni esiza amaseli omzimba okuzivikela ukuthi anamathele futhi alimaze ubuso bamehlo akho ngesikhathi sokusabela okuvuvukalayo.

Lapho ukuvuvukala kwenzeka emehlweni akho, amaseli athile omzimba okuzivikela aba namandla ngokweqile futhi aqale ukuhlasela izicubu zamehlo ezinempilo. I-Lifitegrast isebenza njengebuleki elithambile kule nqubo, ivimbela la maseli omzimba okuzivikela ukuthi angabangeli umonakalo owengeziwe kumaglands akho akhiqiza izinyembezi kanye nobuso bemehlo.

Lo muthi uthathwa njengonamandla ngokulinganisela mayelana nemiphumela yawo yokulwa nokuvuvukala. Iqondiswe ngokuqondile kunezidakamizwa ezijwayelekile zokulwa nokuvuvukala, okusho ukuthi ingasebenza ngenkathi ngokuvamile ibangela imiphumela emibi embalwa kunezidakamizwa ezinamandla. Abantu abaningi baqala ukuqaphela ukuthuthuka ezimpawini zabo phakathi kwamasonto angu-2-4 okusetshenziswa njalo.

Kufanele Ngiyithathe Kanjani I-Lifitegrast?

I-Lifitegrast kufanele isetshenziswe ngendlela eqondile njengoba kunqunywe udokotela wakho wamehlo, ngokuvamile ithonsi elilodwa esweni ngalinye elithintekile kabili ngosuku, cishe amahora angu-12 ngaphandle. Umuthi uza ngamabhodlela amancane, asetshenziswa kanye kuphela okudingeka ukuwavula ngamathonsi amasha ngalinye.

Nakhu ukuthi ungafaka kanjani amaconsi ngokuphepha nangempumelelo:

1. Geza izandla zakho kahle ngaphambi kokuthinta umuthi
2. Susa amalensi uma uwagqoka (lindela okungenani imizuzu engu-15 ngemuva kokusebenzisa amaconsi ngaphambi kokuwabuyisela)
3. Vula ibhodlela elisha ngokusonta phezulu
4. Thambisa ikhanda lakho kancane bese udonsa kancane isihlathi sakho esiphansi
5. Bamba ibhodlela ngaphezu kweso lakho bese ulikhamisa kancane ukuze ukhulule ithonsi elilodwa
6. Vala iso lakho cishe imizuzwana engama-30 ukusiza umuthi ukuthi usabalale
7. Lahla ibhodlela ngemuva kokusebenzisa, noma ngabe kukhona umuthi osele

Ungasebenzisa i-lifitegrast ngaphandle noma ngaphandle kokudla, njengoba isetshenziswa ngqo emehlweni akho kunokuthathwa ngomlomo. Uma udinga ukusebenzisa eminye imithi yamehlo, linda okungenani imizuzu emi-5 phakathi kwamaconsi ahlukene ukuwavimbela ukuthi angagezani.

Zama ukusebenzisa imithamo yakho cishe ngesikhathi esifanayo nsuku zonke ukuze ugcine amazinga aqhubekayo omuthi emehlweni akho. Abantu abaningi bakuthola kuwusizo ukuxhuma imithamo yabo emisebenzini yansuku zonke efana nokuxubha amazinyo ekuseni nakusihlwa.

Ngingayithatha isikhathi esingakanani i-Lifitegrast?

Ubude bokwelashwa nge-lifitegrast buhlukahluka kumuntu nomuntu, kodwa abantu abaningi badinga ukuyisebenzisa okungenani izinyanga ezi-3-6 ukuze babone ukuthuthuka okukhulu ezimpawini zamehlo abo omile. Abanye abantu bangase badinge ukuyisebenzisa isikhathi eside ukuze bagcine imiphumela yabo.

Udokotela wakho wamehlo ngokuvamile uzofuna ukukubona ngemuva kwamasonto angama-6-8 okwelashwa ukuze ahlulele ukuthi umuthi usebenza kahle kangakanani kuwe. Ngesikhathi salokhu kuvakasha, bazohlola ukuthuthuka ezimpawini zakho futhi bahlole amehlo akho ukuze babone ukuthi ukuvuvukala kuyancipha yini.

Kubalulekile ukuqhubeka nokusebenzisa i-lifitegrast noma ngabe awuboni ukuthuthuka ngokushesha. Ngokungafani nezinyembezi zokwenziwa ezinikeza ukukhululeka okusheshayo, imithi elwa nokuvuvukala efana ne-lifitegrast isebenza kancane kancane ukubhekana nezimbangela eziyisisekelo zamehlo akho omile. Abantu abaningi baqala ukuzwa izinzuzo eziphawulekayo ngemuva kwamasonto ama-2-4 okusetshenziswa okuqhubekayo.

Ungayeki ukusebenzisa i-lifitegrast ngokuzumayo ngaphandle kokukhuluma nodokotela wakho kuqala. Uma uyeka umuthi ngokuzumayo, izimpawu zakho zamehlo omile zingase zibuye njengoba ukuvuvukala kubuya.

Yiziphi Izimo Ezingezinhle Ze-Lifitegrast?

Abantu abaningi bayayibekezelela i-lifitegrast kahle, kodwa njengayo yonke imithi, ingabangela imiphumela engemihle kwabanye abantu. Imiphumela engemihle evame kakhulu ngokuvamile ithambile futhi ivame ukuthuthuka njengoba amehlo akho ejwayela umuthi.

Nawa ama-side effects avame ukubikwa kakhulu:

• Ukusha okwesikhashana noma ukugwaza uma uqala ukufaka amaconsi
• Ukubona okungacacile imizuzu embalwa ngemva kokufaka
• Ukuqubuka kwamehlo noma ububomvu
• Ukunambitheka okungavamile emlonyeni wakho (lokhu kwenzeka ngoba umuthi ungahamba ngamashubhu ezinyembezi zakho)
• Ikhanda
• Ukunyuka kwezinyembezi ekuqaleni

Le miphumela engemihle evamile ivame ukungabonakali njengoba uqhubeka usebenzisa umuthi. Umuzwa wokusha, ikakhulukazi, uvame ukwehla kakhulu ngemva kwezinsuku ezimbalwa zokusetshenziswa.

Imiphumela engemihle engavamile kodwa ebucayi ingahlanganisa ubuhlungu obukhulu emehlweni, izinguquko ekuboneni, noma izimpawu zokungezwani komzimba nezinto ezithile njengokuvuvukala eduze kwamehlo akho, ubunzima bokuphefumula, noma ukuqubuka okusabalalele. Uma uhlangabezana nanoma yiziphi zalezi zimpawu, xhumana nodokotela wakho ngokushesha.

Abanye abantu bangase futhi bahlangabezane nokukhipha emehlweni abo noma ukwanda kokuzwela ekukhanyeni. Nakuba lokhu kungabi yingozi, kungase kungakhululeki futhi kufanele kuxoxwe nomhlinzeki wakho wokunakekelwa kwamehlo.

Ubani Ongafanele Athathwe I-Lifitegrast?

I-Lifitegrast ayifanele wonke umuntu, futhi udokotela wakho uzocabangela izici eziningana ngaphambi kokuyinika. Umuthi ngokuvamile awunconyelwe abantu abaye babonisa ukungezwani komzimba nezinto ezithile ku-lifitegrast noma kunoma yiziphi izithako zayo.

Kufanele utshele udokotela wakho uma unanoma yiziphi izimo ezilandelayo ngaphambi kokuqala i-lifitegrast:

• Izifo zamehlo ezisebenzayo (amagciwane, amagciwane, noma isikhunta)
• Ukuhlinzwa kwamehlo kwakamuva noma ukulimala
• Ukukhulelwa noma izinhlelo zokukhulelwa
• Ukuncelisa
• Ezinye izimo zamehlo ezingathi sína ezingaphezu kwesifo samehlo esomile

Ukuvikeleka kwe-lifitegrast ngesikhathi sokukhulelwa nokuncelisa akukamiswanga ngokugcwele, ngakho udokotela wakho uzolinganisela izinzuzo ezingaba khona ngokumelene nanoma yiziphi izingozi ezingenzeka. Uma uzama ukukhulelwa noma uthola ukuthi ukhulelwe ngenkathi usebenzisa i-lifitegrast, xoxa ngalokhu nomhlinzeki wakho wezempilo ngokushesha.

Izingane nentsha engaphansi kweminyaka engu-18 akufanele isebenzise i-lifitegrast, njengoba ukuphepha kwayo nokusebenza kahle kungakamiswanga emaqenjini amancane obudala. Umuthi uvunyelwe ngokuqondile ukusetshenziswa ngabantu abadala kuphela.

Amagama Omkhiqizo we-Lifitegrast

I-Lifitegrast itholakala ngaphansi kwegama lomkhiqizo elithi Xiidra, elikhiqizwa yi-Novartis. Okwamanje le yilona kuphela uhlobo lomkhiqizo we-lifitegrast olutholakala e-United States.

I-Xiidra iza ngamabhodlela okusetshenziswa kanye aqukethe isixazululo se-lifitegrast esingu-5%. Ibhokisi ngalinye ngokuvamile liqukethe amabhodlela angama-60, okuhlinzeka ngesamba senyanga eyodwa uma isetshenziswa kabili ngosuku njengoba kunqunyiwe.

Izinhlobo ze-generic ze-lifitegrast azikatholakali okwamanje, okusho ukuthi i-Xiidra iyona kuphela inketho yalo muthi othile. Kodwa-ke, umshwalense wakho kungenzeka ukuthi unezinye izindlela ezingcono noma udokotela wakho angase asikisele ezinye izindlela zokwelapha iso elomile uma izindleko ziyinkinga.

Ezinye izindlela ze-Lifitegrast

Uma i-lifitegrast ingakulungele noma inganikezi ukukhululeka okwanele, kunezindlela eziningana zokwelapha ezingenye ezitholakalayo zesifo samehlo esomile. Udokotela wakho wamehlo angakusiza ukuthi uhlole lezi zinketho ngokusekelwe ezimpawini zakho ezithile nezidingo zakho.

Ezinye izidakamizwa zamehlo ezinqunyiwe zamehlo omile zihlanganisa:

• I-Cyclosporine (Restasis) - enye ithonsi elilwa nokuvuvukala elisebenza ngendlela ehlukile kune-lifitegrast
• I-Varenicline (Tyrvaya) - isifutho sekhala esikhuthaza ukukhiqizwa kwezinyembezi
• I-Cequa - ifomula entsha ye-cyclosporine

Ezinye izindlela ezingadingi ukubhala incwadi kadokotela zihlanganisa izinyembezi zokwenziwa ezingenazo izinto ezivimbela ukubola, izinto ezifudumele, izithasiselo ze-omega-3 fatty acid, kanye nezinguquko zokuphila njengokusebenzisa i-humidifier noma ukuphumula esikhathini esichithwa phambi kwesikrini.

Abanye abantu bayazuza ezinqubweni ezinjengama-punctal plugs, okuyizinto ezincane ezifakwa emiseleni yezinyembezi ukusiza ukugcina umswakama emehlweni. Udokotela wakho angase futhi ancome ukwelapha izimo ezingaphansi njenge-blepharitis noma ukungasebenzi kahle kwe-meibomian gland.

Ingabe i-Lifitegrast Ingcono Kune-Cyclosporine?

Kokubili i-lifitegrast ne-cyclosporine ziyizindlela zokwelapha ezisebenzayo zesifo samehlo omile, kodwa zisebenza ngezindlela ezihlukene futhi zingase zifaneleke kangcono kubantu abahlukene. Akukho imithi eyodwa engcono kunenye - ukukhetha kuncike esimweni sakho.

I-Lifitegrast ivame ukusebenza ngokushesha kune-cyclosporine, nabantu abaningi beqaphela ukuthuthuka phakathi kwamasonto angu-2-4 uma kuqhathaniswa nezinyanga ezingu-3-6 nge-cyclosporine. Kodwa-ke, i-cyclosporine itholakale isikhathi eside futhi inemininingwane eminingi yokuphepha yesikhathi eside.

Abanye abantu basabela kangcono emuthini owodwa kunomunye, futhi ngezinye izikhathi odokotela bangase bancomise ukusebenzisa zombili ndawonye ezimweni ezinzima. Amaphrofayili emiphumela emibi ahlukile kancane - i-lifitegrast ivame kakhulu ukubangela izinguquko zokunambitheka, kuyilapho i-cyclosporine ingase ibangele ukusha okwengeziwe ekuqaleni.

Udokotela wakho wamehlo uzocabangela izinto ezinjengobunzima bamehlo akho omile, umlando wakho wezokwelapha, eminye imithi oyithathayo, kanye nomshwalense wakho lapho enquma ukuthi yikuphi ukwelashwa okungase kusebenze kangcono kuwe.

Imibuzo Evame Ukubuzwa Mayelana ne-Lifitegrast

Umbuzo 1. Ingabe i-Lifitegrast Iphephile Ku-Diabetes?

I-Lifitegrast ngokuvamile iphephile kubantu abanesifo sikashukela, njengoba isetshenziswa ngokuqondile emehlweni futhi okuncane kakhulu okuthathwa egazini lakho. Kodwa-ke, abantu abanesifo sikashukela basengozini enkulu yezinkinga ezihlukahlukene zamehlo, ngakho-ke kubalulekile ukuba nezivivinyo zamehlo ezivamile.

Uma unesifo sikashukela, udokotela wakho wamehlo uzofuna ukukuqapha eduze ngenkathi usebenzisa i-lifitegrast ukuqinisekisa ukuthi impilo yakho yamehlo iyonke ihlala izinzile. Iso elomile elinobuhlungu besifo sikashukela ngezinye izikhathi lingaba nzima kakhulu ukuliphatha, ngakho-ke udokotela wakho angase ancome ukwelashwa okwengeziwe kanye ne-lifitegrast.

Umbuzo 2. Kufanele Ngenzeni Uma Ngisebenzisa I-Lifitegrast Eningi Ngengozi?

Uma ngengozi usebenzisa amaconsi angaphezu kwelilodwa noma usebenzisa umthamo owengeziwe, ungesabi. Vele ugeze amehlo akho ngamanzi ahlanzekile bese uqhubeka neshejuli yakho ejwayelekile yokulinganisa. Ukusebenzisa i-lifitegrast eningi ngezikhathi ezithile akunakwenzeka ukuthi kubangele izinkinga ezinkulu.

Ungase uhlangabezane nemiphumela engemihle eyandisiwe efana nokusha noma umbono ongacacile, kodwa lokhu kufanele kulungiswe ngokwako. Uma ukhathazekile noma uhlangabezana nezimpawu ezinzima, xhumana nodokotela wakho wamehlo noma usokhemisi ukuze uthole isiqondiso.

Umbuzo 3. Kufanele Ngenzeni Uma Ngedlula Umthamo We-Lifitegrast?

Uma udlula umthamo we-lifitegrast, uyisebenzise ngokushesha lapho ukhumbula, ngaphandle uma sekuseduze isikhathi somthamo wakho olandelayo ohleliwe. Kulokho, weqa umthamo odlulisiwe bese uqhubeka neshejuli yakho ejwayelekile - ungaqedi imithamo.

Zama ukugcina ishejuli eqhubekayo ngangokunokwenzeka ukuze uthole imiphumela engcono kakhulu. Uma uvame ukukhohlwa imithamo, cabanga ukusetha ama-alamu ocingo noma usebenzise uhlelo lokusebenza lokukhumbuza imithi ukukusiza ukuthi uhlale endleleni.

Umbuzo 4. Ngingayeka Nini Ukuthatha I-Lifitegrast?

Kufanele uyeke kuphela ukuthatha i-lifitegrast ngemva kokuxoxa ngayo nodokotela wakho wamehlo. Abantu abaningi badinga ukuqhubeka beyisebenzisa isikhathi eside ukuze bagcine ngcono izimpawu zamehlo omile.

Uma wena nodokotela wakho ninquma ukuyeka i-lifitegrast, kungase kudingeke ukuthi unciphise kancane kancane noma ube nokwelashwa okuhlukile okulungile. Ukuyeka kungazelelwe kungaholela ekubuyeni kwezimpawu zakho zamehlo omile njengoba imiphumela yokulwa nokuvuvukala iphela.

Umbuzo 5. Ngingagqoka yini amalensi okuxhumana ngenkathi ngisebenzisa i-Lifitegrast?

Ungagqoka iilensi zokuxhumana ngenkathi usebenzisa i-lifitegrast, kodwa uzodinga ukuzisusa ngaphambi kokusebenzisa amaconsi bese ulinda okungenani imizuzu eyi-15 ngaphambi kokuzifaka futhi. Lesi sikhathi sokulinda siqinisekisa ukuthi umuthi unethuba lokusebenza ngaphandle kokumuncwa yiilensi zakho zokuxhumana.

Abanye abantu bathola ukuthi ukubekezelelana kwabo ngama-lens okuxhumana kuyathuthuka ngempela ngenkathi besebenzisa i-lifitegrast, njengoba umuthi usiza ukunciphisa ukuvuvukala okwenza ukugqoka ama-lens kungakhululeki. Kodwa-ke, ngaso sonke isikhathi landela izincomo eziqondile zikadokotela wakho wamehlo mayelana nokusetshenziswa kwama-lens okuxhumana ngesikhathi sokwelashwa.